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Linda Sharples; Matthew Glover; Abigail Clutterbuck-James; Maxine Bennett; Jake Jordan; Rebecca Chadwick; Marcus Pittman; Clare East; Malcolm Cameron; Mike Davies; Nick Oscroft; Ian Smith; Mary Morrell; Julia Fox-Rushby; Timothy Quinnell

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Sharples L, Glover M, Clutterbuck-James A, et al. Clinical effectiveness and cost-effectiveness results from the randomised controlled Trial of Oral Mandibular Advancement Devices for Obstructive sleep apnoea–hypopnoea (TOMADO) and long-term economic analysis of oral devices and continuous positive airway pressure. Southampton (UK): NIHR Journals Library; 2014 Oct. (Health Technology Assessment, No. 18.67.)

Cover of Clinical effectiveness and cost-effectiveness results from the randomised controlled Trial of Oral Mandibular Advancement Devices for Obstructive sleep apnoea–hypopnoea (TOMADO) and long-term economic analysis of oral devices and continuous positive airway pressure

Clinical effectiveness and cost-effectiveness results from the randomised controlled Trial of Oral Mandibular Advancement Devices for Obstructive sleep apnoea–hypopnoea (TOMADO) and long-term economic analysis of oral devices and continuous positive airway pressure.

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A&E: accident and emergency
AASM: American Academy of Sleep Medicine
AE: adverse event
AHI: apnoea–hypopnoea index
aMAD: adjustable mandibular advancement device
APAP: auto-adjusting positive airway pressure
AR: adverse reaction
bMAD: bespoke mandibular advancement device
BMI: body mass index
BP: blood pressure
CEAC: cost-effectiveness acceptability curve
CEAF: cost-effectiveness acceptability frontier
CHD: coronary heart disease
CI: confidence interval
CM: conservative management
CPAP: continuous positive airway pressure
CVD: cardiovascular disease
CVE: cardiovascular event
DBP: diastolic blood pressure
DI: desaturation index
DMEC: Data Monitoring and Ethics Committee
EDS: excessive daytime sleepiness
EEG: electroencephalography
EQ-5D-3L: European Quality of Life-5 Dimensions 3-level version
ESS: Epworth Sleepiness Scale
FOSQ: Functional Outcomes of Sleep Questionnaire
GP: general practitioner
HR: hazard ratio
HRQoL: health-related quality of life
HTA: Health Technology Assessment
ICER: incremental cost-effectiveness ratio
INMB: incremental net monetary benefit
IQR: interquartile range
MAD: mandibular advancement device
MCS: mental component scales
MeSH: medical subject heading
MSLT: multiple sleep latency test
MWT: maintenance of wakefulness test
NICE: National Institute for Health and Care Excellence
ODI: oxygen desaturation index
OR: odds ratio
OSA: obstructive sleep apnoea
OSAH: obstructive sleep apnoea–hypopnoea
OSAHS: obstructive sleep apnoea–hypopnoea syndrome
PCS: physical component scales
PSG: polysomnography
PSSRU: Personal Social Services Research Unit
QALY: quality-adjusted life-year
QoL: quality of life
R&D: research and development
RCT: randomised controlled trial
RDI: respiratory disturbance index
rPSG: respiratory polysomnography
RSSC: Respiratory Support & Sleep Centre
RTA: road traffic accident
SAE: serious adverse event
SAQLI: Short Calgary Sleep Apnoea Quality of Life Index
SBP: systolic blood pressure
SD: standard deviation
SE: standard error
SF-36: Medical outcomes study 36-item short form
SF-6D: Short Form questionnaire-6 Dimensions
SP1: SleepPro 1
SP2: SleepPro 2
SpO₂: oxygen saturation
TOMADO: Trial of Oral Mandibular Advancement Devices for Obstructive sleep apnoea–hypopnoea
VAS: visual analogue scale
WTP: willingness to pay

Copyright © Queen’s Printer and Controller of HMSO 2014. This work was produced by Sharples et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.

Included under terms of UK Non-commercial Government License.

Bookshelf ID: NBK262706

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Sharples L, Glover M, Clutterbuck-James A, et al. Clinical effectiveness and cost-effectiveness results from the randomised controlled Trial of Oral Mandibular Advancement Devices for Obstructive sleep apnoea–hypopnoea (TOMADO) and long-term economic analysis of oral devices and continuous positive airway pressure. Southampton (UK): NIHR Journals Library; 2014 Oct. (Health Technology Assessment, No. 18.67.) List of abbreviations.
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Clinical effectiveness and cost-effectiveness results from the randomised controlled Trial of Oral Mandibular Advancement Devices for Obstructive sleep apnoea–hypopnoea (TOMADO) and long-term economic analysis of oral devices and continuous positive airway pressure.

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