Conserved Protein Domain Family
SH2

?
cl15255: SH2 Superfamily 
Src homology 2 (SH2) domain
In general, SH2 domains are involved in signal transduction; they bind pTyr-containing polypeptide ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites. They are present in a wide array of proteins including: adaptor proteins (Nck1, Crk, Grb2), scaffolds (Slp76, Shc, Dapp1), kinases (Src, Syk, Fps, Tec), phosphatases (Shp-1, Shp-2), transcription factors (STAT1), Ras signaling molecules (Ras-Gap), ubiquitination factors (c-Cbl), cytoskeleton regulators (Tensin), signal regulators (SAP), and phospholipid second messengers (PLCgamma), amongst others.
Links
?
Taxonomy: root
PubMed: 229 links
Protein: Related Protein
Related Structure
Statistics
?
Accession: cl15255
PSSM Id: 472789
Name: SH2
Created: 15-Aug-2011
Updated: 4-Oct-2023
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap