6APJ,6APL


Conserved Protein Domain Family
GT29_ST6GALNAC2
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cd23972: GT29_ST6GALNAC2 
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).
Links
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Statistics
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PSSM-Id: 467700
Aligned: 5 rows
Threshold Bit Score: 598.732
Created: 27-Nov-2018
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:6APL: Human alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase binds CMP, contacts at 4A
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
6APJ_A     66 CRHLLHLAIqrhphfrglFNLSIPVLLWGdlftpalWDRLSQHKaPYGWRglsHQVIASTLSLLNgsesaklfapprdtp 145 human
6APL_A     66 CRHLLHLAIqrhphfrglFNLSIPVLLWGdlftpalWDRLSQHKaPYGWRglsHQVIASTLSLLNgsesaklfapprdtp 145 human
Q92184     97 CPRSVAATAkadptfgelFQFDIPVLMWDqhfnpetWDRLKARRvPYGWQglsQAAVGSTLRLLNtssntrlf-drhlfp 175 chicken
NP_989414  82 CPTSLQLRVkndsyfktiFNFEVPLLLWNshltennWDTLSKRPvPYGWKdlpREDVASALKLLNdsankam--ferqgp 159 tropical clawed frog
RXM98108   25 CTVSLRQRIqvqpqlhslFQFDVPVLVRSqhfstseWQRLQHYLpPYGWKglpINVVSSALMLLNdtansgl--fgerlg 102 sterlet

Feature 1              ###                    ###                                             
6APJ_A    146 pKCIRCAVVGNGGILNGSrqGPNIDAhDYVFRLNGAVIKGferDVGtKTSFYGFTVnTXKNSLVSYWNLGFTSVPQGQdL 225 human
6APL_A    146 pKCIRCAVVGNGGILNGSrqGPNIDAhDYVFRLNGAVIKGferDVGtKTSFYGFTVnTXKNSLVSYWNLGFTSVPQGQdL 225 human
Q92184    176 gGCIRCAVVGNGGILNGSrqGRAIDAhDLVFRLNGAITKGfeeDVGsKVSFYGFTVnTMKNSLIAYEAYGFTRTPQGKdL 255 chicken
NP_989414 160 qKCIRCAVVGNGGILNGSkkGKEIDGhDYVFRLNGAVIKGfekDVGtKTSFYGFTVnTMKNSLISYQEHGFTETPKGKdL 239 tropical clawed frog
RXM98108  103 gGCIRCAVVGNGGILNGSrqGRAIDEhDFVFRLNGAVIKGfeeDVGtKTSFYGFTTnTMKNSLIAYRSFGFHRIPQEQgI 182 sterlet

Feature 1                                                                                     
6APJ_A    226 QYIFIPSDIRDYVXLRSAILgVPVPEGLDKGDRPh--------------------------------------------- 260 human
6APL_A    226 QYIFIPSDIRDYVXLRSAILgVPVPEGLDKGDRPh--------------------------------------------- 260 human
Q92184    256 KYIFIPSDARDYIMLRSAIQgSPVPEGLDKGDEPq--------------------------------------------- 290 chicken
NP_989414 240 HYIFIPSDLRDYVMLRSGILgVKVPSGYDEGDKPs--------------------------------------------- 274 tropical clawed frog
RXM98108  183 RYIFIPSEVRDYVMLHSAIQgIPVPHGHDKGDQYtdvpptiqifatialevpflvlchrmyqqegivnvpkvhvvlvkce 262 sterlet

Feature 1                                                   ####                ##         ## 
6APJ_A    261 ---aYFGPEASaSKFKLLHPDFISYLTERFlksklinthfgdlyXPSTGALXLLTALHtCDQVSAYGFitsnywkFSDHY 337 human
6APL_A    261 ---aYFGPEASaSKFKLLHPDFISYLTERFlksklinthfgdlyXPSTGALXLLTALHtCDQVSAYGFitsnywkFSDHY 337 human
Q92184    291 ---kYFGLEASaEKFKLLHPDFLHYLTTRFlrselldmqyghlyMPSTGALMLLTALHtCDQVSAYGFitanyeqFSDHY 367 chicken
NP_989414 275 ---eYFGPKPSpKKFKMLHPDFLLYTRDRFlksdilnteyaslyMPSTGGLMLLTALHsCDQVSAYGFitpdynrYSDHY 351 tropical clawed frog
RXM98108  263 rpwkYFGPNHLaKKFKMLHPDFIRYIKDRFlkshllklayghvyMPSTGALMLMTALHaCDEVSAYGFitdnyraFSDHY 342 sterlet

Feature 1                                          
6APJ_A    338 FERKmkplifyanHDLSLEAALWRDLHKAGilQLYQR 374 human
6APL_A    338 FERKxkplifyanHDLSLEAALWRDLHKAGilQLYQR 374 human
Q92184    368 YEPEkkplvfyanHDMLLEAELWRSLHRAGimELYQR 404 chicken
NP_989414 352 YERQkvplefyanHDMLMEMQLWGRLHDRGiiKLYKR 388 tropical clawed frog
RXM98108  343 YDRVkkplvfyanHDMQLESRLWKRLHSLNvfRLYQR 379 sterlet

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