Conserved Protein Domain Family
TBD
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pfam12845: TBD 
TBD domain
The Tbk1/Ikki binding domain (TBD) is a 40 amino acid domain able to bind kinases, has been found to be essential for poly(I:C)-induced IRF activation. The domain is found in SINTBAD, TANK and NAP1 protein. This domain is predicted to form an a-helix with residues essential for kinase binding clustering on one side.
Links
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Statistics
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PSSM-Id: 463729
Aligned: 10 rows
Threshold Bit Score: 64.3767
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_005993775 215 QKSEEFLQRAYWELKKEMSNLHLVTKVQSEVLRKLRAtLTAANKDSLSFPAQCVED 270
XP_002749442 132 LHERDNIEKTFWDLKEEFHRICMLAKAQKDHLSKLNI-PDTATETQCSVPIQCTDK 186
XP_011381004 288 GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQeQARSGG-QRHSPLSQRHS 342
XP_011381004 288 GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQeQARSGG-QRHSPLSQRHS 342
XP_542751    214 SISSDNMQNAYWELKREMSNLHLVTQVQAELLRKLKIpTTIK---KACSPVGCMED 266
XP_008119738 227 DIHSVNVQHAYWELKKEMSNLHLVTEVQAEMLKKLKLiPLGTRKVPSCTPLQCVED 282
XP_007494317 180 FNKREEIEKTFYEMKEEFHRICMLARAQREHLNRLNI-QEPIPEIQFSMPIQCTDE 234
XP_006636682 138 DDKSKEILEAFQEIQGKFHVIQNLTRKQKDHLNKLCRaNDTAQEQQFSMPIQCTDV 193
XP_001511169 193 SHERADLEKTFLEMKEELHRICMLTRMQTDHLSKFNLkNETAREIQFSMPIQCTDK 248
XP_027317323 190 GHARENLETIFQEMKEECHRICMLAREQTDQLSKFKIkPEPETEIQFSMPIQCTDK 245
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