5AIZ


Conserved Protein Domain Family
Zmiz1_N
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pfam18028: Zmiz1_N 
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Zmiz1 N-terminal tetratricopeptide repeat domain
This is the N-terminal domain found in Zmiz1 proteins (Zinc finger MIZ domain-containing protein 1). Zmiz1 is a direct Notch1 cofactor that heterogeneously regulates Notch target genes. Zmiz1 directly interacts with the RAM1 domain of Notch1 through this N-terminal tetratricopeptide repeat (TPR) domain. Furthermore, it has been shown that Zmiz1 and Notch1 cooperatively recruit each other to chromatin through direct interaction via the N-terminal TPR domain resulting in a slight increase in activating histone marks and decrease of repressive histone marks. Functional analysis indicate that the N-Terminal Domain of Zmiz1 is important for driving Myc transcription and proliferation indirectly.
Links
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Statistics
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PSSM-Id: 375500
Aligned: 4 rows
Threshold Bit Score: 162.357
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5AIZ_A         14 IQQTNDRLQCIKQHLQNPANFHNAATELLDWCGDPRAFQRPFEQSLXGCLTVVSRVAAQQGFDLDLGYRLLAVCAANRDK 93  
EYB83982       11 VQQNNQRLISIKMSLMEEHTFPSACTELTQWCGDQRAFSSYFEENLLAALQVAVENGTKDGFDFTLAHQLISACFTHRKL 90  
VDD93896       23 VQQNNERLLSIKEQLNDARGYEKGCRELLTWCSDSRAFHNSFEINLLNVINEVVTVSTRAGYDEELAYMLLKCCHQYRKL 102 
XP_016852818    8 IQQTNDRLQCIKQHLQNPANFHNAATELLDWCGDPRAFQRPFEQSLMGCLTVVSRVAAQQGFDLDLGYRLLAVCAANRDK 87  

5AIZ_A         94 FTPKSAALLSSWC 106 
EYB83982       91 LSKESATRINRWY 103 
VDD93896      103 LSRQGSMKINRWF 115 
XP_016852818   88 FTPKSAALLSSWC 100
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