Conserved Protein Domain Family
MDFI

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pfam15316: MDFI 
MyoD family inhibitor
Members of this family inhibits the transactivation activity of the MyoD family of myogenic factors. They affect axin-mediated regulation of the Wnt and JNK signaling pathways, and regulate expression from viral promoters.
Statistics
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PSSM-Id: 464641
Aligned: 9 rows
Threshold Bit Score: 144.611
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_001116774  56 SDDALLLPDHIPTISHKIDKGNVK--------PCLPNGTSp---VVNGcaVTCSPPASSPQVSTsrPAAQQKcnphakcn 124
XP_003221258  79 QPQRLPLPNAVPLEKCKEETGKIQng-----hACPNHGSG----FRNG--VKPGIPDGSRRFSA--PVSQKM-------- 137
XP_006002053  78 QPHPLPHPTASALEQTEEETGKLQng-----hVVLTNGSG----IHNG--VTHGAAD-HKKLPA--PVSQKM-------- 135
XP_003403970  66 GPGAPQALDSTDLDVPTEAVTRQPqgnplgctPLLPNGSG----HPSE--LSDARRVGNGALGG--P---KA-------- 126
XP_025010418  40 gdsdscisslplpvlhevmlssedhpenqltnekhtdektvkgivMSS--VAEFSMADTSSKET--KNEKKL-------- 107
XP_007245895  70 SEDALLLPDHVPVLPHKIEKES----------PSPLNGPSppdiVTNGspPICTPPTASKGLRT--PDPAQVpkc----n 133
XP_027719552  34 SSQNPLEDSDTQLTNEKHSDEKSVkg-----------------tVINS--VSEFNIADAPSKEA--PNEKKL-------- 84  common wombat
XP_003202033  76 QPQRLPQPNTSALERGEEESGKVQng-----hAGLSNGSG----MHNG--VKHASAD-NRKLSS--PVSEKM-------- 133 turkey
XP_014317649 126 QPQRLPQLQTSAQEPNEEDIDKTKnc-----hKSLSNGNG----IHHG--AKHVSVD-NRRLSA--PVSQKM-------- 183 little brown bat
NP_001116774 125 ghKQPPRKQMSSTSQSQKSFng---dATQIQRV-----AGDDCCAHCILACLFCEVLSWCSAVAQCLACGLeCD------ 190
XP_003221258 138 --HKKIQSSLSVNSGSSKKS------TAYSHKAg---sLPEDCCVHCILACLFCEFITLCSLVLEQASCGI-CPae---a 202
XP_006002053 136 --HRKLQSSLSVSSDSSKRSkl---sSTNSQKPg---sSPEDCCVHCILACLFCEFLTLCNIVLGQASCGI-CTse---a 203
XP_003403970 127 --HRKLQTHPSLASQGSKKSk----gSTKSAAPqiplqAQEDCCVHCILSCLFCEFLTLCNIVLDCATCGS-CSsedscl 199
XP_025010418 108 --SEASRSSIASLEKC-REFtyiednASVHQR------DSDDECATLILACLFCQFWDF--LIMLPDTCEHwLId----- 171
XP_007245895 134 ghSHPHKKRLHSTSKSQQSLka---sATQIQQV-----AGDDCCVHCILACLFCEVLSLCSAVAQCLACGMeCD------ 199
XP_027719552  85 ---SASSTSLSSPEECQTKFsylqndTSFHQR------DNDDECASLILTCLFCQFLDC--LLMLPDTCETvCIn----- 148 common wombat
XP_003202033 134 --HRKIQSTLSVNSNGSKKSki---sSAFSQKPs---pE--DCCVHCILACLFCEFLTLCNIVLGQASCGI-CTse---a 199 turkey
XP_014317649 184 --HRKIQSSLSVNSDINKKSkv---nAVFSQKPgss---peDCCVHCILACLFCEFLTLCNIVLGQASCGI-CTse---a 251 little brown bat
NP_001116774 191 ALC--------CCGEAAGGglACCAedSCSalLDCGILEDCCQSSDCLEICLECCSICFPA 243
XP_003221258 203 CCC--------CCGEEMGD--DCNC--PCD--MDCGIMDACCESSDCLEICMECCGICFPS 249
XP_006002053 204 CCC--------CCGDDMGD--DCNC--PCD--MDCGIMDACCESSDCLEICMECCGICFPS 250
XP_003403970 200 CCC--------CCGSGECA--DCDL--PCD--LDCGILDACCESADCLEICMECCGLCFSS 246
XP_025010418 172 TCCpsnryyqtSDEDHSNN--DCNC--DCD--IDCSLFESCHETGECLELAMEISEVCYR- 225
XP_007245895 200 AAC--------CCGEACSV--ACCSedPCSalLDCAILEDCCQSSDCLEICLECCSICFPA 250
XP_027719552 149 TCCpshryhhaSDENHPRN--DCNC--NCD--VDCSLFESCHETSECLELAMEISEICYR- 202 common wombat
XP_003202033 200 CCC--------CCGDEMGD--DCNC--PCD--MDCGIMDACCESSDCLEICMECCGICFPS 246 turkey
XP_014317649 252 CCC--------CCGDEMGD--DCNC--PCD--MDCGIMDACCESSDCLEICMECCGICFPS 298 little brown bat
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