Conserved Protein Domain Family
Activator_LAG-3
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pfam11498: Activator_LAG-3 
Transcriptional activator LAG-3
The C.elegans Notch pathway, involved in the control of growth, differentiation and patterning in animal development, relies on either of the receptors GLP-1 or LIN-12. Both these receptors promote signalling by the recruitment of LAG-3 to target promoters, where it then acts as a transcriptional activator. LAG-3 works as a ternary complex together with the DNA binding protein, LAG-1. Its N-terminal region adopts an elongated kinked helix that is required for complex assembly.
Links
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Statistics
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PSSM-Id: 151935
Aligned: 2 rows
Threshold Bit Score: 423.99
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q09260    23 MKPSTSK---TTHSPPPEEPTAPFVNDNLPNPEDEPTIGDLNAFHSGEELHRQRSELARANYEKARPEMIANQRAVTAHL 99  Caenorhabditis elegans
CAP29323   1 MKPSTSKagsSAQSPPPEEPNSAYVNNELPDPDDEPLVSEMTVYNKGQEEARLRSQEAYEKFQKTRQESISSQRAVTAQL 80 

Q09260   100 FNRYTEDEERKRVEQQKNKEAMNASTSapTSSRNGgqSVENRKRRNDvvVAPPTSEEEWKRA-QQQHWMGQQQPQM-QFQ 177 Caenorhabditis elegans
CAP29323  81 YHRFTEDEERKRMEHQKNKEAMNASVA--SASRNG--HIDNRKRRND--VGSLSAEEEWRRAqQQQHWMGQAAPMHpSYQ 154

Q09260   178 MQQQYHsQQQqyimMQQQHHHMTgmqqihhqmpstssadSIRSVPTPaSSMHQPSPAEMRNGCgmsrnatmdmtcspmsg 257 Caenorhabditis elegans
CAP29323 155 MQQQYH-QQQ----VAAQHHQFM----------------APHSVPTP-GSIHRPSPSGMQSVC----------------- 195

Q09260   258 gQPIVDENNLAVPEGEWFDKLALAVAEQYNVDTILGPDTYDTFLAELDFSSSESPTKQSPMEMNgdrmpSTAPPPaQNPQ 337 Caenorhabditis elegans
CAP29323 196 -LPTSDENSLDVPNGEWFDKLAVMVAEKYDATTILGPDTYDVYLNELDAMEPVGETVKTPSEAG-----QSASQP-MNPQ 268

Q09260   338 HiAQLQQQQNKMRLMQQQQQemqrIEQQRRQQIMQQQQQQqqqeHQRQQMLLqQQQQQQQMQQHHQMNgGGQFaTQAHQQ 417 Caenorhabditis elegans
CAP29323 269 Q-QQMAQQQNKMRMLQQQEM----MEQQRQQQMMHQHQQQ----HRQQQMLL-QQQQMHQLQQQNQMN-GGQF-TQAQQH 336

Q09260   418 AAYMQQMQRM---EQIRHQQQQAQQHQQAqQQHQQQAQHHQMGYGIPNGYpQQMHMHPPaYGaHHMPQPTAFANIN 490 Caenorhabditis elegans
CAP29323 337 AVYLQRMQHMrlqQQQQQQQQQAQHHQQA-QQHQQPHQNGVMGYSVPNGY-AHPNGYAP-YG-HHMPHHTPFANIN 408
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