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Tappenden P, Carroll C, Hamilton J, et al. Cabozantinib and vandetanib for unresectable locally advanced or metastatic medullary thyroid cancer: a systematic review and economic model. Southampton (UK): NIHR Journals Library; 2019 Feb. (Health Technology Assessment, No. 23.8.)

Cover of Cabozantinib and vandetanib for unresectable locally advanced or metastatic medullary thyroid cancer: a systematic review and economic model

Cabozantinib and vandetanib for unresectable locally advanced or metastatic medullary thyroid cancer: a systematic review and economic model.

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Appendix 3Additional tables and figures relating to the Sanofi model

FIGURE 17

(Confidential information has been removed.)

TABLE 40

TABLE 40

The AIC and BIC statistics from Sanofi’s covariate-adjusted analysis of the ZETA trial observed OS

FIGURE 18

(Confidential information has been removed.)

TABLE 41

TABLE 41

The AIC and BIC statistics from Sanofi’s covariate-adjusted analysis of ZETA trial observed PFS

TABLE 42

TABLE 42

The HRQoL parameters used in the Sanofi model

TABLE 43

TABLE 43

Use of vandetanib during progression-free period

TABLE 44

TABLE 44

Vandetanib acquisition costs according to pack size

TABLE 45

TABLE 45

Vandetanib monitoring costs assumed in the Sanofi model

TABLE 46

TABLE 46

Incidence and costs associated with grade 3/4 AEs

TABLE 47

TABLE 47

Comparison of DICE model results and double-programmed AG partitioned survival model

FIGURE 19

(Confidential information has been removed.)

TABLE 48

TABLE 48

Health state populations by year, PFS (log-normal) and OS (Weibull)

Copyright © Queen’s Printer and Controller of HMSO 2019. This work was produced by Tappenden et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.
Bookshelf ID: NBK537891
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