Conserved Protein Domain Family
PTZ00108
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PTZ00108: PTZ00108 
DNA topoisomerase 2-like protein; Provisional
Links
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Statistics
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PSSM-Id: 240271
Aligned: 31 rows
Threshold Bit Score: 1627.05
Created: 9-Dec-2010
Updated: 22-Jan-2013
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
66357004    28 KSKKTVEERYQKKTQIEHILLRPDTYIGSTEFHEQALWVWDDSNMKMVYKTI---------------------------- 79  
71650226     1 ---MAEASKYKKLTPIDHVLIRPEMYVGSVDTSSSSMFVFDHEKGRMVWESL---------------------------- 49  
66814704    82 TTTRKIEDIYQKKTPTEHVLLRPDSYIGTIEKIEDDMWVLSNSMFNKEKKTIelnndnneknvesttttttktnkkplty 161 
66826863    98 KKGKSIEEIYQKKELLDQILLRPDTYIGSTERQEEELWVW--EDKRMVHRKV---------------------------- 147 
71744648     1 ---MAEAHKYKKLTPIEHVLTRPEMYIGSLDTTATPMFIYDEQKGHMVWETV---------------------------- 49  
71666676     1 ---MAEASKYKKLTPIDHVLIRPEMYVGSVDTSSSSMFVFDHEKGRMVWESL---------------------------- 49  
157866980    1 ---MTDASKYKKLTPIDHVLLRPEMYVGSIETQPTPMYIFDPEKGRMVWETM---------------------------- 49  
159117354    1 ---MAQKAKIQRVTGSEHVLLRPDMYVGSVSAAETFLWLY-EPGQGLYYTKA---------------------------- 48  
146082133    1 ---MTDASKYKKLTPIDHVLLRPEMYVGSIETQPTPMYIFDPEKGRMVWETM---------------------------- 49  
290995679    5 QLAKSIEQQYQKKTPIEHVLERPDTYVGSTERMKKKLFCLDSVNN-IKLKEV---------------------------- 55  

66357004    80 ------NYVPGLYKIFDEILVNAADVKAREistknnHIFEKCTCIKVEINREKKEITVFNDGEGIPIEIHREHQVYVPEL 153 
71650226    50 ------KVNHGLLKIVDEILLNASDNIANK--------GGRMTYIRVHITEA-GEITIENDGAGIPIVRSKEHKLYIPEM 114 
66814704   162 ihpikaTYIPGLLKIYDEILVNAADNKKRD---------SKMSFIKVEINPNENSISIMNDGKGIPVVMHQTENCYVVEM 232 
66826863   148 ------SFVPGIYKIFDEILVNAADNKQRE---------GNMKFIKVVIDREKGFISVTNDGAGIPIQVHSEHKIYIPEL 212 
71744648    50 ------KLNHGLLKIVDEILLNASDNISNR--------SARMTYIRVTITDT-GEITIENDGAGIPIVRSREHKLYIPEM 114 
71666676    50 ------KVNHGLLKIVDEILLNASDNIANK--------GGRMTYIRVHITEA-GEITIENDGAGIPIVRSKEHKLYIPEM 114 
157866980   50 ------RVNQGLLKIVDEILLNAADNINNS------KGSVRQTYINIHISDT-GEITVENDGAGLPIVRSREHKMYIPEM 116 
159117354   49 ------NIVPGLCKIFDEIIVNASDNKQRDsd---rSAEHKMTYIKCSVDVASGAISVENDGVEGLLHFDEKEKMYLPTL 119 
146082133   50 ------RVNQGLLKIVDEILLNAADNINNS------KGSVRQTYISIHISDT-GEITVENDGAGLPIVRSREHKMYIPEM 116 
290995679   56 ------DFIPALYRIIDEILVNAVDNHHRK--------GTHTNELRVTIDEAKNWIHIRNNGKSVPVEMHKIEKIYVPEL 121 

66357004   154 IFGHLLTSDNYDDNEDRVTGGRNGFGAKLTNIFSKEFKVECGDNNTGRIFKMTWYDNMSKKSEENIKENYSg-KSYVKIT 232 
71650226   115 VFGHLLTSSNYDDTSQNAVAGRHGYGAKLTNILSHRFSVCCRTK--GKEFHMSWHDHMRRATAPRVSNVDPreKNLTRVK 192 
66814704   233 VMGNLMSGSNFNDSELKVVGGRNGFGAKLTNIFSKEFTVETVDKSSGKKYFQRWSNNMGDRSEPIITPIGEgeSDYTKIT 312 
66826863   213 IFGNLLTSSHYDDSEKRLTGGRNGFGAKLANIFSTKFIVECADSKSKKLYKQTFTNNMRSKEDPKITSYQNk-TDYTKIT 291 
71744648   115 VFGHLLTSSNYDDDNQNAVAGRHGYGAKLTNILSLSFSVCCRTN--GREFHMSWQDHMRKATAPRVSNVGTkeKNVTRVK 192 
71666676   115 VFGHLLTSSNYDDTSQNAVAGRHGYGAKLTNILSHRFSVCCRTK--GKEFHMSWHDHMRRATAPRVSNVDPreRNLTRVK 192 
157866980  117 VFGHLLTSSNYNNDSTSTTAGRHGYGAKLTNILSTKFSVVCRTD--GREFHMSWTDHMRMATAPRVNRVDPkeKNVTRVK 194 
159117354  120 AFGILMTSSNYDDTEQRVTGGRNGYGAKLTNIFSTKFTVLLQEN--GQVFEQTWTDNMKNTKPPRIEDVRDkkKNFIRFS 197 
146082133  117 VFGHLLTSSNYNNDSTSTTAGRHGYGAKLTNILSTKFSVVCRTD--GREFHMSWTDHMRMATAPRVNRVDPkeKNVTRVK 194 
290995679  122 VFGNLLTGSNFDDNEVKFTGGRNGYGAKLANIFSTDFTIEIMDHK-GTHYIQNWKKNMSQISTPTIVENKQktEPYIQVS 200 

