U.S. flag

An official website of the United States government

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Walton M, Wade R, Claxton L, et al. Selective internal radiation therapies for unresectable early-, intermediate- or advanced-stage hepatocellular carcinoma: systematic review, network meta-analysis and economic evaluation. Southampton (UK): NIHR Journals Library; 2020 Sep. (Health Technology Assessment, No. 24.48.)

Cover of Selective internal radiation therapies for unresectable early-, intermediate- or advanced-stage hepatocellular carcinoma: systematic review, network meta-analysis and economic evaluation

Selective internal radiation therapies for unresectable early-, intermediate- or advanced-stage hepatocellular carcinoma: systematic review, network meta-analysis and economic evaluation.

Show details

References

1.
European Association for the Study of the Liver. EASL Clinical Practice Guidelines: management of hepatocellular carcinoma. J Hepatol 2018;69:182–236. [PubMed: 29628281]
2.
Villanueva A. Hepatocellular carcinoma. N Engl J Med 2019;380:1450–62. 10.1056/NEJMra1713263 [PubMed: 30970190] [CrossRef]
3.
Yang JD, Roberts LR. Epidemiology and management of hepatocellular carcinoma. Infect Dis Clin North Am 2010;24:899–919, viii. 10.1016/j.idc.2010.07.004 [PMC free article: PMC3949429] [PubMed: 20937457] [CrossRef]
4.
Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, Carbone PP. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 1982;5:649–56. 10.1097/00000421-198212000-00014 [PubMed: 7165009] [CrossRef]
5.
Office for National Statistics. Cancer Registration Statistics, England: 2017. 2019. URL: www​.ons.gov.uk/peoplepopulationandcommunity​/healthandsocialcare​/conditionsanddiseases​/datasets/cancerregistrationstatisticscancerregistrationstatisticsengland (accessed 29 August 2019).
6.
Ryder SD, British Society of Gastroenterology. Guidelines for the diagnosis and treatment of hepatocellular carcinoma (HCC) in adults. Gut 2003;52(Suppl. 3):iii1–8. 10.1136/gut.52.suppl_3.iii1 [PMC free article: PMC1867754] [PubMed: 12692148] [CrossRef]
7.
Park JW, Chen M, Colombo M, Roberts LR, Schwartz M, Chen PJ, et al. Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study. Liver Int 2015;35:2155–66. 10.1111/liv.12818 [PMC free article: PMC4691343] [PubMed: 25752327] [CrossRef]
8.
Cancer Research UK. Liver Cancer Survival. Cancer Research UK. URL: www​.cancerresearchuk​.org/about-cancer/liver-cancer/survival (accessed 28 August 2019).
9.
Mazzaferro V, Regalia E, Doci R, Andreola S, Pulvirenti A, Bozzetti F, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 1996;334:693–9. 10.1056/NEJM199603143341104 [PubMed: 8594428] [CrossRef]
10.
Song JE, Kim DY. Conventional vs drug-eluting beads transarterial chemoembolization for hepatocellular carcinoma. World J Hepatol 2017;9:808–14. 10.4254/wjh.v9.i18.808 [PMC free article: PMC5491403] [PubMed: 28706579] [CrossRef]
11.
National Institute for Health and Care Excellence (NICE). Sorafenib for Treating Advanced Hepatocellular Carcinoma [TA474]. London: NICE; 2017. URL: www​.nice.org.uk/guidance/ta474 (accessed 29 May 2019).
12.
National Institute for Health and Care Excellence (NICE). Lenvatinib for Untreated Advanced Hepatocellular Carcinoma [TA551]. London: NICE; 2018. URL: www​.nice.org.uk/guidance/ta551 (accessed 29 May 2019).
13.
National Institute for Health and Care Excellence (NICE). Regorafenib for Previously Treated Advanced Hepatocellular Carcinoma [TA555]. London: NICE; 2019. URL: www​.nice.org.uk/guidance/ta555 (accessed 29 May 2019).
14.
National Institute for Health and Care Excellence (NICE). Selective Internal Radiation Therapy for Primary Hepatocellular Carcinoma. Interventional Procedures Guidance [IPG460]. London: NICE; 2013. URL: www​.nice.org.uk/guidance/ipg460 (accessed 8 May 2019).
15.
Centre for Reviews and Dissemination. CRD’s Guidance for Undertaking Reviews in Health Care. York: CRD, University of York; 2009.
16.
Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 2009;339:b2535. 10.1136/bmj.b2535 [PMC free article: PMC2714657] [PubMed: 19622551] [CrossRef]
17.
Centre for Reviews and Dissemination. Search Strategies for DARE. 2015. URL: www​.crd.york.ac.uk/crdweb​/searchstrategies.asp (accessed 7 May 2019).
18.
Higgins JP, Savovic J, Page MJ, Sterne JA, ROB2 Development Group. Revised Cochrane Risk-of-bias Tool for Randomized Trials (RoB 2). 2019. URL: https://sites​.google​.com/site/riskofbiastool​/welcome/rob-2-0-tool​/current-version-of-rob-2 (accessed 29 May 2019).
19.
Vilgrain V, Pereira H, Assenat E, Guiu B, Ilonca AD, Pageaux GP, et al. Efficacy and safety of selective internal radiotherapy with yttrium-90 resin microspheres compared with sorafenib in locally advanced and inoperable hepatocellular carcinoma (SARAH): an open-label randomised controlled Phase 3 trial. Lancet Oncol 2017;18:1624–36. 10.1016/S1470-2045(17)30683-6 [PubMed: 29107679] [CrossRef]
20.
Bouattour M, Assenat E, Guiu B, Ilonca Alina D, Pageaux GP, Sibert A, et al. LBA-001 Efficacy, tolerability and impact on quality of life of selective internal radiation therapy (with yttrium-90 resin microspheres) or sorafenib in patients with locally advanced hepatocellular carcinoma: the SARAH trial. Ann Oncol 2017;28(Suppl. 3):iii150–3.
21.
Chow PKH, Gandhi M, Tan SB, Khin MW, Khasbazar A, Ong J, et al. SIRveNIB: Selective internal radiation therapy versus sorafenib in Asia-Pacific patients with hepatocellular carcinoma. J Clin Oncol 2018;36:1913–21. 10.1200/JCO.2017.76.0892 [PubMed: 29498924] [CrossRef]
22.
Kolligs FT, Bilbao JI, Jakobs T, Iñarrairaegui M, Nagel JM, Rodriguez M, et al. Pilot randomized trial of selective internal radiation therapy vs. chemoembolization in unresectable hepatocellular carcinoma. Liver Int 2015;35:1715–21. 10.1111/liv.12750 [PubMed: 25443863] [CrossRef]
23.
Pitton MB, Kloeckner R, Ruckes C, Wirth GM, Eichhorn W, Wörns MA, et al. Randomized comparison of selective internal radiotherapy (SIRT) versus drug-eluting bead transarterial chemoembolization (DEB-TACE) for the treatment of hepatocellular carcinoma. Cardiovasc Intervent Radiol 2015;38:352–60. 10.1007/s00270-014-1012-0 [PMC free article: PMC4355443] [PubMed: 25373796] [CrossRef]
24.
Ricke J, Bulla K, Kolligs F, Peck-Radosavljevic M, Reimer P, Sangro B, et al. Safety and toxicity of radioembolization plus sorafenib in advanced hepatocellular carcinoma: analysis of the European multicentre trial SORAMIC. Liver Int 2015;35:620–6. 10.1111/liv.12622 [PubMed: 24930619] [CrossRef]
25.
