6W17


Conserved Protein Domain Family
P34-Arc

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pfam04045: P34-Arc 
Arp2/3 complex, 34 kD subunit p34-Arc
Arp2/3 protein complex has been implicated in the control of actin polymerization in cells. The human complex consists of seven subunits which include the actin related Arp2 and Arp3, and five others referred to as p41-Arc, p34-Arc, p21-Arc, p20-Arc, and p16-Arc. This family represents the p34-Arc subunit.
Statistics
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PSSM-Id: 461144
Aligned: 80 rows
Threshold Bit Score: 270.577
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6W17_D        52 ISLSMKCYPELVNYGTLDLLKQIYGAYV-HEPEMGYNFSILIDLQQLPATDEEKEQLAMSISMLKRNVLAAPFHRAFTKQ 130 Schizosaccharom...
O96623        50 VSVSLHAAADLLKNGGSALLKSVYGDMLqAKPEGGYDVTLVIQSSF----SGNKEELAKKVSLLKRHLVAAPFLMVFEGI 125 Dictyostelium d...
EGG21722      50 VSISFKGSQDLLKNGGATYLKAVYGAMLqAKPEQGYDITLVVDANA----SGDKEQLANKVANLKRNLMAAPFLMVFEAM 125
XP_654747     55 ISVSTPCWKQLKENRSLEFLQKVYGSDL-VEADSNSEYNLILTIPE---KHDKPEEFAMNAAKLLTNMLIGPAVVLADEV 130
EAY05936      60 VEMKLPCWEAIKQYGAEERYKELYGKWK-VAPTDGRTHAVVVNLWE--MSAAEQKATIELIANLKPNMLGAPFLWVAKKV 136
XP_003103123  57 LSISLKFYAELQQHGADDLLRKIYGGHMrATPESGFNVTLEYDLSALPDN---TSELVQKASALKRNCFASVFEKYFEFQ 133
XP_002608830  57 VSISLKFYKELQQHGADTLLQREYGAFI-TSAEKGYDVSILFDLENVPEN---KEEAVKKAGLLKRNCFASVFEKYFQFQ 132
XP_015791423  57 VSIALKFYKDLQEHGADDLLQREYGSLLqLPPEEGYNVTLLFDLKNLPEN---HQELVKKAGLLKRNCFASVFEKYFEFQ 133
CDS36496      63 VSISLPFYKEIEKFGGSKVLVREYGSYLkPGAQSGTSVTLQFDCNHLPDN---LEDLATKAALLRRNCFASVFEHFFDYQ 139
CCD80928      57 VSIFIKFFHELKEHGVNEVLAREYGDFL-SSAEPNQSVTLCIDLEKLPSD---HNQLAHKCGLLKRNCMAAVFEKFFEYQ 132
6W17_D       131 AELAdlarkdpenapmldkqATSQELMAIHYRD--EETIVLWPEHDRVTVVFSTKFREETDRIFGKVFLQEFVDARRRpa 208 Schizosaccharom...
O96623       126 EAKK-----------------PLPEIIAINYRT--DETFYLKPQGDNVIVIFDIAFKDADDVILSKIFLQSFVDVRKT-- 184 Dictyostelium d...
EGG21722     126 EAKK-----------------PLPETITIDYRT--DESFYIKPQGDNVTVIFDIHFKDADDVILSKIFLQAFVDVRKT-- 184
XP_654747    131 KNNK-----------------ADEKLVQIDYRP--GESYWLKPNGDRLTVIFSIKFDDKDDAVFGRVFINEFSKSAAG-- 189
EAY05936     137 NA------------------KENFAPFEIPYRAhtGESIFLSPAEKGATAIFTIRFNDPGDRIIGNVFFGELAAARTR-- 196
XP_003103123 134 EAg-----------------qEGHKRAVINYRE--DETMYIEAKADRVTVIFSTVFKDADDVIIGKVFLQEFREGRKA-- 192
XP_002608830 133 QEg-----------------qEGKERAVINYRD--DETMYVEAKGDRVTVIFSTVFKDEDDVVIGKVFMQEFKEGRRA-- 191
XP_015791423 134 EKg-----------------lEGNKRAVIHYRE--DETMYVEAKPDRVTVIFSTVFKDESDVIIGKVFMQEFKEGRKA-- 192
CDS36496     140 VAnas-------------spSAKILQGTIHFRS--DETMFVQAMSDRVTVIFSTRFKDLHDIVLGKVFLQEFSEAKRR-- 202
CCD80928     133 IKsn---------------aDSGSKRAVIHYRD--DETMYVQALADRVTVIFSTTFKDPDDLLIGKVFMQEFTEVRRR-- 193
6W17_D       209 IQTAPQVLFSYRDPPLEIRDIQGIq---KG-DDFGFVTFVLFERHF-TPQNREDCISHIQVFRNTLHFHIKASKAYMHQR 283 Schizosaccharom...
O96623       185 ISNVPSITFSQKDPPLELKGVKGVr---AGqANHGFVSFVLFPAHIkKP---QESADLIQTFRDYLHYHIKCAKGYMHTS 258 Dictyostelium d...
EGG21722     185 MTSVPSVTFSQKDPPLELKGVKGVr---AG-VAHGFVSITLFPLHLkRA---QETADLIQTFRDYLHYHIKCSKGYMHTS 257
XP_654747    190 CPSCDVVTRKNAPPPSELKTVEGLa------EDNCYISFLLEKRHLnNPQK---TLEVLMSCRNYINFHIKCSKAFLHIR 260
EAY05936     197 VRSAPIVAFSD-KCPGELEAFHLRpevkDG-SLFAYVSMSLLAASL-SERKRQDTSVYVPMFRDYLHYHIKCTKAFLHQK 273
XP_003103123 193 SQTAPAVLYSLGEPPLELKDLPGAr---VG-DNVGYITFVLFPRHt-NKKTRDNTIDLIHSFRDYLHYHIKCSKVYLHTR 267
XP_002608830 192 SHQAPMVLYSHREPPLELQGT-DAa---TG-DNIAYITFVLYPRHi-TKAARDNTINLIHTFRDYLHYHIKCSKAYIHSR 265
XP_015791423 193 SHTAPHVLFCHKEPPMELQDT-DAl---AG-DKIGYITFVLFPRHt-SKKSRDNTINLIHIFRDYLHYHIKCSKVYIHSR 266
CDS36496     203 YDGAPQVIYQHRDPPKELRGT-DAv---SG-ENIFYITFVLLPRHv-SAQNRAKTIDLIHLMRTYMHYHIKCMKAYLQMR 276
CCD80928     194 LDRAPQVLYSHRVPPKELQGT-DAv---IS-DSVAYITFVLFPRHLsTESARNSTIDLIQTLRNYLHYHIKCSKAYMQMR 268
6W17_D       284 MRKRVADFQKVLNRAKPDV 302 Schizosaccharomyces pombe 972h-
O96623       259 MRNRVESLIQVLNRAKPEP 277 Dictyostelium discoideum
EGG21722     258 MRNRVDSLIQVLNRAKPEP 276
XP_654747    261 MRNKVSHLQLVLNRAKPER 279
EAY05936     274 MRNRTALLLKILDEAKPEP 292
XP_003103123 268 MRAKTTDFLKVLNRARPEV 286
XP_002608830 266 MRAKTSDFLKVLNRARPEN 284
XP_015791423 267 MRAKTSEFLKILNRARPER 285
CDS36496     277 MRAKTSEFLKILNRAHPNA 295
CCD80928     269 MRAKTVEFLKVLNRAHIEH 287
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