6EOJ


Conserved Protein Domain Family
CPSF_A

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pfam03178: CPSF_A 
Click on image for an interactive view with Cn3D
CPSF A subunit region
This family includes a region that lies towards the C-terminus of the cleavage and polyadenylation specificity factor (CPSF) A (160 kDa) subunit. CPSF is involved in mRNA polyadenylation and binds the AAUAAA conserved sequence in pre-mRNA. CPSF has also been found to be necessary for splicing of single-intron pre-mRNAs. The function of the aligned region is unknown but may be involved in RNA/DNA binding.
Statistics
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PSSM-Id: 427182
Aligned: 62 rows
Threshold Bit Score: 188.184
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6EOJ_A        990 QSGILLINP--KSwKViDKIDF--PK-NSVVNEMRSSMIQins---ktkRkREYIIAGVANATTEDTpPT----GAFHIY 1057 Saccharomyces...
EDO42742      801 IGSLLIIDQhtFE-VT-HAHQL--HD-NEQATSLMSCTLSdd--------pHTYYCVGTAYVFPEEPePKa---GRLLLF 864 
XP_002633464  780 TSSFMILDQntFQ-VL-HAHEF--GP-FEAAVSCISGQFSdd--------aRQYYIVGTGLIYPDESdTKl---GRIIVF 843 
O13807        733 LSFLRVYEKntLS-EI-AHHKF--NE-YEMVESIILMNd------------DKRVVVGTGFNFPDQDaPDs---GRLMVF 792  Schizosacchar...
Q7S9R0        792 HSSFKLVDEilFA-RVgKEFMLgtSSySELVEDVIRAELPds-----ygNlVERFIVGTSFLEDPDRgAGtdkrGRILVF 865  Neurospora cr...
Q0UHP7        765 LSHFKLVDEiqFK-EL-DTYAL--NE-EELVECVMRCDLAdg-----sgGtAERFVIGTAYLDDQNStVEr---GRILIL 831  Parastagonosp...
EDN03230      794 ASRFMLADEimFR-EL-DIYDL--NK-DELVESVIRAQFPdgidregndLfKDLFVVGTSYLD-DFGeGSi--rGRILAF 865 
Q0CML9        782 KSQFVLADEilFR-RL-DAFDL--RS-EELVESVIRAEFPvgkdekgrdMfKDRFVVGTAYLDEDEDrDSi--rGRILMF 854  Aspergillus t...
Q5BFT4        781 KSQFVLADEilFR-RL-DAFDL--EG-EEIVECVIRAEAPesk----dgEaKDRFVVGSAYLGEDDG-DSt--lGYIRVF 848  Aspergillus n...
Q10426        711 NYHLELVDSydDN-SF-RVFSF--TE-NERCEKVLKIN-------------ESSLLVGTSIIEQDKLvPVn---GRLILL 769  Schizosacchar...
6EOJ_A       1058 DVIEVvpepgkpdTNYKLKEIFQEEVSGTVSTVCEVSGRFMISQSQKVLVRDIQEDNs----VIPVAFLdIPVFVTDSKS 1133 Saccharomyces...
EDO42742      865 HLSE-----------GKLVQVAEKEVKGAVYSLVEFNGKVLAGINSTVSIFEWTADKe----FRYECSYyDNILALYLKT 929 
XP_002633464  844 EVDDV--------ERTKLRRVHELVVRGSPLALRILNGKLVAAINSSVRLFEWTADKv----LRLECSNfNHIVALDLKV 911 
O13807        793 EMTS----------DNNIEMQAEHKVQGSVNTLVLYKHLIVAGINASVCIFEYEHGT-----MHVRNSIrTPTYTIDISV 857  Schizosacchar...
Q7S9R0        866 GIDS----------NRDPYLVLKHELKGGCRALAVMGSKIVAALHKTVVISQYEETSsteahLVKLASYrCTTYPVDIAV 935  Neurospora cr...
Q0UHP7        832 EVTP----------ERVLKLVTEIAVKGGCRCLAMCEGKIVAALIKTIVVYDIEYRTqskpdLVKAATFrCSTAPIDITV 901  Parastagonosp...
EDN03230      866 EVTA----------NRQLAKVAEMPVKGACRALAIVQDKIVAALMKTVVVYTISKGQfadytLSKTASYrTSTAPIDIAV 935 
Q0CML9        855 EVDN----------GRKLTKVAELAVKGACRALAMLGDKVVAALVKTVVIYKVTGNNfgamkLEKLASYrTSTAPVDITV 924  Aspergillus t...
Q5BFT4        849 EVDN----------GRKLAKVAQERVKGACRALAVMGDKIVAALVKTVVVFQVVPRSgg-lqLQRLASYrTSTAPVDITV 917  Aspergillus n...
Q10426        770 EFEKE---------LQSLKVVSSMVLSAAVIDLGVYNDRYIVAFGQQVAIVKLTEER-----LMIDSRIsLGSIVLQLIV 835  Schizosacchar...
6EOJ_A       1134 FGNLLIIGDAMQGFQFIGFDA---------EPYrMISLGRSMSKFQTMSLEFLvNGgDmYFAATDADRNVHVLKYAPDep 1204 Saccharomyces...
EDO42742      930 KGDFILVGDLMRSMTLLVYLPl--------EGS-FQEIAHDFSPKWMTAIEIL-DD-D-TFLGAENSYNLFTCTKD-Sga 996 
XP_002633464  912 MNEEVAVADLMRSVSLLSYRMm--------EGN-FEEVAKDWNSEWMVTCEFI-TA-E-SILGGEAHLNMFTVEVDKSrp 979 
O13807        858 NQDEIIAADLMKSITVLQFID----------DQ-LIEVARDYHPLWATSVEIL-SE-R-KYFVTEADGNAVILLRD-Nvs 922  Schizosacchar...
