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Takwoingi Y, Whitworth H, Rees-Roberts M, et al. Interferon gamma release assays for Diagnostic Evaluation of Active tuberculosis (IDEA): test accuracy study and economic evaluation. Southampton (UK): NIHR Journals Library; 2019 May. (Health Technology Assessment, No. 23.23.)

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Interferon gamma release assays for Diagnostic Evaluation of Active tuberculosis (IDEA): test accuracy study and economic evaluation.

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List of abbreviations

BAL

bronchoalveolar lavage

BCG

bacillus Calmette–Guérin

CD4

cluster of differentiation 4

CFP-10

culture filtrate protein 10

CI

confidence interval

CRF

case report form

CT

computed tomography

DMG

Data Management Group

ELISA

enzyme-linked immunosorbent assay

ELISpot

enzyme-linked immunospot assay

ESAT-6

early secretory antigenic 6 kDa

GEE

generalised estimating equation

HIV

human immunodeficiency virus

HTA

Health Technology Assessment

IDEA

Interferon gamma release assays for Diagnostic Evaluation of Active tuberculosis study

IFN-γ

interferon gamma

IGRA

interferon gamma release assay

LTBI

latent tuberculosis infection

MRI

magnetic resonance imaging

Mtb

Mycobacterium tuberculosis

NICE

National Institute for Health and Care Excellence

NIHR

National Institute for Health Research

NPV

negative predictive value

PBMC

peripheral blood mononuclear cell

PCR

polymerase chain reaction

PET

positron emission tomography

PI

principal investigator

PPD

purified protein derivative

PPI

patient and public involvement

PPV

positive predictive value

QALY

quality-adjusted life-year

QFT-GIT

QuantiFERON GOLD In-Tube

QFT-Plus

QuantiFERON-TB Gold Plus

R&D

research and development

RPMI

Roswell Park Memorial Institute

SFC

spot-forming cell

SMG

Study Management Group

SSC

Study Steering Committee

STARD

Standards for the Reporting of Diagnostic Accuracy Studies

TB

tuberculosis

TST

tuberculin skin test

Copyright © Queen’s Printer and Controller of HMSO 2019. This work was produced by Takwoingi et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.
Bookshelf ID: NBK541525
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