66357004   233 FKPDLSRFGnMKDFDDD--IISLLNKRVYDISGTSG-VKVYLNGSLIPIKDFKSYTLLYLKSRMNNTNNIENNNNNNnnn 309 
71650226   193 FLPDYERFG-LDANKIShdMKRVLHKRIMDLAAMFPsIEISLNGVPFAFKSFADYAMLYSSPTSSGEMPPAPFVYES--- 268 
66814704   313 FKPDLEKFKiKSLWDDN--ILQLMERRLYDIAGCNTeLMVTLNGKRL-NYNFQSYVKLYEHHLNNSTKREDNEEQYRees 389 
66826863   292 FYPELDRFG-MVEFDDD--LVALLSKRVYDIAGCNPtLKVSLNDEELGIRSFEKYINLYFPDEENAPKVYYEK------- 361 
71744648   193 FLPDYERFG-MKEKKISndMKRVLYKRIMDLSAMFPnIQITLNGSSFGFKSFKDYATLYSAMTPKGEKPPPPYVYES--- 268 
71666676   193 FLPDYERFG-LDANKIShdMKRVLHKRIMDLAAMFPsIEISLNGVPFAFKSFADYAMLYSSPTSSGEMPPAPFVYES--- 268 
157866980  195 FMPDYAHFG-FPSASISldMKRVLHKRVMDLAAMFSkIEVRLNNVPFGFRTFTDYAGLYSLPGLDGSMPPEPFVYTS--- 270 
159117354  198 FTPDYMKFGmTSGLDRD--HAAYMMRRAVDVAGCNIgLKLIINGTELKIANFEQYARMVYRSINPEITQFYETSKGDtaq 275 
146082133  195 FMPDYAHFG-FPNASISldMKRVLHKRIMDLAAMFSkIEVRLNNVPFGFRTFTDYARLYSLPGLDGSMPPEPFVYTS--- 270 
290995679  201 FHPDFKKFQ-STGLNKElnMIDLLKRRIYDLSACNPkLNVYLNDKKVEVDNFKEYVKLFYQNNSSGEHPEKMFVHKH--- 276 

66357004   310 ekktsttrtlrntnkknmsknnsyddefenynvenedeydnnfeedimeddewddepksskkknsnsnskkkklgqngng 389 
71650226       --------------------------------------------------------------------------------     
66814704   390 f------------------------------------------------------------------------------- 390 
66826863       --------------------------------------------------------------------------------     
71744648       --------------------------------------------------------------------------------     
71666676       --------------------------------------------------------------------------------     
157866980      --------------------------------------------------------------------------------     
159117354  276 vntndsdsdldiksaakakpktkrtkk-----------------------------------------------tietns 308 
146082133      --------------------------------------------------------------------------------     
290995679      --------------------------------------------------------------------------------     

66357004   390 sssslilsggggsdtnspliiyeSVPKWEIVISESDgGQFQHVSFVNSICTIKGGTHISYVLDPLINAILKKVQT----K 465 
71650226   269 -----------------------RNGAIAFIPSLTA-GTRRIFGVVNGVVTHNGGTHCNAAQEVLQSSLENVEKA----L 320 
66814704   391 -------------------efgeISPRWKIGIGLSEtGQFTQVSFVNSINTVKGGTHVNFLADQIVRYVGEKLK-----K 446 
66826863   362 -----------------------VSDRWELAVTLSKeSQFNQVSFVNSICTVKGGTHVTHALSNIVTAIQEQVNK----K 414 
71744648   269 -----------------------KSGCVAFIPSVVP-GVRRMFGVVNGVVTYNGGTHCNAAQDILTGCLDGVERE----L 320 
71666676   269 -----------------------RNGAIAFIPSLTA-GTRRIFGVVNGVVTHNGGTHCNAAQEVLQSSLENVEKA----L 320 
157866980  271 -----------------------PNGSVAYVPQLTQ-SPKRIVSVVNGVVTYNGGTHCNAAMDILDACLDSLSKN----F 322 
159117354  309 llipvddlskpsdwthdylkvipVNKFWDIGLGYTDsGELVQVSFVNSINTTDGGTHVDAILDLIMSQLNDVLIKsfqqD 388 
146082133  271 -----------------------PNGSVAYVPQLTQ-SPKRIVGVVNGVVTYNGGTHCNAAMDILDSCLDSLSKN----F 322 
290995679  277 -----------------------ICDGWEIAIGASVgEEFNQISFVNSIATVQGGSHVNFVLNQLSTKISEYIAKt---Y 330 

