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Richards DA, Rhodes S, Ekers D, et al. Cost and Outcome of BehaviouRal Activation (COBRA): a randomised controlled trial of behavioural activation versus cognitive–behavioural therapy for depression. Southampton (UK): NIHR Journals Library; 2017 Aug. (Health Technology Assessment, No. 21.46.)

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Cost and Outcome of BehaviouRal Activation (COBRA): a randomised controlled trial of behavioural activation versus cognitive–behavioural therapy for depression.

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Acknowledgements

We would like to thank all participants, NHS services, MHWs, therapists and GPs involved in the study and acknowledge the vital contributions of study researchers and administrators in Devon, Durham and Leeds, the PenCTU and the NIHR Clinical Research Network.

Contributions of authors

Professor David A Richards (Professor of Mental Health Services Research) was chief investigator, designed the study, was responsible for its conduct, and contributed to the writing and editing of the report.

Dr Shelley Rhodes (Trial Manager) was responsible for study management and data collection, and contributed to the writing and editing of the report.

Dr David Ekers (Nurse Consultant Primary Care Mental Health/Senior Visiting Research Fellow) designed the study, was responsible for its conduct, and contributed to the writing and editing of the report.

Dr Dean McMillan (Senior Lecturer) designed the study, was responsible for its conduct, and contributed to the writing and editing of the report.

Professor Rod S Taylor (Professor of Health Services Research) designed the study, was responsible for its conduct, undertook data analysis, and contributed to the writing and editing of the report.

Professor Sarah Byford (Professor of Health Economics) designed the study, was responsible for its conduct, undertook data analysis, and contributed to the writing and editing of the report.

Dr Barbara Barrett (Senior Lecturer, Health Services and Population Research) undertook data analysis, and contributed to the writing and editing of the report.

Katie Finning (Associate Research Fellow) was responsible for study management and data collection, undertook data analysis, and contributed to the writing and editing of the report.

Poushali Ganguli (Research Associate, Health Services and Population Research) undertook data analysis, and contributed to the writing and editing of the report.

Dr Fiona Warren (Lecturer in Medical Statistics) undertook data analysis, and contributed to the writing and editing of the report.

Dr Paul Farrand (Associate Professor) designed the study, was responsible for its conduct, and contributed to the writing and editing of the report.

Professor Simon Gilbody (Director of the Mental Health and Addictions Research Group) designed the study, was responsible for its conduct, and contributed to the writing and editing of the report.

Professor Willem Kuyken (Professor of Clinical Psychology) designed the study, was responsible for its conduct, and contributed to the writing and editing of the report.

Dr Heather O’Mahen (Senior Lecturer in Clinical Psychology) designed the study, was responsible for its conduct, and contributed to the writing and editing of the report.

Professor Ed Watkins (Professor of Experimental and Applied Clinical Psychology) designed the study, was responsible for its conduct, and contributed to the writing and editing of the report.

Dr Kim Wright (Senior Lecturer) designed the study, was responsible for its conduct, and contributed to the writing and editing of the report.

Nigel Reed (PPI representative) provided expert advice on PPI, and contributed to the writing and editing of the report.

Emily Fletcher (Trial Manager) was responsible for study management and data collection, and contributed to the writing and editing of the report.

Professor Steven D Hollon (Gertrude Conaway Vanderbilt Professor of Psychology) provided expert advice on clinical aspects of cognitive–behavioural therapy, and contributed to the writing and editing of the report.

Dr Lucy Moore (Research Fellow) undertook data analysis, and contributed to the writing and editing of the report.

Amy Backhouse (Associate Research Fellow) contributed to data collection, and contributed to the writing and editing of the report.

Claire Farrow (Associate Research Fellow) contributed to data collection, and contributed to the writing and editing of the report.

Julie Garry (Associate Research Fellow) contributed to data collection, and contributed to the writing and editing of the report.

Deborah Kemp (Associate Research Fellow) contributed to data collection, and contributed to the writing and editing of the report.

Faye Plummer (Associate Research Fellow) contributed to data collection, and contributed to the writing and editing of the report.

Faith Warner (Associate Research Fellow) contributed to data collection, and contributed to the writing and editing of the report.

Rebecca Woodhouse (Associate Research Fellow) contributed to data collection, and contributed to the writing and editing of the report.

All authors had full access to all of the data (including statistical reports and tables) in the study and can take responsibility for the integrity of the data and the accuracy of the data analysis.

Publications

Rhodes S, Richards DA, Ekers D, McMillan D, Byford S, Farrand PA, et al. Cost and outcome of behavioural activation versus cognitive behaviour therapy for depression (COBRA): study protocol for a randomised controlled trial. Trials 2014;15:29.

Richards DA, Ekers D, McMillan D, Taylor RS, Byford S, Warren FC, et al. Cost and outcome of behavioural activation versus cognitive–behavioural therapy for depression (COBRA): a randomised, controlled, non-inferiority trial. Lancet 2016;388:871–80.

Finning K, Richards DA, Moore L, Ekers D, McMillan D, Farrand PA, et al. Cost and outcome of behavioural activation versus cognitive–behavioural therapy for depression (COBRA): a qualitative process evaluation. BMJ Open 2017;7:e014161.

Data sharing statement

The authors confirm that all data underlying the findings are fully available without restriction. The authors have made the clinical and economic data set available through the University of Exeter’s Institutional Repository – Open Research Exeter (see https://ore.exeter.ac.uk). Access to these data is permitted but controlled through requests made via the repository to the chief investigator (Professor Richards: ku.ca.retexe@sdrahcir.a.d). Although use is permitted, this will be on the basis that the source of the data is acknowledged (including the funder) and it includes reference to the data set ‘handle’.

Disclaimers

This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, NETSCC, the HTA programme or the Department of Health. If there are verbatim quotations included in this publication the views and opinions expressed by the interviewees are those of the interviewees and do not necessarily reflect those of the authors, those of the NHS, the NIHR, NETSCC, the HTA programme or the Department of Health.

Copyright © Queen’s Printer and Controller of HMSO 2017. This work was produced by Richards et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.

Included under terms of UK Non-commercial Government License.

Bookshelf ID: NBK448296

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