Salem R, Gordon AC, Mouli S, Hickey R, Kallini J, Gabr A, et al. Y90 Radioembolization significantly prolongs time to progression compared with chemoembolization in patients with hepatocellular carcinoma. Gastroenterology 2016;151:1155–63.e2. 10.1053/j.gastro.2016.08.029 [PMC free article: PMC5124387] [PubMed: 27575820] [CrossRef]
26.
Gabr A, Kallini JR, Lewandowski RJ, Salem R. Fluoroscopic radiation exposure in chemoembolization and radioembolization: results from a prospective randomized study. J Vasc Interv Radiol 2017;28:1272–3. 10.1016/j.jvir.2017.05.005 [PubMed: 28841927] [CrossRef]
27.
Gordon A, Lewandowski R, Hickey R, Kallini J, Gabr A, Sato K, et al. Prospective randomized phase 2 study of chemoembolization versus radioembolization in hepatocellular carcinoma: results from the PREMIERE trial. J Vasc Interv Radiol 2016;27:S61–2. 10.1016/j.jvir.2015.12.168 [CrossRef]
28.
Kulik L, Vouche M, Koppe S, Lewandowski RJ, Mulcahy MF, Ganger D, et al. Prospective randomized pilot study of Y90+/-sorafenib as bridge to transplantation in hepatocellular carcinoma. J Hepatol 2014;61:309–17. 10.1016/j.jhep.2014.03.023 [PubMed: 24681342] [CrossRef]
29.
Lewandowski RJ, Andreoli JM, Hickey R, Kallini JR, Gabr A, Baker T, et al. Angiogenic response following radioembolization: results from a randomized pilot study of yttrium-90 with or without sorafenib. J Vasc Interv Radiol 2016;27:1329–36. 10.1016/j.jvir.2016.03.043 [PubMed: 27266362] [CrossRef]
30.
Vouche M, Kulik L, Atassi R, Memon K, Hickey R, Ganger D, et al. Radiological-pathological analysis of WHO, RECIST, EASL, mRECIST and DWI: imaging analysis from a prospective randomized trial of Y90 +/− sorafenib. Hepatology 2013;58:1655–66. 10.1002/hep.26487 [PMC free article: PMC5097874] [PubMed: 23703789] [CrossRef]
31.
Kirchner T, Marquardt S, Werncke T, Kirstein MM, Brunkhorst T, Wacker F, et al. Comparison of health-related quality of life after transarterial chemoembolization and transarterial radioembolization in patients with unresectable hepatocellular carcinoma. Abdom Radiol 2019;44:1554–61. 10.1007/s00261-018-1802-y [PubMed: 30311050] [CrossRef]
32.
El Fouly A, Ertle J, El Dorry A, Shaker MK, Dechêne A, Abdella H, et al. In intermediate stage hepatocellular carcinoma: radioembolization with yttrium 90 or chemoembolization? Liver Int 2015;35:627–35. 10.1111/liv.12637 [PubMed: 25040497] [CrossRef]
33.
Salem R, Gilbertsen M, Butt Z, Memon K, Vouche M, Hickey R, et al. Increased quality of life among hepatocellular carcinoma patients treated with radioembolization, compared with chemoembolization. Clin Gastroenterol Hepatol 2013;11:1358–65.e1. 10.1016/j.cgh.2013.04.028 [PubMed: 23644386] [CrossRef]
34.
Memon K, Kulik L, Lewandowski RJ, Gupta R, Ryu RK, Miller FH, et al. Prospective evaluation of patients with early-/intermediate-stage hepatocellular carcinoma with disease progression following arterial locoregional therapy: candidacy for systemic treatment or clinical trials. J Vasc Interv Radiol 2013;24:1189–97.e2. 10.1016/j.jvir.2012.12.025 [PubMed: 23474327] [CrossRef]
35.
Hickey R, Mouli S, Kulik L, Desai K, Thornburg B, Ganger D, et al. Independent analysis of albumin-bilirubin grade in a 765-patient cohort treated with transarterial locoregional therapy for hepatocellular carcinoma. J Vasc Interv Radiol 2016;27:795–802. 10.1016/j.jvir.2016.03.005 [PubMed: 27038686] [CrossRef]
36.
Maccauro M, Sposito C, Chiesa C, Romito R, Spreafico C, Morosi C, et al. Trans-arterial radioembolization (TARE) with Y90 glass microspheres plus sorafenib versus tare alone for the treatment of unresectable hepatocellular carcinoma (HCC): a matched case-control study. Eur J Nucl Med Mol Imaging 2014;41(Suppl. 2):S291.
37.
Woodall CE, Scoggins CR, Ellis SF, Tatum CM, Hahl MJ, Ravindra KV, et al. Is selective internal radioembolization safe and effective for patients with inoperable hepatocellular carcinoma and venous thrombosis? J Am Coll Surg 2009;208:375–82. 10.1016/j.jamcollsurg.2008.12.009 [PubMed: 19317999] [CrossRef]
38.
Biederman DM, Tabori NE, Titano JJ, Pierobon ES, Fischman AM, Patel RS, et al. Outcomes of yttrium-90 therapy in the treatment of hepatocellular carcinoma (HCC) with portal vein thrombosis (PVT): resin-based vs. glassbased microspheres. J Vasc Interv Radiol 2015;26:S109–10. 10.1016/j.jvir.2014.12.296 [CrossRef]
39.
Biederman DM, Titano JJ, Tabori NE, Pierobon ES, Alshebeeb K, Schwartz M, et al. Outcomes of radioembolization in the treatment of hepatocellular carcinoma with portal vein invasion: resin versus glass microspheres. J Vasc Interv Radiol 2016;27:812–21.e2. 10.1016/j.jvir.2016.01.147 [PubMed: 27062356] [CrossRef]
40.
Van Der Gucht A, Jreige M, Denys A, Blanc-Durand P, Boubaker A, Pomoni A, et al. Resin versus glass microspheres for 90Y transarterial radioembolization: comparing survival in unresectable hepatocellular carcinoma using pretreatment partition model dosimetry. J Nucl Med 2017;58:1334–40. 10.2967/jnumed.116.184713 [PubMed: 28082436] [CrossRef]
41.
Bhangoo MS, Karnani DR, Hein PN, Giap H, Knowles H, Issa C, et al. Radioembolization with Yttrium-90 microspheres for patients with unresectable hepatocellular carcinoma. J Gastrointest Oncol 2015;6:469–78. 10.3978/j.issn.2078-6891.2015.056 [PMC free article: PMC4570909] [PubMed: 26487939] [CrossRef]
42.
d’Abadie P, Hesse M, Jamar F, Lhommel R, Walrand S. 90Y TOF-PET based EUD reunifies patient survival prediction in resin and glass microspheres radioembolization of HCC tumours. Phys Med Biol 2018;63:245010. 10.1088/1361-6560/aaf205 [PubMed: 30524029] [CrossRef]
43.
Cho YY, Lee M, Kim HC, Chung JW, Kim YH, Gwak GY, et al. Radioembolization is a safe and effective treatment for hepatocellular carcinoma with portal vein thrombosis: a propensity score analysis. PLOS ONE 2016;11:e0154986. 10.1371/journal.pone.0154986 [PMC free article: PMC4858257] [PubMed: 27149067] [CrossRef]
44.
de la Torre MA, Buades-Mateu J, de la Rosa PA, Lué A, Bustamante FJ, Serrano MT, et al. A comparison of survival in patients with hepatocellular carcinoma and portal vein invasion treated by radioembolization or sorafenib. Liver Int 2016;36:1206–12. 10.1111/liv.13098 [PubMed: 26910784] [CrossRef]
45.
