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Claxton L, Simmonds M, Beresford L, et al. Coenzyme Q10 to manage chronic heart failure with a reduced ejection fraction: a systematic review and economic evaluation. Southampton (UK): NIHR Journals Library; 2022 Jan. (Health Technology Assessment, No. 26.4.)

Cover of Coenzyme Q10 to manage chronic heart failure with a reduced ejection fraction: a systematic review and economic evaluation

Coenzyme Q10 to manage chronic heart failure with a reduced ejection fraction: a systematic review and economic evaluation.

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Acknowledgements

We thank Alessandro Grosso (NIHR Methods Research Fellow, Centre for Health Economics, University of York, UK) and Samriti Sharma for translation advice during the study selection and quality assessment stages of the systematic review. We also thank Claire Khouja for proofreading the report.

Contributions of authors

Lindsay Claxton (https://orcid.org/0000-0002-1795-7568) (Research Fellow) contributed to the development of the protocol, developed and built the economic analysis, wrote sections of the report pertaining to the economic analysis and contributed to the writing of all sections of the report.

Mark Simmonds (https://orcid.org/0000-0002-1999-8515) (Senior Research Fellow) contributed to the development of the protocol, developed the statistical analysis plan, performed the statistical analyses, provided oversight of data extraction and quality assessment, wrote sections of the report pertaining to meta-analyses and contributed to the writing of all sections of the report.

Lucy Beresford (https://orcid.org/0000-0001-6803-5566) (Research Fellow) performed study selection, data extraction and quality assessment, and contributed to the writing of all sections of the report.

Richard Cubbon (https://orcid.org/0000-0001-7844-3600) (Associate Professor and Honorary Consultant Cardiologist) provided access to, and answered questions regarding, the ‘West Yorkshire’ data set, was a member of the Project Advisory Group, provided feedback and advice during the project, and commented on the final report.

Mark Dayer (https://orcid.org/0000-0002-0976-9743) (Consultant Cardiologist, Honorary Senior Lecturer, University of Exeter) was a member of the Project Advisory Group, provided feedback and advice during the project and commented on the final report.

Stephen S Gottlieb (Professor of Medicine) provided and answered queries about IPD from his trial and commented on the final report.

Nick Hartshorne-Evans (https://orcid.org/0000-0003-0356-1471) (CEO, The Pumping Marvellous Foundation) was a patient and public involvement and engagement member of the Project Advisory Group, contributed to protocol development, provided feedback and advice during the project, and commented on the final report.

Bruce Kilroy was a patient and public involvement and engagement member of the Project Advisory Group, provided feedback and advice during the project, and commented on the final report.

Alexis Llewellyn (https://orcid.org/0000-0003-4569-5136) (Research Fellow) contributed to the development of the protocol, performed study selection, data extraction and quality assessment, and contributed to the writing of all sections of the report.

Claire Rothery (https://orcid.org/0000-0002-7759-4084) (Senior Research Fellow) contributed to the development of the protocol, provided advice and input to the development of the economic analysis, wrote sections of the report pertaining to the economic analysis and contributed to the writing of all sections of the report.

Sahar Sharif (https://orcid.org/0000-0001-6885-0456) (Research Fellow) performed study selection, data extraction and quality assessment, undertook communications with trial authors and contributed to the writing of all sections of the report.

Jayne F Tierney (https://orcid.org/0000-0002-4734-3014) (Professor and co-lead, Meta-analysis Programme) was a member of the Project Advisory Group, provided feedback and advice during the project, and commented on the final report.

Klaus K Witte (https://orcid.org/0000-0002-7146-7105) (Academic Fellow and Consultant Cardiologist) contributed to the development of the protocol, provided clinical advice and oversight, and contributed to the writing of all sections of the report. He also provided and answered questions about IPD from his RCT.

Kath Wright (https://orcid.org/0000-0002-9020-1572) (Information Service Manager) prepared and performed all database searches for the systematic reviews.

Lesley A Stewart (https://orcid.org/0000-0003-0287-4724) (Director of CRD and Professor of Evidence Synthesis) contributed to the development of the protocol, undertook communications with trial authors, wrote sections of the report, contributed to the writing of all sections of the report and provided oversight of the project as a whole.

Data-sharing statement

Requests for access to the aggregate data used in the systematic review should be addressed to the corresponding author. Requests for IPD from the two trials that shared data should be addressed to the trial authors directly. Queries regarding the ‘West Yorkshire’ database should be directed to ku.ca.sdeel@nobbuc.r.

Disclaimers

This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, NETSCC, the HTA programme or the Department of Health and Social Care. If there are verbatim quotations included in this publication the views and opinions expressed by the interviewees are those of the interviewees and do not necessarily reflect those of the authors, those of the NHS, the NIHR, NETSCC, the HTA programme or the Department of Health and Social Care.

Copyright © 2022 Claxton et al. This work was produced by Claxton et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This is an Open Access publication distributed under the terms of the Creative Commons Attribution CC BY 4.0 licence, which permits unrestricted use, distribution, reproduction and adaption in any medium and for any purpose provided that it is properly attributed. See: https://creativecommons.org/licenses/by/4.0/. For attribution the title, original author(s), the publication source – NIHR Journals Library, and the DOI of the publication must be cited.
Bookshelf ID: NBK577339

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