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Tappenden P, Carroll C, Hamilton J, et al. Cabozantinib and vandetanib for unresectable locally advanced or metastatic medullary thyroid cancer: a systematic review and economic model. Southampton (UK): NIHR Journals Library; 2019 Feb. (Health Technology Assessment, No. 23.8.)

Cover of Cabozantinib and vandetanib for unresectable locally advanced or metastatic medullary thyroid cancer: a systematic review and economic model

Cabozantinib and vandetanib for unresectable locally advanced or metastatic medullary thyroid cancer: a systematic review and economic model.

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Appendix 1Literature search strategies

Clinical effectiveness studies

Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R)

Date range searched: 1946 to present.

Date searched: 2 November 2016.

#Searches
1exp Thyroid Neoplasms/
2exp Goiter, Nodular/
3(thyr?oid* adj5 (cancer* or neoplas* or carcinoma* or malignan* or tumor* or tumour* or adenocarcinoma*)).mp.
4Thyroid Gland/
5exp Neoplasms/
64 and 5
7or/1-3,6
8exp Carcinoma, medullary/
9(medullary or MTC).mp.
108 or 9
117 and 10
12Randomized controlled trials as Topic/
13Randomized controlled trial/
14Random allocation/
15randomized controlled trial.pt.
16Double blind method/
17Single blind method/
18Clinical trial/
19exp Clinical Trials as Topic/
20controlled clinical trial.pt.
21clinical trial$.pt.
22multicenter study.pt.
23or/12-22
24(clinic$ adj25 trial$).ti,ab.
25((singl$ or doubl$ or treb$ or tripl$) adj (blind$ or mask$)).tw.
26Placebos/
27Placebo$.tw.
28(allocated adj2 random).tw.
29or/24-28
3023 or 29
31Case report.tw.
32Letter/
33Historical article/
3431 or 32 or 33
35exp Animals/
36Humans/
3735 not (35 and 36)
3834 or 37
3930 not 38
40meta-analysis/
41meta-analysis as topic/
42(meta analy* or metanaly* or metaanaly*).ti,ab.
43((systematic* or evidence*) adj3 (review* or overview*)).ti,ab.
44(reference list* or bibliograph* or hand search* or manual search* or relevant journals).ab.
45(search strategy or search criteria or systematic search or study selection or data extraction).ab.
46(search* adj4 literature).ab.
47(medline or pubmed or cochrane or embase or psychlit or psyclit or psychinfo or psycinfo or cinahl or scie nce citation index or bids or cancerlit).ab.
48cochrane.jw.
49((multiple treatment* or indirect or mixed) adj2 comparison*).ti,ab.
50or/40-49
5139 or 50
5211 and 51

Cost-effectiveness studies

Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R)

Date range searched: 1946 to present.

Date searched: 3 November 2016.

#Searches
1exp Thyroid Neoplasms/
2exp Goiter, Nodular/
3(thyr?oid* adj5 (cancer* or neoplas* or carcinoma* or malignan* or tumor* or tumour* or adenocarcinoma*)).mp.
4Thyroid Gland/
5exp Neoplasms/
64 and 5
7or/1-3,6
8exp “Costs and Cost Analysis”/
9Economics/
10exp Economics, Hospital/
11exp Economics, Medical/
12Economics, Nursing/
13exp models, economic/
14Economics, Pharmaceutical/
15exp “Fees and Charges"/
16exp Budgets/
17budget$.tw.
18ec.fs.
19cost$.ti.
20(cost$ adj2 (effective$ or utilit$ or benefit$ or minimi$)).ab.
21(economic$ or pharmacoeconomic$ or pharmaco-economic$).ti.
22(price$ or pricing$).tw.
23(financial or finance or finances or financed).tw.
24(fee or fees).tw.
25(value adj2 (money or monetary)).tw.
26quality-adjusted life years/
27(qaly or qalys).af.
28(quality adjusted life year or quality adjusted life years).af.
29or/8-28
307 and 29

EMBASE

Date range searched: 1974 to 1 November 2016.

Date searched: 3 November 2016.