Gramenzi A, Golfieri R, Mosconi C, Cappelli A, Granito A, Cucchetti A, et al. Yttrium-90 radioembolization vs sorafenib for intermediate-locally advanced hepatocellular carcinoma: a cohort study with propensity score analysis. Liver Int 2015;35:1036–47. 10.1111/liv.12574 [PubMed: 24750853] [CrossRef]
46.
Soydal C, Arslan MF, Kucuk ON, Idilman R, Bilgic S. Comparison of survival, safety, and efficacy after transarterial chemoembolization and radioembolization of Barcelona Clinic Liver Cancer stage B-C hepatocellular cancer patients. Nucl Med Commun 2016;37:646–9. 10.1097/MNM.0000000000000486 [PubMed: 26905317] [CrossRef]
47.
Salem R, Lewandowski RJ, Kulik L, Wang E, Riaz A, Ryu RK, et al. Radioembolization results in longer time-to-progression and reduced toxicity compared with chemoembolization in patients with hepatocellular carcinoma. Gastroenterology 2011;140:497–507.e2. 10.1053/j.gastro.2010.10.049 [PMC free article: PMC3129335] [PubMed: 21044630] [CrossRef]
48.
Moreno-Luna LE, Yang JD, Sanchez W, Paz-Fumagalli R, Harnois DM, Mettler TA, et al. Efficacy and safety of transarterial radioembolization versus chemoembolization in patients with hepatocellular carcinoma. Cardiovasc Intervent Radiol 2013;36:714–23. 10.1007/s00270-012-0481-2 [PMC free article: PMC3594060] [PubMed: 23093355] [CrossRef]
49.
Akinwande O, Philips P, Scoggins C, Martin RC. Radioembolization versus chemoembolization (DEBDOX) for the treatment of unresectable hepatocellular carcinoma: a propensity matched study. Anticancer Res 2016;36:239–46. [PubMed: 26722049]
50.
Akinwande O, Martin R. Is radioembolization equivalent to chemoembolization (DEBDOX) for the treatment of HCC? A propensity matched observational study. J Vasc Interv Radiol 2016;27:S248. 10.1016/j.jvir.2015.12.633 [CrossRef]
51.
Radosa CG, Radosa JC, Grosche-Schlee S, Zöphel K, Plodeck V, Kühn JP, et al. Holmium-166 radioembolization in hepatocellular carcinoma: feasibility and safety of a new treatment option in clinical practice. Cardiovasc Intervent Radiol 2019;42:405–12. 10.1007/s00270-018-2133-7 [PubMed: 30603976] [CrossRef]
52.
Steel J, Baum A, Carr B. Quality of life in patients diagnosed with primary hepatocellular carcinoma: hepatic arterial infusion of Cisplatin versus 90-Yttrium microspheres (Therasphere). Psycho-Oncology 2004;13:73–9. 10.1002/pon.725 [PubMed: 14872525] [CrossRef]
53.
Moroz P, Anderson JE, Van Hazel G, Gray BN. Effect of selective internal radiation therapy and hepatic arterial chemotherapy on normal liver volume and spleen volume. J Surg Oncol 2001;78:248–52. 10.1002/jso.1162 [PubMed: 11745819] [CrossRef]
54.
Maccauro M, Spreafico C, Chiesa C, Mira M, De Nila M, Romito R, et al. Personalized treatment planning in radioembolization of hepatocarcinoma with 90 Y glass microspheres: update of clinical outcomes in the Milan experience. Eur J Nucl Med Mol Imaging 2016;43(Suppl. 1):S10.
55.
Pellerito RE, Codegone A, Tabone M, Richetta E, Miranti A, Stasi M. Intrahepatic treatment of advanced hepatocellular carcinoma with 90Y Sirtex or 131I Lipiodol: preliminary results of a case control study. Clin Transl Imaging 2013;1(Suppl. 1):S126–7.
56.
Lammer J, Malagari K, Vogl T, Pilleul F, Denys A, Watkinson A, et al. Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: results of the PRECISION V study. Cardiovasc Intervent Radiol 2010;33:41–52. 10.1007/s00270-009-9711-7 [PMC free article: PMC2816794] [PubMed: 19908093] [CrossRef]
57.
Vogl TJ, Lammer J, Lencioni R, Malagari K, Watkinson A, Pilleul F, et al. Liver, gastrointestinal, and cardiac toxicity in intermediate hepatocellular carcinoma treated with PRECISION TACE with drug-eluting beads: results from the PRECISION V randomized trial. AJR Am J Roentgenol 2011;197:W562–70. 10.2214/AJR.10.4379 [PubMed: 21940527] [CrossRef]
58.
Golfieri R, Giampalma E, Renzulli M, Cioni R, Bargellini I, Bartolozzi C, et al. Randomised controlled trial of doxorubicin-eluting beads vs conventional chemoembolisation for hepatocellular carcinoma. Br J Cancer 2014;111:255–64. 10.1038/bjc.2014.199 [PMC free article: PMC4102934] [PubMed: 24937669] [CrossRef]
59.
Sacco R, Bargellini I, Bertini M, Bozzi E, Romano A, Petruzzi P, et al. Conventional versus doxorubicin-eluting bead transarterial chemoembolization for hepatocellular carcinoma. J Vasc Interv Radiol 2011;22:1545–52. 10.1016/j.jvir.2011.07.002 [PubMed: 21849247] [CrossRef]
60.
van Malenstein H, Maleux G, Vandecaveye V, Heye S, Laleman W, van Pelt J, et al. A randomized phase II study of drug-eluting beads versus transarterial chemoembolization for unresectable hepatocellular carcinoma. Onkologie 2011;34:368–76. 10.1159/000329602 [PubMed: 21734423] [CrossRef]
61.
Llovet JM, Real MI, Montaña X, Planas R, Coll S, Aponte J, et al. Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial. Lancet 2002;359:1734–9. 10.1016/S0140-6736(02)08649-X [PubMed: 12049862] [CrossRef]
62.
Kawai S, Okamura J, Ogawa M, Ohashi Y, Tani M, Inoue J, et al. Prospective and randomized clinical trial for the treatment of hepatocellular carcinoma – a comparison of lipiodol-transcatheter arterial embolization with and without adriamycin (first cooperative study). Cancer Chemother Pharmacol 1992;31(Suppl. 1):S1–6. 10.1007/BF00687096 [PubMed: 1281041] [CrossRef]
63.
Chang JM, Tzeng WS, Pan HB, Yang CF, Lai KH. Transcatheter arterial embolization with or without cisplatin treatment of hepatocellular carcinoma. A randomized controlled study. Cancer 1994;74:2449–53. 10.1002/1097-0142(19941101)74:9<2449::aid-cncr2820740910>3.0.co;2-4 [PubMed: 7922999] [CrossRef]
64.
Meyer T, Kirkwood A, Roughton M, Beare S, Tsochatzis E, Yu D, et al. A randomised phase II/III trial of 3-weekly cisplatin-based sequential transarterial chemoembolisation vs embolisation alone for hepatocellular carcinoma. Br J Cancer 2013;108:1252–9. 10.1038/bjc.2013.85 [PMC free article: PMC3619271] [PubMed: 23449352] [CrossRef]
65.
Yu SC, Hui JW, Hui EP, Chan SL, Lee KF, Mo F, et al. Unresectable hepatocellular carcinoma: randomized controlled trial of transarterial ethanol ablation versus transcatheter arterial chemoembolization. Radiology 2014;270:607–20. 10.1148/radiol.13130498 [PubMed: 24126369] [CrossRef]
66.
