1CLI


Conserved Protein Domain Family
purM

?
TIGR00878: purM 
Click on image for an interactive view with Cn3D
phosphoribosylaminoimidazole synthetase
Alternate name: phosphoribosylformylglycinamidine cyclo-ligase; AIRS; AIR synthase This enzyme is found as a homodimeric monofunctional protein in prokaryotes and as part of a larger, multifunctional protein, sometimes with two copies of this enzyme in tandem, in eukaryotes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Statistics
?
PSSM-Id: 273316
Aligned: 12 rows
Threshold Bit Score: 449.862
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
1CLI_A         7 LSYKDAGVDIDAGNALVGRIKG-----VVKKTRRPEVMGGLGGFGALCALPQK----YREPVLVSGTDGVGTKLRLAMDL 77  Escherichia coli
P12043         3 EAYKNAGVDIEAGYEAVKRMKK-----HVERTKRLGVMGSLGGFGGMFDLSELs---YQKPVLISGTDGVGTKLKLAFSM 74  Bacillus subtil...
P43848         6 LSYKDAGVDIHTGNELVERIKG-----DVKRTRRSEVMGGLGGFGALCALPTK----YKEPILVSGTDGVGTKLRLAIDL 76  Haemophilus inf...
Q57656         2 VTYKDAGVDISHEDKVIKALVSq----ITFKRSDIKPAELGLHYAGAVEFGD--------YYLVLSTDGVGSKMIVAEMA 69  Methanocaldococ...
O27272         2 VTYSESGVDIDLEELTVSSLTSr----LSDTLKYCDVITGAGHFAALVRMGD--------VAIAMSTDGVGSKILVAEMM 69  Methanothermoba...
WP_001336050   7 LSYKDAGVDIDAGNALVGRIKG-----VVKKTRRPEVMGGLGGFGALCALPQK----YREPVLVSGTDGVGTKLRLAMDL 77  Enterobacteriaceae
WP_010873749   1 MDYRQAGVDVEAGREFVSRIRQ-----QVESTFRPEVMGGIGGFAGLFEIPAG----YKAPVLVSGTDGVGTKLKIAQAM 71  Synechocystis s...
WP_003404132  17 ITYASAGVDIEAGDRAIDLFKP-----LASKATRPEVRGGLGGFAGLFTLRGD----YREPVLAASSDGVGTKLAIAQAM 87  Mycobacterium t...
WP_010880467   2 VTYRSAGVDIDKANEFVKFIKE-----KVKKEFNLE---EFGGFASGFPIKG-----YKKPILFSTTDGVGTKLKVAQAV 68  Aquifex aeolicus
WP_010884407   2 LTYAQAGVDEEKTAKALRAIIDaarrtFKFRMNKIGEPGDIGHYSALLDFKD--------FYLAITTDGVGTKILVAEAV 73  Pyrococcus hori...
WP_010879189   4 FDYAKAGVDIREEERAIKSLASv----IKHVRSGFGRPILTSHYAGVIDCGD--------FGITITTDGVGSKILVAEKM 71  Archaeoglobus f...
P07244       450 ITYADSGVSVDNGNNLVQTIKE-----MVRSTRRPGADSDIGGFGGLFDLAQAgfrqNEDTLLVGATDGVGTKLIIAQET 524 Saccharomyces c...
1CLI_A        78 KRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDTASAVISGIAEGCLQSGCSLVGGETAEMPGMYHGEDYDVA 157 Escherichia coli
P12043        75 DKHDTIGVDAVAMCVNDVLAQGAEPLFFLDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIA 154 Bacillus subtil...
P43848        77 KKHDTIGQDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVDVAASVIKGIADGCEMSGCALVGGETAEMPGMYHEGDYDLA 156 Haemophilus inf...
Q57656        70 NKFDTVGIDMIAMNVNDAICIGAEPIALVDYLAVGHITEEIAEQIGKGLNEGAKEANINIVGGETATLPDMIKG--IDLA 147 Methanocaldococ...
O27272        70 NRYDTVGIDCIAMVVNDILCVGARPAALVDYLAVERPDPEVAGEIGKGLAMGAEMARVAIIGGETASLPGIIRN--LDLA 147 Methanothermoba...