Q7S9R0        936 HGNMIAVADMMKSATLVEYVPaktggekseAPK-LVECARHRHSAWATAVAHV-EG-E-SWLEADANGNLIVLQRN-Aeg 1010 Neurospora cr...
Q0UHP7        902 NGTQIAIADLMKSMVVVEYQRge-----tgLPDkLVEVARHFQVTWATAVAEV-DE-N-TYLESDAEGNLLVLYRDPKgv 973  Parastagonosp...
EDN03230      936 TGNLIAVADLMKSVSIVEYQQgsn----glPDS-LTEVARHFQTLWSTAVAHV-AE-D-TWLESDAEGNLVMLHRN-Vng 1006
Q0CML9        925 TDNVIAVSDLMKSSCLVEYIEged----glPDS-LKEVARHFQTVWATGIACI-AP-H-TYLESDAEGNLIILRRN-Lsg 995  Aspergillus t...
Q5BFT4        918 TRNVIAIADLMKSVCVVEYHEgen----gaPDK-LVEVARHFQTVWATGVTSV-AP-D-TYLESDAEGNLIVLRRN-Rsg 988  Aspergillus n...
Q10426        836 EGNEIAIADSIGRFTIMYF-----------DGQkFIVVARYLFGENIVKAALY-EG-T-VYIIATNSGLLKLLRYNKDak 901  Schizosacchar...
6EOJ_A       1205 ns-lsgqRLVHCSSFTLHSTNSCM---MLLPrn-eEFGSpqvpsfqNVGGQVDGSVFKIVP-LSEEKYRRLYVIQQQIID 1278 Saccharomyces...
EDO42742      997 ttdeeryHLQDAGQYHLGEFVNVFrhgSLVMehpgDASTpfq--gcVLFGTVNGRIG-IVAqIAQDLFNFLIQVQKKLNK 1073
XP_002633464  980 itddgryVLEPTGYWYLGELPKVMvraSLVVqp-eDSTIeys--hpIMFGTNQGTIG-MLVqIDDKWKKFLVSIEKAISD 1055
O13807        923 pqlsdrkKLRWYKKFYLGELINKTrhcTFIEp---QDKSlvt--pqLLCATVDGSLM-IVGdAGMSNTPLLLQLQDNIRK 996  Schizosacchar...
Q7S9R0       1011 vtvedqrQLRITSELNLGEQVNKIrpiK-VEt---SPNAiii--prAFLATAEGGIY-MFGtIARE-QDLLLRFQDKLAA 1082 Neurospora cr...
Q0UHP7        974 td-ddkrRLNVSSEMLLGEMVNRIrriDVATap-dAVVVp-----rAFMGTVEGSIY-LFAlISQNYLDLLITLQSNLGN 1045 Parastagonosp...
EDN03230     1007 vtdddrrRLEVTSEILLGEMVNRIrpvN-IQgs-qGAEAais--prAFLGTVEGSIY-LFGiINPTYQDLLMRLQSAMAG 1081
Q0CML9        996 veeddkrRLEVTGEISLGEMVNRIrpvN-IQq---LASVtvt--prAFLGTVEGSIY-LYAiINPEHQDFLMRLQATMAG 1068 Aspergillus t...
Q5BFT4        989 veeddrrRLEVTGEICLNEMVNRIrpvN-IQq---LPSAtvv--prAFLATVEGSIY-LYAiINPDYQDFLMRLQATMAS 1061 Aspergillus n...
Q10426        902 n---fndRFICESVYHLHDKVSKFqnfPIt-----NTNSfle--pkMLFATEIGAIGSIVSlKDKELE--LEELTRKIRK 969  Schizosacchar...
6EOJ_A       1279 REL-QLGGLNPRME-----RLANdfyqm-----ghsmRPMLDFNVIRRFCG 1318 Saccharomyces cerevisiae S288C
EDO42742     1074 VIK-SVGKIDHSLYpfphcSNLshsrk------mepaHGFIDGDLIESFLD 1117
XP_002633464 1056 SVK-NCMQIEHSTY-----RSFifqkr------ieppSGFIDGDLVESILD 1094
O13807        997 VIP-SFGGLSHKEW-----KEYRgene-------tspSDLIDGSLIESILG 1034 Schizosaccharomyces pombe 972h-
Q7S9R0       1083 VIK-TVGELDFNSY-----RAFRnaergpeadgttgpVRFLDGELLERFLD 1127 Neurospora crassa
Q0UHP7       1046 LVV-SPGNMDFAKF-----RAFKnqvrt-----eeepNRFVDGELIERFLD 1085 Parastagonospora nodorum SN15
EDN03230     1082 MVV-TPGGMPFNKF-----RAFRntirq-----aeepYRFVDGELIERFLS 1121
Q0CML9       1069 KIE-SLGDMPFNEF-----RGFRsmvre-----akepYRFVDGELIERFLT 1108 Aspergillus terreus NIH2624
Q5BFT4       1062 RAD-SLGGIPFTDY-----RAFRtmtrq-----atepYRFVDGELIERFLT 1101 Aspergillus nidulans
Q10426        970 LKFsYLSSMDYESI-----EADLis-----------pVPFIDGDLVIDVKR 1004 Schizosaccharomyces pombe 972h-
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