Conserved Protein Domain Family
YhhN
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pfam07947: YhhN 
YhhN family
The members of this family are similar to the hypothetical protein yhhN expressed by E. coli. Many are annotated as possible transmembrane proteins, and in fact they all have a high proportion of hydrophobic residues. A human member of this family, formerly known as TMEM86B, is a lysoplasmalogenase that catalyzes the hydrolysis of the vinyl ether bond of lysoplasmalogen. Putative conserved active site residues have been proposed for the YhhN family.
Links
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Statistics
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PSSM-Id: 429751
Aligned: 62 rows
Threshold Bit Score: 64.9805
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001273766  35 GTMLFKMLSSVAFILGPLLt--tSTEWSPYRLSI-TTGLFFSLVGDFFLLpsrsefydppspdqkkgEVSISFQLGVVAF 111
Q8EXE4        26 LKIGSKIAPILVLIFFSFLe---GNWKGKGGKFI-FAGLIFSLFGDAFLG-----------------VPGNYFVFGLGSF 84  Leptospira inte...
XP_005163887  48 lAAGIKAAPILSLVLLVLS------YNGGWSLVGvAGGLLLSAGGDCCLI------------------WPELFIHGMGCF 103
CAG02714      19 tlaGVKAAPVLILAVTVLS------WSGSQSVLGvAGGLVFSAVGDCCLV------------------WPDYFLHGMGAF 74 
Q3T0W0        46 VNVLLKILPVLYLAGFLGT----AHPGGGYRALL-QGALLCSAVGDACLV------------------WPEALRYGMAAF 102 cattle
Q8N661        48 FAALVKCLPVLCLAGFLWV----MSPSGGYTQLL-QGALVCSAVGDACLI------------------WPAAFVPGMAAF 104 human
Q497J1        48 VSALIKCQPILCLVVFLWA----VAPGGSSTWLL-QGALVCSAVGDACLI------------------WPEAFFYGTAAF 104 house mouse
XP_002020290  38 WTTVLKCLPIVALMFYVVAngfsLKKDYRRSLWI-LLGLVFSCGGDALLN-------------------VNLFPFGMVSF 97 
EDO48808      62 FAALLKILPIACLCGFVTLqgvsLTKQHDYSRRI-LLGLIFSMIGDVCLV-----------------WKHSYFIHGMVAF 123
ABQ13023      38 VSALIKCLPIFCLWLFLLAhglgFLLTHPSATRI-FVGLVFSAIGDAFLIw----------------QDQGYFVHGMLMF 100

XP_001273766 112 ALAHIAYIVAFL------RASQGISANTLATTFIATMVLAKWlgvIYPPEssspwsnllslsiaPD-MKPLVLVYALIIS 184
Q8EXE4        85 LIAQILYSVGFS-------VGNPVHIIRAVPYLVFGISFYIW---ILPGIg-------------TA-LYVPVGVYMIAIC 140 Leptospira inte...
XP_005163887 104 ALAHLLYSVTFLssryssTSSSFSFFFLYLVLWLFGVGIYVY---LMPFLqld---------peADvLVPAIGGYVLLIV 171
CAG02714      75 AVAHLLYSLSFLtsryatYSSSSWSRFLYLILLVVAGGFYTY---IYPFLktd--------praEI-LVPAVGVYVALIT 142
Q3T0W0       103 GLAHLLYLRAFG--------LTPLKPGLLLPLLLVSALYFRV---LHPHMp-------------PQ-VVWPLLAYSIVLV 157 cattle
Q8N661       105 ATAHLLYVWAFG--------FSPLQPGLLLLIILAPGPYLSL---VLQHLe-------------PD-MVLPVAAYGLILM 159 human
Q497J1       105 SVAHLFYLGAFG--------LTPLQPGLLLCTTLASLTYYSF---LLLHLe-------------QG-MVLPVMAYGLILN 159 house mouse
XP_002020290  98 GVAHVFYICAFG--------WKPLKWPIGLALYVAVSLFVYF---VHQKL--------------DEiLIIGVPIYCYLIT 152
EDO48808     124 AIAHLLYMRSFG--------FRPLKPLTGIICLLLMLPFYVF---YFPNLk-------------GL-LFYAVPVYIVVIG 178
ABQ13023     101 AVTHMLYASAFG--------MRPLGLRTGLLMVILSGLCYAF---LYPNLt-------------GA-FTYIVGVYVAIIG 155

XP_001273766 185 AMFAVALATTl------PMSASTWLSQRAFGAAMFVISDLFVAKDAFGkssatRKRGWLQIAVgYGLYFWGQMVIAGTV 257
Q8EXE4       141 VMGWRSVSR---------ECSKSEFWKSLAGSLLFILSDSLIATRKFTt----VPIPWIGVWI-MSTYYAAQFLIYESV 205 Leptospira inter...
XP_005163887 172 IMATMA--------------ARTRRPLILLGSLVFMASDLTIALTKFNv----VDTEYKRHII-MVTYYLAQLMIALGd 231
CAG02714     143 LMGTLA--------------ARTRHSLTLLGSLSFMLSDMSLALQVFHv---mPPIKHGHIVV-MVTYYLAQLLIAAGd 203
Q3T0W0       158 AMLWRGLARG-------G--------SAHWGALLFVLSDSVLAWNIFT-----YLVPHGHLLV-MTTYYSAQMLITLSA 215 cattle
Q8N661       160 AMLWRGL---------------AQGGSAGWGALLFTLSDGVLAWDTFA-----QPLPHAHLVI-MTTYYAAQLLITLSA 217 human
Q497J1       160 SMLWRSLVWG-------G--------SASWGAVLFTFSDGVLAWDTFV-----YSLPFARLVT-MSTYYAAQLLLILSA 217 house mouse
XP_002020290 153 TMLWRALARA-------VDAKNFLAIFCAVGAVLFVVSDALIAVTMFVg----VPLPCPRLQI-MITYYAAQFAIALST 219
EDO48808     179 IMVWRAITGLqaqiysdDGLWRWTKLCACLGALSFAISDAAIGLNKFC-----FPIPHSRAII-MFTYYGGQLGIALST 251
ABQ13023     156 FMGWRAMAGLql----vGAAWRWTELAAGTGALLFIVSDLTIALDKFC-----FPVPYSRALI-MSTYYAAQMLIALSa 224
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