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O’Donnell A, McParlin C, Robson SC, et al. Treatments for hyperemesis gravidarum and nausea and vomiting in pregnancy: a systematic review and economic assessment. Southampton (UK): NIHR Journals Library; 2016 Oct. (Health Technology Assessment, No. 20.74.)
Treatments for hyperemesis gravidarum and nausea and vomiting in pregnancy: a systematic review and economic assessment.
Show details- 1.
- Niebyl JR. Clinical practice. Nausea and vomiting in pregnancy. N Engl J Med 2010;363:1544–50. 10.1056/NEJMcp1003896. [PubMed: 20942670] [CrossRef]
- 2.
- Jarvis S, Nelson-Piercy C. Management of nausea and vomiting in pregnancy. BMJ 2011;342:d3606. 10.1136/bmj.d3606. [PubMed: 21685438] [CrossRef]
- 3.
- Attard CL, Kohli MA, Coleman S, Bradley C, Hux M, Atanackovic G, et al. The burden of illness of severe nausea and vomiting of pregnancy in the United States. Am J Obstet Gynecol 2002;186:S220–7. 10.1067/mob.2002.122605. [PubMed: 12011890] [CrossRef]
- 4.
- Jueckstock JK, Kaestner R, Mylonas I. Managing hyperemesis gravidarum: a multimodal challenge. BMC Med 2010;8:46. 10.1186/1741-7015-8-46. [PMC free article: PMC2913953] [PubMed: 20633258] [CrossRef]
- 5.
- Trogstad LIS, Stoltenberg C, Magnus P, Skjaerven R, Irgens LM. Recurrence risk in hyperemesis gravidarum. Br J Obstet Gynaecol 2005;112:1641–5. 10.1111/j.1471-0528.2005.00765.x. [PubMed: 16305568] [CrossRef]
- 6.
- Vikanes AV, Skjaerven R, Grijibovski AM, Gunnes N, Vangen S, Magnus P. Recurrence of hyperemesis gravidarum across generations: population based cohort study. BMJ 2010;340:c2050. 10.1097/ogx.0b013e3182021d24. [PMC free article: PMC2862151] [PubMed: 21030362] [CrossRef]
- 7.
- Derbent AU, Yanik FF, Simavli S, Atasoy L, Urun E, Kuscu UE, et al. First trimester maternal serum PAPP-A and free beta-HCG levels in hyperemesis gravidarum. Prenat Diagn 2011;31:450–3. 10.1002/pd.2715. [PubMed: 21360554] [CrossRef]
- 8.
- Goodwin TM, Poursharif B, Korst LM, MacGibbon KW, Romero R, Fejzo MS. Secular trends in the treatment of hyperemesis gravidarum. Am J Perinatol 2008;25:141–7. 10.1055/s-2008-1040344. [PubMed: 18260047] [CrossRef]
- 9.
- Ismail SK, Kenny L. Review on hyperemesis gravidarum. Baillieres Best Pract Res Clin Gastroenterol 2007;21:755–69. 10.1016/j.bpg.2007.05.008. [PubMed: 17889806] [CrossRef]
- 10.
- Yamazaki K, Sato K, Shizume K, Kanaji Y, Ito Y, Obara T, et al. Potent thyrotropic activity of human chorionic gonadotrophin variants in terms of 125I incorporation and de novo synthesized thyroid hormone release in human thyroid follicles. J Clin Endocrinol Metab 1995;80:473–9. [PubMed: 7852507]
- 11.
- Verberg MF, Gillott DJ, Al-Fardan N, Grudzinskas JG. Hyperemesis gravidarum, a literature review. Hum Reprod Update 2005;11:527–39. 10.1093/humupd/dmi021. [PubMed: 16006438] [CrossRef]
- 12.
- Sandven I, Abdelnoor M, Nesheim B-I, Melby KK. Helicobacter pylori infection and hyperemesis gravidarum: a systematic review and meta-analysis of case–control studies. Acta Obstet Gynecol Scand 2009;88:1190–200. 10.3109/00016340903284927. [PubMed: 19900137] [CrossRef]
- 13.
- Saberi F, Sadat Z, Abedzadeh-Kalahroudi M, Taebi M. Acupressure and ginger to relieve nausea and vomiting in pregnancy: a randomized study. Iran Red Crescent Med J 2013;15:854–61. 10.5812/ircmj.12984. [PMC free article: PMC3929824] [PubMed: 24616799] [CrossRef]
- 14.
- Mazzotta P, Maltepe C, Navioz Y, Magee LA, Koren G. Attitudes, management and consequences of nausea and vomiting of pregnancy in the United States and Canada. Int J Gynaecol Obstet 2000;70:359–65. 10.1016/S0020-7292(00)00255-1. [PubMed: 10967171] [CrossRef]
- 15.
- Smith C, Crowther C, Beilby J, Dandeaux J. The impact of nausea and vomiting on women: a burden of early pregnancy. Aust N Z J Obstet Gynaecol 2000;40:397–401. 10.1111/j.1479-828X.2000.tb01167.x. [PubMed: 11194422] [CrossRef]
- 16.
- Poursharif B, Korst LM, MacGibbon KW, Fejzo MS, Romero R, Goodwin TM. Elective pregnancy termination in a large cohort of women with hyperemesis gravidarum. Contraception 2007;76:451–6. 10.1016/j.contraception.2007.08.009. [PubMed: 18061703] [CrossRef]
- 17.
- Tan PC, Zaidi SN, Azmi N, Omar SZ, Khong SY. Depression, anxiety, stress and hyperemesis gravidarum: temporal and case controlled correlates. PLOS ONE 2014;9:e92036. 10.1371/journal.pone.0092036. [PMC free article: PMC3956867] [PubMed: 24637791] [CrossRef]
- 18.
