Conserved Protein Domain Family
CompInhib_SCIN
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pfam11546: CompInhib_SCIN 
Staphylococcal complement inhibitor SCIN
SCIN is released by Staphylococcus aureus to counteract the host immune defense. The protein binds to and inhibits C3 convertases on the bacterial surface, reducing phagocytosis and blocking downstream effector functions by C3b deposition on its surface. An 18 residue stretch 31-48 is crucial for SCIN activity.
Links
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Statistics
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PSSM-Id: 371594
Aligned: 3 rows
Threshold Bit Score: 140.877
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q2FZB7   1 MKFKKYILTGTLALLLSSTGIATIEGNKADASSLDKylTESQFHDKRIAEELRTLLNKSNVYALAAGSLNPYYKRTIMMN 80  Staphylococcus aureus...
Q2FWV6   1 MKIRKSILAGTLAIVLASPLVTNLDKNEAQASTSLP--TSNEYQNEKLANELKSLLDELNVNELATGSLNTYYKRTIKIS 78  Staphylococcus aureus...
Q2G1D4   5 MKIKTYLVAGIKAALLDTTGIKLASKSET---------TSHTYQHQALVDQLHELIANTDLNKLSYLNLDAFQKRDILAA 75  Staphylococcus aureus...

Q2FZB7  81 EYRAKAALKKNDFVSMADAKVALEKIYKEIDEIINR 116 Staphylococcus aureus subsp. aureus NCTC 8325
Q2FWV6  79 GLKAMYALKSKDFKKMSEAKYQLQKIYNEIDEALKS 114 Staphylococcus aureus subsp. aureus NCTC 8325
Q2G1D4  76 HYIAKSAIRTKNLDQMTKAKQRLESIYNSISNPLHS 111 Staphylococcus aureus subsp. aureus NCTC 8325
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