Conserved Protein Domain Family
Rav1p_C

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pfam12234: Rav1p_C 
RAVE protein 1 C terminal
This domain family is found in eukaryotes, and is typically between 621 and 644 amino acids in length. This family is the C terminal region of the protein RAVE (regulator of the ATPase of vacuolar and endosomal membranes). Rav1p is involved in regulating the glucose dependent assembly and disassembly of vacuolar ATPase V1 and V0 subunits.
Statistics
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PSSM-Id: 432413
Aligned: 61 rows
Threshold Bit Score: 679.29
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6BYJ7        683 VKFFAINFAKSRDSLEWIETYRLH--TNISEATKIHGASIiNKFAIV---DKTGSRLTIWDTKSGVL----EYEETFdDS 753  Debaryomyces ...
XP_002171588  576 LQTWTATV-TSDNTPRVLELSRVQ--TSVRDATLIKGSTS-KIVAVV---SENGSRLSVFDMRSSEFssqeESSAVF-PE 647 
Q9Y817        576 LQTWMARV-LGDDKAEISEISKVQ--TSIKSATMIKGSTS-KKVAVV---SENNRRLSIFDTRSSEFsekeEFSSVF-DD 647  Schizosacchar...
EPY53766      577 LQTWIAKV-IEPFKASISEFSRLQ--TNIKSSSMVKGSTS-RKVAVV---SDNRLRLSIYDTRSSLFtsneEFTNVF-ND 648 
Q6CBP7        538 FSTWVSEISSDNSTVEWSLLSTVA--TNVINSPLMSQSSL-NKVAIV---SEDRLELSIWDTRHGFL----EQTKKF--- 604  Yarrowia lipo...
EIE80308       66 ilfYSMYITSDDASIEWNVLYTLDlpSSL-SIQHIRYCSP-NIVAVVs--GDNSTQLSIWTGMRAGIapvcEQKISF--- 138 
EPB89763       42 peiifygINTDNTSIEWDALFSMDasSLASSIHQIK-CAP-GTIALVs--GQNRKTLSIWMEMRSGVapscVKTFEF--- 114 
GAC99552      653 FEAMHAT-RDTRGQLRWTAVALLR--ESSGIPQRVRCNVD-GLFAAVtrdDQGTETLVIFDLKTSSFssgeEHRQSF-GA 727 
XP_011386551  656 IEAVHAI-QDATGQLRWTTIAAFH--EPLGTPTLISGSAH-GLVALVtrdKQEKETLVILDSKTSSFssgeEHRQCF-SS 730 
SAM58489      659 VEVWKPT-GNSSNELHLDLVTSLR--PSAGSPQLVRCSAS-GLIAVVhhdEHDSQVLVIYNSKTTSFssgeEHRQTF-GS 733 
Q6BYJ7        754 YGAVTDLDWTFItsnserLTSNAILSVGFLRFVLLYTQLR-YDYTNK-----IPTFAVLKKIDISNYTSHEIGDLIWLDD 827  Debaryomyces ...
XP_002171588  648 LGPIIDLDWTST------PNSHSILAVSFKHDVVLICQNR-RSYIMK-----SPLWVPIVRVNTSSFTDLPIRDSTWLDN 715 
Q9Y817        648 YGPINDLDWTST------PNSHSILAVGFLHDVILLCQNR-RSYMND-----IPCWSRIRRYNLLEYTNSLISDSSWLDN 715  Schizosacchar...
EPY53766      649 YGPIIDLDWTST------PNSHSILAVGFQHEVILLCQNR-RSYISD-----APCWVPIRRYSLSMYTNMLISDSSWLDN 716 
Q6CBP7        605 DTKICDLDWACT------PDNQSVLAIGFGTHVQLWGQLR-FDYTNI-----SPCWGLLKQVDIKPFTNHAIGDSIWMNT 672  Yarrowia lipo...
