Clinical effectiveness: database searches
MEDLINE(R) (via Ovid)
Exact database searched: 1946 to October week 2 2014.
Date searched: 22 October 2014.
Search strategy
MEDLINE(R) In-Process & Other Non-Indexed Citations (via Ovid)
Exact database searched: 21 October 2014.
Date searched: 22 October 2014.
Search strategy
EMBASE Classic and EMBASE
Exact database searched: 1947 to 2014 week 42.
Date searched: 22 October 2014.
Search strategy
The Cochrane Library (via Wiley Online Library)
Date searched: 22 October 2014.
Search strategy
All results (49)
- Cochrane reviews (0).
- Other reviews (1).
- Trials (47).
- Methods studies (0).
- Technology assessments (1).
- Economic evaluations (0).
- Cochrane Groups (0).
Science Citation Index and Conference Proceedings – Science (Web of Science)
Date searched: 22 October 2014.
Search strategy
Index to Theses
Date searched: 22 October 2014.
Search strategy
((adalimumab or infliximab or AntiTNF* or Anti-TNF* or “Anti TNF” or “Anti TNFa” or “Anti TNFalpha” or (TNF* w/2 inhibitor*) or (Anti-Tum*r w/2 Necrosis) or (“anti drug” w/2 antibod*) or ADAb) AND (crohn* or “inflammatory bowel disease” or IBD))
Fourteen documents retrieved.
(((adalimumab or infliximab or AntiTNF* or Anti-TNF* or “Anti TNF” or “Anti TNFa” or “Anti TNFalpha” or (TNF* w/2 inhibitor*) or (Anti-Tum*r w/2 Necrosis) or “anti drug antibody” or “anti drug antibodies” or “anti-drug antibody” or “anti-drug antibodies” or ADAb) w/10 (monitor or monitoring or monitors or monitored or pharmacokinetic or pharmacokinetics or measure or measures or measurement or measuring or level or levels or concentration or concentrations)) AND ((correlate* or correlation* or associate* or association* or “test performance”)))
Four documents retrieved.
Digital Access to Research Theses – Europe
Date searched: 28 October 2014.
Search strategy
(adalimumab or infliximab or AntiTNF* or Anti-TNF* or “Anti TNF” or “Anti TNFa” or “Anti TNFalpha” or (TNF* and inhibitor*) or (Anti-Tum*r and Necrosis) or (“anti drug” and antibod*) or ADAb) and (crohn* or “inflammatory bowel disease” or “inflammatory bowel diseases” or IBD)
One hundred and thirteen documents retrieved.
Dissertations and Theses
Date searched: 29 October 2014.
Search strategy
all(((adalimumab or infliximab or AntiTNF* or Anti-TNF* or “Anti TNF” or “Anti TNFa” or “Anti TNFalpha” or (TNF* n/2 inhibitor*) or (Anti-Tum*r n/2 Necrosis) or (“anti drug” n/2 antibod*) or ADAb) AND (crohn* or “inflammatory bowel disease” or “inflammatory bowel diseases” or IBD)))
Twenty-one documents retrieved.
all(((adalimumab or infliximab or AntiTNF* or Anti-TNF* or “Anti TNF” or “Anti TNFa” or “Anti TNFalpha” or (TNF* n/2 inhibitor*) or (Anti-Tum*r n/2 Necrosis) or “anti drug antibody” or “anti drug antibodies” or “anti-drug antibody” or “anti-drug antibodies” or ADAb) n/10 (monitor or monitoring or monitors or monitored or pharmacokinetic or pharmacokinetics or measure or measures or measurement or measuring or level or levels or concentration or concentrations)) and (correlate* or correlation* or associate* or association* or “test performance”))
Fifteen documents retrieved.
National Institute for Health Research Health Technology Assessment programme
Date searched: 29 October 2014.
Search strategy
adalimumab
Sixteen documents retrieved.
infliximab
Twenty-three documents retrieved.
TNF
Seventeen documents retrieved.
PROSPERO
Date searched: 29 October 2014.
Search strategy
adalimumab in All fields
OR
infliximab in All fields
OR
TNF* inhibitor* in All fields
OR
AntiTNF* in All fields
OR
Anti-TNF* in All fields
Twenty-nine records retrieved.
ClinicalTrials.gov
Date searched: 4 November 2014.