Malagari K, Pomoni M, Kelekis A, Pomoni A, Dourakis S, Spyridopoulos T, et al. Prospective randomized comparison of chemoembolization with doxorubicin-eluting beads and bland embolization with BeadBlock for hepatocellular carcinoma. Cardiovasc Intervent Radiol 2010;33:541–51. 10.1007/s00270-009-9750-0 [PubMed: 19937027] [CrossRef]
67.
Brown KT, Do RK, Gonen M, Covey AM, Getrajdman GI, Sofocleous CT, et al. Randomized trial of hepatic artery embolization for hepatocellular carcinoma using doxorubicin-eluting microspheres compared with embolization with microspheres alone. J Clin Oncol 2016;34:2046–53. 10.1200/JCO.2015.64.0821 [PMC free article: PMC4966514] [PubMed: 26834067] [CrossRef]
68.
Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, et al. New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). EJC 2009;45:228–47. 10.1016/j.ejca.2008.10.026 [PubMed: 19097774] [CrossRef]
69.
Sangro B, Carpanese L, Cianni R, Golfieri R, Gasparini D, Ezziddin S, et al. Survival after yttrium-90 resin microsphere radioembolization of hepatocellular carcinoma across Barcelona clinic liver cancer stages: a European evaluation. Hepatology 2011;54:868–78. 10.1002/hep.24451 [PubMed: 21618574] [CrossRef]
70.
Cardiovascular and Interventional Radiological Society of Europe. CIRSE Registry for SIR-spheres Therapy (CIRT). ClinicalTrials.gov. Bethesda, MD: National Library of Medicine (US); 2014. URL: https:​//ClinicalTrials​.gov/show/NCT02305459 (accessed 1 February 2019).
71.
Vanderbilt-Ingram Cancer Center. Yttrium Y 90 Resin Microspheres Data Collection in Unresectable Liver Cancer: The RESIN Study. ClinicalTrials.gov. Bethesda, MD: National Library of Medicine (US); 2016. URL: https:​//ClinicalTrials​.gov/show/NCT02685631 (accessed 1 February 2019).
72.
Taipei Veterans General Hospital. REgistry of Selective Internal Radiation Therapy in TaiwaN (RESIN). ClinicalTrials.gov. Bethesda, MD: National Library of Medicine (US); 2017. URL: https:​//ClinicalTrials​.gov/show/NCT03292991 (accessed 1 February 2019).
73.
Gebski V, Gibbs E, Gandhi M, Chatellier G, Dinut A, Pereira H, et al. VESPRO: an individual patient data prospective meta-analysis of selective internal radiation therapy versus sorafenib for advanced, locally advanced, or recurrent hepatocellular carcinoma of the SARAH and SIRveNIB trials. JMIR Res Protoc 2017;6:e17. 10.2196/resprot.7016 [PMC free article: PMC5332836] [PubMed: 28202430] [CrossRef]
74.
BTG Ltd. Efficacy Evaluation of Therasphere in Patients with Inoperable Liver Cancer (STOP-HCC). ClinicalTrials.gov. Bethesda, MD: National Library of Medicine (US); 2012. URL: https:​//clinicaltrials​.gov/show/nct01556490 (accessed 28 January 2019).
75.
UMC Utrecht. HEPAR Primary: Holmium-166-Radioembolization in Hepatocellular Carcinoma Patients. ClinicalTrials.gov. Bethesda, MD: National Library of Medicine (US); 2017. URL: https:​//ClinicalTrials​.gov/show/NCT03379844 (accessed 1 February 2019).
76.
Leiden University Medical Center. Holmium Radioembolization as Adjuvant Treatment to RFA for Early Stage HCC: Dose Finding Study (HORA EST HCC). ClinicalTrials.gov. Bethesda, MD: National Library of Medicine (US); 2018. URL: https:​//ClinicalTrials​.gov/show/NCT03437382 (accessed 1 February 2019).
77.
Terumo Europe NV. QuiremSpheres Observational Study (Hope166). ClinicalTrials.gov. Bethesda, MD: National Library of Medicine (US); 2018. URL: https:​//ClinicalTrials​.gov/show/NCT03563274 (accessed 1 February 2019).
78.
Reinders MT, Hoffmann RT, Lam MG, Radosa C. First Results of Homium-166 Radioembolisation Compared with Yttrium-90 Radioembolisation in HCC Patients. Leuven: Terumo Europe NV; 2019.
79.
Kallini JR, Gabr A, Thorlund K, Balijepalli C, Ayres D, Kanters S, et al. Comparison of the adverse event profile of TheraSphere® with SIR-Spheres® for the treatment of unresectable hepatocellular carcinoma: a systematic review. Cardiovasc Intervent Radiol 2017;40:1033–43. 10.1007/s00270-017-1594-4 [PubMed: 28246879] [CrossRef]
80.
Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008;359:378–90. 10.1056/NEJMoa0708857 [PubMed: 18650514] [CrossRef]
81.
Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Piscaglia F, et al. Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial. Lancet 2018;391:1163–73. 10.1016/S0140-6736(18)30207-1 [PubMed: 29433850] [CrossRef]
82.
Lu G, Ades AE. Combination of direct and indirect evidence in mixed treatment comparisons. Stat Med 2004;23:3105–24. 10.1002/sim.1875 [PubMed: 15449338] [CrossRef]
83.
Memon K, Kulik LM, Lewandowski RJ, Wang E, Wang J, Ryu RK, et al. Comparative study of staging systems for hepatocellular carcinoma in 428 patients treated with radioembolization. J Vasc Interv Radiol 2014;25:1056–66. 10.1016/j.jvir.2014.01.010 [PMC free article: PMC5097871] [PubMed: 24613269] [CrossRef]
84.
Vilgrain V, Bouattour M, Sibert A, Lebtahi R, Ronot M, Pageaux GP, et al. SARAH: a randomised controlled trial comparing efficacy and safety of selective internal radiation therapy (with yttrium-90 microspheres) and sorafenib in patients with locally advanced hepatocellular carcinoma. J Hepatol 2017;66:S85–6. 10.1016/S0168-8278(17)30436-1 [CrossRef]
85.
Cho MT, Kessler J, Park J, Singh G, Chen YJ, Ituarte PHG, et al. A single institute retrospective trial of concurrent chemotherapy with SIR-Sphere versus SIR-Sphere alone in patients with chemotherapy-resistant colorectal cancer liver metastases. J Clin Oncol 2016;34. 10.1200/jco.2016.34.4_suppl.770 [PMC free article: PMC5582041] [PubMed: 28890809] [CrossRef]
86.
Dias S, Welton NJ, Sutton AJ, Ades AE. NICE DSU Technical Support Document 2: A Generalised Linear Modelling Framework for Pairwise and Network Meta-analysis of Randomised Controlled Trials. Sheffield: Decision Support Unit, ScHARR, University of Sheffield; 2014. [PubMed: 27466657]
87.
Guyot P, Ades AE, Ouwens MJ, Welton NJ. Enhanced secondary analysis of survival data: reconstructing the data from published Kaplan-Meier survival curves. BMC Med Res Methodol 2012;12:9. 10.1186/1471-2288-12-9 [PMC free article: PMC3313891] [PubMed: 22297116] [CrossRef]
88.
Philips Z, Bojke L, Sculpher M, Claxton K, Golder S. Good practice guidelines for decision-analytic modelling in health technology assessment. PharmacoEconomics 2006;24:355–71. 10.2165/00019053-200624040-00006 [PubMed: 16605282] [CrossRef]
89.
