4KP3


Conserved Protein Domain Family
RILP-like
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cd14445: RILP-like 
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Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
This domain is found in Rab interacting lysosomal protein-like 1 and 2, and appears to be conserved in Bilateria. The Rilp-like proteins regulate the concentration of ciliary membrane proteins in the primary cilium. Rilpl2 interacts with myosin-Va and has been linked to the regulation of cellular morphology in neurons; it forms a complex with Rac1 and activates Rac1-Pak signaling, dependent on myosin-Va.
Links
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Statistics
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PSSM-Id: 271220
Aligned: 32 rows
Threshold Bit Score: 74.1673
Created: 2-Mar-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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homodimerMyoVa-GTD
Conserved site includes 33 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:4KP3: Mouse Rilpl2 forms a homodimer, contacts at 4 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #   #   ##   #       #      ## #        ##  #  ## ### ## ### #       #  #  ##  
4KP3_C        20 EDEGALAKSPLq--LTTDDVYDISYVVGRELMALGs---dPRVTRLQFKIVRVMEMLETLVNEGs---lAVEELRMERDN 91  house mouse
AAX27188      56 QLEAPNDRPSTp-sITVLDVYDIAASIGKEFETIIdkygpYSVSNLMPKVISVLEELEDFATKFesegrEIVALQTAVHR 134 Schistosoma jap...
EJW85282      18 DVRSPADSPSRh--ITVVDVYDLAASIGKDFERIIdefgnDSVRQIMPKVISALETLESLANHNekeneEILMLKKTVER 95  agent of lympha...
XP_002402156   8 NYIDAMESPSEa--LSVDDVYTLAEEIGKEFEIVIdnhgvEAVKKLMTKVICVLEYLEAYAFKNdtareEIVRLKAQIYE 85  black-legged tick
XP_005103408   9 SARIMASEEIHg--ISVTDVYDQAAGIAHEFDKLInaygnDAVTELMPKVIKSLEQLETLACRYekdveEINQLRYKVEK 86  California sea ...
NP_741113      2 AARAASPQSPSk-qITVVDVYDLAASIGNDFEKLIdnygnECVRGIMPKVISALETLEAMAAGNdreneEIMRLSKAVER 80  nematode
XP_001608292  12 RPTAAMEDFNEtaeVSVVDVYDIASEIGKECEKLIdtygaDSITNLMPKVINALELLESFATKNerentTVQELRTKISQ 91  jewel wasp
NP_001259133   9 MGEMVLDAIDD---IGVVDVYDLASDIGKEYERIMdrfgtDAVSGLMPKIINTLELLEALATKNerenaTIQELRDKVAQ 85  fruit fly
XP_003245071   6 FGTSKMDNYKCs--LSVVDVYDMAQDIGREFESIIdaygtDAITGLMPKVVSALEQMEILAMKNerentTVDDLRATIQQ 83  pea aphid
EFX68439      14 DSSSEYDSLPD---ISVVDVFDLASDVGNELEKIIsihgnELVEGLMQKVIRVLELLDKTSRRQeserqLVEELQNNISL 90  common water flea

Feature 1        ## ##  ##  
4KP3_C        92 LKQEVEGLRKA 102 house mouse
AAX27188     135 LELEKLERKED 145 Schistosoma japonicum
EJW85282      96 LENEKQMKQQD 106 agent of lymphatic filariasis
XP_002402156  86 LEHDKSEKAQS 96  black-legged tick
XP_005103408  87 LESEKTEKAQE 97  California sea hare
NP_741113     81 LEQEKHQRNQQ 91  nematode
XP_001608292  92 LESDKIGKAED 102 jewel wasp
NP_001259133  86 LESEKLEKAEF 96  fruit fly
XP_003245071  84 LEMDKQERTED 94  pea aphid
EFX68439      91 LEREKREKAVD 101 common water flea

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