#Searches
1exp thyroid tumor/
2exp nodular goiter/
3(thyr?oid* adj5 (cancer* or neoplas* or carcinoma* or malignan* or tumor* or tumour* or adenocarcinoma*)).mp.
4thyroid gland/
5exp neoplasm/
64 and 5
7or/1-3,6
8Socioeconomics/
9Cost benefit analysis/
10Cost effectiveness analysis/
11Cost of illness/
12Cost control/
13Economic aspect/
14Financial management/
15Health care cost/
16Health care financing/
17Health economics/
18Hospital cost/
19(fiscal or financial or finance or funding).tw.
20Cost minimization analysis/
21(cost adj estimate$).mp.
22(cost adj variable$).mp.
23(unit adj cost$).mp.
24or/8-23
257 and 24

Web of Science Core Collection

Science Citation Index Expanded (1900–).

Conference Proceedings Citation Index – Science (1990–).

Date searched: 3 November 2016.

#Searches
#1TOPIC: ((thyr*oid* NEAR/5 (cancer* or neoplas* or carcinoma* or malignan* or tumor* or tumour* or adenocarcinoma*)))
#2TS=(cost* and (effective* or utilit* or benefit* or minimi*)) OR TS=(cost*) OR TI=(economic* or pharmacoeconomic* or pharmaco-economic*) OR TS=(price* or pricing*) OR TS=(financial or finance or finances or financed) OR TS=(fee or fees) OR TS=(value and (money or monetary)) OR TS=(economic*) OR TS=(economic* and (hospital or medical or nursing or pharmaceutical)) OR TS=(“quality adjusted life year” or “quality adjusted life years”) OR TS=(qaly or qalys) OR TS=(budget*)
#3#2 AND #1

Cochrane Database of Systematic Reviews: Wiley Online Library

Health Technology Assessment database: Wiley Online Library.

NHS Economic Evaluation Database: Wiley Online Library.

Date range searched: 1995–2015.

Date searched: 3 November 2016.

#Searches
#1MeSH descriptor: [Thyroid Neoplasms] explode all trees
#2MeSH descriptor: [Goiter, Nodular] explode all trees
#3(thyr*oid* near/5 (cancer* or neoplas* or carcinoma* or malignan* or tumor* or tumour* or adenocarcinoma*)):ti,ab,kw
#4MeSH descriptor: [Thyroid Gland] this term only
#5MeSH descriptor: [Neoplasms] explode all trees
#6#4 and #5
#730-#3,#6

Cumulative Index to Nursing and Allied Health Literature

Date range searched: 1982 to present.

Date searched: 3 November 2016.

#Searches
S1(MH “Thyroid Neoplasms+”)
S2(thyr?oid* N5 (cancer* or neoplas* or carcinoma* or malignan* or tumor* or tumour* or adenocarcinoma*))
S3(MH “Thyroid Gland”)
S4(MH “Neoplasms+”)
S5S3 AND S4
S6S1 OR S2 OR S5
S7(MH “Costs and Cost Analysis+”)
S8(MH “Economics”)
S9(MH “Economics, Pharmaceutical”)
S10(MH “Fees and Charges+”)
S11(MH “Budgets”)
S12budget*
S13cost*
S14AB cost* and (effective* or utilit* or benefit* or minimi*)
S15TI economic* or pharmacoeconomic* or pharmaco-economic*
S16price* or pricing*
S17financial or finance or finances or financed
S18fee or fees
S19value and (money or monetary)
S20qaly or qalys
S21quality adjusted life year or quality adjusted life years
S22S7 or S8 or S9 or S10 or S11 or S12 or S13 or S14 or S15 or S16 or S17 or S18 or S19 or S20 or S21
S23S6 AND S22

Quality-of-life studies

Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R)

Date range searched: 1946 to present.

Date searched: 3 November 2016.