Rognoni C, Ciani O, Sommariva S, Tarricone R. Real-world data for the evaluation of transarterial radioembolization versus sorafenib in hepatocellular carcinoma: a cost-effectiveness analysis. Value Health 2017;20:336–44. 10.1016/j.jval.2016.09.2397 [PubMed: 28292478] [CrossRef]
90.
Rognoni C, Ciani O, Sommariva S, Tarricone R. Treatment sequence in intermediate stage hepatocellular carcinoma: a cost-effectiveness analysis of two approaches with trans-arterial radioembolization. Value Health 2017;20:A247. 10.1016/j.jval.2016.09.2397 [PubMed: 28292478] [CrossRef]
91.
Rostambeigi N, Dekarske A, Austin E, Golzarian J, Cressman E. Simulation study on cost-effectiveness of radioembolization compared with trans-arterial chemoembolization for hepatocellular carcinoma. J Vasc Interv Radiol 2014;25:S104–5. 10.1016/j.jvir.2013.12.292 [PubMed: 24861664] [CrossRef]
92.
Rostambeigi N, Dekarske AS, Austin EE, Golzarian J, Cressman EN. Cost effectiveness of radioembolization compared with conventional transarterial chemoembolization for treatment of hepatocellular carcinoma. J Vasc Interv Radiol 2014;25:1075–84. 10.1016/j.jvir.2014.04.014 [PubMed: 24861664] [CrossRef]
93.
Marqueen KE, Ang C, Mazumdar M, Buckstein M, Ferket BS. Cost-effectiveness analysis of selective internal radiation therapy with yttrium-90 resin microspheres versus sorafenib in advanced hepatocellular carcinoma. Int J Radiat Oncol Biol Phys 2018;102:e402. 10.1016/j.ijrobp.2018.07.1185 [CrossRef]
94.
Chaplin S, Taylor M, Lapon J, White J. Economic evaluation of glass yttrium-90 microspheres versus sorafenib for the treatment of advanced hepatocellular carcinoma: cost effectiveness analysis in the United Kingdom. Cardiovasc Intervent Radiol 2015;38:S279–80.
95.
Parikh ND, Singal AG, Kulik LM, Hutton D. Cost-effectiveness of sorafenib versus selective internal radiation therapy for patients with advanced hepatocellular carcinoma. Hepatology 2018;68(Suppl. 1):532A–3A.
96.
Palmer D, Ross P, Shah T, Yu D, Shergill S, Patterson K, et al. Cost effectiveness of selective internal radiation therapy (SIRT) with Y- 90 resin microspheres versus sorafenib in Barcelona Clinic Liver Cancer (BCLC) stage C hepatocellular carcinoma patients in the UK. Ann Oncol 2017;28(Suppl. 5):239–40. 10.1093/annonc/mdx369.087 [CrossRef]
97.
Rognoni C, Ciani O, Sommariva S, Tarricone R. Cost-effectiveness analysis of treatments involving radioembolization in intermediate-stage hepatocellular carcinoma. J Comp Eff Res 2018;7:209–21. 10.2217/cer-2017-0050 [PubMed: 29231047] [CrossRef]
98.
Llovet JM, Finn RS. Negative phase 3 study of 90Y microspheres versus sorafenib in HCC. Lancet Oncol 2018;19:e69. 10.1016/S1470-2045(18)30025-1 [PubMed: 29413470] [CrossRef]
99.
IBM. IBM Micromedex with Watson. URL: www​.ibm.com/products​/micromedex-with-watson (accessed 6 September 2019).
100.
National Institutes of Health. SEER – Medicare Linked Database. URL: https:​//healthcaredelivery​.cancer.gov/seermedicare/ (accessed 6 September 2019).
101.
Bruix J, Qin S, Merle P, Granito A, Huang YH, Bodoky G, et al. Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 2017;389:56–66. 10.1016/S0140-6736(16)32453-9 [PubMed: 27932229] [CrossRef]
102.
Sirtex Medical Ltd. Sirtex Medical Company Evidence Submission: SIR-Spheres Y-90 Resin Microspheres. Woburn, MA: Sirtex Medical Ltd; 2019.
103.
BTG. BTG Company Evidence Submission for TheraSphere. London: BTG; 2019.
104.
Terumo. Terumo Company Evidence Submission: Selective Internal Radiation Therapy (SIRT) with Holmium-166 Microspheres (QuiremSpheres) for Treating Unresectable Hepatocellular Carcinoma and Holmium-166 Microspheres Work-up Procedure (QuiremScout). Tokyo: Terumo; 2019.
105.
Fateen W, Khan F, O’Neill RJ, James MW, Ryder SD, Aithal GP. Healthcare costs of transarterial chemoembolization in the treatment of hepatocellular carcinoma. J Hepatocell Carcinoma 2017;4:123–30. 10.2147/JHC.S144068 [PMC free article: PMC5652915] [PubMed: 29082223] [CrossRef]
106.
Curtis L, Burns A. Unit Costs of Health and Social Care 2018. Canterbury: PSSRU, University of Kent; 2018.
107.
NHS Improvement. National Schedule of Reference Costs 2017–2018. 2018. URL: https://improvement​.nhs​.uk/resources/reference-costs/ (accessed 27 August 2019).
108.
Salem R, Gabr A, Riaz A, Mora R, Ali R, Abecassis M, et al. Institutional decision to adopt Y90 as primary treatment for hepatocellular carcinoma informed by a 1,000-patient 15-year experience. Hepatology 2018;68:1429–40. 10.1002/hep.29691 [PubMed: 29194711] [CrossRef]
109.
National Institute for Health and Care Excellence (NICE). Guselkumab for Treating Moderate to Severe Plaque Psoriasis. London: NICE; 2018. URL: www​.nice.org.uk/guidance/ta521 (accessed 21 August 2019).
110.
National Institute for Health and Care Excellence (NICE). Golimumab for Treating Non-radiographic Axial Spondyloarthritis. London: NICE; 2018. URL: www​.nice.org.uk/guidance/ta497 (accessed 21 August 2019).
111.
National Institute for Health and Care Excellence (NICE). Aflibercept for Treating Choroidal Neovascularisation. London: NICE; 2017. URL: www​.nice.org.uk/Guidance/TA486 (accessed 21 August 2019).
112.
Kanwal F, Befeler A, Chari RS, Marrero J, Kahn J, Afdhal N, et al. Potentially curative treatment in patients with hepatocellular cancer – results from the liver cancer research network. Aliment Pharmacol Ther 2012;36:257–65. 10.1111/j.1365-2036.2012.05174.x [PubMed: 22670798] [CrossRef]
113.
Longworth L, Yang Y, Young T, Mulhern B, Hernández Alava M, Mukuria C, et al. Use of generic and condition-specific measures of health-related quality of life in NICE decision-making: a systematic review, statistical modelling and survey. Health Technol Assess 2014;18(9). 10.3310/hta18090 [PMC free article: PMC4780954] [PubMed: 24524660] [CrossRef]
114.
CIRSE Registry for SIR-Spheres Therapy. CIRSE Registry for SIR-Spheres Therapy (CIRT): Preliminary Data on Patients with HCC. Vienna: Cardiovascular and Interventional Radiological Society of Europe; 2019.
115.
Joint Formulary Committee. British National Formulary (Online). BMJ Group and Pharmaceutical Press; 2019. URL: www​.medicinescomplete.com (accessed 17 April 2019).
116.