66357004   466 NKGGMDVKSNHVKNHIWIFIKCLIVNPSFDSQTKETLTTKVS----KFGSVCT----LSEKTINSVV--KSSIVENVLMW 535 
71650226   321 KKDNKVIDTNRVLRHFTILVFLVQVQPKFDSQNKARLVSVPTmp-----------rvPRQELMDFLL--RMPFLEAHVNT 387 
66814704   447 KHSDLEIRPMNIKHHLALFVNCLVDNPSFDSQSKETLTTKPM----LFGSTPE----IPESLLAQFVk-NSKIIERVAGW 517 
66826863   415 NKGSADIKPAFIKNHLSVFVNCLIENPHFDSQTKETLTSKIS----SFGSRCE----PSEKFIKRVLdsKSGIVASILEF 486 
71744648   321 KKENKVMDTNRVLRHFTILVFLVQVQPKFDSQNKARLVSTPTmp-----------rvPRQDVMKYLL--RMPFLEAHVST 387 
71666676   321 KKDNKVIDTNRVLRHFTILVFLVQVQPKFDSQNKARLVSVPTmp-----------rvPKQELMDFLL--RMPFLEAHVNT 387 
157866980  323 KKNGKVVDTNRVQRHFTVLVFLVQAQPKFDSQSKARLVSTVTmp-----------rvPKNTLEKYLE--RMPFLEAHVNS 389 
159117354  389 AKNAKKLTRQQLKSCLVLFIRSLVVNPSFDSQTKISLKTDKAallrSLGSTQAelatLATQLVKRIQ--EIRPLWNSLRQ 466 
146082133  323 KKNGKVVDTNRVQRHFTVLVFLIQTQPKFDSQSKARLVSTVTmp-----------rvPKNTLEKYLE--RMPFLEAHVNS 389 
290995679  331 TDLQLTISPYMVRNHITLFINSLIENPTFDSQTKETLTTKSI----SFAQKVV----ISNDLINSIAn-HTPIIDNIIAF 401 

66357004   536 AQLKQSMELKKKMKSNQkntvTSRLLGIPKLEDANEAGGPHSKKCTLILTEGDSAKTSCLAGLSIV--GRDYFGVFPLRG 613 
71650226   388 VTGQLADELNKEMGAGRrmssKSLISSITKLVDATTTRRDPRFVRTLIVTEGDSAKALAQNSLSSD--QKRYTGVFPLRG 465 
66814704   518 ALMKQKADLIHSTSGRQs--kTTLIKSISKLDDANWAGGLKSKECTLIITEGDSAKSLALAGLSVV--GRNSYGVFPLRG 593 
66826863   487 AQFKDQSALKRSTSSGG----KKGKVSIPKLDDANLAGGTKSEDCTLILTEGDSAKSLATAGISVV--GKDHYGAFPLKG 560 
71744648   388 ITGQLAQELNKEIGTGRrmssKTLLTSITKLVDATSTRRDPKHTRTLIVTEGDSAKALAQNSLSSD--QKRYTGVFPLRG 465 
71666676   388 VTGQLAQELNKEMGAGRrmssKSLISSITKLVDATTTRRDPRFVRTLIVTEGDSAKALAQNSLSSD--QKRYTGVFPLRG 465 
157866980  390 MDDQLTNELNKEIGAGRrlssKTLISSITKLVDATSSRPDGRNIRTLIITEGDSAKALALNSLSSE--QKKYCGVFPLRG 467 
159117354  467 ASYNQAAKLLTKTDGSK----TSQLLGIPKLDDAIAAGTRESSKCTLILTEGDSAKALAVDGISSIedGKKYYGVFPLRG 542 
146082133  390 MDDQLANELNKEIGAGRrlssKTLISAITKLVDATSSRPDGRNIRTLIITEGDSAKALALNSLSSE--QKKYCGVFPLRG 467 
290995679  402 ANYKQSSASSKKFKK------RESKLLIPKLDDANLAGTNRSMECVLILTEGDSAKALAISGLSVV--GRDRFGVFPLKG 473 

