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Walton M, Wade R, Claxton L, et al. Selective internal radiation therapies for unresectable early-, intermediate- or advanced-stage hepatocellular carcinoma: systematic review, network meta-analysis and economic evaluation. Southampton (UK): NIHR Journals Library; 2020 Sep. (Health Technology Assessment, No. 24.48.)

Cover of Selective internal radiation therapies for unresectable early-, intermediate- or advanced-stage hepatocellular carcinoma: systematic review, network meta-analysis and economic evaluation

Selective internal radiation therapies for unresectable early-, intermediate- or advanced-stage hepatocellular carcinoma: systematic review, network meta-analysis and economic evaluation.

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Appendix 3Search strategies for quality-of-life studies

The aim of the search was to identify published studies reporting utility estimates for patients with HCC or cirrhosis. A search strategy was developed in MEDLINE (Ovid), consisting of terms for HCC or cirrhosis combined with a study design search filter to restrict retrieval to health state utility studies.156 Specific named instruments used to measure HRQoL in HCC patients were also included in the strategy. No language or date restrictions were applied to the searches. The MEDLINE strategy was translated to run appropriately on the other databases searched.

The following databases were searched in February 2019: MEDLINE all (Ovid), Cost-Effectiveness Analysis Registry, EMBASE (Ovid), HTA database (CRD databases), NHS EED (CRD databases) and ScHARRHUD database.

Search results were imported into EndNote X9 and deduplicated.

MEDLINE all

Via Ovid (http://ovidsp.ovid.com/).

Date range searched: 1946 to 25 February 2019.

Date searched: 26 February 2019.

Records retrieved: 1837.

A study design search filter developed by Arber et al.156 designed to restrict retrieval to health state utility studies was included in the strategy. The sensitivity-maximising version of the filter was used; see lines 13–35 below.