#Searches
1exp Thyroid Neoplasms/
2exp Goiter, Nodular/
3(thyr?oid* adj5 (cancer* or neoplas* or carcinoma* or malignan* or tumor* or tumour* or adenocarcinoma*)).mp.
4Thyroid Gland/
5exp Neoplasms/
64 and 5
7or/1-3,6
8“Quality of Life”/
9(qol or (quality adj2 life)).ab,ti.
10(value adj2 (money or monetary)).tw.
11value of life/
12quality adjusted life year/
13quality adjusted life.tw.
14(qaly$ or qald$ or qale$ or qtime$).tw.
15disability adjusted life.tw.
16daly$.tw.
17health status indicators/
18(sf36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shorform thirtysix or shortform thirty six or short form thirtysix or short form thirty six).tw.
19(sf 6 or sf6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six).tw.
20(sf12 or sf 12 or short form 12 or shortform 12 or sf twelve or sftwelve or shortform twelve or short form twelve).tw.
21(sf6D or sf 6D or short form 6D or shortform 6D or sf six D or sfsixD or shortform six D or short form six D).tw.
22(sf20 or sf 20 or short form 20 or shortform 20 or sf twenty or sftwenty or shortform twenty or short form twenty).tw.
23(euroqol or euro qol or eq5d or eq 5d).tw.
24(hql or hqol or h qol or hrqol or hr qol).tw.
25(hye or hyes).tw.
26health$ year$ equivalent$.tw.
27health utilit$.tw.
28(hui or hui1 or hui2 or hui3).tw.
29disutilit$.tw.
30rosser.tw.
31(quality adj2 wellbeing).tw.
32qwb.tw.
33(willingness adj2 pay).tw.
34standard gamble$.tw.
35time trade off.tw.
36time tradeoff.tw.
37tto.tw.
38letter.pt.
39editorial.pt.
40comment.pt.
4138 or 39 or 40
42or/8-37
4342 not 41
447 and 43

EMBASE

Date range searched: 1974 to 1 November 2016.

Date searched: 3 November 2016.

#Searches
1exp thyroid tumor/
2exp nodular goiter/
3(thyr?oid* adj5 (cancer* or neoplas* or carcinoma* or malignan* or tumor* or tumour* or adenocarcinoma*)).mp.
4thyroid gland/
5exp neoplasm/
64 and 5
7or/1-3,6
8socioeconomics/
9quality adjusted life year/
10quality adjusted life.tw.
11(qaly$ or qald$ or qale$ or qtime$).tw.
12disability adjusted life.tw.
13daly$.tw.
14health survey/
15(sf36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shortform thirtysix or shortform thirty six or short form thirtysix or short form thirty six).tw.
16(sf6 or sf 6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six).tw.
17(sf12 or sf 12 or short form 12 or shortform 12 or sf twelve or sftwelve or shortform twelve or short form twelve).tw.
18(sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortform sixteen or short form sixteen).tw.
19(sf20 or sf 20 or short form 20 or shortform 20 or sf twenty or sftwenty or shortform twenty or short form twenty).tw.
20(euroqol or euro qol or eq5d or eq 5d).tw.
21(hql or hqol or h qol or hrqol or hr qol).tw.
22(hye or hyes).tw.
23health$ year$ equivalent$.tw.
24health utilit$.tw.
25(hui or hui1 or hui2 or hui3).tw.
26disutili$.tw.
27rosser.tw.
28quality of wellbeing.tw.
29qwb.tw.
30willingness to pay.tw.
31standard gamble$.tw.
32time trade off.tw.
33time tradeoff.tw.
34tto.tw.
358 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26 or 27 or 28 or 29 or 30 or 31 or 32 or 33 or 34
367 and 35

Web of Science Core Collection

Science Citation Index Expanded (1900–).

Conference Proceedings Citation Index – Science (1990–).

Date searched: 3 November 2016.

#Searches
#1TOPIC: ((thyr*oid* NEAR/5 (cancer* or neoplas* or carcinoma* or malignan* or tumor* or tumour* or adenocarcinoma*)))
#2TS=(qol or “quality of life” or “quality adjusted life” or qaly* or qald* or qale* or qtime* or “disability adjusted life" or daly*)
#3TS=(sf36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shorform thirtysix or shortform thirty six or short form thirtysix or short form thirty six) OR TS=(sf 6 or sf6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six) OR TS=(sf12 or sf 12 or short form 12 or shortform 12 or sf twelve or sftwelve or shortform twelve or short form twelve) OR TS=(sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortfrom sixteen or short form sixteen) OR TS=(sf20 or sf 20 or short form 20 or shortform 20 or sf twenty or sftwenty or shortform twenty or short form twenty)
#4TS=(euroqol or euro qol or eq5d or eq 5d or hql or hqol or h qol or hrqol or hr qol or disutilit* or rosser “quality of wellbeing” or qwb or “willingness to pay” or “standard gamble*” or “time trade off” or “time tradeoff” or tto)
#5#4 OR #3 OR #2
#6#5 AND #1

Cochrane Database of Systematic Reviews: Wiley Online Library

Health Technology Assessment database: Wiley Online Library.

