The authors are grateful to Joanne Hinde for her clerical support. The authors would like to thank members of the expert clinical advisory group for their participation in the expert consensus work and the PPI representatives for their advice.
Patient and public involvement representatives
Expert advisory group
Professor Matt Costa (Orthopaedic Surgery, Oxford).
Associate Professor Xavier Griffin (Orthopaedic Surgery, Oxford).
Mr David Johnson (Orthopaedic Surgery, Stockport).
Mr Dilraj Sandher (Orthopaedic Surgery, Stockport).
Ms Vicky Lyle (Orthopaedic Surgery, Salford).
Dr Gordon Fuller (Emergency Medicine, Sheffield).
Professor Jason Smith (Emergency Medicine, Derriford).
Professor Rick Body (Emergency Medicine, Manchester).
Dr Graham Johnson (Emergency Medicine, Derby).
Dr Jamie Cooper (Emergency Medicine, Aberdeen).
Dr Catherine Roberts (Emergency Medicine, Preston).
Dr Rowena Thomas-Dewing (Haematology, Salford).
Dr Rhona Maclean (Haematology, Sheffield).
Dr Jecko Thachil (Haematology, Manchester).
Dr Henry Watson (Haematology, Aberdeen).
We would also like to extend our thanks to Professor Matt Stevenson (University of Sheffield), who was a co-applicant on the bid and provided advice, as necessary, relating to health economics.
Contributions of authors
Abdullah Pandor (Senior Research Fellow) co-ordinated the review and was responsible for the design of the study, acquisition of data, analysis and interpretation of data (for the systematic review), and drafting and revision of the final report.
Daniel Horner (Professor at the Royal College of Emergency Medicine and Substantive NHS Consultant Emergency Physician) was responsible for the conception and design of the study, acquisition of data, analysis and interpretation of data (for the systematic reviews and health economic evaluations), and drafting and revision of the final report.
Sarah Davis (Senior Lecturer) was responsible for the design of the study, acquisition of data, analysis and interpretation of data and model construction (for the health economic evaluations), and drafting and revision of the final report.
Steve Goodacre (Professor of Emergency Medicine) was responsible for the conception and design of the study, acquisition of data, analysis and interpretation of data (for the systematic reviews and health economic evaluations), and drafting and revision of the final report.
John W Stevens (Reader in Decision Science) was responsible for the design of the study, statistical analyses, interpretation of data, and drafting and revision of the final report.
Mark Clowes (Information Specialist) was responsible for developing and undertaking the electronic literature searches.
Beverley J Hunt (Professor of Thrombosis and Haemostasis) was responsible for the design of the study, interpretation of data (for the systematic reviews and health economic evaluations), and drafting and revision of the final report.
Tim Nokes (Consultant Haematologist) was responsible for the design of the study, interpretation of data (for the systematic reviews and health economic evaluations), and drafting and revision of the final report.
Jonathan Keenan (Consultant Orthopaedic Surgeon) was responsible for the design of the study, interpretation of data (for the systematic reviews and health economic evaluations), and drafting and revision of the final report.
Kerstin de Wit (Assistant Professor and Thrombosis Physician) was responsible for the design of the study, interpretation of data (for the systematic reviews and health economic evaluations), and drafting and revision of the final report.
Publications
Horner D, Pandor A, Goodacre S, Clowes M, Hunt BJ. Individual risk factors predictive of venous thromboembolism in patients with temporary lower limb immobilisation due to injury: a systematic review. J Thromb Haemost 2019;17:329–44.
Davis S, Goodacre S, Pandor A, Horner D, Stevens JW, de Wit K, Hunt BJ. Decision-analysis modelling of the effects of thromboprophylaxis for people with lower limb immobilisation for injury. Br J Haematol 2019;186:130–95.
Horner D, Stevens J, Pandor A, Nokes T, Keenan J, de Wit K, Goodacre S. Pharmacological thromboprophylaxis to prevent venous thromboembolism in patients with temporary lower limb immobilisation after injury: a systematic review and network meta-analysis [published online ahead of print October 26 2019]. J Thromb Haemost 2019.
Horner D, Goodacre S, Pandor A, Nokes T, Keenan J, Hunt BJ, et al. Thromboprophylaxis in Lower Limb Immobilisation after Injury (TiLLI) [published online ahead of print November 6 2019]. Emergency Medicine Journal 2019.
Data-sharing statement
Most of the data used in this study are already publicly available. Requests for access to other data should be addressed to the corresponding author for consideration.
Disclaimers
This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, NETSCC, the HTA programme or the Department of Health and Social Care. If there are verbatim quotations included in this publication the views and opinions expressed by the interviewees are those of the interviewees and do not necessarily reflect those of the authors, those of the NHS, the NIHR, NETSCC, the HTA programme or the Department of Health and Social Care.