Search strategy

  1. Carcinoma, Hepatocellular/ (77,760)
  2. Liver Neoplasms/ (137,948)
  3. ((liver or hepato$ or hepatic$) adj3 (carcinoma$ or cancer$ or neoplas$ or tumour$ or tumor$ or malign$)).ti,ab. (132,386)
  4. hepatocarcinoma$.ti,ab. (3764)
  5. hepatoma$.ti,ab. (27,397)
  6. or/1-5 (208,036)
  7. exp Liver Cirrhosis/ (84,653)
  8. (cirrhos$ or cirrhot$).ti,ab. (93,295)
  9. ((liver or hepatic$) adj3 fibros$).ti,ab. (22,118)
  10. (biliary adj3 (cirrhos$ or cirrhot$ or cholangitis)).ti,ab. (9992)
  11. or/7-10 (132,914)
  12. 6 or 11 (311,502)
  13. quality-adjusted life years/ (10,727)
  14. (quality adjusted or adjusted life year$).ti,ab,kf. (14,531)
  15. (qaly$ or qald$ or qale$ or qtime$).ti,ab,kf. (9350)
  16. (illness state$1 or health state$1).ti,ab,kf. (5828)
  17. (hui or hui1 or hui2 or hui3).ti,ab,kf. (1350)
  18. (multiattribute$ or multi attribute$).ti,ab,kf. (814)
  19. (utility adj3 (score$1 or valu$ or health$ or cost$ or measur$ or disease$ or mean or gain or gains or index$)).ti,ab,kf. (13,429)
  20. utilities.ti,ab,kf. (6374)
  21. (eq-5d or eq5d or eq-5 or eq5 or euro qual or euroqual or euro qual5d or euroqual5d or euro qol or euroqol or euro qol5d or euroqol5d or euro quol or euroquol or euro quol5d or euroquol5d or eur qol or eurqol or eur qol5d or eur qol5d or eur?qul or eur?qul5d or euro$ quality of life or european qol).ti,ab,kf. (9564)
  22. (euro$ adj3 (5 d or 5d or 5 dimension$ or 5dimension$ or 5 domain$ or 5domain$)).ti,ab,kf. (3329)
  23. (sf36$ or sf 36$ or sf thirtysix or sf thirty six).ti,ab,kf. (20,320)
  24. (time trade off$1 or time tradeoff$1 or tto or timetradeoff$1).ti,ab,kf. (1743)
  25. quality of life/and ((quality of life or qol) adj (score$1 or measure$1)).ti,ab,kf. (10,526)
  26. quality of life/and ec.fs. (9271)
  27. quality of life/and (health adj3 status).ti,ab,kf. (8092)
  28. (quality of life or qol).ti,ab,kf. and Cost-Benefit Analysis/ (11,091)
  29. ((qol or hrqol or quality of life).ti,kf. or *quality of life/) and ((qol or hrqol$ or quality of life) adj2 (increas$ or decrease$ or improv$ or declin$ or reduc$ or high$ or low$ or effect or effects or worse or score or scores or change$1 or impact$1 or impacted or deteriorat$)).ab. (32,288)
  30. Cost-Benefit Analysis/and (cost-effectiveness ratio$ and (perspective$ or life expectanc$)).ti,ab,kf. (2980)
  31. *quality of life/and (quality of life or qol).ti. (48,595)
  32. quality of life/and ((quality of life or qol) adj3 (improv$ or chang$)).ti,ab,kf. (23,881)
  33. quality of life/and health-related quality of life.ti,ab,kf. (27,802)
  34. models,economic/ (9191)
  35. or/13-34 (146,623)
  36. 12 and 35 (1437)
  37. (utility adj3 (score$1 or scoring or valu$ or measur$ or evaluat$ or scale$1 or instrument$1 or weight or weights or weighting or information or data or unit or units or health$ or life or estimat$ or elicit$ or disease$ or mean or cost$ or expenditure$1 or gain or gains or loss or losses or lost or analysis or index$ or indices or overall or reported or calculat$ or range$ or increment$ or state or states or status)).ti,ab,kf. (29,854)
  38. disutili$.ti,ab,kf. (405)
  39. (short form$ or shortform$).ti,ab,kf. (29,550)
  40. (sf12 or sf 12 or sf twelve or sftwelve).ti,ab,kf. (4154)
  41. or/37-40 (61,362)
  42. 12 and 41 (709)
  43. 36 or 42 (1801)
  44. “European Organization for Research and Treatment of Cancer Quality of Life”.ti,ab. (830)
  45. “European Organisation for Research and Treatment of Cancer Quality of Life”.ti,ab. (336)
  46. EORTC quality of life.ti,ab. (412)
  47. (EORTC QLQ$ or EORTCQLQ$).ti,ab. (3173)
  48. (QLQ-C30$ or QLQC30$ or QLQ-C-30$ or QLQC-30$).ti,ab. (3609)
  49. (FACT-Hep or FACTHep).ti,ab. (35)
  50. FACT-hepatobiliary.ti,ab. (10)
  51. Functional Assessment of Cancer Therapy Hepatobiliary.ti,ab. (45)
  52. (FHSI-8 or FHSI8).ti,ab. (6)
  53. (FACT-G or FACTG).ti,ab. (554)
  54. FACT-General.ti,ab. (69)
  55. Functional Assessment of Cancer Therapy General.ti,ab. (452)
  56. (QLQ-LC$ or QLQLC$).ti,ab. (114)
  57. (QLQ-HCC18$ or QLQHCC18$ or QLQ-HCC-18$ or QLQHCC-18$).ti,ab. (11)
  58. (QLQ-PAN$ or QLQPAN$).ti,ab. (40)
  59. (Gastrointestinal Quality of Life adj (index$ or indices)).ti,ab. (387)
  60. GIQLI$.ti,ab. (329)
  61. or/44-60 (5833)
  62. 12 and 61 (132)
  63. 43 or 62 (1837).

Key:

  • / = indexing term (MeSH)
  • exp = exploded indexing term (MeSH)
  • $ = truncation
  • $1 = limited truncation – restricts to one character only after word
  • ti,ab = terms in either title or abstract fields
  • ec.fs. = floating economics subheading search
  • kf = author keywords field
  • adj3 = terms within three words of each other (any order).

Cost Effectivieness Analysis Registry

URL: http://healtheconomics.tuftsmedicalcenter.org/cear2n/search/search.aspx.

Date searched: 26 February 2019.

Records retrieved: 124.

The Cost-Effectiveness Analysis Registry was searched using the basic search interface using a set of simple searches for the population. Duplicates were removed before exporting records.

Search strategy

  1. hepatocellular carcinoma (86)
  2. hepatocellular cancer (1)
  3. hepatocellular neoplasm (0)
  4. hepatocellular tumor (0)
  5. hepatocellular tumour (0)
  6. hepatocellular malignancy (0)
  7. hepatocarcinoma (0)
  8. hepatoma (1)
  9. liver cancer (12)
  10. liver carcinoma (0)
  11. liver neoplasm (6)
  12. liver tumor (2)
  13. liver tumour (1)
  14. liver malignancy (0)
  15. liver cirrhosis (21)
  16. liver fibrosis (15).

EMBASE

Via Ovid (http://ovidsp.ovid.com/).

Date range searched: 1974 to 25 February 2019.

Date searched: 26 February 2019.

Records retrieved: 2415.

Retrieval was restricted to health state utility studies using terms based on a study design search filter developed by Arber et al.156 for use in Ovid MEDLINE. This was translated for use in Ovid EMBASE; see lines 13–42 below.

