1BD3,3DMP


Conserved Protein Domain Family
UPRTase

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pfam14681: UPRTase 
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Uracil phosphoribosyltransferase
This family includes the enzyme uracil phosphoribosyltransferase (EC:2.4.2.9). This enzyme catalyzes the first step of UMP biosynthesis.
Statistics
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PSSM-Id: 434124
Aligned: 87 rows
Threshold Bit Score: 172.292
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1BD3_A        40 QTAQLRAMMTIIRDKETPKEEFVFYADRLIRLLIEEALNE-LPFQKKEVTTPLDVSYHG-VSFYs-KICGVSIVRAGESM 116
Q5AWP2       472 DSHATKLLSTPMRDDSIRGPSLQEAHENAGRYLATRYLVElIGTEVLAIRHPQGNFVAGyRLLDeeQTLIVPLMRGGQSM 551 Aspergillus nid...
XP_002556998 504 DRPAAKLLMTPMRDASISGSALRKVHGRVGFYLATELCTQiMGLEAYPIPHVQGHQADGyRLLHeeATLIVPLMRGGEPM 583
Q0TVS3       477 DRNAAKLLMTSMRDAAVSGPELRKFHGRVGWYLATDLLAQlIGIQEYPIQHVQGHTTSGfRLLHegQTLIVALMRGGEPM 556 Parastagonospor...
CAZ84860     497 DRGAARLLMTPMRDATVAGPALREAHRRVGWYLATEFLTEmIGLEEYQIPHVQGHPTTGyRLCReeNTSIVALMRGGEAM 576
Q2GUM1       476 DQNATKLLMTPTRDARVFGPDLRKAHRRVGWYLATLFLADiVGLEQYDIPHVQSRSTEGyRVRHenRTTIVALMRGGEPM 555 Chaetomium glob...
XP_008096276 470 AKNAAKLLMTPTRDAAIAGHSLRAAHHQVGWYLATEFLTSvLGVEEYPIAHVQGRTTDGyRLLDedSTVIVALMRGGEPM 549
XP_002540787 395 DRNAAKLLATQMRDAKVAGPDLREAHRRAGWYLATETLADiLGVEECPIQHVLGRPTSGyRLLNesQTLIVALMRGGEPM 474
XP_003040006 507 EKCAAKLLMSPMRDASVSGPPLRAAHQRVGLYLANEFVSQlIGVEEYPIPHVQGHQSNGyRLRHeqQTSIVALMRGGEPM 586
Q0CK66       517 DKSAAKLLMTPMRDAALAGPRLREAHRQCGRYLALEYVSDlIGVEPCDILHVQGHNTTGfRLAReeRTLIVALMRGGEPM 596 Aspergillus ter...
1BD3_A       117 ESGLRAVCRGVRIGKILIQRDETTAEpklIYEKLPADI-RERWVMLLDPMCATAGSVCKAIEVLLRlgVKEERIIFVNIL 195
Q5AWP2       552 ASGIFKVFPKARLHDA---KEPTDVK--------EEHLkGIVNVILVDSVINSGESMAQFVQRIREvdGAVRIIIVAGVI 620 Aspergillus nid...
XP_002556998 584 AFGVNEAFPLAMFHHAKVPCDLQH-------E----HLkDMATIILVDSVVNTGRSVLEFVEHIRSlnAAIYIVVVAGVI 652
Q0TVS3       557 AFGVNEAFPRAMFLHARCPGDV-----------LQDHVkGKVTVILVDSVVNSGKTVVDFVQHIRDihATVHLVVVAGVI 625 Parastagonospor...
CAZ84860     577 ALGVNDAFPRAMFVHA--KRPE-DIE--------PNHL-RQHTVVLVDSVVNSGKTVVNFVKHIRSlhATIRIVVVAGVL 644
Q2GUM1       556 AVGVNDALPGAMFLHAK---QPDELR--------PGHIkGQCTVVLVDSVVNSGKSIVDFAQRIRSfdATISIVVVAGVI 624 Chaetomium glob...
XP_008096276 550 ALGVSEAFPKAMFLHAGSPKDLNS-------ENLAGK----QTVLLVDSVVNSGKTIVEFVEQIRKl-dTIKRIVVVAGV 617
XP_002540787 475 AFGVNDAFPLAMFLHA---RSPDDI----KQEHLQGRL----TVLLVDSVVNSGKTVIEFLHHVRRlhG-SIRIMVVAGV 542
XP_003040006 587 ACGVSEAFPTAMFIHAASASDIKD-----------HHLkNQRTVILVDSVVNSGKSITEFVMRIRNs-HPSIRIVVVAGV 654
Q0CK66       597 AFGINDAFPRAMFLHASTPDNVQS-----------HHLlGLSAVVLVDSVVNNGKTVVSFVRHIRSldANVR-IIVAAGV 664 Aspergillus ter...
1BD3_A       196 --AAPQ----GI------ERVFKEYPK-VR-MVTAAVDICLNSRYYIVPGIGDFGDRYFGT 242
Q5AWP2       621 qdQAVK----GC------SQLRAVARS-TE-LTVVAL--RLSANKYTGKGTTDTGNRLFNT 667 Aspergillus nidulans
XP_002556998 653 --HSQTvstsRI------ARALSRFDG-LS-FVAL----RLSDNQFTGRGTTDTGNRLFNT 699
Q0TVS3       626 --QAECmt-gGL------QSLA-QDPQ-LD-LVAL----RLSENKFTGRGTTDTGNRLFNT 670 Parastagonospora nodorum SN15
CAZ84860     645 --QAQS----VSeg--spAHALARHAD-FS-LVAL----RLSDNKFTGRGTTDTGNRLFNT 691
Q2GUM1       625 --QTQSl---DV------AGLLGRVLE-TD-KALSVIALRLSNNRFQGRGGTDTGNRLFNT 672 Chaetomium globosum CBS 148.51
XP_008096276 618 --VQEK----AV------SGVLEPLANaTD-LSLVAL--RLSENKFTGKGGTDTGNRLFNT 663
XP_002540787 543 --AQSQ----SLskgsdlTRALNSYTN-VG-LVTLR----ISDTKFTGKGANDTGNRLFNT 591
XP_003040006 655 --VQAE----VV------AKSHDWHRR-MWcFGISLVALRLSENKFTGTKSTDTGNRLFNT 702
Q0CK66       665 --VQAQ----AVssy-saIQALARYGE-LN-VVAL----RLSDNKYTGSGGTDTGNRLFNT 712 Aspergillus terreus NIH2624
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