Conserved Protein Domain Family
MAGE_N
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pfam12440: MAGE_N 
Melanoma associated antigen family N terminal
This domain family is found in eukaryotes, and is typically between 82 and 96 amino acids in length. The family is found in association with pfam01454. This family is the N terminal of various melanoma associated antigens. These are tumour rejection antigens which are expressed on HLA-A1 of tumour cells and they are recognized by cytotoxic T lymphocytes (CTLs).
Links
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Statistics
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PSSM-Id: 463582
Aligned: 131 rows
Threshold Bit Score: 39.5884
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_013841927   29 HMSEHCKPEeDPHAPTEAQGLEGVQDPMVeKGEatatttpsltspsAPSPITPLILGTPEEVPATGALGPLPSSKIVCfs 108
XP_003513410    5 QKSKLYAWEkRHQTQDEARAYRGRRAWEIpEET---------------PEAAEEFSAASQSQPGAESSTTPEAPQKATps 69 
ELV12915        5 KESPHHT-DqQLHAHSETQDLEIAQISKAmEETfl----------ySPFPSHPLMSDNLKEAPDAEMPSTSEGPGSAGas 73 
XP_006161990    6 QESPQCTDDqHLQKHGEAQGSQVAQGSKAvEETsh----------ySS---HTLMPVNLSEAASAEAPSAPEGPQGFFts 72 
XP_017205209    5 QERLQYAHYqQLHSFSESQDLEVSQISQAlEVT-------------FLSSSHSIMSDNMKEASPSKKTSTPDSPQSFCss 71 
21_pfamImport   1 KMSPKCTPDeHLHTQSETQGLESAQVPKPvEETlp----------sSS---LLPISGNLKEVPAAKVLSAPEGPQSFCss 67 
10_pfamImport   1 KKSPRCPPDqHLQTQSETQGLESAQVTKPvEEAlp----------sSS---LLPMSGNLKEAPAAKLLSAPEGPQSFCss 67 
XP_002922854    5 QEIPSCTQEq-HDAPSEIQGLEAAQVSKAvEET-------------SPS-PCPVMPGNMEEAVAAGTSSTAQSPQSAYps 69 
19_pfamImport   1 QEGPRCTHEqHLEAYSESEGWEAAQIVKAlRIIsp----------pSS---HSLMSGNMEEVPAAETPSTHQDPWSGCss 67 
XP_017206348   66 KKSKIFKLEeALHSQCKVQGLVNARDLEAkKEAatsff---pscstSSASCSYLTSSNTKGVSVAGGQISCHGPHRAScs 142

XP_013841927  109 PTAAPAMPRSQ-SAESSRREEEEGAC 133
XP_003513410   70 ASTPLSVSSSEsY-ESSSEESEKFEE 94 
ELV12915       74 ATAIAAASPRKl-SDSSSSLEDNSTS 98 
XP_006161990   73 SIAIIATLWRRc-DVGFSSEEEESSS 97 
XP_017205209   72 SIANAVTSSNK-PDEISSSQDEEDVP 96 
21_pfamImport  68 PGDITATSSNKp-DEGTRSKEEKKSL 92 
10_pfamImport  68 SGDNTAMSSSKs-DEDARSEEEKKSL 92 
XP_002922854   70 YAVLTAVSPSK-SDEGSSSQEKEDSS 94 
19_pfamImport  68 STAITTTSSSKs-DEGSRSPDKEESP 92 
XP_017206348  143 ATSVVTPSVEL--DQGSSSQEEKNPC 166
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