Conserved Protein Domain Family
NCU-G1

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pfam15065: NCU-G1 
Lysosomal transcription factor, NCU-G1
NCU-G1 is a set of highly conserved nuclear proteins rich in proline with a molecular weight of approximately 44 kDa. Especially high levels are detected in human prostate, liver and kidney. NCU-G1 is a dual-function family capable of functioning as a transcription factor as well as a nuclear receptor co-activator by stimulating the transcriptional activity of peroxisome proliferator-activated receptor-alpha (PPAR-alpha).
Statistics
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PSSM-Id: 464480
Aligned: 33 rows
Threshold Bit Score: 251.085
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFN86794      29 TTLYLRADGAnDT---LHYLWDFAiGR--PSVLLALTSS---SAW---LN-----------ITWPDYL---DK------Q 77 
XP_001629687  55 SLVYVSAESA-DHdnvVHFVWSGF-QG--PSIINAYSEKlpeKHAkpgLN-----------VKWENLF---KNd-----T 111
XP_004990792  33 DAVLLAQPGVpSQ---YVFTWSGV-GL--PTFGITSFKQ---PVDakdFS-----------VNCSRLAegyVSd------ 86 
XP_001746362  34 TSVEI-AMGSlDA------------QP--GTLFLAVASQ---DFTyfaLNfddhvdpgavaINWTLFR---NPtitpalV 92 
XP_002109294  56 NLIHVMAKNPyNNghdIHYVWSTI-GS--PAVLIAYTVK---STE---IK-----------IDWAKFI---SDn-----P 107
EFX77012      57 TLVHVQQEGIaDV---LHHIWTMe-NV--PTFFYARTEL---NTE---ML-----------IDWEKML---SGn-----Y 105
1_pfamImport   1 VLVHVAADGInDT---LHHIWDFt-RK--PTIFLALTPL---NTE---LI-----------IDWDNFL---SKn-----E 49 
EEN65953      23 NLVHILARGSrDS---IHYIWSTI-GA--PTVLMVHTTS---KESe--LI-----------VDWEKLLratNGd-----N 75 
EKC32813      43 GVVYVQAKGDnDI---LHYVVSALgGP--PTALVIKTNR---PKEryqLN-----------INCKMMAsknDTe-----R 98 
CDS42208      87 KLIQIIARHPnAT---FHFLLPGShPDapLSIVMLETNT---RPSe--LQ-----------VNWTQFLarnGS------I 141
EFN86794      78 ENSIHFSEPP--VYVFGVIVNKIIEFNDVN------------DTALIDTADVASTn--vLRPEYFYWRLVS--MSKTD-- 137
XP_001629687 112 EGALEFTPKV--DYITAFSLSSVLQFADPK------------DEIYFTKTGGVIE----HNLRSVQWRKVIldKDNDN-- 171
XP_004990792  87 ---VVVTPAGv-EDHQSTTLASLIEFSGPTldkgefvrrtilDTLTFKPVNMTSSsatl--------------------- 141
XP_001746362  93 AEAITIKSGNrlQYGQAFVLDALLEFNDTK------------VEALHREm--------pLSLRSSAWTVKP--------- 143
XP_002109294 108 ANSITFDPEP--FYTSGMQLTHLIEFVDVN------------DTARLNS----SAeihmYPFHDMLWDSTS--------- 160
EFX77012     106 SQAISFNKEP--QYFAAVLIFKFFMYNDLN------------DTGVIPETDNFDIv--sYSTKKMSWELKS--SNCSGni 167