66357004   614 KLLNVREASFKQQIGNVEIQNILKILGLGIG-QKYd--NGPVNLRYGSLMLMTDQDHDGSHIKGLIINLIHYYWPSLI-H 689 
71650226   466 KLLNVRNKNLKRLKNCKELQELFCALGLELG-KIY---KDAEELRYQRLLVMTDQDADGSHIKGLVINAFEALWPSLLnR 541 
66814704   594 KLLNVRDVASKQLLSNEEINNLTTILGLSHK-NSYdtdESMEDLRYGRVMIMADQDHDGSHIKGLVMNFIHYFWPNLL-K 671 
66826863   561 KLLNVRDQS-TKVINNDEINNIVTILGLKYG-KVY---ETLSDLRYGHLMIMTDQDHDGSHIKGLIINMVHHFWPTLL-R 634 
71744648   466 KLLNVRNKNLKRLRNCKELQELFCALGLELD-KDY---TDADELRYQRILIMTDQDADGSHIKGLVINAFESLWPSLLvR 541 
71666676   466 KLLNVRNKNLKRLKNCKELQELFCALGLELG-KIY---KDAEELRYQRLLVMTDQDADGSHIKGLVINAFEALWPSLLnR 541 
157866980  468 KLLNVRNKNLKRLKTCKELQDLFLSLGLELG-KEY---RSPAELRYQRLLVMTDQDADGSHIKGLVINAFESLWPKLLqN 543 
159117354  543 KVINVRNESIDKVSNNAEITNLKKILGLKQG-MDYstqEARNTLRYGHVMIMTDQDPDGSHIKGLLINLFDTYWNGLA-R 620 
146082133  468 KLLNVRNKNLKRLKTCKELQDLFLSLGLELG-KEY---RSPAELRYQRLLVMTDQDADGSHIKGLVINAFESLWPKLLqN 543 
290995679  474 KLLNVREASADQIRDNQEIQNLKKILGLDDVsKTDsfeELTKRLRYGKVMLMCDQDHDGSHIKGLLLNMIHFFYPELL-- 551 

66357004   690 FRGFLKQFVTPIVKAKK---GSNEISFFTLYEYEQWRKNNSs-nLNGWRFKYYKGLGTSTDLEFKEYFTKIENHSIEFDW 765 
71650226   542 NPGFISIFSTPIVKVRLr--DKSTHSFFSLKEFHKWQKTHG---NVSYTAKYYKGLGTSTTAEGKEYFKDMDKHTMRLV- 615 
66814704   672 -RGFLVEFVTPIIKATKs--STQKKSFFTIKDYEKWRETISsdqLKQYTIKYYKGLGTSTSAEAKEYFSNLDKHVIKFIW 748 
66826863   635 MPGFLVEFITPIVKVFKn--NQKPISFYTMPEFLKWRETND----KGWDVKYYKGLGTSTPGEGKEYFSDLERHKIDFEW 708 
71744648   542 NPGFISIFSTPIVKARLr--DKSVVSFFSMKEFHKWQRSNA---NTPYTCKYYKGLGTSTTAEGKEYFKDMEKHTMRLL- 615 
71666676   542 NPGFISIFSTPIVKVRLr--DKSTHSFFSLKEFHKWQKTHG---NVSYTAKYYKGLGTSTTAEGKEYFKDMDKHTMRLV- 615 
157866980  544 NPGYISLFSTPIVKIKVsgkSKEAIAFHSFRDFHRWQRAHP---SARYTAKYYKGLGTSTTAEGKEYFADMEKNVMQLT- 619 
159117354  621 SNKFLDFFITPIVRCTQ---ARNMKTFYTIPEYKKWTQTVTd--LPKWNINYYKGLGSSNTTDAKQYFQQIANNRKTLIY 695 
146082133  544 NPGYISLFSTPIVKIKVsgkSKEVIAFHSFRDFHRWQRAHP---SARYTAKYYKGLGTSTTAEGKEYFADMEKNIMQLT- 619 
290995679  552 RNNFVDEFITPIIKVSK---GSDVKSFFSIPEFQNWWTKVPeneKNRWNQKYYKGLGTNSSKEAKDYFSNLKRHVIALQY 628 

66357004   766 MDDQDDEAIDMAFSKKRTEDRKNWIES---YKEGTYVDYSInnqcRNLRYFDFIHKELVLFSRYDTTRSIPNLLDGLKPG 842 
71650226   616 VERNDHKLLDSVFDSQEVEWRKDWMTKanaYTGEVDIDRSK----KTLTVPDFVHKEMVHFALAGNARALAHAVDGLKPS 691 
66814704   749 GDEADDL-IKMAFAKDLSSLRQRWIKE---TDMSQGIDHSI----KEITYPDFINKELIHYSWAANLRSIPSLIDGLKPG 820 
66826863   709 DEGANDN-IELAFSKSRADDRKKWMAE---HIEGTFLEQFGv---KKLTYSDFINKELVLFSIADCERSIPNIVDGLKTS 781 
71744648   616 VDRSDHKLLDNVFDSQEVEWRKDWMTKanaFTGEVDIDRSK----KMLTVTDFVHKEMVHFALVGNARALAHSVDGLKPS 691 
71666676   616 VERNDHKLLDSVFDSQEVEWRKDWMTKanaYTGEVDIDRSK----KTLTVPDFVHKEMVHFALAGNARALAHAVDGLKPS 691 
157866980  620 VDARDHQLLDSVFDAAEVEWRKEWMTKanaFQGEVDIDRSK----KTLTIPEFVHKEMVHFALVGNARAIPHCVDGLKPS 695 
159117354  696 NPESASK-LKLAFDKKLADDRKTWISG---TDPDTYLDLSP----TKIDITAFVDKELVLYDIESNQRAIPSLMDGLKPG 767 
146082133  620 VDARDHQLLDSVFDAAEVEWRKEWMTKanaFQGEIDIDRSK----KTLTIPEFVHKEMVHFALVGNARAIPHCVDGLKPS 695 
290995679  629 DDDSEPN-IELAFSKDLANARKSWVAS---LKDGTFLDTTN----GKVTITDFINNELILFSNQNNIRSIPSIVDGLKPS 700 