Search strategy
Search Terms (any field): adalimumab OR infliximab OR (TNF AND (anti OR inhibitor OR blocker)) OR “anti drug antibody” OR “anti drug antibodies” OR ADAb
AND
Condition: crohn OR “inflammatory bowel disease” OR “inflammatory bowel diseases”
AND
Title: monitor OR pharmacokinetic OR measure OR measuring OR level OR concentration OR assay
Fourteen studies retrieved.
Current Controlled Trials
Date searched: 4 November 2014.
Search strategy
(adalimumab OR infliximab OR TNF* OR AntiTNF* OR Anti-TNF* OR anti drug antibod* OR ADAb) AND (crohn* OR inflammatory bowel disease*) AND (monitor* OR pharmacokinetic* OR measure* OR measuring OR level* OR concentration* OR assay*)
Thirty studies retrieved.
UK Clinical Research Network Portfolio Database
Date searched: 4 November 2014.
Search strategy
Specialty: Gastroenterology
Research Summary: adalimumab infliximab TNF AntiTNF Anti-TNF ADAb
‘Any’ selected (combines terms with Boolean OR)
Four studies retrieved.
World Health Organization’s International Clinical Trials Registry Platform
Date searched: 10 November 2014.
Advanced search
In Title: adalimumab OR infliximab OR AntiTNF* OR Anti-TNF* OR TNF inhibitor* OR TNF-α inhibitor* OR TNF alpha inhibitor* OR TNFalpha inhibitor* OR anti drug antibody OR anti drug antibodies OR ADAb
AND
In Condition: Crohn* OR inflammatory bowel disease*
AND
In Intervention: monitor* OR pharmacokinetic* OR measure* OR measuring OR level* OR concentration* OR assay*
Thirty-nine trials found.
Espacenet (European Patent Office)
Date searched: 10 November 2014.
Advanced search
Applicant(s): Theradiag – 1 result “Methods for detecting antibodies” (relevant)
Applicant(s): Immundiagnostik – 27 results (sifted online, none relevant)
Checked how known Theradiag patent found above is classified and combined the following two most relevant classification numbers:
G01N2333/525 Assays involving biological materials from specific organisms or of a specific nature - Tumor necrosis factor (TNF)
G01N2800/52 Detection or diagnosis of diseases - Predicting or monitoring the response to treatment; Prognosis
Advanced search
Cooperative Patent Classification: G01N2333/525 AND G01N2800/52 – 27 results (browsed for manufacturer’s name, found relevant Proteomika patent)
Sifted online and used ‘Also published as’ to find English language versions
Clinical effectiveness: conference proceedings
Date searched: 22 January 2015.
Specifically looked for studies with clinical outcomes and based on the use of an algorithm (i.e. ‘management’ studies).
European Crohn’s and Colitis Organisation
Abstracts published in Journal of Crohn’s and Colitis
2011–2014 Indexed in EMBASE. Checked and the search of EMBASE has picked them up.
2015 searchable via website
Sifted 2015 online. Five potentially relevant abstracts saved.
Digestive Diseases Week (meeting of the American Gastroenterology Association)
Abstracts in Gastroenterology
2009–2014 Indexed in EMBASE. Checked and the search of EMBASE has picked them up.
Note: Promonitor have sent two abstracts submitted to Digestive Diseases Week May 2015.
British Society of Gastroenterology
Abstracts in Gut.
Indexed in EMBASE (2011, 2012 and 2014). Checked and the search of EMBASE has picked these years up.
Checked 2010 and 2013 via organisation’s website: www.bsg.org.uk/education/meeting/index.html
Searches
infliximab
adalimumab
TNF
Sifted online. Two potentially relevant abstracts saved.
United European Gastroenterology Week
Searched 2013 and 2014 in United European Gastroenterology journal, available via PubMed Central. Not indexed in EMBASE.
Checked via PubMed.
Previous years not available.
American College of Gastroenterology
Meeting abstracts in American Journal of Gastroenterology.
2010–13 indexed in EMBASE. Checked and the search of EMBASE has picked them up.
2014 conference website says ‘All abstracts submitted will be published in a supplement to the October 2014 issue of The American Journal of Gastroenterology.’ Check via journal website: www.nature.com/ajg/journal/v109/n2s/pdf/ajg2014281a.pdf
Searches
infliximab
adalimumab
TNF
2014 sifted online – no ‘management’ studies with clinical outcomes based on use of an algorithm.