WP_001336050  78 KRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDTASAVISGIAEGCLQSGCSLVGGETAEMPGMYHGEDYDVA 157 Enterobacteriaceae
WP_010873749  72 DQHHTIGIDLVAMCVNDILTTGAEPLYFLDYLATGKLEPAQLADVVTGIVEGCKQSGCALLGGETAEMPGFYGAGEYDAA 151 Synechocystis s...
WP_003404132  88 DKHDTVGLDLVAMVVDDLVVCGAEPLFLLDYIAVGRIVPERLSAIVAGIADGCMRAGCALLGGETAEHPGLIEPDHYDIS 167 Mycobacterium t...
WP_010880467  69 GVHNTVGIDLVAMNVNDLITTGADPFIFLDYIATGKLDLEVMKQVMEGIIKGCREGEVILAGGETAEMPGFYPEGVYDLA 148 Aquifex aeolicus
WP_010884407  74 NKFDTIGIDMIAMNVNDLICVGAEPVALVDYLAVKEPNEDVFQQIAKGLYEGAKEAGIAIVGGETAVMPDLING--YDLA 151 Pyrococcus hori...
WP_010879189  72 RKFDTIGIDCVAMNVNDLLAIGSEPLAMVDYIAIEKPDEWIMAEIAKGLEEGCRIANITLLGGETATLPEIIRG--FDLA 149 Archaeoglobus f...
P07244       525 GIHNTVGIDLVAMNVNDLVVQGAEPLFFLDYFATGALDIQVASDFVSGVANGCIQSGCALVGGETSEMPGMYPPGHYDTN 604 Saccharomyces c...
1CLI_A       158 GFCVGVVEKSEIIDGS-KVSDGDVLIALGSSGPHSNGYSLVRKILEVSGC--DPQTTELDGKPLADHLLAPTRIYVKSVL 234 Escherichia coli
P12043       155 GFSVGVAEKDEIVTGE-KIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAEldLDTTYEPFERPLGEELLEPTRIYVKPVL 233 Bacillus subtil...
P43848       157 GFCVGVVEKSEIIDGT-AVKTGDTLIALGSSGAHSNGYSLIRKVLEVSGA--NP-TDLLEGKPLSEHLLAPTKIYVKSIL 232 Haemophilus inf...
Q57656       148 GTVLAIVKKDEIITGK-DVKAGDVIVGLRSSGIHSNGLSLARKVFFDIAKldINDKLSY-GKTVAEELLTPTRIYVKPVL 225 Methanocaldococ...
O27272       148 ATGIGFVDVDRIITGE-DVSPGDTVIGLESSGIHSNGLSLARRVFFDELElsPEDEMPGSSSSVGDELLRPTRIYVEPIM 226 Methanothermoba...
WP_001336050 158 GFCVGVVEKSEIIDGS-KVSDGDVLIALGSSGPHSNGYSLVRKILEVSGC--DPQTTELDGKPLADHLLAPTRIYVKSVL 234 Enterobacteriaceae
WP_010873749 152 GFAVGIVEKSQLLNGS-QVNIGDVAIAVESSGVHSNGFSLVRKIIESNGWqwSDCLPEWGGQSLGEIFLEPTRIYVKPIQ 230 Synechocystis s...
WP_003404132 168 ATGVGVVEADNVLGPD-RVKPGDVIIAMGSSGLHSNGYSLVRKVLLEIDRmnLAGHVEEFGRTLGEELLEPTRIYAKDCL 246 Mycobacterium t...
WP_010880467 149 GFCVGLCEEDEVITGK-EIKPGDLLLGLPSSGFHSNGYSLIRKVLEMNNVs-YEDYVEELGKKVWEVLLVPTRIYVKEIK 226 Aquifex aeolicus
WP_010884407 152 GTAVGIVEKDKVVTGE-KIKPDDIVIGISSSGIHSNGLTLARKLLIPKYGldYEYN----GKKLWEWLLEPTRIYVKPIL 226 Pyrococcus hori...
WP_010879189 150 GTAIGWVKKDAIITGE-KIEEGDVIFAIPSSGIHSNGLTLARKVV-EAAGlsYHDKFG--DKTIGEELLTPTRIYME-IL 224 Archaeoglobus f...
P07244       605 GTAVGAVLRQDILPKInEMAAGDVLLGLASSGVHSNGFSLVRKIIQHVALpwDAPCPWDESKTLGEGILEPTKIYVKQLL 684 Saccharomyces c...
