Conserved Protein Domain Family
ARID_ARID3B
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cd16879: ARID_ARID3B 
ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3B (ARID3B) and similar proteins
ARID3B, also called Bright and dead ringer protein, or Bright-Dri-like protein (Bdp), is a DNA binding protein involved in cellular immortalization, epithelial-mesenchymal transition (EMT), and tumorigenesis. Its expression is differentially regulated in normal and malignant tissues. It is required for heart development by regulating the motility and differentiation of heart progenitors. ARID3B is overexpressed in neuroblastoma and ovarian cancer. It acts as a novel target with roles in cell motility in breast cancer cells, promotes migration of mouse embryo fibroblasts (MEFs) and breast cancer cells, and induces tumor necrosis factor alpha (TNFalpha)-mediated apoptosis. ARID3B contains an AT-rich DNA-interacting domain (ARID, also known as BRIGHT), a SUMO-I conjugation (SUMO) motif and a multifunctional homomerization/nuclear export REKLES domain, which consists of two subdomains: a modestly conserved N-terminal REKLES alpha and a highly conserved (among ARID3 orthologous proteins) C-terminal REKLES beta.
Links
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Statistics
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PSSM-Id: 350643
Aligned: 5 rows
Threshold Bit Score: 258.405
Created: 12-Sep-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on the structure evidence that Drosophila melanogaster Dead Ringer (1KQQ) binds DNA through its ARID domain.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                          #######                        # ##  #       #
Q8IVW6       204 RDFAKLYELDGDPERKEFLDDLFVFMQKRGTPINRIPIMAKQILDLYMLYKLVTEKGGLvEIINKKIWREITKGLNLPTS 283 human
ADV31340     214 RDFAKLYELDSDPERKEFLDDLFIFMQKRGTPINRIPIMAKQILDLYMLYKLVTEKGGLvEIINKKIWREITKGLNLPTS 293 chicken
AAI06446     207 RDFAKLYELDSDPKRKEFLDDLFLFMQKKGTPISRIPIMAKQLLDLYMLYKLVTEKGGLvEVINKKIWREITKGLSLPTS 286 African clawed ...
XP_007907377 242 KDFAKLYELDNDPNRKEFLDNLFAFMQKRGTPVNRIPIMAKQVLDLYMLYKLVTEKGGLvEVINKKIWREITKGLNLPTS 321 elephant shark
NP_001076471 180 RDFAKLYELDNDPKRKEFLDDLFAYMQKRGTPVNRIPIMAKQVLDLYMLYKLVTEKGGLvEVINKKIWREITKGLNLPTS 259 zebrafish

Feature 1        ### ### #                             ##      
Q8IVW6       284 ITSAAFTLRTQYMKYLYAYECEKKALSSPAELQAAIDGNRREGRRP 329 human
ADV31340     294 ITSAAFTLRTQYMKYLYAYECEKKSLSSPAELQAAIDGNRREGRRP 339 chicken
AAI06446     287 ITSAAFTLRTQYMKYLYIYECEKKSLSSPAELQAAIDGNRREGRRP 332 African clawed frog
XP_007907377 322 ITSAAFTLRTQYMKYLYPYECEKKSLSSPAELQAAIDSNRREGRRP 367 elephant shark
NP_001076471 260 ITSAAFTLRTQYMKYLYPYECEKKGLSSPGELQAAIDSNRREGRRP 305 zebrafish

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