EIE80308      139 DQSIKDIAWSVT------SDAQFILAVAFSDHISIYGQKRaYNNGYE------AEWSCYADFKVD--TPEDITALAWVDY 204 
EPB89763      115 DEPVCDIAWNVT------SDAQFILAIAFPKSVSIFGQKRaSNNVNN-----DDIWACYTTFKVD--TPEDITALAWVDC 181 
GAC99552      728 EESVVGLDWSPS------PLSSNMLAVAFHHHVDIVAPRR-FSPYEAhdattGSQWQLLVRLDLRSCTSSAIRAACWIGS 800 
XP_011386551  731 EEVVVALDWSPS------PLSSNVLAVAFEHHVDIVASRR-SSPFDLnqarsSPQWQLLVRLDLRICTPSMLRSACWLTC 803 
SAM58489      734 RDRIIALDWSPS------PLSNNALAVVFEHHVDVMAPGR-ASTFDSksangGSRWEQLARLDLLSCTPSSIRAACWLGS 806 
Q6BYJ7        828 GYLVIGCGNQFFIDDKWVKLgssannsldstirqlmvgytniENEdyDSsqketksTYDmiYDIEQLVRILNGPLPVYHP 907  Debaryomyces ...
XP_002171588  716 GTLVLACGTGIYYFDKTLPQ---------------------------NPsllypysVNRqsKDLFDLVYQLNGILPVYHP 768 
Q9Y817        716 GTLVTAIGNGLFYFDNSLPE---------------------------DQsllfpasLKRsaKNIFDLAYQLNGILPVFHP 768  Schizosacchar...
EPY53766      717 GTLVTAAGNNLFFFKNKIPN---------------------------NKsllfpasLKRsaNNIFDLAYQLNGILPVFHP 769 
Q6CBP7        673 GVLVVAAGNQLFVDDNCVHEe---------------------EAGvrDFsdmlhssRAFhiHHLFEICSIVNGPLPAYHP 731  Yarrowia lipo...
EIE80308      205 GVLTVAAGNQLRCYLKWLTE-----------------------QDtvIKssdslndKMEpmSSIYDISYEMNGPLPFYHP 261 
EPB89763      182 GVLTVAAGNQLRCYLKWLID----------------------DETisKAvqvhgvsQVEpmSSIFDISYEMNGPLPFYHP 239 
GAC99552      801 EQLVIASGSLLFLYGPFVQPssq-------------------------------vaGEPkkVHLAELVAEVGGPVVQYHP 849 
XP_011386551  804 EQLVVASGSLLLIYGPWVQPclp-------------------------------ctEVPkdMHLAELVAEVGGPVVQYHP 852 
SAM58489      807 EQLVVASGAVLFVYGPFVQSsls-------------------------------ngIGSerMHLAELVAEVGGPVVQYHP 855 
Q6BYJ7        908 QFLIQCLFMHQISLVKDVFVRLFQILRkgdSIQWDlsMDLTNEVLENNESRQ-----SGASTPSlsSKid--iiNDAFSS 980  Debaryomyces ...
XP_002171588  769 QFLQQLMLNNKISLILLILHRVYECLQq--------nNPLHFLLNIEAEKLIlpsaaQDDVQSQvnSVldeiksGNDSVE 840 
Q9Y817        769 QLLQQLLLRNQPFLFTNILLRFYLCLKd--------dVDMHFLLNMDCSEFY-----CCDEEISkdLLikslsqNSAEIL 835  Schizosacchar...
EPY53766      770 QFLQQLLLKNQEFLIRKILLLFYICLKn--------dYPMHFLLNMDCSDFY-----EHNDEKLmeKFfevlttYANEIp 836 
Q6CBP7        732 QLLVQCILAGQLTVVRDTLYRLYKELQ---YANQElvQDMDSTLGMDPSDYE-----DGDKSGS---------------- 787  Yarrowia lipo...