- McCarthy FP, Khashan AS, North RA, Moss-Morris R, Baker PN, Dekker G, et al. A prospective cohort study investigating associations between hyperemesis gravidarum and cognitive behavioural and emotional well-being in pregnancy. PLOS ONE 2011;6:e27678. 10.1371/journal.pone.0027678. [PMC free article: PMC3220681] [PubMed: 22125621] [CrossRef]
- 19.
- Ayyavoo A, Derraik JGB, Hofman PL, Cutfield WS. Hyperemesis gravidarum and long-term health of the offspring. Am J Obstet Gynecol 2014;210:521–5. 10.1016/j.ajog.2013.11.035. [PubMed: 24280249] [CrossRef]
- 20.
- NHS Information Centre. Hospital Episode Statistics for England. In-Patient Statistics – Diagnosis. Leeds: NHS Information Centre; 2012.
- 21.
- Locock L, Alexander J, Rozmovitz L. Women’s responses to nausea and vomiting in pregnancy. Midwifery 2008;24:143–52. 10.1016/j.midw.2006.12.001. [PubMed: 17316935] [CrossRef]
- 22.
- Veenendaal MV, van Abeelen AF, Painter RC, van der Post JA, Roseboom TJ. Consequences of hyperemesis gravidarum for offspring: a systematic review and meta-analysis. BJOG 2011;118:1302–13. 10.1111/j.1471-0528.2011.03023.x. [PubMed: 21749625] [CrossRef]
- 23.
- Bolin M, Akerud H, Cnattingius S, Stephansson O, Wikstrom AK. Hyperemesis gravidarum and risks of placental dysfunction disorders: a population-based cohort study. Br J Obstet Gynaecol 2013;120:541–7. 10.1111/1471-0528.12132. [PMC free article: PMC3613752] [PubMed: 23360164] [CrossRef]
- 24.
- Koren G, Boskovic R, Hard M, Maltepe C, Navioz Y, Einarson A. Motherisk-PUQE (pregnancy-unique quantification of emesis and nausea) scoring system for nausea and vomiting of pregnancy. Am J Obstet Gynecol 2002;186:S228–31. 10.1067/mob.2002.123054. [PubMed: 12011891] [CrossRef]
- 25.
- Koren G, Piwko C, Ahn E, Boskovic R, Maltepe C, Einarson A. Validation studies of the Pregnancy Unique-Quantification of Emesis (PUQE) scores. J Obstet Gynaecol 2005;25:241–4. 10.1080/01443610500060651. [PubMed: 16147725] [CrossRef]
- 26.
- Lacasse A, Rey E, Ferreira E, Morin C, Berard A. Validity of a modified Pregnancy-Unique Quantification of Emesis and Nausea (PUQE) scoring index to asses severity of nausea and vomiting of pregnancy. Am J Obstet Gynecol 2008;198:71.e1 –71.e7. 10.1016/j.ajog.2007.05.051. [PubMed: 18166311] [CrossRef]
- 27.
- Rhodes V, Watson P, Johnson M. Development of reliable and valid measures of nausea and vomiting. Cancer Nurs 1984;7:33–41. 10.1097/00002820-198402000-00003. [PubMed: 6559094] [CrossRef]
- 28.
- Zhou Q, O’Brien B, Soeken K. Rhodes Index of nausea and vomiting-Form 2 in pregnant women. A confirmatory factor analysis. Nurs Res 2001;50:251–7. 10.1097/00006199-200107000-00009. [PubMed: 11480534] [CrossRef]
- 29.
- O’Brien B, Relyea MJ, Taerum T. Efficacy of P6 acupressure in the treatment of nausea and vomiting during pregnancy. Am J Obstet Gynecol 1996;174:708–15. 10.1016/S0002-9378(96)70454-4. [PubMed: 8623811] [CrossRef]
- 30.
- Melzack R, Rosberger Z, Hollingsworth M. New approaches to measuring nausea. CMAJ 1985;133:755–8. [PMC free article: PMC1346462] [PubMed: 4042058]
- 31.
- Lacroix R, Eason E, Melzack R. Nausea and vomiting during pregnancy: a prospective study of its frequency, intensity, and patterns of change. Am J Obstet Gynecol 2000;182:931–7. 10.1016/S0002-9378(00)70349-8. [PubMed: 10764476] [CrossRef]
- 32.
- Swallow BL, Lindow SW, Masson EA, Hay DM. Women with nausea and vomiting in pregnancy demonstrate worse health and are adversely affected by odours. J Obstet Gynaecol 2005;25:544–9. 10.1080/01443610500230783. [PubMed: 16234137] [CrossRef]
- 33.
- Swallow BL, Lindow SW, Masson EA, Hay DM. Development of an instrument to measure nausea and vomiting in pregnancy. J Obstet Gynaecol 2002;22:481–5. 10.1080/0144361021000003582. [PubMed: 12521412] [CrossRef]
- 34.
- Chandra K, Magee L, Einarson A, Koren G. Nausea and vomiting in pregnancy: results of a survey that identified interventions used by women to alleviate their symptoms. J Psychosom Obstet Gynaecol 2003;24:71–5. 10.3109/01674820309042804. [PubMed: 12854391] [CrossRef]
- 35.
- Thomson M, Corbin R, Leung L. Effects of ginger for nausea and vomiting in early pregnancy: a meta-analysis. J Am Board Fam Med 2014;27:115–22. 10.3122/jabfm.2014.01.130167. [PubMed: 24390893] [CrossRef]
- 36.
- Ashkenazi-Hoffnung L, Merlob P, Stahl B, Klinger G. Evaluation of the efficacy and safety of bi-daily therapy with pyridoxine and doxylamine for nausea and vomiting of pregnancy. IMAJ 2013;15:23–6. [PubMed: 23484234]
- 37.