  1. liver cell carcinoma/ (136,695)
  2. liver cancer/ (28,869)
  3. ((liver or hepato$ or hepatic$) adj3 (carcinoma$ or cancer$ or neoplas$ or tumour$ or tumor$ or malign$)).ti,ab. (184,856)
  4. hepatocarcinoma$.ti,ab. (4990)
  5. hepatoma$.ti,ab. (30,679)
  6. or/1-5 (242,352)
  7. exp liver cirrhosis/ (141,130)
  8. (cirrhos$ or cirrhot$).ti,ab. (135,400)
  9. ((liver or hepatic$) adj3 fibros$).ti,ab. (36,133)
  10. (biliary adj3 (cirrhos$ or cirrhot$ or cholangitis)).ti,ab. (13,554)
  11. or/7-10 (194,904)
  12. 6 or 11 (388,577)
  13. quality adjusted life year/ (23,009)
  14. (quality adjusted or adjusted life year$).ti,ab,kw. (21,303)
  15. (qaly$ or qald$ or qale$ or qtime$).ti,ab,kw. (17,652)
  16. (illness state$1 or health state$1).ti,ab,kw. (10,032)
  17. (hui or hui1 or hui2 or hui3).ti,ab,kw. (2027)
  18. (multiattribute$ or multi attribute$).ti,ab,kw. (1040)
  19. (utility adj3 (score$1 or valu$ or health$ or cost$ or measur$ or disease$ or mean or gain or gains or index$)).ti,ab,kw. (21,358)
  20. utilities.ti,ab,kw. (10,356)
  21. (eq-5d or eq5d or eq-5 or eq5 or euro qual or euroqual or euro qual5d or euroqual5d or euro qol or euroqol or euro qol5d or euroqol5d or euro quol or euroquol or euro quol5d or euroquol5d or eur qol or eurqol or eur qol5d or eur qol5d or eur?qul or eur?qul5d or euro$ quality of life or european qol).ti,ab,kw. (17,622)
  22. (euro$ adj3 (5 d or 5d or 5 dimension$ or 5dimension$ or 5 domain$ or 5domain$)).ti,ab,kw. (5144)
  23. short form 36/ (24,680)
  24. (sf36$ or sf 36$ or sf thirtysix or sf thirty six).ti,ab,kw. (34,476)
  25. (time trade off$1 or time tradeoff$1 or tto or timetradeoff$1).ti,ab,kw. (2512)
  26. quality of life/and ((quality of life or qol) adj (score$1 or measure$1)).ti,ab,kw. (22,209)
  27. “quality of life”/and pe.fs. (8003)
  28. “quality of life”/and de.fs. (300)
  29. “quality of life”/and (health adj3 status).ti,ab,kw. (14,248)
  30. (quality of life or qol).ti,ab,kw. and “cost benefit analysis”/ (5014)
  31. ((qol or hrqol or quality of life).ti,kw. or *”quality of life”/) and ((qol or hrqol$ or quality of life) adj2 (increas$ or decrease$ or improv$ or declin$ or reduc$ or high$ or low$ or effect or effects or worse or score or scores or change$1 or impact$1 or impacted or deteriorat$)).ab. (49,462)
  32. “cost benefit analysis”/and (cost-effectiveness ratio$ and (perspective$ or life expectanc$)).ti,ab,kw. (726)
  33. *”quality of life”/and (quality of life or qol).ti. (74,391)
  34. “quality of life”/and ((quality of life or qol) adj3 (improv$ or chang$)).ti,ab,kw. (65,833)
  35. “quality of life”/and health-related quality of life.ti,ab,kw. (50,090)
  36. economic model/ (1547)
  37. (utility adj3 (score$1 or scoring or valu$ or measur$ or evaluat$ or scale$1 or instrument$1 or weight or weights or weighting or information or data or unit or units or health$ or life or estimat$ or elicit$ or disease$ or mean or cost$ or expenditure$1 or gain or gains or loss or losses or lost or analysis or index$ or indices or overall or reported or calculat$ or range$ or increment$ or state or states or status)).ti,ab,kw. (45,473)
  38. disutili$.ti,ab,kw. (802)
  39. (short form$ or shortform$).ti,ab,kw. (39,683)
  40. short form 12/ (5132)
  41. (sf12 or sf 12 or sf twelve or sftwelve).ti,ab,kw. (7154)
  42. or/13-41 (294,270)
  43. 12 and 42 (3994)
  44. “European Organization for Research and Treatment of Cancer Quality of Life”.ti,ab. (1083)
  45. “European Organisation for Research and Treatment of Cancer Quality of Life”.ti,ab. (445)
  46. EORTC quality of life.ti,ab. (678)
  47. (EORTC QLQ$ or EORTCQLQ$).ti,ab. (6855)
  48. (QLQ-C30$ or QLQC30$ or QLQ-C-30$ or QLQC-30$).ti,ab. (7303)
  49. (FACT-Hep or FACTHep).ti,ab. (88)
  50. FACT-hepatobiliary.ti,ab. (21)
  51. Functional Assessment of Cancer Therapy Hepatobiliary.ti,ab. (58)
  52. (FHSI-8 or FHSI8).ti,ab. (14)
  53. (FACT-G or FACTG).ti,ab. (1231)
  54. FACT-General.ti,ab. (112)
  55. Functional Assessment of Cancer Therapy General.ti,ab. (678)
  56. (QLQ-LC$ or QLQLC$).ti,ab. (254)
  57. (QLQ-HCC18$ or QLQHCC18$ or QLQ-HCC-18$ or QLQHCC-18$).ti,ab. (21)
  58. (QLQ-PAN$ or QLQPAN$).ti,ab. (77)
  59. (Gastrointestinal Quality of Life adj (index$ or indices)).ti,ab. (526)
  60. GIQLI$.ti,ab. (550)
  61. or/44-60 (11,272)
  62. 12 and 61 (236)
  63. 43 or 62 (4054)
  64. (animal/or animal experiment/or animal model/or animal tissue/or nonhuman/) not exp human/ (5,661,185)
  65. 63 not 64 (3979)
  66. limit 65 to conference abstracts (1564)
  67. 65 not 66 (2415).

