Conserved Protein Domain Family
PRC2_HTH_1

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pfam18118: PRC2_HTH_1 
Polycomb repressive complex 2 tri-helical domain
This domain can be found in the Polycomb repressive complex 2 (PRC2) present in Homo sapiens. Polycomb complexes maintain repressive chromatin states by silencing gene expression. PRC2 does this by methylating lysine 27 of histone H3. This domain makes up part of the N-lobe which is involved in regulation.
Statistics
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PSSM-Id: 436286
Aligned: 13 rows
Threshold Bit Score: 120.187
Created: 28-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KFB43971             153 HGDK-EGSFIDDAMFVELVHALMVVTAKDA-------ADEPDGKKLHSRAsssgetidtskadeslrksklK----KTEK 220  Anophe...
KZC13636             148 HGDR-ESGFMDDSIFVDLVNALAQYEKDDK-------EREHTKKGKEKEE---------------------DkdkrDSSS 198  Dufour...
KZS17283             361 HGDR-EGGVIDDDIFVELVTALVPYCEEDE-------RSEPPSSLKADKA---------------------EkpdeGARC 411  Daphni...
WGS:AANI:GJ11699-PA  147 HGDK-DPSFMDDAIFVELVHALMRSHSKEL-------EETVTSPSAKTETpta---------------pklK------EE 197  Drosop...
KFO97549             145 HGEE-GSVLISDAVFLELVNALNQYSDEEE-------EGHNDSEVKQEDG---------------------KeelpVTKK 195  Anna's...
1_pfamImport           1 HGDR-EGGFISDEIFKELVDALSQYSDHEE-------DEEEEASAGTVGDmt------------------gKkeeeRVMR 54  
3_pfamImport           1 HGDRgETLFFNGVIFTDLKAGLTQRSDADS-------SSAGHDANGLCQH---------------------KrsirPSRP 52  
2_pfamImport           1 HGDR-EGDFINDELFLELVTSLNQFHMQSSdlvliegTSKSGQHEER--Snkflcfcsv----ilnfyhyqKnkesSADE 73  
XP_002605895         140 HGER-EGGFINDEIFVELVRNLSELEAPKS-------SSSSEAEKADSQS---------------------TkdneEASE 190  Florid...
EEC12589             154 HGDR-DAGSVNDELFLELVHALMTYEDEPG-------TTNRTLTEANYYD---------------------IcwfrTL-- 202  black-...
KOF99173             220 HGDR-DTKFINDDLFMELVDALWANYNDTD-------PEQRELSSPSSQN---------------------TndgiKTE- 269  Octopu...
EKC36964             209 HGEK-HCNVMDNDTFVELVNSLWLNYPDPD-------VDGEEGIEHC--------------------------------- 247  Pacifi...
XP_009048483         179 HGER-PSNFMSDDIYIELVNNLHANYPDID-------DNGFKIIAYMAKL---------------------N----FLD- 224  owl li...
KFB43971             221 --NNESEtngdgter-------------ddgrqiehSTDGGNDLPSAKAFPAPIIFQAISSQFPEQGSAEELRDKYIELT 285  Anophe...
KZC13636             199 ikAEVKS-----------------------------EKSSEDVKTEVNPFPTMHIFNAISSMFPDKGRPEELKEKYIELT 249  Dufour...
KZS17283             412 --DAVTVtk--------------------------eKPAGTSGSTSAKDLPNIIVFQAIASVFPDKGTPEELRERYMELT 463  Daphni...
WGS:AANI:GJ11699-PA  198 --DEKTEtttsseptaaasssatedkeavpvaviadTKCKVEKVKEKLPFPAPIIFQAISANFPDKGTPQELKEKYIELT 275  Drosop...
KFO97549             196 --RKR-------------------------------IAVEGNKKCSKKRFPNDMIFTAISSMFPEYGFPEDMKERYRELT 242  Anna's...
1_pfamImport          55 --RSSLE-----------------------------GSEENKDVSSSKKIPNDKIFTAIASMFPYKGTTEELKEKYKDLL 103 
3_pfamImport          53 --C--------------------------------------KESQAPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELT 92  
2_pfamImport          74 --DGEDD-----------------------------NKIGDENNDAISTFPCDKIFSAIADLFPDKGSIDDLKEKYKELT 122 
XP_002605895         191 --DTPDDttd------------------------slKDASGTDSGSRRRFPCDQIFEAISSMFPDKGSAEELREKYKELI 244  Florid...
EEC12589             203 --ARRPL-----------------------------RNLFPEKCEEKAPSPSDFIFAAICSVFPDKRTPEELKERYRELM 251  black-...
KOF99173             270 -------------------------------------LKEDEVDKSRKTPPADIIFQSISAMFPDKGTQEELKEKYIDLM 312  Octopu...
EKC36964             248 -----------------------------------------NQDEQKSPFPSDAIFEAISAEFPEKGSGDDLKEKYKDLI 286  Pacifi...
XP_009048483         225 --------------------------------------DDDDKSFPKPTAVRDIIFKSISEVFPEKGNPEELREKYRELN 266  owl li...
KFB43971             286 E 286  Anopheles sinensis
KZC13636             250 E 250  Dufourea novaeangliae
KZS17283             464 E 464  Daphnia magna
WGS:AANI:GJ11699-PA  276 E 276  Drosophila virilis
KFO97549             243 E 243  Anna's hummingbird
1_pfamImport         104 E 104 
3_pfamImport          93 E 93  
2_pfamImport         123 E 123 
XP_002605895         245 E 245  Florida lancelet
EEC12589             252 E 252  black-legged tick
KOF99173             313 E 313  Octopus bimaculoides
EKC36964             287 E 287  Pacific oyster
XP_009048483         267 E 267  owl limpet
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