Rapid review searches

MEDLINE(Ovid) and Epub Ahead of Print, In-process, In-data-review and Other Non-indexed Citations and Daily: 1946–4 October 2022

Searched 5 October 2022

1. ((CaRi adj3 heart) or CaRi-Heart or CaRiHeart).af. (2)
2. (Caristo or CariCloud).ti,ab,ot. (1)
3. (CRD42020181158 or CRD42021229491 or CRD42021297228 or NCT05169333).af. (2)
4. 1 or 2 or 3 (5)
5. ((Fat or PVAT or ‘perivascular adipose tissue’) adj2 Attenuation$).ti,ab,ot. (282)
6. (FAI adj3 (Scor$ or Index$ or indic$ or measure$ or map$ or coronary or plaque$ or arter$ or heart$ or athero$)).ti,ab,ot. (974)
7. (FAITM or pFAI).ti,ab,ot. (17)
8. or/5–7 (1229)
9. 4 or 8 (1232)
10. exp animals/not (exp animals/and humans/) (5,053,872)
11. 9 not 10 (1203)

EMBASE (Ovid): 1974–4 October 2022

Searched 5 October 2022

1. ((CaRi adj3 heart) or CaRi-Heart or CaRiHeart).af. (8)
2. (Caristo or CariCloud).ti,ab,ot. (1)
3. (CRD42020181158 or CRD42021229491 or CRD42021297228 or NCT05169333).af. (2)
4. 1 or 2 or 3 (11)
5. ((Fat or PVAT or ‘perivascular adipose tissue’) adj2 Attenuation$).ti,ab,ot. (443)
6. (FAI adj3 (Scor$ or Index$ or indic$ or measure$ or map$ or coronary or plaque$ or arter$ or heart$ or athero$)).ti,ab,ot. (1381)
7. (FAITM or pFAI).ti,ab,ot. (26)
8. or/5–7 (1783)
9. 4 or 8 (1791)
10. animal/ (1,589,563)
11. animal experiment/ (2,876,011)
12. (rat or rats or mouse or mice or murine or rodent or rodents or hamster or hamsters or pig or pigs or porcine or rabbit or rabbits or animal or animals or dogs or dog or cats or cow or bovine or sheep or ovine or monkey or monkeys).ti,ab,ot,hw. (7,353,556)
13. or/10–12 (7,353,556)
14. exp human/ (24,163,444)
15. human experiment/ (596,121)
16. or/14–15 (24,165,573)
17. 13 not (13 and 16) (5,550,502)
18. 9 not 17 (1746)

MEDLINE(Ovid) PubMed-not-MEDLINE: 1946–4 October 2022

Searched 5 October 2022

1. ((CaRi adj3 heart) or CaRi-Heart or CaRiHeart).af. (0)
2. (Caristo or CariCloud).ti,ab,ot. (0)
3. (CRD42020181158 or CRD42021229491 or CRD42021297228 or NCT05169333).af. (0)
4. 1 or 2 or 3 (0)
5. ((Fat or PVAT or ‘perivascular adipose tissue’) adj2 Attenuation$).ti,ab,ot. (56)
6. (FAI adj3 (Scor$ or Index$ or indic$ or measure$ or map$ or coronary or plaque$ or arter$ or heart$ or athero$)).ti,ab,ot. (95)
7. (FAITM or pFAI).ti,ab,ot. (4)
8. or/5–7 (142)
9. 4 or 8 (142)
10. exp animals/ not (exp animals/ and humans/) (1)
11. 9 not 10 (142)

PubMed (NIH): up to 5 October 2022

Searched 5 October 2022

(PubMed top up)

• 10 #2 or #4 or #5 or #7 or #8 or #9 (415)
• 9 FAITM[Title/Abstract] OR pFAI[Title/Abstract] (18)
• 8 (FAI[Title/Abstract] AND (coronary[Title/Abstract] OR plaque*[Title/Abstract] OR arter*[Title/Abstract] OR heart*[Title/Abstract] OR athero*[Title/Abstract]) (135)
• 7 ‘Fat attenuation’ or ‘PVAT attenuation’ or ‘perivascular adipose tissue attenuation’ (306)
• 5 (Caristo[Title/Abstract] OR CariCloud[Title/Abstract]) (1)
• 4 CRD42020181158 or CRD42021229491 or CRD42021297228 or NCT05169333 (2)
• 2 ‘CaRi heart’ or CaRi-Heart or CaRiHeart (1)