1_pfamImport  50 KGAVKFSNDV--IYAFSLVFDKIIEYNDVN------------NTAQYNPTNNSETyatvLQPELYNWTVER--KHDTD-- 111
EEN65953      76 SGAITFEPSNevDFSMAVMFNKIWEYEDLH------------DKSELPE--DDTEmfkpYDLSQMRWGDFN--LTMNT-- 137
EKC32813      99 KAAITLPSGLkeIYSYG-----LFQYNDTA------------DKADITAYNINSTkwrvYDFTEFEWQDITtwSSNNL-- 159
CDS42208     142 SNSIFLNGT---HTSYGVILYEFCTYSDIN------------DDARLTPTDVQSQchhlLG-KNLLWTLTD--------- 196
EFN86794     138 -EFVYLDMEGnsyndta--knisryGSIKLSLRGFCTVDHSDIVPHMLHTEN-STQVDIILDDIqtnasFSRS-RFA--- 209
XP_001629687 172 -ATFVGEFLG---------------GTISFSCAAADHDDRDEEPPRPRYSSN-STRFTVNLSHLk----TNSTdRLA--- 227
XP_004990792 142 ---------------------vstdNLIAVTMEVNTKSGISKTNPHNFFATN-SFSVDLVISGYty--nSTKS-RLA--- 193
XP_001746362 144 ---------GatsdtltfntsftrdCSVNVSLLMHTGKGYAAVAPAIPIMPN-ASDINLILLGCna--tIKNS-RFGtrn 210
XP_002109294 161 -WVNSEKSDGrvnftte--ygtntnGSILLSFDAGKSKERISRLPFLMITSN-SSAVDLALHNLst--iSNHS-RFG--- 230
EFX77012     168 sASVAFRLRSydgve------ldssSNIEITLTAYGTRGRSPILPHLAFTEN-STQVDFVFDHVetkesFTNA-RLA--- 236
1_pfamImport 112 -NVIAFAMKSsdykse----nmtktGSVKITLNAFGNSDHSSLQPHLLHTTN-ATQVDVVLDGLqv--kYTKS-RYA--- 179
EEN65953     138 -TGLTGNFTGattqsdm--eslfqnGSISFRIHAFKTDDRSADLPHLQYTSN-QTQFDFTIDSVep--rGNMS-RYA--- 207
EKC32813     160 -IVMKVKTSGevmda------afynESLVLQFHMFDHSDRSKELPHLLYDAD-STQFDFTLQDIdt-gnYSSA-RWG--- 226
CDS42208     197 -NAVGKNPPNfvytatnstdsldglGKIVVNISFPREKSEFAQRGVLSLEPGnGMLFDITIDSVra---peQG-RVAmil 271
EFN86794     210 ---------------------------IELL-------VVGGGD---PEIPMFVDP-KKSLDDEH--------TPGIFEV 243
XP_001629687 228 ---------------------------LEFV-------SVVKSE---ESMPSCSRE-FQSIDDEH--------SPGIFRT 261
XP_004990792 194 ---------------------------MEIV-------TTTL-----ERSVVRIEQ-SRDINDEY--------SPSIFRR 225
XP_001746362 211 hvytsrtvrstiaplsrerhfsnlmpfLQTV----------------LATDMKLKT-EMSIDDEH--------SPAVFKL 265
XP_002109294 231 ---------------------------LEMM-------FVNSYTqkpS----KFKS-YRSIDDEY--------CPAVFTM 263
EFX77012     237 ---------------------------MELAa------VVSE-----PDSRFTLNV-SQSLDDEY--------TPGVFKL 269
1_pfamImport 180 ---------------------------LGLL-------IVSTDH---KHSNLTQIK-RKSLDDEH--------SPGIFTI 213
EEN65953     208 ---------------------------MELM-------LLTEDKhl------dLKK-MKSIDDEY--------TPGVFEL 238
EKC32813     227 ---------------------------LETV-------LLGSDKktaG---MHIET-KKSIDDEY--------TPGVFEM 260
CDS42208     272 lp--------------------fshdpLQMEedfveslSLSENR---RETLFNLHLgQRQLLQEYgkpdmqvvAPRVFGH 328