Department of Health and Social Care. Drugs and Pharmaceutical Electronic Market Information Tool (eMIT). 2019. URL: www​.gov.uk/government​/publications/drugs-and-pharmaceutical-electronic-market-information-emit (accessed 20 August 2019).
117.
Latimer N. NICE DSU Technical Support Document 14: Survival Analysis for Economic Evaluations Alongside Clinical Trials - Extrapolation with Patient-Level Data. Sheffield: Decision Support Unit, School of Health and Related Research, University of Sheffield; 2013. 10.1177/0272989X12472398 [PubMed: 27905716] [CrossRef]
118.
Lewandowski RJ, Kulik LM, Riaz A, Senthilnathan S, Mulcahy MF, Ryu RK, et al. A comparative analysis of transarterial downstaging for hepatocellular carcinoma: chemoembolization versus radioembolization. Am J Transplant 2009;9:1920–8. 10.1111/j.1600-6143.2009.02695.x [PubMed: 19552767] [CrossRef]
119.
Yao FY, Xiao L, Bass NM, Kerlan R, Ascher NL, Roberts JP. Liver transplantation for hepatocellular carcinoma: validation of the UCSF-expanded criteria based on preoperative imaging. Am J Transplant 2007;7:2587–96. 10.1111/j.1600-6143.2007.01965.x [PubMed: 17868066] [CrossRef]
120.
NHS Blood and Transplant. Annual Report on Liver Transplantation. London: NHS Blood and Transplant; 2018.
121.
NHS England. Liver Transplantation Service (Adults): London: NHS England; 2017.
122.
Bellavance EC, Lumpkins KM, Mentha G, Marques HP, Capussotti L, Pulitano C, et al. Surgical management of early-stage hepatocellular carcinoma: resection or transplantation? J Gastrointest Surg 2008;12:1699–708. 10.1007/s11605-008-0652-2 [PubMed: 18709418] [CrossRef]
123.
Gordon-Weeks AN, Snaith A, Petrinic T, Friend PJ, Burls A, Silva MA. Systematic review of outcome of downstaging hepatocellular cancer before liver transplantation in patients outside the Milan criteria. Br J Surg 2011;98:1201–8. 10.1002/bjs.7561 [PubMed: 21618496] [CrossRef]
124.
National Institute for Health and Care Excellence (NICE). Lenvatinib for Untreated Advanced Hepatocellular Carcinoma [TA551] - Evidence. London: NICE; 2018. URL: www​.nice.org.uk/guidance/ta551/evidence (accessed 28 August 2019).
125.
Lim KC, Wang VW, Siddiqui FJ, Shi L, Chan ES, Oh HC, et al. Cost-effectiveness analysis of liver resection versus transplantation for early hepatocellular carcinoma within the Milan criteria. Hepatology 2015;61:227–37. 10.1002/hep.27135 [PubMed: 24638991] [CrossRef]
126.
Ratcliffe J, Buxton M, Young T, Longworth L. Determining priority for liver transplantation: a comparison of cost per QALY and discrete choice experiment-generated public preferences. Appl Health Econ Health Policy 2005;4:249–55. 10.2165/00148365-200504040-00007 [PubMed: 16466276] [CrossRef]
127.
Kind P, Hardman G, Macran S. UK Population Norms for EQ-5D. York: Centre for Health Economics, University of York; 1999.
128.
Georghiou T, Bardsley M. Exploring the Cost of Care at the End of Life. London: Nuffield Trust; 2014.
129.
Salem R, Lewandowski RJ, Mulcahy MF, Riaz A, Ryu RK, Ibrahim S, et al. Radioembolization for hepatocellular carcinoma using Yttrium-90 microspheres: a comprehensive report of long-term outcomes. Gastroenterology 2010;138:52–64. 10.1053/j.gastro.2009.09.006 [PubMed: 19766639] [CrossRef]
130.
Bryce K, Tsochatzis EA. Downstaging for hepatocellular cancer: harm or benefit? Transl Gastroenterol Hepatol 2017;2:106. 10.21037/tgh.2017.11.18 [PMC free article: PMC5763034] [PubMed: 29354763] [CrossRef]
131.
Duvoux C, Roudot-Thoraval F, Decaens T, Pessione F, Badran H, Piardi T, et al. Liver transplantation for hepatocellular carcinoma: a model including α-fetoprotein improves the performance of Milan criteria. Gastroenterology 2012;143:986–94. 10.1053/j.gastro.2012.05.052 [PubMed: 22750200] [CrossRef]
132.
NHS Blood and Transplant Organ Donation and Transplantation Directorate – Liver Advisory Group. Update on the HCC Down-staging Service Evaluation. Bristol: NHS Blood and Transplant; 2019.
133.
Samuel D, Coilly A. Management of patients with liver diseases on the waiting list for transplantation: a major impact to the success of liver transplantation. BMC Med 2018;16:113. 10.1186/s12916-018-1110-y [PMC free article: PMC6069832] [PubMed: 30064414] [CrossRef]
134.
NHS Blood and Transplant. UK Transplant Registry Data. Bristol: NHS Blood and Transplant; 2019.
135.
de’Angelis N, Landi F, Carra MC, Azoulay D. Managements of recurrent hepatocellular carcinoma after liver transplantation: a systematic review. World J Gastroenterol 2015;21:11185–98. 10.3748/wjg.v21.i39.11185 [PMC free article: PMC4607916] [PubMed: 26494973] [CrossRef]
136.
National Institute for Health and Care Excellence (NICE). Midostaurin for Untreated Acute Myeloid Leukaemia [TA523]. London: NICE; 2018. URL: www​.nice.org.uk/Guidance/TA523 (accessed 3 September 2019).
137.
National Institute for Health and Care Excellence (NICE). Tisagenlecleucel for Treating Relapsed or Refractory B-cell Acute Lymphoblastic Leukaemia in People Aged up to 25 Years [TA554]. London: NICE; 2018. URL: www​.nice.org.uk/guidance/ta554 (accessed 3 September 2019).
138.
National Institute for Health and Care Excellence (NICE). Gemtuzumab Ozogamicin for Untreated Acute Myeloid Leukaemia [TA545]. London: NICE; 2018. URL: www​.nice.org.uk/guidance/ta545 (accessed 3 September 2019).
139.
Mazzaferro V, Sposito C, Bhoori S, Romito R, Chiesa C, Morosi C, et al. Yttrium-90 radioembolization for intermediate-advanced hepatocellular carcinoma: a phase 2 study. Hepatology 2013;57:1826–37. 10.1002/hep.26014 [PubMed: 22911442] [CrossRef]
140.
National Institute for Health and Care Excellence (NICE). Sorafenib for the Treatment of Advanced Hepatocellular Carcinoma [TA189]. London: NICE; 2010.
141.
European Medicines Agency. Stivarga 40mg Film-Coated Tablets: Summary of Product Characteristics. 2018. URL: www​.medicines.org.uk​/emc/product/1263/smpc/history#gref (accessed 6 September 2019).
142.
National Institute for Health and Care Excellence (NICE). Guide to the Methods of Technology Appraisal 2013. London: NICE; 2013. [PubMed: 27905712]
143.
White JD, Dale M, Morgan H, Sewell B, Carolan-Rees G. Comissioning Through Evaluation: Selective Internal Radiation Therapy (SIRT). Cardiff: CEDAR Healthcare Technology Research Centre; 2017.
144.
Woodcock F, Doble B, CANCER 2015 Consortium. Mapping the EORTC-QLQ-C30 to the EQ-5D-3L: an assessment of existing and newly developed algorithms. Med Decis Making 2018;38:954–67. 10.1177/0272989X18797588 [PubMed: 30226101] [CrossRef]
145.