66357004   843 QRKVLFATFKKKLNNELKVAQLAGYVAEHSAYHHGESSLQSTIVNMAQNFVGSNNLNLLEPCGQFGSRKEGGKDASAARY 922 
71650226   692 QRKILWAIMRRSGNESAKVAQLSGYISEVSAFHHGEMSLQETIIKMAQNFTGGNNINLLIPEGQFGSRQQLGNDHAAARY 771 
66814704   821 QRKILFASFKRRLTNEIKVSQLSGYVAEQTSYHHGEQSLNSTIVKMAHNFVGSNNLPLLTPSGQFGTRLQGGSDSASARY 900 
66826863   782 HRKTLYSCFKRNLKKEIKVAQLIGYVSEHSAYHHGEASLYSTIVGMAQEFVGSNNINLLNPAGSYGTRIAGGKDCSSARY 861 
71744648   692 QRKIIWALMRRSGNEAAKVAQLSGYISEASAFHHGETSLQETMIKMAQSFTGGNNVNLLVPEGQFGSRQQLGNDHAAPRY 771 
71666676   692 QRKILWAIMRRSGNESAKVAQMSGYISEVSAFHHGEMSLQETIIKMAQNFTGGNNINLLIPEGQFGSRQQLGNDHAAARY 771 
157866980  696 QRKILWAMLRRHNSEASKVAQLSGYISEASAFHHGEASLQETIVKMAQNFTGGNNINLLVPEGQFGSRQQLGSDHAAPRY 775 
159117354  768 QRKVLYACFKRNLKTKLKVSQLSGFVSDKAAYHHGEASLNGTIVNMAQSFTGSNNIALLYPAGIFGSRARGGKDSSAPRY 847 
146082133  696 QRKILWAMLRRHNSEASKVAQLSGYISEASAFHHGEASLQETIVKMAQNFTGGNNINLLVPEGQFGSRQQLGNDHAAPRY 775 
290995679  701 QRKILFACLKRDLKDEIKVAQLAGYVSEHSAYHHGEQSLYGTITSMAQDFVGANNIPLLYPSGQFGTRLQGGDDAASARY 780 

66357004   923 IFTKLSKWTRYIFPEADDPLLTYLYDDGQQIEPLYYVPIIPMILVNGTDGIGTGWSSSVPNYNPKDIIMNLKRMLKG--- 999 
71650226   772 IFTKLSSLARILFPSEDEPLLDYVTEEGQQVEPNHYVPILPLLLCNGSVGIGFGFASNIPPFHPLDVSAAVRSMINGea- 850 
66814704   901 IFTKLEPVARYLFNELDDPLLNYLEEEGESIQPDYYIPIIPMLLVNGSEGIGVGMSTSIPLFSPIDIIDQLMLRLNNq-- 978 
66826863   862 IHTRLNDIARAVYHADDDPILSCVVDDGKKVQPKFYIPVIPMILVNGCVGIGTGWSSTIPNYNPRDLIQNMRLAIDG--- 938 
71744648   772 IFTKLSKVARLLFPSEDDPLLDYIVEEGQQVEPNHYVPILPLLLCNGSVGIGFGFASNIPPFHPLDVSAAVRAMISGea- 850 
71666676   772 IFTKLSSLARILFPSEDEPLLDYVTEEGQQVEPNHYVPILPLLLCNGSVGIGFGFASNIPPFHPLDVSAAVRSMINGea- 850 
157866980  776 IFTKLSRFARLLFPEEDDPLLDYMDEEGTFVEPHHYVPILPMLLCNGAVGIGFGFATTIPSFHPLDVSAAVRAMINGes- 854 
159117354  848 ISTYLDPLARYLFPEPDDAIMQYKEDDGKVIEPFYYAPILPMVLINGSDGIGTGFSTTIPQFDPLDMLHSIRLRIYGkt- 926 
146082133  776 IFTKLSRFARLLFPEEDDPLLDYMDEEGTFVEPHHYVPILPMLLCNGAVGIGFGFATTIPSFHPLDVSAAVRAMINGes- 854 
290995679  781 IYTRLNKLTRLIFLKEDDQILDYQEEDGMIIEPKFYLPIIPMLLVNGAEGMGTGWSTSIPSFNPIDLIDSLNILLDSnae 860 

