Conserved Protein Domain Family
Auts2

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pfam15336: Auts2 
Autism susceptibility gene 2 protein
Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family of eukaryotic proteins associated both with a susceptibility to autism and with influencing the number of corpora lutea produced by breeding sows.
Statistics
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PSSM-Id: 464656
Aligned: 16 rows
Threshold Bit Score: 115.707
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ARQ80401      169 KPGKWCAVHVQIAWQIYHHQQKMK-QMHLDPHKLDMNGKLD-------LFSRPPAP---------GVFPG-FPYPHDLAR 230 
EFN62620      192 KSGKWNAMHVRIAWEIYHHQQKQQaEAK---AGSVVSTKTEllrppghLYPGGPGS---------GLGLG----APSMAP 255 
1_pfamImport    1 KTGKWCAMHVRVAYMILRHQDKVKkETVLQVHSDSVQLQTEsvahsasVLSRKA-----------------VTPPHKMVV 63  
XP_007259178  560 KPGKWCAMHVRVAWMILRHQEKVK-LMQADPQKLDFRND---------LLPRLPGPggiggigglGPLGGpLPPTHELSR 629 
XP_005156361  545 KPGKWCAMHVRVAWMILRHQEKVK-LMHADPQKLDLRNE---------LLPRLPGPgigg-lgglGPLGGpLGPAHDLTR 613 
XP_007499011  290 KPGKWCAMHVRVAYMILRHQEKMK-LMQGDPHKLDFRND---------LLPCLPGA-----------YGG-LPPGQELSH 347 
XP_003227747  597 KPGKWCAMHVRVAYMILRHQEKMK-LMQGDPHKLDFRND---------LLAGLPGT---------GVFGG-LPHAQEMAR 656 
XP_005891280  475 KPGKWCAVHVQIAWQIYHHQQKIK--MQLEPHKLDVGTKLD-------LFSRPPAP---------GVFAG-FHYPQDLAR 535 
XP_013004125  460 KPGKWCAVHVQIAWQILHHQRKVK--LQLDPHKLEVGVKLD-------LSSRLPAP---------GVVSG-AHYPQDLAR 520  domestic guin...
XP_005990289  194 rpgalphtllqkdprvsdpyrspvrQMQLEPHKLDMNGKLD-------LFSRPPGP---------TVFPG-FPYPHDLAR 256  coelacanth
ARQ80401      231 P--LFSSTGSGHP-AASPY-G--PSPHH-A---GFL--PPSHLag----kYPFSR-SSTFGGLSNLSSSAFGGLGNPALG 293 
EFN62620      256 P--FPTNMPSAHP----------PPPPHpV---GFLstPASHLgnrgtgmSPFGRyPSTFGP----SNPNFPGLST---- 312 
1_pfamImport   64 KaaAVSVLGAA---------P--PSAPH-N---AFIn-ASAHI-------DPFGH-PAGFAPLGALSNGAFGGLGNLSSC 119 
XP_007259178  630 PgsIFTAAGGVNP-SSTPFiS--PSTPH-S---SFLt-PATHL-------DPYGR-SPPFPPLGALSSGAFGGLGSPSLS 693 
XP_005156361  614 PggLFAATGGVNP-SSTPFmP--PSTPH-S---SFLt-PAAHL-------DPYVH-SPHFSSLGALGSGAFGGLGSPTI- 676 
XP_007499011  348 PasLFTATGAVHP-AANPFtA--APGPP-T---SFLs-PGTHI-------DPFGR-PTSFASLAALSNGAFGGLGSPTFN 411 
XP_003227747  657 PatLFTASGVVHPgSGASFgP--PGTPH-G---SFLs-PGPHI-------DPFSR-PPSFASLGALSNGAFGGLGSPSFN 721 
XP_005891280  536 P--LFSSSGATHP-TANPF-G--PSAHP-G---SFL--PTGHLt------DPFSR-SSTFGGLGSLGSNAFGGLGSHALT 596 
XP_013004125  521 P--LFPGTGTAHP-AAHPL-G--PSAHH-A---SFL--PAAHLt------DPFSR-SGTFGGLGSLGSHAFGGLGSHTLA 581  domestic guin...
XP_005990289  257 P--LFSSTGGSKQ-DLAIF-PdlPSQGE-GgvtCLT--QNVVKplf-vfsDPFSR-SNSFSSLGSLNTNAFGGLANHNLA 327  coelacanth
ARQ80401      294 --ANSVFGPK-EGPGLPGL--SSPhHDTWNRLHRTPPSFPTPP------QW---PKSVDAERSSSANSHDRERDRereke 359 
EFN62620      313 ------FPPR-EMPPLGGL--SSV-HDPWRGLQRATTGFPPTTv-----SWglkPEPPTIDRRAELEERERERERer--- 374 
1_pfamImport  120 --CSSLYGQK-ESPSAQGF--SSP-HDPWNRLHRTPSSFPMAPapapsqPW---PKPGELERHP--------HDRdr--- 179 
XP_007259178  694 --ASSVFGHKaESSASAVGglSNP-HDPWNRLHVAPPSFPSGP------PW---AKGLE--KRD-------ERDRgk--- 749 
XP_005156361  677 --AASVFGHKtEPSASAVGglGNP-HDPWNRLHVPPASFPSGS------SW---AKGPE--KRE---------DRgk--- 730 
XP_007499011  412 --TGAVFAQK-ESPGAPPAf-ASP-PDPWARLHRGPPAFP---------AW---ARPPEAARTP-------GSDKer--- 464 
XP_003227747  722 --SSAVFGQK-DSPGAPPF--PNP-HDTWNRLHRTPPSFPTAP------AW---PKSGTGDGTE-----RGGPQHdk--- 778 
XP_005891280  597 pgSGSIFAPK-EGPTLHGL--PSP-HEAWNRLHRAPPSFPTPP------PW---PKPLDAERVSALTNHNRELDK----- 658 
XP_013004125  582 p-GGSIFTPK-EGSPLHGL--PSP-HEAWSRLHRAPSSFPTPP------PW---PTPTD--KLSSHAREPQELEPgh--- 642  domestic guin...
XP_005990289  328 --PNSVFANK-EGPCMQNF--GSP-HEPWNRLHRTPPSFPTPP------QW---PKLSDSDRSSSATNHDRDRERer--- 389  coelacanth
ARQ80401      360 kererEKRDSSVGKEEKDkdRDSLDRnRHSNRSSP 394 
EFN62620      375 ---erERER---ERAERE--RERIRReRERERERE 401 
1_pfamImport  180 ---epDKRDTPVIKDERD--RDAL-YnRHSIRVSP 208 
XP_007259178  750 ---dlERRE-LHIKDEKD--RENL-YgRPPVRMSP 777 
XP_005156361  731 ---evERRELTHIKDEKD--RDSILYgRQPVRMSP 760 
XP_007499011  465 ---pvERREPSAPKEEKD--RD-LPFsRPQLRVSP 493 
XP_003227747  779 ---egEKPDGPVIKDEKD--RDV-LFsRHPLRASP 807 
XP_005891280  659 ------------GKEERD--RDLLEKtRLLSRASP 679 
XP_013004125  643 ---eeFE-------------RDLLEKtRLPRPPVT 661  domestic guinea pig
XP_005990289  390 ---elEKRDSSVAKEERDkeRDGTDKnRHSNRSSP 421  coelacanth
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