7L9R,6W3Z,6DFT


Conserved Protein Domain Family
DS

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pfam01916: DS 
Deoxyhypusine synthase
Eukaryotic initiation factor 5A (eIF-5A) contains an unusual amino acid, hypusine [N epsilon-(4-aminobutyl-2-hydroxy)lysine]. The first step in the post-translational formation of hypusine is catalyzed by the enzyme deoxyhypusine synthase (DS) EC:1.1.1.249. The modified version of eIF-5A, and DS, are required for eukaryotic cell proliferation.
Statistics
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PSSM-Id: 460382
Aligned: 213 rows
Threshold Bit Score: 239.601
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7L9R_A                39 ELVNSYLTT-GIQSSNVGRAINIINKMltwqpseeekkeyvegdERLKRCTIYLGFTSEMMTSGLR-DTFRYLVEHKCVD 116 Entamoe...
ESQ11789              27 ELVSLMGAT-SFEARRVHRGAHLFADM------------------INEGDTIWLGVAGAGIAGGMG-GMVISLIEHGFID 86 
goetting:Ngar_c06260  25 DLIRFYGST-GYNARRLAEAAEILQDM------------------IDTNSTVCLTLAGAMTPIGLG-RTISEMIEKGFID 84 
jgi:Nmar_0928         24 DVVEVFAQS-GYNGRQLGEAAKLYAKM------------------IDDGATICLTIAGAMTPVGFG-GIFKTLIERGFVD 83 
ABK76895               5 ELVEAYSKT-GFNGRQLGEAAKLFGKM------------------ISEDATICLTISGALTPVGFG-GIFKELIERGLVD 64 
jgi:Anae109_1276      31 DLVDVYRRAgAFNGGRLAEGCDLFARM------------------IDSDATIALTVTGAMAPAGLG-GAIQAMIEAGFVD 91 
Q8DKP1                33 ltelidkYFtAYNSARLREICQLLSQR-----------------VFKPEVTVGLSLSGAMTPTGLGiSALAPLVRAGFVD 95  Thermos...
jgi:Dret_1312         38 DLLSAMSQT-SFGGRGLGEALGVLEEM-----------------VQDPDCHVVGTFSGAMTVAKMG-KLLCSMIDKGWID 98 
AEB08604              32 ELLAGYSLT-AFGGRSLGEAAEVLQAM-----------------VTDPEVTIVGTFSGAMTVAKMG-LLICDMIDRGWLQ 92 
WP_012238611          38 DLLRAMSRT-AFSGRALGEACDVLEAM-----------------VRDEDCLVVATFSGAMTVAKMG-VVIVRMIEAGMID 98  Sorangi...
7L9R_A               117 YIVTTAGAIETDIMKCFGN-MNI---GDFYMKPEEVQGE---RHGNMIIPKELI-EKTKQWLKEFILDIQEcqdtsmpF- 187 Entamoe...
ESQ11789              87 VICSTGAQVYHDLHFAFGLpVKAinpA---ADDDLLRASgdtRIYDIGIRDKETlDAQDELIRAFVRDRYQe-----lGg 158
goetting:Ngar_c06260  85 WIVATGANVYHDLHFAYDLpVRQ---GHFDVDDDILYAKqivRIYDVYIKEMGTlQAQDLIVQKEIRRAKD-------Mp 154
jgi:Nmar_0928         84 WIITTGANVYHEDHFAHKLpVKQ---GHFDVDDMVLYEKgivRIRDVYIDFEKT-MKAEDKIMQNMFKEKF-------Id 152
ABK76895              65 WIITTGANVYHEDHFAWGLpVRQ---GHHEVDDMQLYDKgivRIRDVFIKFYET-LEVEDQIMQRMFRDRL-------Ld 133
jgi:Anae109_1276      92 LVIATGANLYHDLHFALKLpVVQ---GHFHVDDKELYQAgieRIYDVFITEDSL-LDTDAFVREALEKAPKs------Lr 161
Q8DKP1                96 YIISTGANLYHDIHYALGMdLYA---AHPFVDDVQLRKEskiRIYDIIFDYDVL-LETDAFLRQVLRSET--------Fq 163 Thermos...
jgi:Dret_1312         99 TVISTGALMAHGFIESIGLkHYKyvpE--RMNDAALFERgfnRVYDTLEPEINF-AQAEDVVHAVMAEIEDwn------- 168
AEB08604              93 VIISTGALMAHGLIEAVGQvHYKhnpG---RSDEELYRLgynRVYDTLEMESNL-DYAEAVFKTVLNRMDKeq------- 161
WP_012238611          99 CIISTGALMAHGLSEAVGLtHYKanpG---ISDETYFEKgynRVYDTLEMEKNL-NAIEVFVRKELDKLDPgs------- 167 Sorangi...
7L9R_A               188 ---TPSQLITMMGERLN--------DTTSVITWAAKNNITIFCPALTDGLFGTcITELN--E-I-------------NPV 240 Entamoe...