Cochrane Database of Systematic Reviews (Wiley): up to 2022/10/Iss10

Cochrane Database of Systematic Reviews – Protocols (CDSR_P) (Wiley): up to 2022/10/Iss10

Cochrane Central Register of Controlled Trials (Wiley): up to 2022/10/Iss10

Searched 5 October 2022

ID Search Hits

CDSR = 20

CDSR Protocols = 1

CENTRAL = 225

Database of Abstracts of Reviews of Effects (CRD): up to March 2015

Health Technology Assessment Database (CRD): up to March 2018

Searched 5 October 2022

1. (((CaRi Near3 heart) or CaRi-Heart or CaRiHeart)) 0 Delete
2. ((Caristo or CariCloud)) 0 Delete
3. ((CRD42020181158 or CRD42021229491 or CRD42021297228 or NCT05169333)) 0 Delete
4. (((Fat or PVAT or ‘perivascular adipose tissue’) Near3 Attenuation*)) 0 Delete
5. ((FAI Near3 (Scor* or Index* or indic* or measure* or map* or coronary or plaque* or arter* or heart* or athero*))) 0 Delete
6. ((FAITM or pFAI)) 0 Delete
7. #1 OR #2 OR #3 OR #4 OR #5 OR #6 0 Delete

CINAHL (EBSCOhost Research Databases): up to 6 October 2022

Searched 6 October 2022

• S7 S1 OR S2 OR S3 OR S4 OR S5 OR S6 510
• S6 TI ((FAI N3 (Scor* or Index* or indic* or measure* or map* or coronary or plaque* or arter* or heart* or athero*))) OR AB ((FAI N3 (Scor* or Index* or indic* or measure* or map* or coronary or plaque* or arter* or heart* or athero*))) 367
• S5 TI ((Fat or PVAT or ‘perivascular adipose tissue’) N3 Attenuation*)) OR AB ((Fat or PVAT or ‘perivascular adipose tissue’) N3 Attenuation*)) 138
• S4 (FAITM or pFAI) 4
• S3 (CRD42020181158 or CRD42021229491 or CRD42021297228 or NCT05169333) 0
• S2 (Caristo or CariCloud) 11
• S1 (CaRi N3 heart) or CaRi-Heart or CaRiHeart) 1

KSR Evidence (https://ksrevidence.com/): up to 5 October 2022

Searched 5 October 2022

1. ((CaRi Adj/3 heart) or CaRi-Heart or CaRiHeart) in All text 0 results
2. (Caristo or CariCloud) in All text 0 results
3. (CRD42020181158 or CRD42021229491 or CRD42021297228 or NCT05169333) in All text 2 results
4. ((Fat or PVAT or ‘perivascular adipose tissue’) adj/3 Attenuation*) in All text 4 results
5. (FAI adj/3 (Scor* or Index* or indic* or measure* or map* or coronary or plaque* or arter* or heart* or athero*)) in All text 24 results
6. (FAITM or pFAI) in All text 0 results
7. #1 or #2 or #3 or #4 or #5 or #6 in All text 28 results

Epistemonikos (https://www.epistemonikos.org/): up to 6 October 2022

Searched 6 October 2022

• Advanced search Limits: Systematic Review/ (advanced_title_en:(‘CaRi heart’ OR CaRi-Heart OR CaRiHeart) OR advanced_abstract_en:(‘CaRi heart’ OR CaRi-Heart OR CaRiHeart)) OR (advanced_title_en:(Caristo OR CariCloud) OR advanced_abstract_en:(Caristo OR CariCloud)) OR (advanced_title_en:(CRD42020181158 OR CRD42021229491 OR CRD42021297228 OR NCT05169333) OR advanced_abstract_en:(CRD42020181158 OR CRD42021229491 OR CRD42021297228 OR NCT05169333)) OR (advanced_title_en:(‘Fat attenuation’ OR ‘PVAT attenuation’ OR ‘perivascular adipose tissue attenuation’) OR advanced_abstract_en:(‘Fat attenuation’ OR ‘PVAT attenuation’ OR ‘perivascular adipose tissue attenuation’)) OR (advanced_title_en:((FAI AND (Scor* OR Index* OR indic* OR measure* OR map* OR coronary OR plaque* OR arter* OR heart* OR athero*))) OR advanced_abstract_en:((FAI AND (Scor* OR Index* OR indic* OR measure* OR map* OR coronary OR plaque* OR arter* OR heart* OR athero*)))) OR (advanced_title_en:(FAITM OR pFAI) OR advanced_abstract_en:(FAITM OR pFAI)) [Filters: classification = systematic-review, protocol = no]