- American Congress of Obstetricians and Gynecologists. American Congress of Obstetricians and Gynecologists (ACOG) practice bulletin #52: nausea and vomiting of pregnancy. Obstet Gynecol 2004;103:803–16. [PubMed: 15051578]
- 38.
- Maina A, Todros T. A novel approach to hyperemesis gravidarum: evaluation by a visual analogue scale score and treatment with transdermal clonidine. Obstetric Medicine 2011;4:156–9. 10.1258/om.2011.110050. [PMC free article: PMC4989646] [PubMed: 27579115] [CrossRef]
- 39.
- Guttuso TJr, Robinson LK, Amankwah KS. Gabapentin use in hyperemesis gravidarum: a pilot study. Early Hum Dev 2010;86:65–6. 10.1016/j.earlhumdev.2009.11.003. [PubMed: 20015600] [CrossRef]
- 40.
- O’Donnell A, Vale L, Moloney E, Muirhead C, Bryant A, Beyer F, et al. A Systematic Review and Economic Modelling of the Relative Clinical- and Cost-Effectiveness of Interventions for Hyperemesis gravidarum. PROSPERO 2013:CRD42013006642 URL: www
.crd.york.ac.uk/PROSPERO /display_record .asp?ID=CRD42013006642 (accessed on 4 September 2014). - 41.
- Vutyavanich T, Wongtra-ngan S, Ruangsri R. Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial. Am J Obstet Gynecol 1995;173:881–4. 10.1016/0002-9378(95)90359-3. [PubMed: 7573262] [CrossRef]
- 42.
- Pongrojpaw D, Somprasit C, Chanthasenanont A. A randomized comparison of ginger and dimenhydrinate in the treatment of nausea and vomiting in pregnancy. J Med Assoc Thai 2007;90:1703–9. [PubMed: 17957907]
- 43.
- Can Gurkan O, Arslan H. Effect of acupressure on nausea and vomiting during pregnancy. Complement Ther Clin Pract 2008;14:46–52. 10.1016/j.ctcp.2007.07.002. [PubMed: 18243942] [CrossRef]
- 44.
- Pham B, Klassen TP, Lawson ML, Moher D. Language of publication restrictions in systematic reviews gave different results depending on whether the intervention was conventional or complementary. J Clin Epidemiol 2005;58:769–76. 10.1016/j.jclinepi.2004.08.021. [PubMed: 16086467] [CrossRef]
- 45.
- GRADE Working Group. Grading quality of evidence and strength of recommendations. BMJ 2004;328:1490–4. 10.1136/bmj.328.7454.1490. [PMC free article: PMC428525] [PubMed: 15205295] [CrossRef]
- 46.
- Higgins J, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration; 2011. URL: www
.cochrane-handbook.org (accessed 16 March 2015). - 47.
- National Collaborating Centre for Methods and Tools. Quality Assessment Tool for Quantitative Studies Method. Hamilton, ON: McMaster University; 2008. URL: www
.nccmt.ca/registry/view/eng/15.html (accessed April 2011). - 48.
- Armijo-Olivio S, Stiles CR, Hagen NA, Biondo PD, Cummings GG. Assessment of study quality for systematic reviews: a comparison of the Cochrane Collaboration Risk of Bias Tool and the Effective Public Health Practice Project Quality Assessment Tool: methodological research. J Eval Clin Pract 2010;18:12–18. 10.1111/j.1365-2753.2010.01516.x. [PubMed: 20698919] [CrossRef]
- 49.
- Thomas BH, Ciliska D, Dobbins M, Micucci S. A process for systematically reviewing the literature: providing the research evidence for public health nursing interventions. Worldviews Evid Based Nurs 2004;1:176–84. 10.1111/j.1524-475X.2004.04006.x. [PubMed: 17163895] [CrossRef]
- 50.
- Guyatt GH, Oxman AD, Kunz R, Brozek J, Alonso-Coello P, Rind D, et al. GRADE guidelines 6. Rating the quality of evidence – imprecision. J Clin Epidemiol 2011;64:1283–93. 10.1016/j.jclinepi.2011.01.012. [PubMed: 21839614] [CrossRef]
- 51.
- Guyatt GH, Oxman AD, Kunz R, Woodcock J, Brozek J, Helfand M, et al. GRADE guidelines 8. Rating the quality of evidence – indirectness. J Clin Epidemiol 2011;64:1303–10. 10.1016/j.jclinepi.2011.04.014. [PubMed: 21802903] [CrossRef]
- 52.
- Guyatt GH, Oxman AD, Kunz R, Woodcock J, Brozek J, Helfand M, et al. GRADE guidelines 7. Rating the quality of evidence – inconsistency. J Clin Epidemiol 2011;64:1294–302. 10.1016/j.jclinepi.2011.03.017. [PubMed: 21803546] [CrossRef]
- 53.
- Guyatt GH, Oxman AD, Montori V, Vist G, Kunz R, Brozek J, et al. GRADE guidelines 5. Rating the quality of evidence – publication bias. J Clin Epidemiol 2011;64:1277–82. 10.1016/j.jclinepi.2011.01.011. [PubMed: 21802904] [CrossRef]
- 54.
- Guyatt GH, Oxman AD, Vist G, Kunz R, Brozek J, Alonso-Coello P, et al. GRADE guidelines 4. Rating the quality of evidence – study limitations (risk of bias). J Clin Epidemiol 2011;64:407–15. 10.1016/j.jclinepi.2010.07.017. [PubMed: 21247734] [CrossRef]
- 55.
- Jones B, Roger J, Lane PW, Lawton A, Fletcher C, Cappelleri JC, et al. Statistical approaches for conducting network meta-analysis in drug development. Pharmaceut Stat 2011;10:523–31. 10.1002/pst.533. [PubMed: 22213533] [CrossRef]
- 56.