66357004  1000 ---E-MMVPMTPWYKSFKGKIfpikQKSKKnsasngggnnnrkktainsfnngsnssiligsqvdaedddlqqiqrtnnm 1075
71650226   851 -akV-VVRRLVPWAVGYQGEV----RRGPE-------------------------------------------------- 874 
66814704   979 ---V-ALKKLIPWYRGFKGTI----SPDRH-------------------------------------------------- 1000
66826863   939 ---K-PLKPIKPWYRGFLGSI----EANQGskv----------------------------------------------- 963 
71744648   851 -akS-VVRRLVPWAVGFQGEI----RRGPE-------------------------------------------------- 874 
71666676   851 -akV-VVRRLVPWAVGYQGEV----RRGPE-------------------------------------------------- 874 
157866980  855 -akQ-VVRNLVPWAVGFQGTV----RRGPD-------------------------------------------------- 878 
159117354  927 -trR-EKRTLKPFSNGWKGTMtheyDKSGKf------------------------------------------------- 955 
146082133  855 -akQ-VVRNLVPWAVGFQGTV----RRGPD-------------------------------------------------- 878 
290995679  861 nigNvKLPSLDMWARGFKGKI----EMNDS-------------------------------------------------- 886 

66357004  1076 gngiieetlelgANYETFGNWYKKNEE-TLV--ITELPVRRWTQDYKEWLEStllpa----------pnadNDNIE---- 1138
71650226   875 ------------GEFIAAGSYQYYVDG-RVH--VTEIPWTLSIEAFRDHISV---------------------LAS---- 914 
66814704  1001 -------------TYRTNGVIKLVGRN--LE--ITELPIGRWTSDYKEVLNDl---------------------iD---- 1038
66826863   964 ----------qgGQYLSKGIWKKLSDN-RFE--ITELPIGFWTQDYRELLDEletpg---------trkkkKEEKEkkaa 1021
71744648   875 ------------GEFIAVGTYTYCKGG-RVH--VTELPWTCSVEAFREHISY---------------------LAT---- 914 
71666676   875 ------------GEFIAAGSYQYYVDG-RVH--VTEIPWTLSIEAFRDHISV---------------------LAS---- 914 
157866980  879 ------------NEFIAVGKYTAHPNG-RFH--ISEIPWMTSIEAFRLHISS---------------------LAS---- 918 
159117354  956 ------------VRWRMTGCFSVVDLK-TIQ--ITDLPIGVWTESYREEIETwvkgnedagtakkpatkvsATTKGkakl 1020
146082133  879 ------------NEFIAVGKYTAHPNG-RFH--ISEIPWMTSIEAFRLHISS---------------------LAS---- 918 
290995679  887 ------------GKFISKGIFKMKSRGdSIEfdISELPIGEWTENYKSHLQS--------------------LVKK---- 930 

66357004  1139 ----------------------------NSWIIDYRDNSSHESVHITVRMRPE---KLQQAEMEG--------------I 1173
71650226   915 ----------------------------KDVVQRIADYSGANHVDIDLELTNG---AMTTYAE----------------C 947 
66814704  1039 ----------------------------KDVIKSFQESNTENSVHFTILLNNNqleQMEDLTENE--------------L 1076
66826863  1022 srkgtkakptttkrskrvdddddnekvtEATVKSYTNYSSESTIHFIID-------TIQPVDEIN--------------I 1080
71744648   915 ----------------------------KDIVNRIADYSGANHVDIDVEVAQG---AVNTYAE----------------C 947 
71666676   915 ----------------------------KDVVQRIADYSGANHVDIDLELTNG---AMTTYAE----------------C 947 
157866980  919 ----------------------------ADVVQRIADYSGANHIDIDLIVRDG---SLTTWAE----------------C 951 
159117354 1021 kgasgaakekpaakdqlydsvtgyykgiHPALMKVIDMSDNNTVNIIVTLSDEcarYLIGTSDVDietcntagtarydnI 1100
146082133  919 ----------------------------ADVVQRIADYSGANHIDIDLIVRDG---SLTTWAE----------------C 951 
290995679  931 ----------------------------GLIKSKITERNTENSVGFTIAINDP-----DEFSESQ--------------- 962 