EIE80308      262 DHIIHYIMWGKMELVHNVFLTMYGFLK---QFVDEedNVMNELPPVSFSNML-----KLQDINGs-TKknkggyDVLFDN 332 
EPB89763      240 DHLIHYIMWGKMDLVHSVLISLYTFFK---QFVDDedNIINEFPPVSFSKML-----KLQNGKS--SKsakqeyNGLFED 309 
GAC99552      850 AFLLQCAIWGKMEVAMAVISNLENAVL---AYDGQdtGDSWAFQEVPLDAVL-----LHDSAAGngRTrsa-lpSRHTVD 920 
XP_011386551  853 TFLLQCAIWGKIGLASAIIGNLEKALL---ACSAQdmGETWAFEEVSLDAML-----KDDRTADqgATklv-psTQKNTL 923 
SAM58489      856 AFLLQCALWGKMGLAKAIISNLDKAAF---ACNAQdvLETWAFEQVPLDILL-----KDDAKADeaRPra---pQRHGVQ 924 
Q6BYJ7        981 Kf--------dSSGIHIFNSFNDNLLDLLIEKLMKISLPLLTRHQQITLISIISIVKELGKYLMSLDENGLRFLMGF--K 1050 Debaryomyces ...
XP_002171588  841 EtavnslnewrNS---------LDWLSSLEAQLKSQKVQTLTRTSQFLLLNFIEAFHKTLSVGSFLDLNGRRYCLML--N 909 
Q9Y817        836 Npael--dfeeTSVSKHLGLYIDEMIKKLTALLKVKKVKTLTRSSQFLLLNLIEAFNKARALRDSLDLNGKRYCIML--N 911  Schizosacchar...
EPY53766      837 vead--sfgekPSVSEDVTTYMNAFMTHLCLLLKNKKVGTLTRSSQFYLLNVIEAFDKAYHLRESLDLNGRRFCIML--N 912 
Q6CBP7        788 -------------------KLLPDEYSNLTEKLQQVSLPFITQHQQVTLASLCEVVAEVAGWS---DIMAIRFYLGY--K 843  Yarrowia lipo...
EIE80308      333 Gdete---gtdDEEDEEVRFMTSNEAKNLAHCLKHKNLPGLSKRDKYQLIAMVNTIVEITNQGESIDANGARFIALVenH 409 
EPB89763      310 DddaedvdkkqDDDDDVVRALTSNEAKNLAHYLKVKVLPGLNENERIHLIAMVDTIVEITNQGESLDENGARFTALLenH 389 
GAC99552      921 Gsifd--eldrSDDADDSGLFGLDRIDSLAQRIRDVQPPHLSPSDLDVLVNLVKSIGEVAREHRSLDPSGLRYTLAL--R 996 
XP_011386551  924 Ssifd--epasVGDARDTDLFAIDRINTLARHLQEIKPPHVSAADIEVLVCLIKTISEAIREHRSLDASGLRYTLAL--R 999 
SAM58489      925 Rsifd--epdlSGDQADTDPFSSERIEKLVVQLKQVRPPHLSDSDLHMLVNLIKTIGEAVREHGSMDPSGLRYMFAL--R 1000
Q6BYJ7       1051 LFQLSSK---------QSKLTTRDISWALHSDNKEMLLTMVEEYFKNRLKWENVKQIGLVYWVET-IRLTKIMESCARNE 1120 Debaryomyces ...
XP_002171588  910 QYTLLRHqt-----keKSQLPFRDCMWAFYSSNQDVLLGYSKQLLGNFLLWDDVRELGLPYWLSQ-SSLCQVFRELAQNH 983 
Q9Y817        912 QYVLSKHqr------qLTSLPTREMAWAFHSSNKAVLLDHTKKLHGKPLLWNAVEEYAIPFWLNE-QLLKDVFLELSRNH 984  Schizosacchar...
EPY53766      913 QYVLNKYqr------rSNRLPTRDILWGFYSTNKSVLLDYTVKVHGKTLLWPVVEEYGLPFWLNQ-QALINVFGELSRNH 985 
Q6CBP7        844 LYRMHRKt--------QKQMTVRDFCWALNSESQAMLLEQID---GPKLVWPDAQAAGVGYWLEH-HKLVELFDVLAKNQ 911  Yarrowia lipo...