EFN86794     244 V--EvrtppykdlDIalnAGAYLQWRPVSYNTGS-REVTSSTETMQYPPKK----------VSNRTNAIDNSMLYCYYGK 310
XP_001629687 262 VviN---------NTyatYSSFISWKPVMYTKLD-RGLKTQLPAFNYLYKNgkfeqtkissKHCFHLTERKTLLPKIILG 331
XP_004990792 226 T--TlqstdntgaNE-----AHHAWKPVVFGNTT-RKSTNMTVSFIGELAAl--------dYSPANTYPQHIITASYDGA 289
XP_001746362 266 S--IlgtekapqaPSnqvTHGYLAFKPVVYGSAS-RGSSNMTSVQt--------------nVSSLVPVDNATLPSSLFGG 328
XP_002109294 264 IdvNlyg----edAS---NGSYCQFRPVCYVNPH-RALSGQKEVQYYEFVQa--------------SILPHGILTAFYGE 321
EFX77012     270 M--Eihs---------alNQHWIQWRPVCYTSTQ-RDIGDSTGLYQTDIRNv--------sDDNIL---DNTLLEWLSLD 326
1_pfamImport 214 G--EvlttqnvsgD----KGGYLQWRTVAYTSSG-RLMTNSTNVIETKASH----------VEFPDKRLNLTVAGSYFSE 276
EEN65953     239 F--Eltmt------hsdqTDSYVQWKPVCYTKST-RSMAVATPTKTYKLKD-----------LDTTSIPADTIARAYFTN 298
EKC32813     261 S--Nwltr--pgnEA---NGGYLQWKPVCYLKPG-RARSVATKVDYTSLASt--------sDVNVDTFLQSSIMYSYFPD 324
CDS42208     329 T------------------PAFMQWTTTCEVSMDgVAKRSATAGPRMQIPS------------KTQSKYRYSLPLAVYGD 378
EFN86794     311 DTDA----------LLLQKVTVSFGSKGDGFYRKTSYSTWTFIIGYGTPPE---ERFSNLVIMIISIGLGLPLlIMVIVG 377
XP_001629687 332 AMSKd---------IITYPIRLSSGQKKDGWYKATQLLSWSGQAGCGQPLF---DSISKTLYITIIAGLGIPA-LIILGG 398
XP_004990792 290 RT-------------AMNVVNVTFSTKGDK-ATAEKIIAWGSIVGPGKPFV---PAMSTTLLATNITSYGVTIfAFIAGS 352
XP_001746362 329 AGEGs-------------ELILLFGSKGDGWENASSYYM-SAVLGTGDHGS---NQFSFALLMTTIVSFGVPFiAFIVGG 391
XP_002109294 322 QD------------INIYGMNITFGQKKDGFYVATQFTSWTSTFGFGIPPV---EKLSLAIIMIISVGLGAPVvLLIFGG 386
EFX77012     327 LDTRf---------LLMKGFNVSFGVEGDGFYRASNYTAWTLVTGHGRPVG---DQFSLMVILVMAIGLGLPAiVLILGG 394
1_pfamImport 277 KLSH----------LPVHEMFVSFGAEEDGFYPKSGYLSWTVLAGLGRPAE---EGFSLLVLLILAIGLGLPAlLIIVGT 343
EEN65953     299 LDr-----------LQRKALNVSFGLTGDGSYVASNFTSWTASVGYGEPPS---ERLSLLIIIVISTGLGIPVvIIMFGG 364
EKC32813     325 IMs-----------VSRSATNFTFGLESDGGFTKTNFTSWTAQLGFGAPPE---DKVSSLVVGVISAGLGLPViLIMFGG 390
CDS42208     379 AFSQkhnpdqvnrsVGVRLQAVSFGSPHDGFYVATNFVRWRGILSMGEPKEpsdEKFGSLIAVGIALSLMLLAmISVTAG 458
EFN86794     378 LYLCIRRMPK 387
XP_001629687 399 FYCLAADLRK 408
XP_004990792 353 IYLLVLRATR 362
XP_001746362 392 VYAVWKRSRL 401
XP_002109294 387 IGVFIKARRK 396
EFX77012     395 AAIALRNHRN 404
1_pfamImport 344 ICIITRRVAR 353
EEN65953     365 LFICCRQKDG 374
EKC32813     391 LFVIIKKKTS 400
CDS42208     459 ILMYRRHKAA 468
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