TABLE 6.2Characteristics of available pangenotypic and non-pangenotypic DAAs

Pangenotypic regimensSofosbuvir/ledipasvir
Sofosbuvir/velpatasvirSofosbuvir/daclatasvirGlecaprevir/pibrentasvir
Efficacy in infection with HCV genotypes 1–6PangenotypicPangenotypicPangenotypicGenotype dependent
TolerabilityHighHighHighHigh
Registration status in low- and middle-income countriesVery lowLowVery lowLow
Access plans in low- and middle-income countriesIn developmentLarge number of countries included in voluntary license agreementsNo information availableLarge proportion of countries included in voluntary license agreements
Acceptability by health providersHighestHighestHighestHigh
Health system costs (genotyping; laboratory; personnel)LowLowLowHigh

From: 6, Simplified Service Delivery for a Public Health Approach to Testing, Care and Treatment for HCV Infection

Cover of Guidelines for the Care and Treatment of Persons Diagnosed with Chronic Hepatitis C Virus Infection
Guidelines for the Care and Treatment of Persons Diagnosed with Chronic Hepatitis C Virus Infection [Internet].
Geneva: World Health Organization; 2018 Jul.
© World Health Organization 2018.

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