1CLI_A       235 ELIEK-VD-VHAIAHLTGGGFWENIPRVLPDNTQAVIDESSWQWPEVFNWLQTAGNVEHHEMYRTFNCGVGMIIALPAPE 312 Escherichia coli
P12043       234 AAVKS-GK-IDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIPPIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEH 311 Bacillus subtil...
P43848       233 QLIKQ-TE-VHAIAHLTGGGFWENIPRVLPDNTKAVIDESSWQWPAIFNWLQEKGNISRYEMYRTFNCGVGMVIALPEKE 310 Haemophilus inf...
Q57656       226 EMIRDkDIeVKGLAHITGGSFRK--LKRLNDKVTYYIDNLPEPLP-IFKEIQRLGNVPDEEMFRTFNMGIGFCVIVDEED 302 Methanocaldococ...
O27272       227 ELIES-DVdVHGLAHITGGGFGN--LKRLRKDVGYRLDSLPEPQQ-IFRVIHEAG-VDIREMYRVFNMGVGFCAVVAPDD 301 Methanothermoba...
WP_001336050 235 ELIEK-VD-VHAIAHLTGGGFWENIPRVLPDNTQAVIDESSWQWPEVFNWLQTAGNVEHHEMYRTFNCGVGMIIALPAPE 312 Enterobacteriaceae
WP_010873749 231 ALLKS-GInIHGMAHITGGGLPENLPRCLGQGQSIQVKAGSWQPLPVFNWLADKGQVNSTAMLETFNLGVGFVVLVSPEQ 309 Synechocystis s...
WP_003404132 247 ALAAE-TR-VRTFCHVTGGGLAGNLQRVIPHGLIAEVDRGTWTPAPVFTMIAQRGRVRRTEMEKTFNMGVGMIAVVAPED 324 Mycobacterium t...
WP_010880467 227 KLKKN-VK-IKGIAHITGGGIPENLIRILPEGTKAVVYKKNIPQNPVFSWIQRLGNVEEREMFRTFNMGVGMIVILDKEE 304 Aquifex aeolicus
WP_010884407 227 KLINE-VE-VHGLAHITGGGLLN--LKRLTK-YGFELEMPPIDG--IFKLIYENG-VPLEEMFRVFNMGVGFMVIVPQEE 298 Pyrococcus hori...
WP_010879189 225 DVLR--ECeVHGLAHITGSGLLK--LKRLKN-MKYVIDKPLKPQE-IFRFIQKLGEVEEAEMYRTFNMGMGFMVILPEDE 298 Archaeoglobus f...
P07244       685 PSIRQ-RL-LLGLAHITGGGLVENIPRAIPDHLQARVDMSTWEVPRVFKWFGQAGNVPHDDILRTFNMGVGMVLIVKREN 762 Saccharomyces c...
1CLI_A       313 VDKALALLNANGENAWKIGIIKAS 336 Escherichia coli
P12043       312 LTDVIGTLESHGEKAYLIGRVKKG 335 Bacillus subtilis subsp. subtilis str. 168
P43848       311 VETALALLEQSGEKAWVIGKIEHL 334 Haemophilus influenzae Rd KW20
Q57656       303 ANKVIKIANKYNIPAQVIGRVVDS 326 Methanocaldococcus jannaschii DSM 2661
O27272       302 VDEALSILG---DRAHPIGEVTDR 322 Methanothermobacter thermautotrophicus str. Delta H
WP_001336050 313 VDKALALLNANGENAWKIGIIKAS 336 Enterobacteriaceae
WP_010873749 310 RQTTLDFFSGQGLVANQIGTVIEG 333 Synechocystis sp. PCC 6803
WP_003404132 325 TTRALAVLTARHLDCWVLGTVCKG 348 Mycobacterium tuberculosis complex
WP_010880467 305 FDKARELIPE----SFYLGEILAG 324 Aquifex aeolicus
WP_010884407 299 KENALQILNKYYE-SFELGKVIKE 321 Pyrococcus horikoshii
WP_010879189 299 ADKLKKLCE-----GRVVGYVEKG 317 Archaeoglobus fulgidus
P07244       763 VKAVCDSLTEEGEIIWELGSLQER 786 Saccharomyces cerevisiae S288c
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap