TABLE 19, Manufacturers of human anthrax vaccine - Anthrax in Humans and Animals

COUNTRY	MANUFACTURER	DESCRIPTION	DOSE
China	Lanzhou Institute of Biological Products 178 Yanchang Road Lanzhou, Gansu 730046 Tel.: +86 931 834 0311-8621 Fax: +86 931 834 3199	Live spore suspension of strain A16R in 50% glycerol and distilled water No other active ingredient/adjuvant	Single dose (approx. 2 x 10⁸ spores) by scarification of 50 µl in two spots on the skin with single booster after 6 or 12 months and annual boosters thereafter
Russian Federation	Research Institute of Microbiology 610024 Kirov Oktyabrskiy Prospect 119 Tel.: +7 8330 38 15 27 Fax: +7 8332 62 95 98	Lyophilized live spore suspension of strain STI-1 (Sanitary Technical Institute), Nikolaiv Ginsberg 1940 No other active ingredient/adjuvant	Initial 2 doses 20–30 days apart and single annual booster doses. Administered by scarification of 0.05 ml into the skin (approx. 5 x 10⁸ spores), or, in urgent situations, injection s.c. of 0.5 ml (approx. 5 x 10⁷ spores)
United Kingdom	Health Protection Agency Porton Down Salisbury Wiltshire SP4 0JG England Tel: +44 1980 612 100 Fax: +44 1980 611 096	Alum precipitated filtrate of strain 34F₂ culture	3 primary doses of 0.5 ml i.m. at 3week intervals with booster at 32 weeks and thereafter annually
United States of America	BioPort Corp 3500 N. Martin Luther King Jr Blvd, Lansing MI 48906 Tel.: +1 517 327 1500 Fax: +1 517 327 1501	Aluminium hydroxide-adsorbed filtrate of strain V770 culture	3 s.c. doses, 0.5 ml each, given 2 weeks apart followed by 3 additional s.c. injections, 0.5 ml each, at 6, 12, and 18 months. Subsequent booster injections of 0.5 ml annually

COUNTRY

MANUFACTURER

DESCRIPTION

DOSE

China

Lanzhou Institute of Biological Products
178 Yanchang Road
Lanzhou, Gansu 730046
Tel.: +86 931 834 0311-8621
Fax: +86 931 834 3199

Live spore suspension of strain A16R in 50% glycerol and distilled water
No other active ingredient/adjuvant

Single dose (approx. 2 x 10⁸ spores) by scarification of 50 µl in two spots on the skin with single booster after 6 or 12 months and annual boosters thereafter

Russian Federation

Research Institute of Microbiology
610024 Kirov
Oktyabrskiy Prospect 119
Tel.: +7 8330 38 15 27
Fax: +7 8332 62 95 98

Lyophilized live spore suspension of strain STI-1 (Sanitary Technical Institute), Nikolaiv Ginsberg 1940
No other active ingredient/adjuvant

Initial 2 doses 20–30 days apart and single annual booster doses. Administered by scarification of 0.05 ml into the skin (approx. 5 x 10⁸ spores), or, in urgent situations, injection s.c. of 0.5 ml (approx. 5 x 10⁷ spores)

United Kingdom

Health Protection Agency
Porton Down
Salisbury
Wiltshire SP4 0JG
England
Tel: +44 1980 612 100
Fax: +44 1980 611 096

Alum precipitated filtrate of strain 34F₂ culture

3 primary doses of 0.5 ml i.m. at 3week intervals with booster at 32 weeks and thereafter annually

United States of America

BioPort Corp
3500 N. Martin Luther King Jr
Blvd, Lansing
MI 48906
Tel.: +1 517 327 1500
Fax: +1 517 327 1501

Aluminium hydroxide-adsorbed filtrate of strain V770 culture

3 s.c. doses, 0.5 ml each, given 2 weeks apart followed by 3 additional s.c. injections, 0.5 ml each, at 6, 12, and 18 months. Subsequent booster injections of 0.5 ml annually

From: Annex 5, Vaccines and therapeutic sera

Anthrax in Humans and Animals. 4th edition.

Geneva: World Health Organization; 2008.

All rights reserved. Publications of the World Health Organization can be obtained from WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791 3264; fax: +41 22 791 4857; e-mail: tni.ohw@sredrokoob). Requests for permission to reproduce or translate WHO publications – whether for sale or for noncommercial distribution – should be addressed to WHO Press, at the above address (fax: +41 22 791 4806; e-mail: tni.ohw@snoissimrep).

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TABLE 19Manufacturers of human anthrax vaccine