Search retrieved 138 records

INAHTA (https://www.inahta.org/): up to 6 October 2022

Searched 6 October 2022

Advanced search

• (‘CaRi heart’ OR CaRi-Heart OR CaRiHeart) OR (Caristo OR CariCloud) OR (CRD42020181158 OR CRD42021229491 OR CRD42021297228 OR NCT05169333) OR (‘Fat attenuation’ OR ‘PVAT attenuation’ OR ‘perivascular adipose tissue attenuation’) OR ((FAI AND (Scor* OR Index* OR indic* OR measure* OR map* OR coronary OR plaque* OR arter* OR heart* OR athero*))) OR (FAITM OR pFAI)

Search retrieved two records

NIHR HTA (Journals: www.journalslibrary.nihr.ac.uk/): up to 6 October 2022

Searched 6 October 2022

Simple search

Results = 0

PROSPERO (CRD): up to 5 October 2022

Searched 5 October 2022

INPLASY (https://inplasy.com/): up to 6 October 2022

Searched 6 October 2022

LILACS (http://regional.bvsalud.org/php/index.php?lang=en): up to 6 October 2022

Searched: 6 October 2022

(Limit = Not MEDLINE)

Retrieved 9 hits (LILACs only)

DOAJ (https://doaj.org/): up to 6 October 2022

Searched 6 October 2022

ClinicalTrials.gov (https://clinicaltrials.gov/ct2/home): up to 6 October 2022

Searched 6 October 2022

EUCTR (www.clinicaltrialsregister.eu): up to 6 October 2022

Searched 6 October 2022

WHO ICTRP (www.who.int/ictrp/search/en/): up to 6 October 2022

Searched 6 October 2022

ScanMedicine (https://scanmedicine.com/): up to 6 October 2022

Searched: 6 October 2022

Northern Light Life Sciences Conference Abstracts (Ovid): 2010–22/wk38

Searched 5 October 2022

1. ((CaRi adj3 heart) or CaRi-Heart or CaRiHeart).af. (1)
2. (Caristo or CariCloud).af. (16)
3. (CRD42020181158 or CRD42021229491 or CRD42021297228 or NCT05169333).af. (0)
4. 1 or 2 or 3 (17)
5. ((Fat or PVAT or ‘perivascular adipose tissue’) adj2 Attenuation$).af. (42)
6. (FAI adj3 (Scor$ or Index$ or indic$ or measure$ or map$ or coronary or plaque$ or arter$ or heart$ or athero$)).af. (44)
7. (FAITM or pFAI).af. (2)
8. or/5-7 (86)
9. 4 or 8 (103)