- Salanti G, Higgins JP, Ades AE, Ioannidis JP. Evaluation of networks of randomized trials. Stat Methods Med Res 2008;17:279–301. 10.1177/0962280207080643. [PubMed: 17925316] [CrossRef]
- 57.
- Abas MN, Tan PC, Azmi N, Omar SZ. Ondansetron compared with metoclopramide for hyperemesis gravidarum: a randomized controlled trial. Obstet Gynecol 2014;123:1272–9. 10.1097/AOG.0000000000000242. [PubMed: 24807340] [CrossRef]
- 58.
- Adamczak J, Kasdaglis J, Rinehart B, Antebi Y, Wolf E, Terrone D. A prospective randomized trial of solumedrol dose pack vs. Phenergan for the treatment of symptomatic nausea and vomiting in pregnancy. Am J Obstet Gynecol 2007;197:S88. 10.1016/j.ajog.2007.10.292. [CrossRef]
- 59.
- Babaei AH, Foghaha MH. A randomized comparison of vitamin B6 and dimenhydrinate in the treatment of nausea and vomiting in early pregnancy. Iran J Nurs Midwifery Res 2014;19:199–202. [PMC free article: PMC4020031] [PubMed: 24834091]
- 60.
- Basirat Z, Moghadamnia AA, Kashifard M, Sarifi-Razavi A. The effect of ginger biscuit on nausea and vomiting in early pregnancy. Acta Med Iran 2009;47:51–6.
- 61.
- Bayreuther J, Lewith GT, Pickering R. A double–blind cross-over study to evaluate the effectiveness of acupressure at pericardium 6 (P6) in the treatment of early morning sickness (EMS). Complement Ther Med 1994;2:70–6. 10.1016/0965-2299(94)90002-7. [CrossRef]
- 62.
- Belluomini J, Litt RC, Lee KA, Katz M. Acupressure for nausea and vomiting of pregnancy: a randomized, blinded study. Obstet Gynecol 1994;84:245–8. [PubMed: 8041539]
- 63.
- Biswas SC, Dey R, Kamliya GS, Bal R, Hazra A, Tripathi SK. A single-masked, randomized, controlled trial of ginger extract in the treatment of nausea and vomiting of pregnancy. JIMSA 2011;24:167–9.
- 64.
- Bondok RS, El Sharnouby NM, Eid HE, Abd Elmaksoud AM. Pulsed steroid therapy is an effective treatment for intractable hyperemesis gravidarum. Crit Care Med 2006;34:2781–3. 10.1097/01.CCM.0000242156.15757.70. [PubMed: 16957638] [CrossRef]
- 65.
- Capp S, Oliveira L, Carstairs S, You W. Ondansetron versus doxylamine/pyridoxine for treatment of nausea and vomiting in pregnancy: a prospective randomized double-blind trial. Am J Obstet Gynecol 2014;210:S39. 10.1016/j.ajog.2013.10.092. [CrossRef]
- 66.
- Carlsson CP, Axemo P, Bodin A, Carstensen H, Ehrenroth B, Madegard-Lind I, et al. Manual acupuncture reduces hyperemesis gravidarum: a placebo-controlled, randomized, single-blind, crossover study. J Pain Symptom Manage 2000;20:273–9. 10.1016/S0885-3924(00)00185-8. [PubMed: 11027909] [CrossRef]
- 67.
- Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15–20. [PubMed: 17621727]
- 68.
- Diggory PL, Tomkinson JS. Nausea and vomiting in pregnancy. A trial of meclozine dihydrochloride with and without pyridoxine. Lancet 1962;2:370–2. 10.1016/S0140-6736(62)90228-3. [PubMed: 13886359] [CrossRef]
- 69.
- Ditto A, Morgante G, la Marca A, De Leo V. Evaluation of treatment of hyperemesis gravidarum using parenteral fluid with or without diazepam. A randomized study. Gynecol Obstet Invest 1999;48:232–6. 10.1159/000010189. [PubMed: 10592423] [CrossRef]
- 70.
- Ensiyeh J, Sakineh MA. Comparing ginger and vitamin B6 for the treatment of nausea and vomiting in pregnancy: a randomised controlled trial. Midwifery 2009;25:649–53. 10.1016/j.midw.2007.10.013. [PubMed: 18272271] [CrossRef]
- 71.
- Erez S, Schifrin BS, Dirim O. Double-blind evaluation of hydroxyzine as an antiemetic in pregnancy. J Reprod Med 1971;7:35–7. [PubMed: 4948652]
- 72.
- Eftekhari N, Mehralhasani Y. A comparison of ondansetron and promethasin in treating hyperemesis gravidarum. JKUMS 2013;20:354–65.
- 73.
- Evans AT, Samuels SN, Marshall C, Bertolucci LE. Suppression of pregnancy-induced nausea and vomiting with sensory afferent stimulation. J Reprod Med 1993;38:603–6. [PubMed: 8410865]
- 74.
- Fischer-Rasmussen W, Kjaer SK, Dahl C, Asping U. Ginger treatment of hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol 1991;38:19–24. 10.1016/0028-2243(91)90202-V. [PubMed: 1988321] [CrossRef]
- 75.
- Ghahiri AA, Abdi F, Mastoo R, Ghasemi M. The effect of ondansetron and metoclopramide in nausea and vomiting of pregnancy. JIMS 2011;29:259–65.
- 76.
- Ghani RMA, Ibrahim ATA. The effect of aromatherapy inhalation on nausea and vomiting in early pregnancy: a pilot randomized controlled trial. J Nat Sci Res 2013;3:10–22.
- 77.