Rowen D, Brazier J, Roberts J. Mapping SF-36 onto the EQ-5D index: how reliable is the relationship? Health Qual Life Outcomes 2009;7:27. 10.1186/1477-7525-7-27 [PMC free article: PMC2683169] [PubMed: 19335878] [CrossRef]
146.
Szende A, Janssen B, Cabasés J, editors. Self-reported Population Health: An International Perspective Based on EQ-5D. Dordrecht: Springer; 2014. 10.1007/978-94-007-7596-1 [PubMed: 29787044] [CrossRef]
147.
Russell RT, Feurer ID, Wisawatapnimit P, Lillie ES, Castaldo ET, Pinson CW. Profile of health-related quality of life outcomes after liver transplantation: univariate effects and multivariate models. HPB 2008;10:30–7. 10.1080/13651820701883106 [PMC free article: PMC2504851] [PubMed: 18695756] [CrossRef]
148.
Estraviz B, Quintana JM, Valdivieso A, Bilbao A, Padierna A, de Urbina JO, Sarabia S. Factors influencing change in health-related quality of life after liver transplantation. Clin Transplant 2007;21:481–99. 10.1111/j.1399-0012.2007.00672.x [PubMed: 17645707] [CrossRef]
149.
Telles-Correia D, Barbosa A, Mega I, Mateus E, Monteiro E. When does quality of life improve after liver transplantation? A longitudinal prospective study. Transplant Proc 2009;41:904–5. 10.1016/j.transproceed.2009.01.051 [PubMed: 19376385] [CrossRef]
150.
Tome S, Wells JT, Said A, Lucey MR. Quality of life after liver transplantation. A systematic review. J Hepatol 2008;48:567–77. 10.1016/j.jhep.2007.12.013 [PubMed: 18279999] [CrossRef]
151.
Younossi ZM, McCormick M, Price LL, Boparai N, Farquhar L, Henderson JM, Guyatt G. Impact of liver transplantation on health-related quality of life. Liver Transpl 2000;6:779–83. 10.1053/jlts.2000.18499 [PubMed: 11084068] [CrossRef]
152.
Bryan S, Ratcliffe J, Neuberger JM, Burroughs AK, Gunson BK, Buxton MJ. Health-related quality of life following liver transplantation. Qual Life Res 1998;7:115–20. 10.1023/a:1008849224815 [PubMed: 9523492] [CrossRef]
153.
Vilgrain V, Abdel-Rehim M, Sibert A, Ronot M, Lebtahi R, Castéra L, Chatellier G, SARAH Trial Group. Radioembolisation with yttrium-90 microspheres versus sorafenib for treatment of advanced hepatocellular carcinoma (SARAH): study protocol for a randomised controlled trial. Trials 2014;15:474. 10.1186/1745-6215-15-474 [PMC free article: PMC4265525] [PubMed: 25472660] [CrossRef]
154.
National Institute for Health and Care Excellence (NICE). Lenvatinib and Sorafenib for Treating Differentiated Thyroid Cancer after Radioactive Iodine. (TA535). London: NICE; 2018.
155.
Vogel A, Cervantes A, Chau I, Daniele B, Llovet J, Meyer T, et al. Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2018;29:iv238–55. 10.1093/annonc/mdy308 [PubMed: 30285213] [CrossRef]
156.
Arber M, Garcia S, Veale T, Edwards M, Shaw A, Glanville JM. Performance of Ovid MEDLINE search filters to identify health state utility studies. Int J Technol Assess Health Care 2017;33:472–80. 10.1017/S0266462317000897 [PubMed: 29065942] [CrossRef]
157.
Canadian Agency for Drugs and Technologies in Health (CADTH). CADTH Database Search Filters. Ottawa, ON: CADTH; 2016. URL: www​.cadth.ca/resources​/finding-evidence/strings-attached-cadths-database-search-filters (accessed 7 March 2019).
158.
Liver Advisory Group – NHS Blood and Transplant. Update on the HCC Down-staging Service Evaluation. Bristol: NHS Blood and Transplant; 2018.
159.
She WH, Cheung TT, Yau TC, Chan AC, Chok KS, Chu FS, et al. Survival analysis of transarterial radioembolization with yttrium-90 for hepatocellular carcinoma patients with HBV infection. Hepatobiliary Surg Nutr 2014;3:185–93. 10.3978/j.issn.2304-3881.2014.07.09 [PMC free article: PMC4141294] [PubMed: 25202695] [CrossRef]
160.
Kooby DA, Egnatashvili V, Srinivasan S, Chamsuddin A, Delman KA, Kauh J, et al. Comparison of yttrium-90 radioembolization and transcatheter arterial chemoembolization for the treatment of unresectable hepatocellular carcinoma. J Vasc Interv Radiol 2010;21:224–30. 10.1016/j.jvir.2009.10.013 [PubMed: 20022765] [CrossRef]
161.
Kwok PC, Leung KC, Cheung MT, Lam TW, Szeto LT, Chou SQ, et al. Survival benefit of radioembolization for inoperable hepatocellular carcinoma using yttrium-90 microspheres. J Gastroenterol Hepatol 2014;29:1897–904. 10.1111/jgh.12621 [PubMed: 24734957] [CrossRef]
162.
Song JE, Jung KS, Kim DY, Song K, Won JY, Lee HW, et al. Transarterial radioembolization versus concurrent chemoradiation therapy for locally advanced hepatocellular carcinoma: a propensity score matching analysis. Int J Radiat Oncol Biol Phys 2017;99:396–406. 10.1016/j.ijrobp.2017.05.049 [PubMed: 28871990] [CrossRef]
163.
Oladeru OT, Miccio JA, Yang J, Xue Y, Ryu S, Stessin AM. Conformal external beam radiation or selective internal radiation therapy-a comparison of treatment outcomes for hepatocellular carcinoma. J Gastrointest Oncol 2016;7:433–40. 10.21037/jgo.2015.10.04 [PMC free article: PMC4880776] [PubMed: 27284477] [CrossRef]
164.
Rühl R, Seidensticker M, Peters N, Mohnike K, Bornschein J, Schütte K, et al. Hepatocellular carcinoma and liver cirrhosis: assessment of the liver function after yttrium-90 radioembolization with resin microspheres or after CT-guided high-dose-rate brachytherapy. Dig Dis 2009;27:189–99. 10.1159/000218352 [PubMed: 19546558] [CrossRef]
165.
D’Avola D, Lñarrairaegui M, Bilbao JI, Martinez-Cuesta A, Alegre F, Herrero JI, et al. A retrospective comparative analysis of the effect of Y90-radioembolization on the survival of patients with unresectable hepatocellular carcinoma. Hepatogastroenterology 2009;56:1683–8. [PubMed: 20214218]
166.
Carr BI, Kondragunta V, Buch SC, Branch RA. Therapeutic equivalence in survival for hepatic arterial chemoembolization and yttrium 90 microsphere treatments in unresectable hepatocellular carcinoma: a two-cohort study. Cancer 2010;116:1305–14. 10.1002/cncr.24884 [PMC free article: PMC2829376] [PubMed: 20066715] [CrossRef]
167.
Kallini JR, Gabr A, Ali R, Abouchaleh N, Riaz A, Baker T, et al. Pretransplant intra-arterial liver-directed therapy does not increase the risk of hepatic arterial complications in liver transplantation: a single-center 10-year experience. Cardiovasc Intervent Radiol 2018;41:231–8. 10.1007/s00270-017-1793-z [PubMed: 28900709] [CrossRef]
168.