NHS Economic Evaluation Database: Wiley Online Library.

Date range searched: 1995–2015.

Date searched: 3 November 2016.

#Searches
#1MeSH descriptor: [Thyroid Neoplasms] explode all trees
#2MeSH descriptor: [Goiter, Nodular] explode all trees
#3(thyr*oid* near/5 (cancer* or neoplas* or carcinoma* or malignan* or tumor* or tumour* or adenocarcinoma*)):ti,ab,kw
#4MeSH descriptor: [Thyroid Gland] this term only
#5MeSH descriptor: [Neoplasms] explode all trees
#6#4 and #5
#7{or #1-#3, #6}

Cumulative Index to Nursing and Allied Health Literature

Date range searched: 1982 to present.

Date searched: 3 November 2016.

#Searches
S1(MH “Thyroid Neoplasms+”)
S2(thyr?oid* N5 (cancer* or neoplas* or carcinoma* or malignan* or tumor* or tumour* or adenocarcinoma*))
S3(MH “Thyroid Gland”)
S4(MH “Neoplasms+”)
S5S3 AND S4
S6S1 OR S2 OR S5
S7(MH “Quality of Life”)
S8TI ( qol or (quality N2 life) ) or AB ( qol or (quality N2 life) )
S9TI value and TI ( money or monetary ) or AB value and AB ( money or monetary )
S10(MH “Economic Value of Life”)
S11(MH “Quality-Adjusted Life Years”)
S12TI ( qaly* or qald* or qale* or qtime* ) or AB ( qaly* or qald* or qale* or qtime* )
S13TI disability adjusted life or AB disability adjusted life
S14TI daly* or AB daly*
S15(MH “Health Status Indicators”)
S16TI ( sf36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shorform thirtysix or shortform thirty six or short form thirtysix or short form thirty six ) or AB ( sf36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shorform thirtysix or shortform thirty six or short form thirtysix or short form thirty six )
S17TI ( sf 6 or sf6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six ) or AB ( sf 6 or sf6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six )
S18TI quality adjusted life or AB quality adjusted life
S19TI ( sf12 or sf 12 or short form 12 or shortform 12 or sf twelve or sftwelve or shortform twelve or short form twelve ) or AB ( sf12 or sf 12 or short form 12 or shortform 12 or sf twelve or sftwelve or shortform twelve or short form twelve )
S20TI ( sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortfrom sixteen or short form sixteen ) or AB ( sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortfrom sixteen or short form sixteen )
S21TI ( sf20 or sf 20 or short form 20 or shortform 20 or sf twenty or sftwenty or shortform twenty or short form twenty ) or AB ( sf20 or sf 20 or short form 20 or shortform 20 or sf twenty or sftwenty or shortform twenty or short form twenty )
S22TI ( euroqol or euro qol or eq5d or eq 5d ) or AB ( euroqol or euro qol or eq5d or eq 5d )
S23TI ( hql or hqol or h qol or hrqol or hr qol ) or AB ( hql or hqol or h qol or hrqol or hr qol )
S24TI ( hye or hyes ) or AB ( hye or hyes )
S25TI health* year* equivalent* or AB health* year* equivalent*
S26TI health utilit* or AB health utilit*
S27TI ( hui or hui1 or hui2 or hui3 ) or AB ( hui or hui1 or hui2 or hui3 )
S28TI disutilit* or AB disutilit*
S29TI rosser or AB rosser
S30TI quality N2 wellbeing or AB quality N2 wellbeing
S31TI qwb or AB qwb
S32TI willingness N2 pay or AB willingness N2 pay
S33TI standard gamble* or AB standard gamble*
S34TI time trade off or AB time trade off
S35TI time tradeoff or AB time tradeoff
S36TI tto or AB tto
S37PT letter
S38PT editorial
S39PT comment
S40S37 or S38 or S39
S41S7 or S8 or S9 or S10 or S11 or S12 or S13 or S14 or S15 or S16 or S17 or S18 or S19 or S20 or S21 or S22 or S23 or S24 or S25 or S26 or S27 or S28 or S29 or S30 or S31 or S32 or S33 or S34 or S35 or S36
S42S41 NOT S40
S43S6 AND S42
Copyright © Queen’s Printer and Controller of HMSO 2019. This work was produced by Tappenden et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.
Bookshelf ID: NBK537884
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