EIE80308      410 FHLNLQLpee----qrQPNLQTRDFTWALHSQSQDLLLQKCMQLCGDKFVWEDARSLGIFLWLQKiDTVREQMTTIARNI 485 
EPB89763      390 FHLNKSLppe----qrQMQLESRDYVWALHSQSQDLLLERCIRLCDNKLVWEDARNLGLFIWLQKiDVVRDQMATIARNI 465 
GAC99552      997 QMLNRTDmskqaknapSIELTYRDYLWAFHSDNQETLLAYVESAYPNKLDWRAARSAGLFTWLKNpSALRTQAEAVARAQ 1076
XP_011386551 1000 QMLNRSSpwkqakqasAVSLTYRDYLWAFHSHNQETLLSSIESVYHNQLDWPAARATGLFIWLQNpSMLRNQAEAVARAQ 1079
SAM58489     1001 QTLNGSDpvkdaqatpVAELSYRDFLWAFHSDNQETLLSAVESSYRNKLDWPAARSTGLFAWLKSpQALRTQAEAVARAQ 1080
Q6BYJ7       1121 FS----DTRDPSgRVSLFYLAIRKKQVLIGLWRTVS-HTEQQKMLKFLANDFNESRWKSAALKNAYVLMGKHRYIDAAYF 1195 Debaryomyces ...
XP_002171588  984 YTh--nDERNPE-FVSLYYMALRKKAVLVNLWKLASwHKESARTVKLLSNDFTLPRWRVAAAKNAFALLSRHRYFYAAAF 1060
Q9Y817        985 YAe--iDDRNPE-NVSLYHIALHKINVFRDLWRLASwHKESARTVKLLSNDFSKKKWKVVASKNAFALLSKHRYFYASAF 1061 Schizosacchar...
EPY53766      986 YIn--nGERDPE-KVSLYHVALGKVAVLRSLWSLASwHKESGPTVKFLSNDFTQKRWKVAASKNAFALLSKHRYFYAAAF 1062
Q6CBP7        912 FMa--tERQDPS-EASLFYLALRKKQVLQALWRSAStHPEQTKMVKFLKNDFSEPRWRTAALKNAFALLSKHRYAYAASF 988  Yarrowia lipo...
EIE80308      486 YLsk-eDFRDPV-DCTLFYFALRKKNLVQGLWRSASyHKEQGAMLKFLANDFSQPRWQTAASKNAFALLGKQRFEYAAAF 563 
EPB89763      466 YLsksaEARDPV-DCTLFYLALRKKNLIEGLWKSTSsHKEQAAMKKFLANDFTDPRWQRAASKNAFALLGKQRFEYAAAF 544 
GAC99552     1077 FMs--sEDRDPV-KCSLLYSALGKRKVVQGLWRQAVwHPEQKKMLQFLSHDFDEQRWKTAAQKNAFALLSQRRYEFAASF 1153
XP_011386551 1080 FMs--sEDRDPV-KCSLLYFALGKRKVVQGLWRQAVwHPEQKKMLQFLSHDFDEQRWKTAAQKNAFALLSQRRYEFAASF 1156
SAM58489     1081 FMt--gEDRDPV-KCSLLYFALGKRKVVQGLWRQAVwHPEQKKMLQFLLHDFDEERWKTAACKNAFALLSQRRYEFAASF 1157
Q6BYJ7       1196 FLLADALKDCCNIIATKLNDVQLAIAIAKIYSAtskgtiSEGEIIKNLIENYMVPEVLKNGDRWITSWIFWELEEHEISI 1275 Debaryomyces ...
XP_002171588 1061 FLLGDQCLDAVRVCIRNLNDPALAIAVARVYEG------DDGPTFSKLLVEFMLPISQRYYDRFLACWCFEMLKNKAKAI 1134
Q9Y817       1062 FLLADSCYDAAKVCIRNLKSISLAIAMTRVYEG------DDGPTLKRLINEYVLPLAVSQNDRWLTNWSFTILKQEKKAL 1135 Schizosacchar...
EPY53766     1063 FLLADSPYDAAKVCIRNLRCLSLAVAVVRVYEG------DGKTCLKRIIEEFVLPSAAYHNDRWLTNWGFAMINEKMKSV 1136
Q6CBP7        989 FLLGDSLKDCVNVITRKLNDTGLAIAVCRVYEG------DNGPVLNELIKNEILPEALKMGDQWVIYWCLWSQDRRGDAV 1062 Yarrowia lipo...
