3CW1


Conserved Protein Domain Family
U1snRNP70_N
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pfam12220: U1snRNP70_N 
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U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
This domain is found in eukaryotes. This domain is about 90 amino acids in length. This domain is found associated with pfam00076. This domain is part of U1 snRNP, which is the pre-mRNA binding protein of the penta-snRNP spliceosome complex. It extends over a distance of 180 A from its RNA binding domain, wraps around the core domain of U1 snRNP consisting of the seven Sm proteins and finally contacts U1-C, which is crucial for 5'-splice-site recognition.
Links
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Statistics
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PSSM-Id: 432406
Aligned: 129 rows
Threshold Bit Score: 29.4642
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3CW1_6         3 QFLPPNLLALFAPRDPIPYLPPLekl---pheKHHn-qPYCGIAPYIREFe------------DPRDAP----PPTRAET 62 
XP_001485777   7 DKYPPTIKKLFAPRPPLLHVPPLdyp---pekRSTk--PVSPVSKWKEIYqeha------qriREENET----TDTAVET 71 
EEQ40463      21 EKYPRKIEKLFTPKLPFLHKQPIdyp---pheRATp--VITSISAWKSEIekyc---------------------tefKS 74 
EGW33058       5 EKYPPNIQKLFGPKPPFLYIPPTdyp---peqRSTt--AIAPISSIKDHIssyi------tqyKSEPKP----TTSTTIS 69 
EMG50681       6 EKYPPNIQKLFQPKLPFPHLQSSdyp---penRSTv--PIGSISSLKSEIdkyistelpkletEVPENP----PKIPKII 76 
EER34697       6 EKYPPNIQKLFQAKPPFPHFEPTdyp---pekRRTa--SISPISSIKEVIneyliselpnhedKSSSKS----KKSLRII 76 
EGV62100       8 ERYPAAIQKLFRPRLPLPFIPPTdya---sntRKTa--SITPISAYALLIrnyv-----dqelPQIEAE----RQSPDKT 73 
EFC44943       1 ---PPQIQALFTPGPPVSFLPPLdak----rrKKTkhrDLNGISEFVDKFeqeq------veyDAEGQAirtkKYSMPES 67 
XP_001743275   3 AFLPPYLRDLFEPGPPIKHVPAAelqvenferKYNa--PLTGISAYLDQFe-----------tTAPPPR----VGQFLET 65 
EDV28681       3 YCLPPHLSAFFTPKEPIKYLPPLdt-----psHLRkrrPYTGVSVFLSQFe------------TVRNSA----PSVVTET 61 

3CW1_6        63 REERMERKRREKIERRQQEVETELKMWDPHND 94 
XP_001485777  72 TLQKQAKARAKRERAQAESFQRQMEEWLDPSl 103
EEQ40463      75 SDEEQKQRPLTKKQLREASLKRQMDDWEDAEa 106
EGW33058      70 T----VEAFRQKKQRHQESFTRQLAQWNDPEl 97 
EMG50681      77 QHRQRQKDAKIKKLKNEENLQRQLKDWNDPav 108
EER34697      77 KHKQKQEEAKIRKTAKQKEFQRQLDEWNDPav 108
EGV62100      74 PFQIQAEKTQRRRLDIQKSRQRQLTDWNNPEl 105
EFC44943      68 RRKRKESRQKDKAIKVENVVRKGLQDWDPNND 99 
XP_001743275  66 REARKQRKAKEAIERQEPQLSAALEAWKPKEN 97 
EDV28681      62 REEKRTRQKKERLDKVSAKLQKDLAQWDPHNN 93
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