Conserved Protein Domain Family
DIE2_ALG10

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pfam04922: DIE2_ALG10 
DIE2/ALG10 family
The ALG10 protein from Saccharomyces cerevisiae encodes the alpha-1,2 glucosyltransferase of the endoplasmic reticulum. This protein has been characterized in rat as potassium channel regulator 1.
Statistics
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PSSM-Id: 461481
Aligned: 118 rows
Threshold Bit Score: 279.827
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEQ29325      29 LPDPYLDEVFHVRQAQAYWDHRWKQWDPKITTPPGLYLVSYAITSTSsilfakpveL-------SASVLRCINGLVLFnA 101
XP_002495600  68 VPYEFIDEKFHVGQTIEYITGHWRSWNPKITTPPGLYLLGWLNYKWC---------Sfft-swsTLTILRLVNLFGGVvV 137
XP_003955853  62 IPYLFIDEKFHINQTITYIKGDWAQWDPKITTPPGLYILGWCNYHIIk--------Pifk-swsNLTILRLTNLMGGLlI 132
XP_003669807  65 IPYEFIDEKFHINQTLTYLNGHWTQWDPKITTPPGLYILGWLNYKIVhi------iPfikswfsDLTTLRLTNLFGGLiV 138
CCK67849      74 VPYQFIDEKFHIGQTLTYLNGKWSQWDKKITTPPGLYLLGWANHHLLk--------Pifk-swsTLTILRLVNLFGGVvI 144
XP_004179078  25 VPFDFIDEKFHVNQTIEYIKGNWFNWDPKITTPPGLYIMGWLNWKFF---------Hyif-nwsTRCILRMTNLLGGAvI 94 
Q6CN27        84 LPYVFIDEKFHVDQTLRYLRGKWYSWNGKITTPPGLYLLGWLQYHAT---------Rfit-nwsTLTVLRLTNLIGGViV 153 Kluyveromyces l...
Q75AQ8        57 VPYPFIDEKFHVGQTVRYLAGRWREWDSKITTPPGLYVIGWAVQRTV---------Gllv-gwnTLSLLRLSNVIGGLvV 126 Eremothecium go...
XP_003644651  57 VPHPFIDEIFHLNQTVKYIGGHWGTWDPKITTPPGLYVIGWLEYHVM---------Rwvt-swnILSILRFANLVGGMvI 126
CAR21868      53 VPYQFIDEVFHVKQTIQYIGGNWKTWDPKITTPPGLYVLGWLNYKWL---------Rllt-swsSLTILRLTNLFGGMiI 122
EEQ29325     102 LQFTIRRflsirqDKSLAKGetranpwtLSLNALNICLFPPIFFFSGLYYTDLAALLTVLEV-------CNIDLGRSlpr 174
XP_002495600 138 LPITVLR------PLFLFNA--------IGFWPVALMSFPLLTSFYYLYYTDLWSTIFILQSltcvltlPFG-TNGS--- 199
XP_003955853 133 LPICILR------PLFLFNA--------IGFWPISLMCFPLMSTYYYLYYTDVWSTILILQSltlvmtlSCG-PKLS--- 194
XP_003669807 139 LPIFILR------PIFQLNA--------VGFWPVSLMCFPLLSTFYYLYYTDVWSTVFILWSltvaltlPFGDNKWS--- 201
CCK67849     145 FPWVVLR------PLFLFNA--------IGFWPITLMCFPLLTTYYYLYYTDVWSTIFIVESltliltlPLG-ERKS--- 206
XP_004179078  95 LPLIVLR------PLFFHNA--------IGFWPINLMIFPLLSMYYYLYYTDVWSSILILESltlmltrPVG--KYS--- 155
Q6CN27       154 WPWVVLR------PLYLFNA--------LGFWPVTLMCFPLMASYYFLYYTDIWSTIFIVESlnlalvlPFG-ETAS--- 215 Kluyveromyces l...
Q75AQ8       127 WPWFVLR------PLYFFNA--------LAFWPATLSVFPLLTSYYFLYYTDVWSTILIVGSltlavtvPFG-ERAS--- 188 Eremothecium go...