- Haji Seid Javadi E, Salehi F, Mashrabi O. Comparing the effectiveness of vitamin B6 and ginger in treatment of pregnancy-induced nausea and vomiting. Obstet Gynecol Int 2013;927834. 10.1155/2013/927834. [PMC free article: PMC3819920] [PubMed: 24250336] [CrossRef]
- 78.
- Heazell A, Thorneycroft J, Walton V, Etherington I. Acupressure for the in-patient treatment of nausea and vomiting in early pregnancy: a randomized control trial. Am J Obstet Gynecol 2006;194:815–20. 10.1016/j.ajog.2005.08.042. [PubMed: 16522418] [CrossRef]
- 79.
- Hsu E, Pei V, Shofer FS, Abbuhl SB. A prospective randomized controlled trial of acupressure vs. sham for pregnancy-related nausea and vomiting in the emergency department. Acad Emerg Med 2003;10:437. 10.1197/aemj.10.5.437. [CrossRef]
- 80.
- Jamigorn M, Phupong V. Acupressure and vitamin B6 to relieve nausea and vomiting in pregnancy: a randomized study. Arch Gynecol Obstet 2007;276:245–9. 10.1007/s00404-007-0336-2. [PubMed: 17318558] [CrossRef]
- 81.
- Kashifard M, Basirat Z, Kashifard M, Golsorkhtabar-Amiri M, Moghaddamnia A. Ondansetrone or metoclopromide? Which is more effective in severe nausea and vomiting of pregnancy? A randomized trial double-blind study. Clin Exp Obstet Gynecol 2013;40:127–30. [PubMed: 23724526]
- 82.
- Keating A, Chez RA. Ginger syrup as an antiemetic in early pregnancy. Altern Ther Health Med 2002;8:89–91. [PubMed: 12233808]
- 83.
- Knight B, Mudge C, Openshaw S, White A, Hart A. Effect of acupuncture on nausea of pregnancy: a randomized, controlled trial. Obstet Gynecol 2001;97:184–8. 10.1016/S0029-7844(00)01152-2. [PubMed: 11165579] [CrossRef]
- 84.
- Koren G, Clark S, Hankins GD, Caritis SN, Miodovnik M, Umans JG, et al. Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial. Am J Obstet Gynecol 2010;203:571.e1–7. 10.1016/j.ajog.2010.07.030. [PubMed: 20843504] [CrossRef]
- 85.
- Maina A, Arrotta M, Cicogna L, Donvito V, Mischinelli M, Todros T, et al. Transdermal clonidine in the treatment of severe hyperemesis. A pilot randomised control trial: CLONEMESI. BJOG 2014;121:1556–62. 10.1111/1471-0528.12757. [PubMed: 24684734] [CrossRef]
- 86.
- Maltepe C, Koren G. The management of nausea and vomiting of pregnancy and hyperemesis gravidarum – a 2013 update. J Popul Ther Clin Pharmacol 2013;20:e184–92. [PubMed: 23863612]
- 87.
- Mao ZN, Liang CE. Observation on therapeutic effect of acupuncture on hyperemesis gravidarum. Zhongguo Zhen Jiu 2009;29:973–6. [PubMed: 20088416]
- 88.
- McParlin C, Carrick-Sen D, Steen IN, Taylor P, Robson SC. Hyperemesis in pregnancy study: a randomised controlled trial of midwife-led ‘outpatient’ care. Arch Dis Child Fetal Neonatal Ed 2008;93:Fa9.
- 89.
- Mohammadbeigi R, Shahgeibi S, Soufizadeh N, Rezaiie M, Farhadifar F. Comparing the effects of ginger and metoclopramide on the treatment of pregnancy nausea. Pak J Biol Sci 2011;14:817–20. 10.3923/pjbs.2011.817.820. [PubMed: 22545357] [CrossRef]
- 90.
- Monias M. Evaluation of cyclizine with pyridoxine in vomiting of pregnancy. Mil Med 1957;121:403–4. [PubMed: 13483168]
- 91.
- Naeimi Rad M, Lamyian M, Heshmat R, Jaafarabadi MA, Yazdani S. A randomized clinical trial of the efficacy of KID21 point (youmen) acupressure on nausea and vomiting of pregnancy. Iran Red Crescent Med J 2012;14:697–701. 10.5812/ircmj.2153. [PMC free article: PMC3560537] [PubMed: 23397064] [CrossRef]
- 92.
- Narenji F, Delavar M, Rafiei M. Comparison the effects of the ginger fresh root and vitamin B6 on the nausea and vomiting in pregnancy. IJOGI 2012;15:39–43.
- 93.
- Nelson-Piercy C, Fayers P, Swiet M. Randomised, double-blind, placebo-controlled trial of corticosteroids for the treatment of hyperemesis gravidarum. BJOG 2001;108:9–15. 10.1016/s0306-5456(00)00017-6. [PubMed: 11213010] [CrossRef]
- 94.
- Neri I, Allais G, Schiapparelli P, Blasi I, Benedetto C, Facchinetti F. Acupuncture versus pharmacological approach to reduce Hyperemesis gravidarum discomfort. Minerva Ginecol 2005;57:471–5. [PubMed: 16170293]
- 95.
- Oliveira LG, Capp S, You WB, Carstairs SD. Ondansetron versus doxylamine/pyridoxine for treatment of nausea and vomiting in first trimester pregnancy: a prospective randomized double-blind controlled study. Acad Emerg Med 2013;1:S101. 10.1097/AOG.0000000000000479. [CrossRef]
- 96.
- Ozgoli G, Goli M, Simbar M. Effects of ginger capsules on pregnancy, nausea, and vomiting. J Altern Complement Med 2009;15:243–6. 10.1089/acm.2008.0406. [PubMed: 19250006] [CrossRef]
- 97.
