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David Jayne; Michael Walsh; Peter A Merkel; Chen Au Peh; Wladimir Szpirt; Xavier Puéchal; Shouichi Fujimoto; Carmel Hawley; Nader Khalidi; Rachel Jones; Oliver Flossmann; Ron Wald; Louis Girard; Adeera Levin; Gina Gregorini; Lorraine Harper; William Clark; Christian Pagnoux; Ulrich Specks; Lucy Smyth; Toshiko Ito-Ihara; Janak de Zoysa; Biljana Brezina; Andrea Mazzetti; Carol A McAlear; Donna Reidlinger; Samir Mehta; Natalie Ives; Elizabeth A Brettell; Hugh Jarrett; Keith Wheatley; Elizabeth Broadhurst; Alina Casian; Charles D Pusey

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Jayne D, Walsh M, Merkel PA, et al. Plasma exchange and glucocorticoids to delay death or end-stage renal disease in anti-neutrophil cytoplasm antibody-associated vasculitis: PEXIVAS non-inferiority factorial RCT. Southampton (UK): National Institute for Health and Care Research; 2022 Sep. (Health Technology Assessment, No. 26.38.)

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Plasma exchange and glucocorticoids to delay death or end-stage renal disease in anti-neutrophil cytoplasm antibody-associated vasculitis: PEXIVAS non-inferiority factorial RCT.

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List of abbreviations

AAV: anti-neutrophil cytoplasm antibody-associated vasculitis
ANCA: anti-neutrophil cytoplasm antibody
BCTU: Birmingham Clinical Trials Unit
BVAS/WG: Birmingham Vasculitis Activity Score/Wegener’s Granulomatosis version
CDA: Combined Damage Assessment Index
CI: confidence interval
CONSORT: Consolidated Standards of Reporting Trials
CYC: cyclophosphamide
DMC: Data Monitoring Committee
eGFR: estimated glomerular filtration rate
EQ-5D: EuroQoL-5 Dimensions
ESRD: end-stage renal disease
EUVAS: European Vasculitis Study Group
GC: glucocorticoid
GFR: glomerular filtration rate
GPA: granulomatosis with polyangiitis
HR: hazard ratio
IgG: immunoglobulin G
IgM: immunoglobulin M
IRR: incidence rate ratio
ITT: intention to treat
i.v.: intravenous
MEPEX: Methylprednisolone versus Plasma Exchange
MPA: microscopic polyangiitis
MPO: myeloperoxidase
PEXIVAS: Plasma Exchange In VASculitis
PLEX: plasma exchange
PR3: proteinase 3
RR: relative risk
SAE: serious adverse event
SF-36: Short Form questionnaire-36 items
TRALI: transfusion-associated acute lung injury
VCRC: Vasculitis Clinical Research Consortium

Copyright © 2022 Jayne et al. This work was produced by Jayne et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This is an Open Access publication distributed under the terms of the Creative Commons Attribution CC BY 4.0 licence, which permits unrestricted use, distribution, reproduction and adaption in any medium and for any purpose provided that it is properly attributed. See: https://creativecommons.org/licenses/by/4.0/. For attribution the title, original author(s), the publication source – NIHR Journals Library, and the DOI of the publication must be cited.

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Jayne D, Walsh M, Merkel PA, et al. Plasma exchange and glucocorticoids to delay death or end-stage renal disease in anti-neutrophil cytoplasm antibody-associated vasculitis: PEXIVAS non-inferiority factorial RCT. Southampton (UK): National Institute for Health and Care Research; 2022 Sep. (Health Technology Assessment, No. 26.38.) List of abbreviations.
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Plasma exchange and glucocorticoids to delay death or end-stage renal disease in anti-neutrophil cytoplasm antibody-associated vasculitis: PEXIVAS non-inferiority factorial RCT.

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