XP_003644651 127 WSWVVLR------PLYLFNA--------IGFWPITLISFPLMVNYYFLYYTDVWSTIFIVESmtlaltlPFG-EKLS--- 188
CAR21868     123 LPLVVLR------PLFLFNA--------IGFWPASLICFPLMASYYYLYYTDVWSSIFILESltlaitlPFG-ETTS--- 184
EEQ29325     175 nghdTaKNSlgttimqflsfLVLGLAALVFRQTNIFWVaVFLGGLRVVntlQARSVVCISsdvwriikgswylnqiydpp 254
XP_002495600 200 ----I-WAS-----------SILAGLSCLFRQTNIVWT-GFIMVVAIE---RRAVIQKQFnsn----------------- 242
XP_003955853 195 ----I-WLS-----------GLFAGLSCIFRQTNIIWS-GFVMLICIE---RKAMITKQFnsn----------------- 237
XP_003669807 202 ----I-WFS-----------SGLALISCLFRQTNIVWT-GFIMIIVVE---RKAIIDKKFdnh----------------- 244
CCK67849     207 ----I-WAS-----------SLCAAISCLFRQTNIIWT-GFIMVLAVE---RRAILTKKFnth----------------- 249
XP_004179078 156 ----I-WAS-----------SIVGGLSCCFRQTNIIWN-AYIMVVGLE---RETMMKKGFnqs----------------- 198
Q6CN27       216 ----I-WMS-----------ALCGLISCLFRQTNIVWN-VLIMILVVE---RRAMIEKNFntl----------------- 258 Kluyveromyces l...
Q75AQ8       189 ----I-WAS-----------AICGLLSCLFRQTNIVWN-AFVLVVVLE---RRTMIHKGFnsl----------------- 231 Eremothecium go...
XP_003644651 189 ----I-RAS-----------ALCGLISCFFRQTNIVWN-GFVMLLVLE---RRALIQKDFnnf----------------- 231
CAR21868     185 ----I-WLS-----------ALSALVSCLFRQTNIVWN-IFIMVVVIE---RRALIHKDFnnv----------------- 227
EEQ29325     255 asdasiegkasptdlpgrqprtniltDYFKVGFSLAISFv-aNLsailvavlPYLFFLGCFGLFVLVNGSVVLGHKEFHS 333
XP_002495600 243 -----------------------nanNYLKFFIHAIDEFgtlVQ--------PYAVNFFVFFLYLVWNRSITLGDKSNHS 291
XP_003955853 238 -----------------------nfnNYLKCFILSIEEFkdvTL--------PYFINFILFFFYLLWNRSITLGDKSNHT 286
XP_003669807 245 -----------------------tfnNFLKLFIHSIDQFnmlVL--------PYFVNFVLFALFLIWNRSITLGDKSNHS 293
CCK67849     250 -----------------------nvnNYLKAFIFAVEEFnhvVM--------PYALNFVLFFIYLIWNRSITLGDKSNHS 298
XP_004179078 199 -----------------------hlnNYIKVLINSIEEFpriVL--------PFFINFALFLIFIIWNGSITLGDKANHV 247
Q6CN27       259 -----------------------nfnNYLKLVLHTLENFkslVL--------PYAINFGLFLAFLLYNRSITLGDKSNHV 307 Kluyveromyces l...
Q75AQ8       232 -----------------------rinNYLKLIIHGIENWnslVL--------PYAVNFALFLIFLLYNGSVTLGDKSSHV 280 Eremothecium go...
XP_003644651 232 -----------------------hinNYLKLMLHGIENFsslVL--------PYAINFLLFIAFLVYNKSLALGDKSSHV 280
CAR21868     228 -----------------------hfnNYLKFIIHALENFkqvVL--------PYGLNLMLFAMFVIYNRSLTLGDKDNHT 276
EEQ29325     334 VGLHLPQMLYIWPYFMFFSWPVILYpwaisvwecicqpdpknlRQLMnklprl-----gvvlgYLAAMITIVHLNTIVHP 408
XP_002495600 292 AGFHLAQLFYCYLFIAFFSVPLWFS------------------SSFLkiyknrllqnpirylvEILGIMLVIRFFTKVHP 353
XP_003955853 287 AGLHLVQIFYCFTFITVFSLPLWCS------------------RNFLksyklrclsrpvrtifELLGIMLIIRYFTSVHP 348
XP_003669807 294 AGIHLVQLFYCFTFLTVLSLPLWYS------------------KVFMklylirwrlklfrtifELLMIMLVIRYFTKIHP 355
CCK67849     299 VGLHFMQIFYLFLFIAAFSVPIWGS------------------RNFLrsyknrflskpirtffEIIGIMLIIRYFTKVHP 360
XP_004179078 248 AGLHLVQIFYCIMFIMIFSIPIWIS------------------RRFLenylircllkpfrtffEIIGIMLVIRYFTVIHP 309
Q6CN27       308 AGLHIVQFFYCLMFIAFFSVPVWFS------------------KQVTlsylirfvmnpvkyllELLGIMLIIRYFTVVHP 369 Kluyveromyces l...