Gabr A, Abouchaleh N, Ali R, Vouche M, Atassi R, Memon K, et al. Comparative study of post-transplant outcomes in hepatocellular carcinoma patients treated with chemoembolization or radioembolization. Eur J Radiol 2017;93:100–6. 10.1016/j.ejrad.2017.05.022 [PubMed: 28668402] [CrossRef]
169.
Riaz A, Ryu RK, Kulik LM, Mulcahy MF, Lewandowski RJ, Minocha J, et al. Alpha-fetoprotein response after locoregional therapy for hepatocellular carcinoma: oncologic marker of radiologic response, progression, and survival. J Clin Oncol 2009;27:5734–42. 10.1200/JCO.2009.23.1282 [PubMed: 19805671] [CrossRef]
170.
Biederman DM, Titano JJ, Korff RA, Fischman AM, Patel RS, Nowakowski FS, et al. Radiation segmentectomy versus selective chemoembolization in the treatment of early-stage hepatocellular carcinoma. J Vasc Interv Radiol 2018;29:30–7.e2. 10.1016/j.jvir.2017.08.026 [PubMed: 29169782] [CrossRef]
171.
Ahmad J, Rhee J, Carr BI. The effects of hepatic artery chemotherapy on viral hepatitis in patients with hepatocellular carcinoma. Dig Dis Sci 2005;50:331–5. 10.1007/s10620-005-1606-0 [PubMed: 15745096] [CrossRef]
172.
Padia SA, Johnson GE, Horton KJ, Ingraham CR, Kogut MJ, Kwan S, et al. Segmental yttrium-90 radioembolization versus segmental chemoembolization for localized hepatocellular carcinoma: results of a single-center, retrospective, propensity score-matched study. J Vasc Interv Radiol 2017;28:777–85.e1. 10.1016/j.jvir.2017.02.018 [PubMed: 28365172] [CrossRef]
173.
Padia SA, Johnson GE, Horton KJ, Kwan S, Vaidya S, Ingraham CR, et al. Segmental yttrium-90 radioembolization versus chemoembolization for localized hepatocellular carcinoma. J Clin Oncol 2016;34:4084. 10.1200/JCO.2016.34.15_suppl.4084 [PubMed: 28365172] [CrossRef]
174.
Newell PH, Wu Y, Hoen H, Uppal R, Thiesing JT, Sasadeusz K, et al. Multimodal treatment of unresectable hepatocellular carcinoma to achieve complete response results in improved survival. HPB 2015;17:454–60. 10.1111/hpb.12377 [PMC free article: PMC4402057] [PubMed: 25580988] [CrossRef]
175.
Taussig MD, Irene Koran ME, Mouli SK, Ahmad A, Geevarghese S, Baker JC, et al. Neutrophil to lymphocyte ratio predicts disease progression following intra-arterial therapy of hepatocellular carcinoma. HPB 2017;19:458–64. 10.1016/j.hpb.2017.01.013 [PubMed: 28190710] [CrossRef]
176.
McDevitt JL, Alian A, Kapoor B, Bennett S, Gill A, Levitin A, et al. Single-center comparison of overall survival and toxicities in patients with infiltrative hepatocellular carcinoma treated with yttrium-90 radioembolization or drug-eluting embolic transarterial chemoembolization. J Vasc Interv Radiol 2017;28:1371–7. 10.1016/j.jvir.2017.05.017 [PubMed: 28689934] [CrossRef]
177.
Akinwande O, Kim D, Edwards J, Brown R, Philips P, Scoggins C, et al. Is radioembolization (90Y) better than doxorubicin drug eluting beads (DEBDOX) for hepatocellular carcinoma with portal vein thrombosis? A retrospective analysis. Surg Oncol 2015;24:270–5. 10.1016/j.suronc.2015.06.008 [PubMed: 26133576] [CrossRef]
178.
Philips P, Edwards J, Russell B, Scoggins CR, Martin RC. A comparative analysis of transarterial therapy for unresectable hepatocellular carcinoma with portal vein thrombosis: radioembolization 90Y versus doxorubicin drug eluting beads (DEB-DOX). Ann Surg Oncol 2015;22:S109.
179.
Biederman DM, Titano JJ, Bishay VL, Durrani RJ, Dayan E, Tabori N, et al. Radiation segmentectomy versus TACE combined with microwave ablation for unresectable solitary hepatocellular carcinoma up to 3 cm: a propensity score matching study. Radiology 2017;283:895–905. 10.1148/radiol.2016160718 [PubMed: 27930089] [CrossRef]
180.
Biederman D, Titano J, Bishay V, Durrani R, Dayan E, Schwartz M, et al. Radiation segmentectomy vs. microwave ablation for unresectable solitary hepatocellular carcinoma < 3 cm: a propensity score matching study. J Vasc Interv Radiol 2016;27:S5–6. 10.1016/j.jvir.2015.12.030 [CrossRef]
181.
Padia SA, Chewning RH, Kogut MJ, Ingraham CR, Johnson GE, Bhattacharya R, et al. Outcomes of locoregional tumor therapy for patients with hepatocellular carcinoma and transjugular intrahepatic portosystemic shunts. Cardiovasc Intervent Radiol 2015;38:913–21. 10.1007/s00270-014-1009-8 [PubMed: 25373795] [CrossRef]
182.
Radunz S, Saner FH, Treckmann J, Rekowski J, Theysohn JM, Müller S, et al. Hepatic artery and biliary complications in liver transplant recipients with radioembolization bridging treatment for hepatocellular carcinoma. Clin Transplant 2017;31. 10.1111/ctr.13096 [PubMed: 28836737] [CrossRef]
183.
Ali R, Gabr A, Abouchaleh N, Al Asadi A, Mora RA, Kulik L, et al. Survival analysis of advanced HCC treated with radioembolization: comparing impact of clinical performance status versus vascular invasion/metastases. Cardiovasc Intervent Radiol 2018;41:260–9. 10.1007/s00270-017-1791-1 [PubMed: 28879621] [CrossRef]
184.
Kudo M. Systemic therapy for hepatocellular carcinoma: 2017 update. Oncology 2017;93(Suppl. 1):135–46. 10.1159/000481244 [PubMed: 29258077] [CrossRef]
185.
National Institute for Health and Care Excellence (NICE). Pertuzumab with Trastuzumab and Docetaxel for Treating HER2-positive Breast Cancer. [TA509]. London: NICE; 2018.
186.
NHS England. Schedule 2 – The Services. Liver Transplantation Service (Adults). Service Specification 170003/S. Redditch: NHS England; 2017.
187.
NHS Blood and Transplant. Organ Donation and Transplantation. Cambridge: NHS Blood and Transplant; 2018.
188.
National Institute for Health and Care Excellence (NICE). SIR-Spheres for Treating Inoperable Hepatocellular Carcinoma. Medtech Innovation Briefing [MIB63]. London: NICE; 2016. URL: www​.nice.org.uk/advice/mib63 (accessed 8 May 2019).
189.
Department of Health and Social Care (DHSC). NHS Reference Costs 2016–17. London: DHSC; 2017.
Copyright © Queen’s Printer and Controller of HMSO 2020. This work was produced by Walton et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.
Bookshelf ID: NBK562647

Views

  • PubReader
  • Print View
  • Cite this Page
  • PDF version of this title (3.2M)

Other titles in this collection

Related information

  • PMC
    PubMed Central citations
  • PubMed
    Links to PubMed

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...