66357004  1174 EKIFRLKSTLSTSNMTLFDHNSRIVRYETELDILKEFIPIRLEMYEKRKNYLLSKLNYEKCLLEQKILFLKLVIQGVIGL 1253
71650226   948 ESELSLTQRIYINGTVFSPTGVLTPLEGDLAPVLQWHYDRRLDLYKKRRQRNLGLLEAELAREKSTLKFVTHFREGKIDI 1027
66814704  1077 IKLFKLSASLNF-HLTCFDENSKIQKLESVEEIIDQFYKVRLQFYGKRREYLLKSLDNQIKRLTTTIQFLEVIASGKLKI 1155
66826863  1081 EKVFKLVSTINETNMVVFDEEGRIQRFATTTALQEHFFPLRIKHYQMRKDFLSERLSEEYSRLSNKARFILAVVNKELVI 1160
71744648   948 ESELGLTQRIHINGTVFSPNGTLSPLESDLTPVLQWHYDRRLDLYKKRRQRNLMLLEQELAREKSTLKFVQHFRAGHIDF 1027
71666676   948 ESELSLTQRIYINGTVFSPTGVLTPLEGDLAPVLQWHYDRRLDLYKKRRQRNLGLLEAELAREKSTLKFVTHFREGKIDI 1027
157866980  952 ETDLALAQRIYINGTVFSPAGTLSPIDSDLSPVLQWHYDRRLDLYKRRRTRKIGLMEMDLARLQSTRKFVEHFRQGQIDF 1031
159117354 1101 VKGFKLDGSIRPSNMWLYNERNMLCLYHTPFKIIDAFYAKRLDLYRVRRNNQIIDMDDRSLMLNEKARFIKLIIEDKLNI 1180
146082133  952 ETDLALAQRIYINGTVFSPTGTLSPIDSDLSPVLQWHYDRRLDLYKRRRTRKIGLMEMDLARLQSTRKFVEHFRQGQIDF 1031
290995679  963 LKKLKLEKSFSLSNMTVFSENFDIIQFSNVNDIIKQFYLVRLSYYHQRKSHLMKQLEKQIRILSNKVKFLNFITSNESNL 1042

66357004  1254 S---NKSKETLVSDL-----------KKNNIKSIKQVQELTqwvgvggsnlAQNSISGSGIGGNPSFVDSGDNSMDYINF 1319
71650226  1028 V---NATDDSLAKTC-----------SKLGMVRVDD-------------------------------------------- 1049
66814704  1156 Q---GRSKQDLIKEL-----------ESGEIVGFENFGTHP----------PE--------------------------- 1184
66826863  1161 S---NVKKVDLINKL-----------KEMKFDRIINKNSNK----------SARDKIKKKKNAFDEEDAAISSDEEKDGA 1216
71744648  1028 A---NATEATLEKVC-----------SKLGLVRVDD-------------------------------------------- 1049
71666676  1028 V---NATDDSLAKTC-----------SKLGMVRVDD-------------------------------------------- 1049
157866980 1032 L---NATDDTLHKTC-----------VKLGLVRVDE-------------------------------------------- 1053
159117354 1181 K---NVPRDSVTELLwgkyqfhpsrkHRIILLSHRNLINKR----------QALKIDEDSERPEEDDDADQRDLEKHLEA 1247
146082133 1032 L---NATDDTLHKTC-----------VKLGLVRVDE-------------------------------------------- 1053
290995679 1043 NtfiKTKKENIPSFL-----------TNVVGIVVDPTTIEQ--------------------------------------- 1072

66357004  1320 emnsfdylessqqdgilestsysretnkgnelkLFDYLLSMPLWSLTKEKMELLEADLIKKTEEYEKLLKTSIEEIWNTE 1399
71650226  1050 ---------------------------------SYDYVLRKPITFYTKTSLENLNRKISETEKRIDKLKKTTPVQMWLDE 1096
66814704  1185 ---------------------------------VYQHLFSLSILDITKERIDNLTNQLTKRKSEHQSISSSDPKSLWTAD 1231
66826863  1217 qeeqd------------------------ddtkGYDYLLSLPLWSLTLERVKKLIEERDSKKKEWDILLSTPIQEIYKRD 1272
71744648  1050 ---------------------------------SFDYILRKPITFYTKTSFENLLKKIAETERRIEALKKTTPVQLWLGE 1096
71666676  1050 ---------------------------------SYDYVLRKPITFYTKTSLENLNRKIGETEKRIDKLKKTTPVQMWLDE 1096
157866980 1054 ---------------------------------SFDYILKKPITFFTRTSTEKLQADIAKTQAQIEELKRTTPVKMWLTE 1100
159117354 1248 tvkdligpqffdai------nswsgftvqdrneCYEYLLRMPISTMTKESYRNLLSSAELIRAEAEKLRNTTVENMWLRD 1321
146082133 1054 ---------------------------------SFDYILKKPITFFTRTSTEKLQADIAKTQAQIEELKRTTPVKMWLTE 1100
290995679 1073 ---------------------------------SFNYLTDMNILSLTHEHKDRINKQLESAQQELQQVSSDDPKLMWKRD 1119