EIE80308      564 FLLADKLRDAVNVILRNVKDYQLAIAICRVYEG------DHSPILREILENTVIPTAIKSNDRWLISMTYWLLGKQKESI 637 
EPB89763      545 FLLADKLKDAVNVILKNVKDFHLAIAICRVYEG------DHSPLLREILENSVIPMAIENNDRWLISMAYWLLDKHKDAV 618 
GAC99552     1154 FMLGESLRDAVNVCVRNLDDLPLAIALARIKEGc-----DDGPVLTDLLKTRVLPLAFERGDRWMGSWAFWMLKRRDLAV 1228
XP_011386551 1157 FMLGESLRDAVNVCVRNLDDLPLAIALARIHEGr-----DDGPVLIDILKTRVLPLAFETGDRWMGSWAFWMLKRRDLAV 1231
SAM58489     1158 FMLGESLRDAVNVCVRNMDDLPLAIALARVKEGc-----DDGPVFTDLLRTRVLPLAFERGDRWMGSWAFWMLKRRDLAV 1232
Q6BYJ7       1276 QALIKSPIEIINhHkakf-sddCSKNyiski--------tprfSSMSFLK----------DDPVLIILFHALRQ------ 1330 Debaryomyces ...
XP_002171588 1135 QCLVSPLYSTIRdDaelkkettATATllprddd----alpghpQDKNGAA----------DDPALILLYVWLRDqfctfg 1200
Q9Y817       1136 QSLVSPIRSLVSdNdfiqlytsDKNDqeihenkdsqrnstnepVRNKFPS----------DDPAFILLYECLRS------ 1199 Schizosacchar...
EPY53766     1137 QSLLVPVRSLIEvDndliesfgIIGDypletet---teenhdkTKNEYTS----------DDPALILLYDFLRS------ 1197
Q6CBP7       1063 RSLVSHEYQDKKrGsah-----------------------ivsNSRSFLS----------NDPALLILYQFLRD------ 1103 Yarrowia lipo...
EIE80308      638 RSLIVPLSQFTDeLihdedsaaAV------------------------------------QDPNAFILYHQLKK------ 675 
EPB89763      619 RAMVVPLTQFTDkDidttdadfAAVV----------------------------------HDPNAFILYQHLKK------ 658 
GAC99552     1229 RIIVTPLRDLIAdK-----------------------------DVASLLGstltcgndsyGDPALALLFQQLRS------ 1273
XP_011386551 1232 RIIVTPLRDLLAdK-----------------------------DVAVLIGssitcgndsySDPSLALLFQQLRA------ 1276
SAM58489     1233 RIIVTPLRDLLAdE-----------------------------GVASLLGsnvtcgndsyNDPALALLFQQLRS------ 1277
Q6BYJ7       1331 ---KTIKYLKGSLSIAPDEEFNFIIKVCSIYTRMGCDYLAVV 1369 Debaryomyces hansenii
XP_002171588 1201 gsaSQLRPLGNLAPVNPSHEFKFVLHMARVYDQMGCDLTALS 1242
Q9Y817       1200 ----------SNVQIDESLEYRFVLHNANVYCQLGCDLIALG 1231 Schizosaccharomyces pombe 972h-
EPY53766     1198 ----------DLLRKDQILEYRFVLNSARVYNEMGCDLIALD 1229
Q6CBP7       1104 ---SKFKVVSSNNGVTSATELQSVFTTAKLYSRMGCEVIALN 1142 Yarrowia lipolytica
EIE80308      676 ---GQTQVLS----VPYDLEYHFSLLVSKAYERLGCPLLALH 710 
EPB89763      659 ---SLIQDQK--SIVSYSIEYGFSLLVSRSYERLGCPLLALy 695 
GAC99552     1274 ---KSLQTIKGLYDIPEKKVFDFVLNTNRALCRMGCHSIGLS 1312
XP_011386551 1277 ---KSLQTIKGLYDIPEKKVFDFVLNTNRGLCRMGCHSIGLS 1315
SAM58489     1278 ---KSLQTIKGLYHIPEKKIFDFVLNTNRALCRMGCHSIGLS 1316
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