Conserved Protein Domain Family
Sarcoglycan_1

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pfam04790: Sarcoglycan_1 
Sarcoglycan complex subunit protein
The dystrophin glycoprotein complex (DGC) is a membrane-spanning complex that links the interior cytoskeleton to the extracellular matrix in muscle. The sarcoglycan complex is a subcomplex within the DGC and is composed of several muscle-specific, transmembrane proteins (alpha-, beta-, gamma-, delta- and zeta-sarcoglycan). The sarcoglycans are asparagine-linked glycosylated proteins with single transmembrane domains. This family contains beta, gamma and delta members.
Statistics
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PSSM-Id: 461428
Aligned: 50 rows
Threshold Bit Score: 153.158
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFN78643             54 RLGVYGWRKRCLYSLILTLMIIVVLNLAL--------------TVWLLKVMGFSSEGIGSLKVVPG----------GIEL 109
XP_003375995         40 LVGLRGRKLIALLVCVGLMWLIAIVNLVIiisvivlnkfslkcNILLVMFLKIGNQGMDGVQFGRTvdg-----kpVVQF 114
2_pfamImport          1 VTGLRAKRLLSMLICLLVLFLLTLLLLIL--------------NIVIINTLRMDPTGIKFLRFHHSvshng-emekTVEM 65 
EFO99103             22 VTGLRAKRLIATLICLFVLFLVTLITLAL--------------NIWIITTLRMTSNGIPFLRFYHSfnektkemekTIEM 87 
EKC36065             28 RTGVRGRRAYLLYCLVVILIVLALLNILM--------------TAGILYMLKVTTAGLEMLEFIPAds-------nLLRF 86 
XP_002023875         67 HPGQHGRNSFAFWTVVIILLALTVGNLIL--------------TLTIVGVLRLG-KGVHGMELIPEv--------dVVKF 123
WGS:AAPU:GI22789-PA 110 HPGRQNRNSYAFWTAVVVLLMLTIGNLIL--------------TLTIMSVLRLG-KGVKGMELIPEv--------dLIKF 166
XP_001994846         70 QPVRKGRSSFAFWTAVTILLLLTIGNLIL--------------TLTIMGVLRLG-KGLQGMELIPEv--------dLIKF 126
Q9VG77               68 HPGHQGRNTFAFWTIVVLLLVLTVGNLLL--------------TLTIVGVLRLG-KGVQGMEVIPEv--------dLVKF 124 fruit fly
WGS:AAQB:GK12845-PB  67 HPGRQGRNTFAFWTIVIILLALTVGNMIL--------------TLTIVGVLRLG-KGVHGMEVIPEv--------dVIKF 123
EFN78643            110 RGQAAVLDALVASS---LRSRRGKNLVLESWSN-----FTAS---ARSHDGRL--------------------LARLTVG 158
XP_003375995        115 AASETYFQHMVSKTg-tVGGYRDTDLNADAARI-----VIRTnnsTTL-------------------------PVGLIID 163
2_pfamImport         66 AGEKIHFEKVVSNK---IVGFPNKDILIQAPRM-----LVSSke----------------------------nDSMLAIN 109
EFO99103             88 SGNRIEFEKVVSNK---IVGFPEKDITITAPRM-----LMTSrq----------------------------nDSLLVMS 131
EKC36065             87 -LAGTTLPSVKVFQg-gVGSRHSSSIQLDSDKQ-----IVFNtssIKKK------------------------DVEGLIG 135
XP_002023875        124 -YGSTELERLQTNSigqVHGFTDVPVTISSDGSsddnpDAGVhvrVFRNGNGas-----------------seRDRIVVD 185
WGS:AAPU:GI22789-PA 167 -YDETDLDRVQTNAl-gIHGFSDVPVSISSDGE-----YSGVhlrVFRNLNSAsal---------------neRDLVVLD 224
XP_001994846        127 -YDETDLDRIQTNFi-gIHGFSDVPVSISSDGG-----DSGVhfrIFRNSNSGvsgaa-----------ttneRDRVVLN 188
Q9VG77              125 -YGTTDLERVQTNSigqIHGFSDVPVTISSDAGd---gEGGVhvrVFRNGNGaa-----------------seRDRIVLN 183 fruit fly
WGS:AAQB:GK12845-PB 124 -YGTTDMEKVYTHSigqIHGFTDVPVSISSDAV-----ENADgveDGLHEESSanevhvrvfrngngngpaqeRDRIVIN 197
