6HRE,6HRE,6QJP


Conserved Protein Domain Family
Tubulin-binding
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pfam00418: Tubulin-binding 
Tau and MAP protein, tubulin-binding repeat
This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.
Links
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Statistics
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PSSM-Id: 459807
Aligned: 78 rows
Threshold Bit Score: 38.1607
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6HRE_A       275 VQIINKKLD-LS-NVQSKCGSKDNIKHVPGGG 304
CAG03020      50 LAAAAAPMPdLK-NIKSKIGSTDNIKHQPGGG 80 
XP_005469267 194 VEIKSEKVD-FK-AVQSKVGSLENVTHVPGGG 223
XP_022524990 345 IEIRSEKLE-F--KVQSKVGSLDNIGHVAGGG 373
EGF84323      78 AIIFSEKKS-FS-HVKSKVGSLENTTYSPSGG 107
6HRE_A       337 VEVKSEKLD-FKdRVQSKIGSLDNITHVPGGG 367
XP_019133312 431 IEIKNEKLE-F--KVQSKIGSLDNIGHVPGGG 459 large yellow croaker
CAG03020     311 VEIKNEKLE-F--RAQSKVGSLDNITHMPGGG 339
XP_002426661 511 VQVGAAPSPnLK-AAKSKVGSLANTLHKPGGG 541 human body louse
XP_029344583 517 VQVGSAPSPnLK-VVRSKVGSLQNTSHKPGGG 547 pea aphid
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