MedRxiv (medRxiv.org): up to 6 October 2022

Searched 6 October 2022

Advanced search

Additional focused searches

Search (1) Statins and risk of CAD

EMBASE < 1974–24 October 2022

Searched 26 October 2022

Statins + Risk of CAD + Symptomatic + RCTS No A

1. exp coronary artery disease/ or CAD.ti,ab,ot. (403,106)
2. (coronary artery adj3 (disease$ or syndrome$ or anomal$ or aneurysm or atherosclerosis or calcification or constriction or dissection or obstruction or occlusion or perforation or thrombosis)).ti,ab,ot. (174,891)
3. or/1-2 (438,155)
4. risk$.ti,ab,ot. (3,926,246)
5. 3 and 4 (151,732)
6. exp hydroxymethylglutaryl coenzyme A reductase inhibitor/ or (statin$ or vastatin$).ti,ab,ot. (199,326)
7. ((HMG or hydroxymethylglutaryl) adj2 (CoA or coenzyme A) adj2 (‘reductase inhibitor’ or ‘reductase inhibitors’)).ti,ab,ot. (6241)
8. (Atorvastatin or astator or ator or atorab or atoris or atorlip or atorvadivid or atorvastine or atostin or atovans or atovarol or cardyl or ci 981 or ci981 or glustar or lipibec or Lipitor or liprimar or liptonorm or lowlipen or obradon or orbeos or prevencor or sortis or statorva or storvas or tahor or torvast or totalip or xarator or ym 548 or ym548 or zarator or 110862-48-1 or 134523-00-5 or 134523-03-8).ti,ab,ot,tn,rn. (44,225)
9. (Simvastatin or avastinee or belmalip or cholestat or clinfar or colastatina or coledis or colemin or colestricon or corolin or covastin or denan or epistatin or esvat or ethical or eucor or flolipid or ifistatin or jabastatina or kavelor or klonastin or kolestevan or ‘l 644128’ or l644128 or labistatin or lipcut or lipecor or lipex or lipinorm or liponorm or lipovas or lodales or medipo or mersivas or ‘mk 0733’ or mk 733 or mk0733 or mk733 or nivelipol or nor-vastina or normofat or orovas or pantok or Rechol or rendapid or simbado or simcard or simchol or simovil or simtin or simva or simvac or Simvahex or simvalord or simvastar or simvastatina or simvastatine or simvata or simvatin or simvor or simvotin or sinvacor or simvastatin or sinvinolin or sivastin or starzoco or synvinolin or torio or valemia or vasilip or vasotenal or vazim or velostatin or vidastat or zimmex or zocor or zocord or zorced or zosta or zovast or 79902-63-9).ti,ab,ot,tn,rn. (171571)
10. (Rosuvastatin or coupet or crestor or epri or ezallor or ‘hgp 0816’ or hgp0816 or mertenil or provisacor or rostat or rosudia or rosumop or rosuvador or rosuvas or rosuvastatina or rosuvastatine or roswera or roxera or rozuva-teva or ‘s 4522’ or s4522 or simestat or sorvasta or visacor or xeter or zahron or zaranta or zd 4522 or zd4522 or 147098-18-8 or 147098-20-2 or 287714-41-4).ti, ab,ot,tn,rn. (18,972)
11. or/6–10 (330,511)
12. symptomatic.ti,ab,ot,hw. (321,504)
13. stable angina pectoris/ or (stable adj2 angina$).ti,ab,ot,hw. (18,774)
14. secondary prevention/ or (‘secondary prevention’ or ‘secondary preventions’).ti,ab,ot,hw. (46,952)
15. computed tomographic angiography/ or ((computed tomographic or CT) adj2 angiograph$).ti,ab,ot. (87,721)
16. thorax pain/ or ((chest or thorax or thoracic) adj3 (discomfort or pain$ or ache$ or ‘abnormal feeling’)).ti,ab,ot,hw. (131,468)
17. or/12–16 (584,720)
18. 5 and 11 and 17 (4165)
19. crossover-procedure/or double-blind procedure/or randomized controlled trial/or single-blind procedure/ (812,505)
20. (random$ or factorial$ or crossover$ or cross over$ or cross-over$ or placebo$ or (doubl$ adj blind$) or (singl$ adj blind$) or assign$ or allocat$ or volunteer$).ti,ab,ot. (2,641,780)
21. 19 or 20 (2,750,001)
22. animal/or animal experiment/ (4,459,556)
23. (rat or rats or mouse or mice or murine or rodent or rodents or hamster or hamsters or pig or pigs or porcine or rabbit or rabbits or animal or animals or dogs or dog or cats or cow or bovine or sheep or ovine or monkey or monkeys).ti,ab,ot,hw. (7,369,171)
24. 22 or 23 (7,369,171)
25. exp human/or human experiment/ (24,240,337)
26. 24 not (24 and 25) (5,560,969)
27. 21 not 26 (2,472,774)
28. 18 and 27 (746)

