6BCU


Conserved Protein Domain Family
eIF_4EBP
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pfam05456: eIF_4EBP 
Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
This family consists of several eukaryotic translation initiation factor 4E binding proteins (EIF4EBP1,2 and 3). Translation initiation in eukaryotes is mediated by the cap structure (m7GpppN, where N is any nucleotide) present at the 5' end of all cellular mRNAs, except organellar. The cap is recognized by eukaryotic initiation factor 4F (eIF4F), which consists of three polypeptides, including eIF4E, the cap-binding protein subunit. The interaction of the cap with eIF4E facilitates the binding of the ribosome to the mRNA. eIF4E activity is regulated in part by translational repressors, 4E-BP1, 4E-BP2 and 4E-BP3 which bind to it and prevent its assembly into eIF4F.
Links
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Statistics
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PSSM-Id: 461656
Aligned: 42 rows
Threshold Bit Score: 113.86
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6BCU_X        13 Q---TPSRAIPa-tRRVVLGdgvqlppgDYSTTPGGTLFSTTPGGTRIIYDRKFLMECRNSPVTKTPPRDLPT------- 81 
NP_001077103   9 Ql--SAGRDIPs--KRVTVNdpsq-lphDYSTTPGGTLFSTTPGGTRIIYDRNFLLNMRNSPLSQTPPKNLPS------- 76 
EDS43555       9 Qa----AMTIPs--RKVLIHdasd-lpdLYSSTPGGTLYSTTPGGTRIVYERAFLMNLKNSPLARTPPTNLNN------- 74 
Q17JZ5         9 Qa-cSQTQAIPs--KRVLIHdase-lpdLYSSTPGGTLYSTTPGGTRIVYERAFLMNLKNSPLARTPPSNLNN------- 77  yellow fever mo...
Q7PN41         9 QacaSISQAIPs--KRVLIHdase-lpdLYSSTPGGTLYSTTPGGTRIVYERAFLMNLKNSPLARTPPNN---------- 75  Anopheles gambi...
XP_002045320   9 Q---AITQALPmitRKVVISdpiq-mpeVYSSTPGGTLYSTTPGGTKLIYERAFMKNLRGSPLSQTPPSNVPScllrgtp 84 
NP_001040409   9 Qa--THSQSIPs--RRVLITdpaq-mpdVYSSTPGGTIYSTTPGGTRIVYERSFMLSLRQSPISQTPPQCA--------- 74 
XP_011066562   9 Qa--TQSQSIPs--KRIVIHdpnq-lpvDYSSTPGGTLYSTTPGGTRIVYERAFLMNLRNSPISRTPPRNPLT------- 76 
XP_001604271   9 Qa--TQTQSIPa--KKVVIHdanq-lpaDYSSTPGGTLYSTTPGGTRIVYERAFLMNLRNSPISQTPPKNMPT------- 76 
EFA09088       9 Qv--TESKAIPt--KKVLINdpse-lpsHYSSTPGGTLYSTTPGGTKIVYEKAFLMNLRNSPISKTPPSYG--------- 74 

6BCU_X        82 ---------IPGVTSP-------------SS--DEPPMEASQSHLRNSPEDKRAGGEESQFEMD 121
NP_001077103  77 ---------IPGVTCP-------------------EVGAGAEKPNGARKTATKTDPAEDQFQMD 112
EDS43555      75 ---------LPHNILR-------------NSptANRQQQHVPQAKKQPNAQPKFDEHQEQFDMD 116
Q17JZ5        78 ---------LPHNILRngtt------gvtSKpkPQQQPQNSPP---------KFDEHQEQFDMD 117 yellow fever mosquito
Q7PN41        76 ---------VPMNLLRtgvvspntkpmttlsvkQQKPARNSPP---------KYDEHQEQFDMD 121 Anopheles gambiae str. PEST
XP_002045320  85 rtpfrkcvpVPTELVK--------------------------------QTKSLKIEDQEQFQLD 116
NP_001040409  75 ---------LPAALLKn---------------pSSVPNVQPASTQKPRSNSISFDESQETFSMD 114
XP_011066562  77 ---------IPSELLK-----------------GNTPVITKDPAKNTNKDSLMIEESAEQFEMD 114
XP_001604271  77 ---------IPASLLKg---------------aAPTVTAPNKIPSPPAKDAAVLDESAEQFEMD 116
EFA09088      75 ---------IPENLMR-------------GKtnGSAPIRRFSPPTKNHSAKIEDSHDEHQFQID 116
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