EFN78643            159 ED-RVDCVSRG----------------FRVTDPRG-GVLFSADREQVIVGAD-----MLRVTgdggavfqgSVQTPLVRG 215
XP_003375995        164 ENrIRMQNVNT----------------FIVRERNTlNKTFDASQP--ILHLQkn-ikKISTK---------LIKTKKIRA 215
2_pfamImport        110 EKlCKLERINN----------------FQVLSQNG-RTLFSARNP--TVKVDkr-ikKLAAE---------KIITNKVRS 160
EFO99103            132 EKlCKLERVNSfqvsplkhdplnmlsfFQVISPKDgRTLFSARHP--TVTIDkr-ikKLAAE---------RIITNKIRS 199
EKC36065            136 PNkIQFQSLDE----------------FILEDLESkSTLFSTKSQTWTNVQNpg--iNLHVP---------SLTTAHIQS 188
XP_002023875        186 KDaIVIDATNV----------------FDVKDPADrQSIFSTHRP--QYNIPag-vaALQAK---------VVSASGISS 237
WGS:AAPU:GI22789-PA 225 KGgIAIEA-NM----------------FEIKDPTDhATIFTTHRP--QYNIPdgvegVLQTK---------VASASRVSS 276
XP_001994846        189 KDgITIQA-NL----------------FEVKDPNDhSTVFSTHRP--QYTIPagvdgMLQTK---------VASSSRITS 240
Q9VG77              184 REgILVQATNL----------------FEVKDPVDkQPIFTTHRP--QYNIPgg-veALQAK---------VVSASGIVS 235 fruit fly
WGS:AAQB:GK12845-PB 198 KEgIVIQATNL----------------FEVKDPTDrQPVFTTHRP--QYNIPag-vnVLQAK---------AVSASGISS 249
EFN78643            216 -ESGRGLRLESATRaLKISAPQRVVIESWASEISASCLTDLKLQSVH-GAIKLDAK-SVYMKGL----KAAIpvqghssr 288
XP_003375995        216 -PLDNALTLDVEN--LSFRGNEGTLLSSRAMNIRST--QSITLKTGDrGVMNLTAGqGLFLTSAqr-lPLSD-------- 281
2_pfamImport        161 -AVDETLKITGHD--VVLRGNEQVRVDARNINFEAM--KRIAFNISRdGLLHMKG--RVRLGDGssslPMST-------- 225
EFO99103            200 -AVDETLKINGEN--VVLRGNEQVRIDARNVNFEGM--KRMVFNISRdGILHMRG--RIRLGDGasslPMST-------- 264
EKC36065            189 kTGVERLVMEADK--MYLTGFEGVVMTSEREYFHADLGRRLYIQSKD-GDINIEATnHTFINKNi---PNSS-------- 254
XP_002023875        238 -PIDVPLNMESDGR-IVVKGSEGVFFDAASIDLQAE--HHVSINSTQ-GATVLEAGtGIFLDMDr--iPIVS-------- 302
WGS:AAPU:GI22789-PA 277 -PIDVPLIMDSDGH-IAIKGSEGVFFDGATIEVQVE--HHVSLNSTQ-GATVLEAGkGIFLDMDr--iPVVS-------- 341
XP_001994846        241 -PIGAPLILQSDGH-MAIRGSEGVFFDGATIELQVE--HHVSINSTQ-GATVLEAGkGVFLDMDr--iPIVS-------- 305
Q9VG77              236 -PIDESLVLESDGR-MAIRGSEGVYFDGASVDMQAE--HHILINSTQ-GATILEAGtGIFLDMDr--iPIVS-------- 300 fruit fly
WGS:AAQB:GK12845-PB 250 -PLDQPLSIESDGR-LAIKGSEGAHMDGANIQVQAE--HHVSINSSQ-GATILEAGgGIFLDMEr--iPIIS-------- 314
EFN78643            289 eqqqqhsgrsssvhQSQRETTI---YQLCAC-A-SGKLFLARPDGS 329
XP_003375995        282 ---------------SPSFRANvlgRRLCSCaG-TGRLFTVAGNMP 311
2_pfamImport        226 ---------------SPSLSASldgMRLCACaQhHYKLFIVPANKH 256
EFO99103            265 ---------------SPSLSASldgMRLCACaQfNHKLFIVPANKH 295
EKC36065            255 ---------------QFSPVTNitvYKVCLCiP-SVSLHKLKTNLN 284
XP_002023875        303 --------------SELGIRTGsvqYKICVCmP-QGTLFRIAIPRI 333
WGS:AAPU:GI22789-PA 342 --------------SELGLRTGsvqYKICVCmP-IGVLFRIAIPRV 372
XP_001994846        306 --------------SELGLRTGsvqYKICVCmP-NGILFRIAIPRV 336
Q9VG77              301 --------------SELGLRTGsvqYKICVCmP-HGTLFRIAIPRV 331 fruit fly
WGS:AAQB:GK12845-PB 315 --------------SELGLRTGsvqYKICVCmP-QGNLFRIAIPRV 345
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