Q75AQ8       281 AGFHLVQMFYCLLFITFFSVPVWFC------------------RSFLlnyvsrtvvypiwtifEILGIMMIIRFFTVVHP 342 Eremothecium go...
XP_003644651 281 AGFHLVQMFYCFMFITFFSLPIWLS------------------GNFLrryiirflqrplivifETLGIMLAIRMFTVLHP 342
CAR21868     277 AGIHLTQMFYCITFIAFFSAPLWIS------------------KAGLdyyrfrvqakkfrtflELLGIMLVIRFFSVVHP 338
EEQ29325     409 FTLADNRHYVFYIFRL-LLRH-PLIKY-AVTPIYLLCGWATIAAFnsRSAsisselaqtpskqkgskeldkvqaersips 485
XP_002495600 354 FILADNRHFAFYIFKRfLGNPsKMVKYlMMSPIYHFVTYSYFETF--RPSemvfenvapipv------------kdpidl 419
XP_003955853 349 FLLADNRHYTFYLFKKlIGRKsRLIKYaLMSIIYHFCCFNYMELM--RPNemvfntnqplpi------------kdqtql 414
XP_003669807 356 FLLADNRHYTFYLFKKlIGNKhKLIKYfLMAPIYHFSTFVYMGLI--KESelnltlttqqif------------knsyel 421
CCK67849     361 FLLADNRHYTFYLFRKlLGHKrKLIKYwFMAPVYHFCTFIYLELM--RPNemvfhpvlplpv------------retihl 426
XP_004179078 310 FLLADNRHYTFYLFKRiINNPyKIIKYgFMSGVYHFSTFVYYEVL--RPCellssslqplvv------------edikem 375
Q6CN27       370 FLLADNRHITFYLFKKlIGRS-SLFKYcVMAPIYHFSAYVYLEVM--RPStmifhpilpiei------------knpidl 434 Kluyveromyces l...
Q75AQ8       343 YLLADNRHIAFYLFKKlIGRN-RFLKYfVMAPIYHFSTFVYLEAV--RPTvfffhpilpiev------------kspvdl 407 Eremothecium go...
XP_003644651 343 FILADNRHFTFYLMRKlIGRN-RFFKYvVMAPIYHFSTFVYLEVL--RPStlyfhpilpvki------------rnpadl 407
CAR21868     339 FLLADNRHYTFYLFKKvIARN-FWFKYlLMPWIYHFSTLNYIEIM--RQKvmhfhpilpiei------------kspvel 403
EEQ29325     486 gasirTSFVLLWLVSTSLSLITAPLVEPRYFIIPWVVWRL 525
XP_002495600 420 piqlsHVSWTALIACTFVTIVPSPLFEPRYYILPYMFWRL 459
XP_003955853 415 pvqltHISWTGLLLCTFITIVPSPLFEPRYYILPYYFWRI 454
XP_003669807 422 piqltHISRLALVVCTIFTIVPSPLFEPRYYILPYFFWRI 461
CCK67849     427 plqltHISWTALIVCTFATLIPSPLLEPRYYILPYLFWRI 466
XP_004179078 376 plqltHVSWSALILCTLATVVPSPLFEPRYYILPYLFWRL 415
Q6CN27       435 piqltHISWTALIMCTFMTVVPSPLFEPRYYILPFIFWRL 474 Kluyveromyces lactis NRRL Y-1140
Q75AQ8       408 plqftHISWSALIICTLLTVVPSPLFEPRYYILPYIFWRI 447 Eremothecium gossypii ATCC 10895
XP_003644651 408 plqlsHITWTALIICTFVTIVPSPLFEPRYYILPYLFWRV 447
CAR21868     404 pvqltHISWTALIICTFMTVVPSPLFEPRYYILPYFFWRL 443
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