Clinical effectiveness: websites
Searched on 2 February 2015.
European Crohn’s and Colitis Organisation
URL: www.ecco-ibd.eu
Browsed consensus statements for Crohn’s Disease, Publications and Research Projects.
No additional ‘management’ studies identified.
The American Gastroenterology Association
URL: www.gastro.org
Browsed: ‘Technical Reviews’.
Browsed: Research > Research Resource Library > Immunology, Microbiology and IBD.
No additional ‘management’ studies identified.
British Society of Gastroenterology
URL: www.bsg.org.uk
Browsed: ‘Research’ and ‘Clinical’ sections.
No additional ‘management’ studies identified.
United European Gastroenterology
URL: www.ueg.eu
Browsed: ‘Research’ section.
No additional ‘management’ studies identified.
American College of Gastroenterology
URL: http://gi.org
Browsed: ‘Research and Awards’ and ‘Clinical Guidelines’ sections.
No additional ‘management’ studies identified.
International Network of Agencies for Health Technology Assessment publication
URL: www.inahta.org
Searched within publications for:
infliximab
adalimumab
TNF
No additional ‘management’ studies identified.
US Food and Drug Administration medical devices
URL: www.fda.gov/MedicalDevices/ProductsandMedicalProcedures
Searched for:
infliximab
adalimumab
TNF
Filtered by topic to limit to ‘Medical Devices’.
No additional ‘management’ studies identified.
European Commission medical devices
URL: http://ec.europa.eu/growth/sectors/medical-devices
Searches
infliximab
adalimumab
TNF
No additional ‘management’ studies identified.
Theradiag
URL: www.theradiag.com/en
Browsed Theranostics > LISA-TRACKER
Saved and sifted list of publications for LISA-TRACKER assays. No additional ‘management’ studies identified.
Immundiagnostik
URL: www.immundiagnostik.com/en
Browsed website.
No specific lists of publications, but manuals for relevant assays contain references. The manuals have been sent with other information from manufacturer and references already sifted.
Proteomika
URL: www.proteomika.com
Browsed website.
Brochure has a list of references. Sifted. No additional ‘management’ studies identified.
Cost-effectiveness: searches for published cost-effectiveness studies
MEDLINE(R) (via Ovid)
Exact database searched: 1946 to October week 3 2014.
Date searched: 12 December 2014.
Search strategy
MEDLINE(R) In-Process & Other Non-Indexed Citations (via Ovid)
Exact database searched: 11 December 2014.
Date searched: 16 December 2014.
Search strategy
EMBASE Classic and EMBASE (via Ovid)
Exact database searched: 1947 to 15 December 2014.
Date searched: 16 December 2014.
Search strategy
NHS Economic Evaluation Database (via The Cochrane Library)
Date searched: 17 December 2014.
Science Citation Index 1970 – present (via Web of Knowledge)
Date searched: 17 December 2014.
Search strategy
Cost-effectiveness Analysis Registry
Date searched: 17 December 2014.
Search strategy
Search for: Articles
Full Search Contents: crohn
Total: 24
Search for: Articles
Full Search Contents: inflammatory bowel disease
Total: 6
Total with duplicates from search above removed: 5
Total: 29
EconPapers (research papers in economics)
Date searched: 17 December 2014.
Search strategy
crohn* OR inflammatory bowel disease* among working papers and articles and books & chapters and software and authors (25)
School of Health and Related Research Health Utilities Database
Date searched: 17 December 2014.
Search strategy
crohn* in Any field
OR
inflammatory bowel disease* in Any field
Total: 1.
Publication Details
Copyright
Included under terms of UK Non-commercial Government License.
Publisher
NIHR Journals Library, Southampton (UK)
NLM Citation
Freeman K, Connock M, Auguste P, et al. Clinical effectiveness and cost-effectiveness of use of therapeutic monitoring of tumour necrosis factor alpha (TNF-α) inhibitors [LISA-TRACKER® enzyme-linked immunosorbent assay (ELISA) kits, TNF-α-Blocker ELISA kits and Promonitor® ELISA kits] versus standard care in patients with Crohn’s disease: systematic reviews and economic modelling. Southampton (UK): NIHR Journals Library; 2016 Nov. (Health Technology Assessment, No. 20.83.) Appendix 3, Search strategies.