KSR Evidence: up to 26 October 2022

Searched 26 October 2022

1. CAD in Title or Abstract 743 results
2. (coronary artery adj3 (disease* or syndrome* or anomal* or aneurysm or atherosclerosis or calcification or constriction or dissection or obstruction or occlusion or perforation or thrombosis)) in All text 1974 results
3. #1 or #2 in All text 2138 results
4. risk* in Title or Abstract 90,582 results
5. #3 and #4 in All text 1300 results
6. (statin* or vastatin*) in All text 1384 results
7. ((HMG or hydroxymethylglutaryl) adj2 (CoA or coenzyme A) adj2 (‘reductase inhibitor’ or ‘reductase inhibitors’)) in All text 237 results
8. (Atorvastatin or astator or ator or atorab or atoris or atorlip or atorvadivid or atorvastine or atostin or atovans or atovarol or cardyl or ci 981 or ci981 or glustar or lipibec or Lipitor or liprimar or liptonorm or lowlipen or obradon or orbeos or prevencor or sortis or statorva or storvas or tahor or torvast or totalip or xarator or ym 548 or ym548 or zarator) in All text 301 results
9. 9 (Simvastatin or avastinee or belmalip or cholestat or clinfar or colastatina or coledis or colemin or colestricon or corolin or covastin or denan or epistatin or esvat or ethical or eucor or flolipid or ifistatin or jabastatina or kavelor or klonastin or kolestevan or ‘l 644128’ or l644128 or labistatin or lipcut or lipecor or lipex or lipinorm or liponorm or lipovas or lodales or medipo or mersivas or ‘mk 0733’ or mk 733 or mk0733 or mk733 or nivelipol or nor-vastina or normofat or orovas or pantok or Rechol or rendapid or simbado or simcard or simchol or simovil or simtin or simva or simvac or Simvahex or simvalord or simvastar or simvastatina or simvastatine or simvata or simvatin or simvor or simvotin or sinvacor or simvastatin or sinvinolin or sivastin or starzoco or synvinolin or torio or valemia or vasilip or vasotenal or vazim or velostatin or vidastat or zimmex or zocor or zocord or zorced or zosta or zovast) in All text 21,697 results
10. 10 (Rosuvastatin or coupet or crestor or epri or ezallor or ‘hgp 0816’ or hgp0816 or mertenil or provisacor or rostat or rosudia or rosumop or rosuvador or rosuvas or rosuvastatina or rosuvastatine or roswera or roxera or rozuva-teva or ‘s 4522’ or s4522 or simestat or sorvasta or visacor or xeter or zahron or zaranta or zd 4522 or zd4522) in All text 35,033 results
11. #6 or #7 or #8 or #9 or #10 in All text 52,705 results
12. symptomatic in All text 3969 results
13. (stable adj2 angina*) in All text 98 results
14. (‘secondary prevention’ or ‘secondary preventions’) in All text 828 results
15. ((computed tomographic or CT) adj2 angiograph*) in All text 118 results
16. ((chest or thorax or thoracic) adj3 (discomfort or pain* or ache* or ‘abnormal feeling’)) in All text 519 results
17. in All text 0 results
18. #12 or #13 or #14 or #15 or #16 in All text 5451 results
19. #5 and #11 and #18 in All text 45 results

Search (2) Major adverse cardiac events and utilities

KSR Evidence: up to 24 October 2022

Searched 24 October 2022

(MACE/4named + Focused HRQoL filter)

1. MACE or ‘major adverse cardiac event’ or ‘major adverse cardiac events’ in All text 1184 results
2. stroke or strokes or apoplexia or apoplexy or ‘insultus cerebralis’ in All text 9081 results
3. ((brain or cerebral or cerebrum) Adj/3 (accident* or attack* or insult* or insufficiency)) in All text 140 results
4. (cerebrovascular Adj/3 (arrest* or failure* or injury* or insult*)) in All text 100 results
5. CVA in Title or Abstract 92 results
6. (ischaemic or ischemic) Adj/2 seizure in All text 4 results
7. ((cardiac or heart or cardial or myocardial or myocardium or subendocardial) Adj/3 (infarct* or attack)) in All text 4301 results
8. angina or anginal or stenocardia in All text 608 results
9. revascularisation or revascularization in All text 1760 results
10. #1 or #2 or #3 or #4 or #5 or #6 or #7 or #8 or #9 in All text 12,451 results
11. sf6D or sf 6D or sf-6D or short form 6D or shortform 6D or sf six D or sfsixD or shortform six D or short form six D in All text 110 results
12. Quality adjusted life or Quality-adjusted-life in All text 1216 results
13. euroqol or euro qol or eq5d* or eq 5d in All text 465 results
14. QALY* or DALY* or HALY* or YHL or HYES or YPLL or YHLL or qald* or qale* or qtime* or AQoL* in All text 703 results
15. timetradeoff or time tradeoff or time trade-off or time trade off or TTO or Standard gamble* or ‘willingness to pay’ in All text 315 results
16. HSUV* or health state* value* or health state* preference* or HSPV* in All text 2511 results
17. (utilit* Adj/3 (‘quality of life’ or valu* or scor* or measur* or health or life or estimat* or elicit* or disease*)) in All text 555 results
18. #11 or #12 or #13 or #14 or #15 or #16 or #17 in All text 4668 results
19. #10 and #18 in All text 282 results