- Pasha H, Behmanesh F, Mohsenzadeh F, Hajahmadi M, Moghadamnia AA. Study of the effect of mint oil on nausea and vomiting during pregnancy. Iran Red Crescent Med J 2012;14:727–30. 10.5812/ircmj.3477. [PMC free article: PMC3560544] [PubMed: 23396673] [CrossRef]
- 98.
- Rosen T, de Veciana M, Miller HS, Stewart L, Rebarber A, Slotnick RN. A randomized controlled trial of nerve stimulation for relief of nausea and vomiting in pregnancy. Obstet Gynecol 2003;102:129–35. 10.1016/S0029-7844(03)00375-2. [PubMed: 12850618] [CrossRef]
- 99.
- Safari HR, Fassett MJ, Souter IC, Alsulyman OM, Goodwin TM. The efficacy of methylprednisolone in the treatment of hyperemesis gravidarum: a randomized, double-blind, controlled study. Am J Obstet Gynecol 1998;179:921–4. 10.1016/S0002-9378(98)70189-9. [PubMed: 9790371] [CrossRef]
- 100.
- Sahakian V, Rouse D, Sipes S, Rose N, Niebyl J. Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: a randomized, double-blind placebo-controlled study. Obstet Gynecol 1991;78:33–6. [PubMed: 2047064]
- 101.
- Smith C, Crowther C, Beilby J. Acupuncture to treat nausea and vomiting in early pregnancy: a randomized controlled trial. Birth 2002;29:1–9. 10.1046/j.1523-536X.2002.00149.x. [PubMed: 11843784] [CrossRef]
- 102.
- Smith C, Crowther C, Willson K, Hotham N, McMillian V. A randomized controlled trial of ginger to treat nausea and vomiting in pregnancy. Obstet Gynecol 2004;103:639–45. 10.1097/01.AOG.0000118307.19798.ec. [PubMed: 15051552] [CrossRef]
- 103.
- Sripramote M, Lekhyananda N. A randomized comparison of ginger and vitamin B6 in the treatment of nausea and vomiting in pregnancy. J Med Assoc Thai 2003;86:846–53. [PubMed: 14649969]
- 104.
- Steele NM, French J, Gatherer-Boyles J, Newman S, Leclaire S. Effect of acupressure by sea-bands on nausea and vomiting of pregnancy. J Obstet Gynecol Neonatal Nurs 2001;30:61–70. 10.1111/j.1552-6909.2001.tb01522.x. [PubMed: 11277163] [CrossRef]
- 105.
- Sullivan CA, Johnson CA, Roach H, Martin RW, Stewart DK, Morrison JC. A pilot study of intravenous ondansetron for hyperemesis gravidarum. Am J Obstet Gynecol 1996;174:1565–8. 10.1016/S0002-9378(96)70607-5. [PubMed: 9065130] [CrossRef]
- 106.
- Tan PC, Khine PP, Vallikkannu N, Omar SZ. Promethazine compared with metoclopramide for hyperemesis gravidarum: a randomized controlled trial. Obstet Gynecol 2010;115:975–81. 10.1097/AOG.0b013e3181d99290. [PubMed: 20410771] [CrossRef]
- 107.
- Tan PC, Yow CM, Omar SZ. A placebo-controlled trial of oral pyridoxine in hyperemesis gravidarum. Gynecol Obstet Invest 2009;67:151–7. 10.1159/000181182. [PubMed: 19077388] [CrossRef]
- 108.
- Tan PC, Norazilah MJ, Omar SZ. Dextrose saline compared with normal saline rehydration of hyperemesis gravidarum: a randomized controlled trial. Obstet Gynecol 2013;121:291–8. 10.1097/AOG.0b013e31827c5e99. [PubMed: 23232754] [CrossRef]
- 109.
- Veciana M, Stewart L, Miller H, Slotnick R, Rebarber A, Rosen T. Multicenter randomized controlled trial of nerve stimulation therapy for the relief of nausea and vomiting in pregnancy. Am J Obstet Gynecol 2001;185:S182. 10.1016/S0002-9378(01)80402-6. [CrossRef]
- 110.
- Vutyavanich T, Kraisarin T, Ruangsri R. Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial. Obstet Gynecol 2001;97:577–82. 10.1016/S0029-7844(00)01228-X. [PubMed: 11275030] [CrossRef]
- 111.
- Werntoft E, Dykes AK. Effect of acupressure on nausea and vomiting during pregnancy. A randomized, placebo-controlled, pilot study. J Reprod Med 2001;46:835–9. [PubMed: 11584487]
- 112.
- Wibowo N, Purwosunu Y, Sekizawa A, Farina A, Tambunan V, Bardosono S. Vitamin B6 supplementation in pregnant women with nausea and vomiting. Int J Gynaecol Obstet 2012;116:206–10. 10.1016/j.ijgo.2011.09.030. [PubMed: 22189065] [CrossRef]
- 113.
- Willetts KE, Ekangaki A, Eden JA. Effect of a ginger extract on pregnancy-induced nausea: a randomised controlled trial. Aust N Z J Obstet Gynaecol 2003;43:139–44. 10.1046/j.0004-8666.2003.00039.x. [PubMed: 14712970] [CrossRef]
- 114.
- Yost NP, McIntire DD, Wians FH Jr, Ramin SM, Balko JA, Leveno KJ. A randomized, placebo-controlled trial of corticosteroids for hyperemesis due to pregnancy. Obstet Gynecol 2003;102:1250–4. 10.1016/j.obstetgynecol.2003.08.013. [PubMed: 14662211] [CrossRef]
- 115.
- Zhang HH. Observation on therapeutic effect of acupuncture and moxibustion on hyperemesis gravidarum. Zhongguo Zhen Jiu 2005;25:469–70. [PubMed: 16309132]
- 116.