Key:

  • / = indexing term (Emtree heading)
  • exp = exploded indexing term (Emtree heading)
  • $ = truncation
  • $1 = limited truncation – restricts to one character only after word
  • ti,ab = terms in either title or abstract fields
  • pe.fs = floating pharmacoeconomics subheading search
  • de.fs = floating device economics subheading search
  • kw = terms in the author keywords field
  • adj3 = terms within three words of each other (any order).

Health Technology Assessment database

Via www.crd.york.ac.uk/CRDWeb/.

Date range searched: inception to 31 March 2018.

Date searched: 26 February 2019.

Records retrieved: 188.

Search strategy

  1. MeSH DESCRIPTOR Carcinoma, Hepatocellular IN NHSEED,HTA (97)
  2. MeSH DESCRIPTOR Liver Neoplasms IN NHSEED,HTA (174)
  3. ((liver or hepato* or hepatic*) NEAR3 (carcinoma* or cancer* or neoplas* or tumour* or tumor* or malign*)) IN NHSEED, HTA (343)
  4. ((carcinoma* or cancer* or neoplas* or tumour* or tumor* or malign*) NEAR3 (liver or hepato* or hepatic*)) IN NHSEED, HTA (202)
  5. (hepatocarcinoma*) IN NHSEED, HTA (8)
  6. (hepatoma*) IN NHSEED, HTA (5)
  7. #1 OR #2 OR #3 OR #4 OR #5 OR #6 (365)
  8. MeSH DESCRIPTOR Liver Cirrhosis EXPLODE ALL TREES IN NHSEED,HTA (129)
  9. (cirrhos* or cirrhot*) IN NHSEED, HTA (340)
  10. ((liver or hepatic*) NEAR3 fibros*) IN NHSEED, HTA (43)
  11. (fibros* NEAR3 (liver or hepatic*)) IN NHSEED, HTA (11)
  12. (biliary NEAR3 (cirrhos* or cirrhot* or cholangitis)) IN NHSEED, HTA (14)
  13. ((cirrhos* or cirrhot* or cholangitis) NEAR3 biliary) IN NHSEED, HTA (8)
  14. #8 OR #9 OR #10 OR #11 OR #12 OR #13 (350)
  15. #7 OR #14 (540)
  16. (#15) IN NHSEED (352)
  17. (#15) IN HTA (188).

Key:

  • MeSH DESCRIPTOR = indexing term (MeSH)
  • * = truncation
  • NEAR3 = terms within three words of each other (order specified).

NHS Economic Evaluations Database

Via www.crd.york.ac.uk/CRDWeb/.

Date range searched: inception to 31 March 2015.

Date searched: 26 February 2019.

Records retrieved: 352.

See above under Health Technology Assessment database for search strategy used.

ScHARRHUD

URL: www.scharrhud.org/.

Date searched: 26 February 2019.

Records retrieved: 11.

Search strategy

  1. liver OR hepato* OR hepatic*
  2. cirrhos* OR cirrhot*
  3. biliary AND cholangitis
  4. (#1 OR #2 OR #3).

Key:

  • * = truncation.
Copyright © Queen’s Printer and Controller of HMSO 2020. This work was produced by Walton et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.
Bookshelf ID: NBK562668
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