Search (3) Colchicine and CAD

EMBASE (Ovid): 1974–24 October 2022

Searched 25 October 2022

1. Colchicine/or (aqua colchin or colchichine or colchicine or colchicine or colchicum-dispert or colchily or colchimedio or colchiquim or colchisol or colchysat or colcine or colcrys or colctab or colgout or colrefuz or gloperba or goutichine or goutnil or kolkicin or kolkisin or mitigare or ‘mpc 004’ or mpc004 or myinfla or nsc 757 or tolchicine or 64-86-8).ti,ab,ot,hw,tn,rn.  38,959
2. exp coronary artery disease/or CAD.ti,ab,ot. 403,106
3. (coronary artery adj3 (disease$ or syndrome$ or anomal$ or aneurysm or atherosclerosis or calcification or constriction or dissection or obstruction or occlusion or perforation or thrombosis)).ti,ab,ot. 174,891
4. or/2-3 438,155
5. 1 and 4 918

KSR Evidence (https://ksrevidence.com/): up to 25 October 2022

Searched: 25 October 2022

1. ‘aqua colchin’ or colchichine or colchicine or colchicine or ‘colchicum-dispert’ or colchily or colchimedio or colchiquim or colchisol or colchysat or colcine or colcrys or colctab or colgout or colrefuz or gloperba or goutichine or goutnil or kolkicin or kolkisin or mitigare or ‘mpc 004’ or mpc004 or myinfla or ‘nsc 757’ or tolchicine in All text 192 results
2. CAD in All text 822 results
3. ‘coronary artery’ adj3 (disease* or syndrome* or anomal* or aneurysm or atherosclerosis or calcification or constriction or dissection or obstruction or occlusion or perforation or thrombosis) in All text 1906 results
4. #2 or #3 in All text 2136 results
5. #1 and #4 in All text 37 results

Search (4) Heart failure and utilities

KSR Evidence: up to 15 November 2022

Searched 15 November 2022

(Heart failure + Focused HRQoL filter)

# Query Results

1. ((Heart or cardiac or cardial or myocardial or cordis or cardis) adj3 (failure* or decompensat* or incompetence or insufficien* or ‘stand still’)) in All text 4002 results
2. (HF or CHF) in Title or Abstract 1267 results
3. #1 or #2 in All text 4175 results
4. sf6D or sf 6D or sf-6D or short form 6D or shortform 6D or sf six D or sfsixD or shortform six D or short form six D in All text 112 results
5. Quality adjusted life or Quality-adjusted-life in All text 1223 results
6. euroqol or euro qol or eq5d* or eq 5d in All text 467 results
7. QALY* or DALY* or HALY* or YHL or HYES or YPLL or YHLL or qald* or qale* or qtime* or AQoL* in All text 711 results
8. timetradeoff or time tradeoff or time trade-off or time trade off or TTO or Standard gamble* or ‘willingness to pay’ in All text 319 results
9. HSUV* or health state* value* or health state* preference* or HSPV* in All text 2531 results
10. (utilit* Adj/3 (‘quality of life’ or valu* or scor* or measur* or health or life or estimat* or elicit* or disease*)) in All text 558 results
11. #4 or #5 or #6 or #7 or #8 or #9 or #10 in All text 4707 results
12. #3 and #11 in All text 111 results