ESQ11789             159 snlASWRFNHELGSWAAata---phPELSFVVAAAKAGVPIFFDSATNHSIGMvLAQLSl-----------------DEH 218
goetting:Ngar_c06260 155 pnaSTADIAYALGKAAKena---khPEKSFLVKAYEHKVPVYMPAISDSSIGLnMLPLLf-----------------EGK 214
jgi:Nmar_0928        153 ksfTSAELCNFIGKITKeka---knPEKSFLASAYKYDVPVYISTIGDSSIAMnLAVHRl-----------------RGK 212
ABK76895             134 ssfTSAEFCNVIGEISSaka---phPERSFVAAAHKYDVPVYVSTLKDSSLALnLAVHRl-----------------RGK 193
jgi:Anae109_1276     162 ghiSTPQLHHYLGQLVNqqa---plPEKSWVATAARYDVPIFTSSPGDSSIGMnVAAMKl-----------------RGG 221
Q8DKP1               164 rrmGTAEFHYHLGHYVRelevqrgqPHSCLLATAYECGVPIYTSSPGDSSIGMnVAAIAl-----------------EGS 226 Thermos...
jgi:Dret_1312        169 -rmGSASLCRAIGAYLDgh-----fQGPGILKSAFQRDVPVFIPAFTDSELALdVASHIlrHsPqavsd----sgaaTEL 238
AEB08604             162 -tlCSTVICRELGKYLAev-----tDQPGILRNAYLKGVPVFIPAFTDSELGLdVANWMiqKaCqegkt---ipeafTTL 232
WP_012238611         168 -pwSSEIICRQLGKALAem-----gDSPGVLRSAYLRDVPVYVPAFTDSEMGLdVATWMlrKvKaqhgdkpgfdvwrEAV 241 Sorangi...
7L9R_A               241 rLMVDLVQDLRLINSSTIHSV-------ETGVIILGGGVMKHHIMNAN-LM-----------R--N-EADFAVYINTAGD 298 Entamoe...
ESQ11789             219 aVQICAHDDILDSAALMFCAD-------KTGFVELGGGGPKNFIQQTApTLdqmlg-------ikfdGAERGLQIGTAVE 284
goetting:Ngar_c06260 215 gVFPNVILDVAESAAILWKSD-------RSGGLELGGGVPKNFFQQTGpALyqilk-------ikeggQDYLIQLTDARP 280
jgi:Nmar_0928        213 eYNFDFVKELLEQAAILYNSK-------KSGILELGGGVPKNTAQQTGpTLdqild-------redggQDYIIQITDARP 278
ABK76895             194 eHSLDFVREILEQAAIVHGSK-------KSGIVELGGGVPKNAAQQTGpLLdqilr-------rdhggQDYIIQVTDARP 259
jgi:Anae109_1276     222 eTTVDPDLDVLQSTAIVYDAK-------VNGVVILGGGSPKNFYLQTQpTLwqild-------lnrggHEYVLQISTDSP 287
Q8DKP1               227 kLIIDPAIDVNETAAIAYFAreaaggkgKSAALIIGGGSPKNFLLQTQpQIhevlg-------leergHDYFIQITDARP 299 Thermos...
jgi:Dret_1312        239 pFQFNPFYDLFEYTRRVCGAK-------RLGIFTIGGGVPRNWAQQVG-PFveivnqrveglDlpVrRFQYGVRICPEPA 310
AEB08604             233 sLNFNPFLDLGLYGQEIFKAE-------KLGIFTIGGGVPRNWAQQVG-PFfdilq-nrlglElpFvRFHYGVRICPEPV 303
WP_012238611         242 pPPYNPFLDLLSYARLVRKKK-------RLGIFTIGGGVPRNWAQQVA-PFydivg-drldiEvdHpRFQYGVRICPEPV 312 Sorangi...
7L9R_A               299 FDGSDASARPDEAVSWGKIKI---DS--ENVKVLAEASLVFPLIVSKT 341 Entamoeba histolytica HM-1:IMSS
ESQ11789             285 REGSLSGCTFGEAVTWGKYKE---ADsnRLIQIWAEYSLVLPLLTASV 329
goetting:Ngar_c06260 281 DTGGLSGATLQEGKSWGKIK----TShrGNVIVYGDSSVYFPLLCSYA 324
jgi:Nmar_0928        279 DTGGLSGATLQEGKSWGKVQ----DAheDVVTVYADATIAFPILALYA 322
ABK76895             260 DTGGLSGATLQEGKSWGKVQ----DAheGMVTVYSDATIAFPIMALYA 303
jgi:Anae109_1276     288 QWGGLSGATPSEAISWGKVQA---NMmkNHVVVYSDTTIAAPVVFSYA 332
Q8DKP1               300 DTGGLSGAVPSEAVSWGKVDP---QGlrDTVVCYTDSTIALPILTAYC 344 Thermosynechococcus vestitus BP-1
jgi:Dret_1312        311 HWGGLSGCTYQEGISWGKFVPpaqGG--RFAEVHSDATIAWPILIKgl 356
AEB08604             304 HWGGLSGCTYREGVSWGKFVPaseGG--RFAEVLCDATIAWPILIKAV 349
WP_012238611         313 HWGGLSGCTYSEGVSWGKFTPpqeGG--RFAEVYADATVAWPLLVRAL 358 Sorangium cellulosum
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