66357004  1400 LDELLKVIEEEETQDELIEAEHNSLIQKRRLSVDWNDSKKKKTGASRKRKNETTKKQESLKVKNPQKsnlkktsakptkk 1479
71650226  1097 LDRFDRAFEEHEKTAVATILKERRVNPPTGDVSRNLQQPRLELEEVKVSSSGGK-------------------------- 1150
66814704  1232 LQQLKEYLEKSDKEFQKKPLKTSSSSSFDVSSSSESAKLSSTRKSKTDKIKSK--------------------------- 1284
66826863  1273 LDALEKALDDQDAYDESLKNQTESLKKRTKTKALPRAKKISAKVVKDTKEAPLTKLVKPTVKIPTTT------------- 1339
71744648  1097 LDQFDRFFQDHEKKMVEAILKERRQRSPPSDLLPGLQQPRLEVEEAKGGKKFEM-------------------------- 1150
71666676  1097 LDRFDRAFEEHEKTAVATILKERRVNPPTGDVSRTLQQPRLELEEVKVSSSGGK-------------------------- 1150
157866980 1101 LDKFDKTFQEYERVLINSIQKEQRSSSITGGVELPALRQPLLLLEASVKGATAY-------------------------- 1154
159117354 1322 LAAFEAAYEVDRHMEQTKSAETRRLTVTETMIQGKLEESERKYKAMDDRVGDSD-------------------------- 1375
146082133 1101 LDKFDKTFQEYERVLINSIQKEQRSSSITGGVELPALRQPLLMLEASAKGATAY-------------------------- 1154
290995679 1120 LKRLRDELTKSENWVV---------------------------------------------------------------- 1135

66357004  1480 sriddsdeeddyidgdnysdeddyyddigddfygsdnsndsndriilnneeseneefdnltsdlddisddggvgnkgkrt 1559
71650226       --------------------------------------------------------------------------------     
66814704       --------------------------------------------------------------------------------     
66826863       --------------------------------------------------------------------------------     
71744648       --------------------------------------------------------------------------------     
71666676       --------------------------------------------------------------------------------     
157866980      --------------------------------------------------------------------------------     
159117354      --------------------------------------------------------------------------------     
146082133      --------------------------------------------------------------------------------     
290995679      --------------------------------------------------------------------------------     

66357004  1560 qktlanksktdnqgktklnnlkkakntsSVKSSSKDKKQGLLKVPKSTGGNSFGGIGGGVAGTGISNTNSSSTSNNTSTK 1639
71650226       --------------------------------------------------------------------------------     
66814704       --------------------------------------------------------------------------------     
66826863  1340 ----------------------------DSNVSGSKRKKSDDTTSTSTSTTTSSNTKPIESFFAKEDKKPTPAVKKSTLV 1391
71744648       --------------------------------------------------------------------------------     
71666676       --------------------------------------------------------------------------------     
157866980      --------------------------------------------------------------------------------     
159117354      --------------------------------------------------------------------------------     
146082133      --------------------------------------------------------------------------------     
290995679      --------------------------------------------------------------------------------     

66357004  1640 KENIESSSSKPLESVSXLQRLQQRTNLVNSLNQSLNSLSSNLTKVASTTSSSSSGGVPATKQTKITDLFKSKDSEDIESR 1719
71650226  1151 -------------------SVPMRVRVRKYVPPPPSKRPHVGQSVGGGGGS---------VRSSAAAVVAHVKAEKKAAR 1202
66814704       --------------------------------------------------------------------------------     
66826863  1392 SLDSDSDFDDDVVVSSKPKAPPKKTSKVIELSDESDQESDQESDQGSDPESPPKRSKAPPKKPTTIATKKATTSKSKVID 1471
71744648  1151 -----------------------RVQVRKYVPPPTKRGAGGRSDGDGGATAAG-----------AAAAVGGRGEKKGPGR 1196
71666676  1151 -------------------SVPMRVRVRKYVPPPPSKRPNVGQSVGGGGGGSV--------RSSAAAVVAHVKAEKKAAR 1203
157866980 1155 -----------------------RVHACQYEKPPPSKRRPGESFGGARSSDSAVRGVGKRLVGSRAVFKKKKPMGRKNNV 1211
159117354 1376 -------------------NEIEYSTTRDDQGLKIKGEPKPKKEHVPKTAPASKAKVQKPEEGLETAPTEPKRKRPAAAP 1436
146082133 1155 -----------------------RVHACQYEKPPPSKRRPGESVGGARPSDSAARTVGKRLVGSRSVFKNKKPMSRKNNV 1211
290995679      --------------------------------------------------------------------------------     

66357004  1720 TAKSGSQKKQNSQNSENEIISRPKRGKRKTIIESEEEEEDGEEEEEEDDDDEIED 1774
71650226  1203 ARSMQKMLLDVVARQVARVLPRLPWFLF--------------------------- 1230
66814704       -------------------------------------------------------     
66826863  1472 DKSSDDEVIKAPTNRPTRSRVPPPKSLSFLDSDSDDDDLYDNEESSSDSD----- 1521
71744648  1197 AGGVRRMVLDALAKRVTRLLPRLLF------------------------------ 1221
71666676  1204 ARSMQKMLLDVVARQVARVLPRLPWFLF--------------------------- 1231
157866980 1212 KVSLSTRVAQFAGAQLGRLLPHILV------------------------------ 1236
159117354 1437 VDTKKASAKRGKKEESSFTESETSATELDSSVLEDDYSYVSYTYDEDDENGEDDL 1491
146082133 1212 KVSLSTRVAQFAGAQLGRLLPHVLM------------------------------ 1236
290995679      -------------------------------------------------------
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