- Ziaei S, Hosseiney FS, Faghihzadeh S. The efficacy low dose of prednisolone in the treatment of hyperemesis gravidarum. Acta Obstet Gynecol Scand 2004;83:272–5. 10.1111/j.0001-6349.2004.0141.x. [PubMed: 14995924] [CrossRef]
- 117.
- Maltepe C, Koren G. Preemptive treatment of nausea and vomiting of pregnancy: results of a randomized controlled trial. Obstet Gynecol Int 2013;809787. 10.1155/2013/809787. [PMC free article: PMC3588181] [PubMed: 23476657] [CrossRef]
- 118.
- Smith C, Crowther C, Beilby J. Pregnancy outcome following women’s participation in a randomised controlled trial of acupuncture to treat nausea and vomiting in early pregnancy. Complement Ther Med 2002;10:78–83. 10.1054/ctim.2002.0523. [PubMed: 12481955] [CrossRef]
- 119.
- Biswas SC, Bal R, Kamilya GS, Mukherjee J, Hazra A, Narender S, et al. A single-masked, randomized, controlled trial of ginger extract in the treatment of nausea and vomiting of pregnancy. 49th All India Congress of Obstetrics and Gynaecology: Cochin, Kerala State, India; 6–9 January 2006. URL: http:
//onlinelibrary .wiley.com/o/cochrane /clcentral/articles /832/CN-00582832/frame.html (accessed 28 November 2014). - 120.
- Alalade AO, Khan R, Dawlatly B. Day-case management of hyperemesis gravidarum: feasibility and clinical efficacy. J Obstet Gynaecol 2007;27:363–4. 10.1080/01443610701327396. [PubMed: 17654186] [CrossRef]
- 121.
- Einarson A, Maltepe C, Navioz Y, Kennedy D, Tan MP, Koren G. The safety of ondansetron for nausea and vomiting of pregnancy: a prospective comparative study. BJOG 2004;111:940–3. 10.1111/j.1471-0528.2004.00236.x. [PubMed: 15327608] [CrossRef]
- 122.
- Ferreira E, Bussieres JF, Turcotte V, Duperron L, Ouellet G. Case-control study comparing droperidol plus diphenhydramine with conventional treatment in hyperemesis gravidarum. JPT 2003;19:349–54. 10.1177/875512250301900602. [CrossRef]
- 123.
- Hsu JJ, Clark-Glena R, Nelson DK, Kim CH. Nasogastric enteral feeding in the management of hyperemesis gravidarum. Obstet Gynecol 1996;88:343–6. 10.1016/0029-7844(96)00174-3. [PubMed: 8752236] [CrossRef]
- 124.
- Markose MT, Ramanathan K, Vijayakumar J. Reduction of nausea, vomiting, and dry retches with P6 acupressure during pregnancy. Int J Gynaecol Obstet 2004;85:168–9. 10.1016/j.ijgo.2003.09.008. [PubMed: 15099782] [CrossRef]
- 125.
- Moran P, Taylor R. Management of hyperemesis gravidarum: the importance of weight loss as a criterion for steroid therapy. QJM 2002;95:153–8. 10.1093/qjmed/95.3.153. [PubMed: 11865170] [CrossRef]
- 126.
- Saha S, Loranger D, Pricolo V, Degli-Esposti S. Feeding jejunostomy for the treatment of severe hyperemesis gravidarum: a case series. J Parenter Enteral Nutr 2009;33:529–34. 10.1177/0148607109333000. [PMC free article: PMC3640279] [PubMed: 19556608] [CrossRef]
- 127.
- Koren G, Maltepe C. Preemptive Diclectin therapy for the management of nausea and vomiting of pregnancy and hyperemesis gravidarum. Am J Obstet Gynecol 2013;208:S20. 10.1016/j.ajog.2012.10.205. [CrossRef]
- 128.
- Safari HR, Fassett MJ, Souter IC, Goodwin TM. Randomized double-blind trial of methylprednisolone versus promethazine in the treatment of hyperemesis gravidarum. Am J Obstet Gynecol 1998;178:S60.
- 129.
- Yang LC, Jawan B, Chen CN, Ho RT, Chang KA, Lee JH. Comparison of P6 acupoint injection with 50% glucose in water and intravenous droperidol for prevention of vomiting after gynecological laparoscopy. Acta Anaesthesiol Scand 1993;37:192–4. 10.1111/j.1399-6576.1993.tb03699.x. [PubMed: 8447210] [CrossRef]
- 130.
- Evers S, Goossens M, de Vet H, van Tulder M, Ament A. Criteria list for assessment of methodological quality of economic evaluations: consensus on health economic criteria. Int J Technol Assess Health Care 2005;21:240–5. [PubMed: 15921065]
- 131.
- Philips Z, Bojke L, Sculpher M, Claxton K, Golder S. Good practice guidelines for decision-analytic modelling in health technology assessment: a review and consolidation of quality assessment. Pharmacoeconomics 2006;24:355–71. 10.2165/00019053-200624040-00006. [PubMed: 16605282] [CrossRef]
- 132.
- Joint Formulary Committee. British National Formulary. 65th ed. London: BMJ Group and Pharmaceutical Press; 2014.
- 133.
- Department of Health. Payment by Results in the NHS: Tariff for 2012 to 2013. URL: www
.gov.uk/government /publications/confirmation-of-payment-by-results-Pbr-arrangements-for-2012–13 (accessed 28 November 2014). - 134.
- Curtis L. Unit Costs of Health and Social Care 2013. University of Kent: Personal Social Services Research Unit; 2013.
- 135.
- Grimshaw J, Thomas R, MacLennan G, Fraser C, Ramsay C, Vale L, et al. Effectiveness and efficiency of guideline dissemination and implementation strategies. Health Technol Assess 2004;8(6). 10.3310/hta8060. [PubMed: 14960256] [CrossRef]
- 136.
