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Freeman K, Connock M, Auguste P, et al. Clinical effectiveness and cost-effectiveness of use of therapeutic monitoring of tumour necrosis factor alpha (TNF-α) inhibitors [LISA-TRACKER® enzyme-linked immunosorbent assay (ELISA) kits, TNF-α-Blocker ELISA kits and Promonitor® ELISA kits] versus standard care in patients with Crohn’s disease: systematic reviews and economic modelling. Southampton (UK): NIHR Journals Library; 2016 Nov. (Health Technology Assessment, No. 20.83.)

Cover of Clinical effectiveness and cost-effectiveness of use of therapeutic monitoring of tumour necrosis factor alpha (TNF-α) inhibitors [LISA-TRACKER® enzyme-linked immunosorbent assay (ELISA) kits, TNF-α-Blocker ELISA kits and Promonitor® ELISA kits] versus standard care in patients with Crohn’s disease: systematic reviews and economic modelling

Clinical effectiveness and cost-effectiveness of use of therapeutic monitoring of tumour necrosis factor alpha (TNF-α) inhibitors [LISA-TRACKER® enzyme-linked immunosorbent assay (ELISA) kits, TNF-α-Blocker ELISA kits and Promonitor® ELISA kits] versus standard care in patients with Crohn’s disease: systematic reviews and economic modelling.

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Appendix 7Ongoing trials

Ongoing trials using an algorithm to determine treatment change according to test results

TABLE 48

Ongoing trials using an algorithm to direct treatment

Title (acronym)Status; start date; estimated completion dateURL
Pediatric Crohn’s disease AdalImumab Level-based Optimization Treatment (PAILOT)Ongoing – not yet open for participant recruitment; start: November 2014; primary completion due: July 2018http:​//clinicaltrials​.gov/ct2/show/NCT02256462 (accessed 11 November 2014)
A randomized controlled trial investigating tailored treatment with infliximab for active luminal Crohn’s disease (TAILORIX)Ongoing; start: March 2012; primary completion due: June 2015www​.clinicaltrialsregister​.eu/ctr-search​/search?query=eudract​_number:2011-003038-14 (accessed 11 November 2014)
Adjusting infliximab dose in IBD patients in remission, based on infliximab trough levels: the study on Infliximab Levels in IBD patients Steering Treatment, the ILIST pilot (ILIST)Ongoing; start: October 2013; primary completion due: December 2014www​.trialregister.nl​/trialreg/admin/rctview.asp?TC=4067 (accessed 11 November 2014)

Ongoing correlation studies

TABLE 49

Ongoing studies aiming to correlate test results and clinical status

Title (acronym)Status; start date; expected completion dateURL
Anti-TNF-alpha trough level measurements in inflammatory bowel diseaseOngoing; study start: May 2013; study primary completion due: May 2016http:​//clinicaltrials​.gov/ct2/show/NCT02073526 (accessed 11 November 2014)
Improving treatment of inflammatory bowel diseases through better understanding infliximab drug and antibody levels (OPTIMISE)Ongoing; study start: March 2014; study primary completion due: March 2015https:​//clinicaltrials​.gov/ct2/show/NCT01787786 (accessed 11 November 2014)
Personalised anti-TNF therapy in Crohn’s disease (PANTS)Ongoing; currently recruitinghttp://public​.ukcrn.org​.uk/Search/StudyDetail​.aspx?StudyID=14175 (accessed 11 November 2014)
Utilising drug levels and anti-drug antibodies to predict response to treatment in patients with Inflammatory Bowel DiseaseOngoing; start: October 2012www​.clinicaltrialsregister​.eu/ctr-search​/search?query=eudract​_number:2011-006084-22 (accessed 11 November 2014)
Copyright © Queen’s Printer and Controller of HMSO 2016. This work was produced by Freeman et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.

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Bookshelf ID: NBK396025
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