- Portnoi G, Chng L, Karimi-Tabesh L, Koren G, Tan MP, Einarson A. Prospective comparative study of the safety and effectiveness of ginger for the treatment of nausea and vomiting in pregnancy. Am J Obstet Gynecol 2003;190:1140–374. 10.1067/s0002-9378(03)00649-5. [PubMed: 14634571] [CrossRef]
- 137.
- Heitmann K, Nordeng H, Holst L. Safety of ginger use in pregnancy: results from a large population-based cohort study. Eur J Clin Pharmacol 2013;69:269–77. 10.1007/s00228-012-1331-5. [PubMed: 22706624] [CrossRef]
- 138.
- Einarson T, Leeder J, Koren G. A method for metaanalysis of epidemiological studies. Drug Intell Clin Pharm 1988;22:813–24. [PubMed: 3229352]
- 139.
- McKeigue PM, Lamm SH, Linn S, Kutcher JS. Bendectin and birth defects: I. A meta-analysis of the epidemiologic studies. Teratology 1994;50:27–37. 10.1002/tera.1420500105. [PubMed: 7974252] [CrossRef]
- 140.
- Seto A, Einarson T, Koren G. Pregnancy outcome following first trimester exposure to antihistamines: meta-analysis. Am J Perinatol 1997;14:119–24. 10.1055/s-2007-994110. [PubMed: 9259911] [CrossRef]
- 141.
- Mazzotta P, Magee LA. A risk-benefit assessment of pharmacological and nonpharmacological treatments for nausea and vomiting of pregnancy. Drugs 2000;59:781–800. 10.2165/00003495-200059040-00005. [PubMed: 10804035] [CrossRef]
- 142.
- Matok I, Gorodischer R, Koren G, Sheiner E, Wiznitzer A, Levy A. The safety of metoclopramide use in the first trimester of pregnancy. N Engl J Med 2009;360:2528–35. 10.1056/NEJMoa0807154. [PubMed: 19516033] [CrossRef]
- 143.
- Pasternak B, Svanstrom H, Molgaard-Nielsen D, Melbye M, Hviid A. Metoclopramide in pregnancy and risk of major congenital malformations and fetal death. JAMA 2013;310:1601–11. 10.1001/jama.2013.278343. [PubMed: 24129464] [CrossRef]
- 144.
- Anderka M, Mitchell AA, Louik C, Werler MM, Hernandez-Diaz S, Rasmussen SA, et al. Medications used to treat nausea and vomiting of pregnancy and the risk of selected birth defects. Birth Defects Res A Clin Mol Teratol 2012;94:22–30. 10.1002/bdra.22865. [PMC free article: PMC3299087] [PubMed: 22102545] [CrossRef]
- 145.
- Pasternak B, Svanstrom H, Hviid A. Ondansetron in pregnancy and risk of adverse fetal outcomes. N Engl J Med 2013;368:814–23. 10.1056/NEJMoa1211035. [PubMed: 23445092] [CrossRef]
- 146.
- Freedman SB, Uleryk E, Rumantir M, Finkelstein Y. Ondansetron and the risk of cardiac arrhythmias: a systematic review and postmarketing analysis. Ann Emerg Med 2014;64:19–25,e1–6. 10.1016/j.annemergmed.2013.10.026. [PubMed: 24314899] [CrossRef]
- 147.
- Park-Wyllie L, Mazzotta P, Pastuszak A, Moretti M, Beique L, Hunnisett L, et al. Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiological studies. Teratology 2000;62:385–92. 10.1002/1096-9926(200012)62:6<385::AID-TERA5>3.0.CO;2-Z. [PubMed: 11091360] [CrossRef]
- 148.
- Czeizel AE, Rockenbauer M. Population-based case-control study of teratogenic potential of corticosteroids. Teratology 1997;56:335–40. 10.1002/(SICI)1096-9926(199711)56:5<335::AID-TERA7>3.0.CO;2-W. [PubMed: 9451758] [CrossRef]
- 149.
- Tata LJ, Lewis SA, McKeever TM, Smith CJP, Doyle P, Smeeth L, et al. Effect of maternal asthma, exacerbations and asthma medication use on congenital malformations in offspring: a UK population-based study. Thorax 2008;63:981–987. 10.1136/thx.2008.098244. [PubMed: 18678701] [CrossRef]
- 150.
- Guttuso T Jr, Shaman M, Thornburg LL. Potential maternal symptomatic benefit of gabapentin and review of its safety in pregnancy. Eur J Obstet Gynecol Reprod Biol 2014;181:280–3. 10.1016/j.ejogrb.2014.08.013. [PubMed: 25195202] [CrossRef]
- 151.
- McCarthy FP, Murphy A, Khashan AS, McElroy B, Spillane N, Marchocki Z, et al. Day care compared with inpatient management of nausea and vomiting of pregnancy: a randomized controlled trial. Obstet Gynecol 2014;124:743–8. 10.1097/AOG.0000000000000449. [PubMed: 25198263] [CrossRef]
- 152.
- UK Teratology Information Service (UKTIS). Use of Ginger in Pregnancy. London: UKTIS; 2013.
- 153.
- UK Teratology Information Service (UKTIS). Use of Vitamin B12 in Pregnancy. London: UKTIS; 2013.
- 154.
- UK Teratology Information Service (UKTIS). Use of Vitamin B6 in Pregnancy. London: UKTIS; 2011.
- 155.
- UK Teratology Information Service (UKTIS). Use of Promethazine in Pregnancy. London: UKTIS; 2010.
- 156.
- UK Teratology Information Service (UKTIS). Use of Ondansetron in Pregnancy. London: UKTIS; 2014.
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