Conserved Protein Domain Family
HGAL

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pfam15666: HGAL 
Germinal center-associated lymphoma
HGAL is a family of mammalian sequences typically between 104 and 179 amino acids in length. Members were discovered in a search for proteins precipitating diffuse large B-cell lymphomas. HGAL interacts with the cytoskeleton and aids the activity of interleukin-6 on cell migration. It also modulates the RhoA signalling pathway.
Statistics
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PSSM-Id: 464789
Aligned: 14 rows
Threshold Bit Score: 111.012
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_001231059  65 EETSSSPFqEENVDQSSVEDLCYTLIDHSTPARRPIGTPAE-----ECYENVSLKTERPRESLGGTETEYSLIHVSSTLG 139
EHB03100      35 KGTTSSPT-KDGGNQIYEDEVCYVLINHKAPGRKPLGNSTEeevigELYENIPCKSNRPRESLGGTETEYSLLRVSATPK 113
XP_004002963  65 EETSSAPIqQDNGDHGSSEDLCYTLINHSVLGKRPSGISAE-----ESYENVSLKAERPRASLGGTETEYSLLRVPSTPK 139
XP_005639532  65 KEMSSAPT-QDSADQSSSEDLCYTLINHSVLGGKSSGISAE-----RCYENISPKTETPRESLGKTEVSYALLRVPSSPR 138
ELK18162     306 egTSSVTNqQDNADQNSAEELCYTLINHNILMRRPSGTSAE-----GHYENVPHQAERPRKLLGRTETEYSLLHVPSTPR 380
XP_012033759  48 KGVPFTSN-QENENVSGCEEVCYTVINHRP-YRRPSLNSSD-----DGYENI---TKRVRPLREGPETEYALLKKPCTIR 117
XP_005623208  48 KGVSPTSN-QENENGSGSEELCYSVISHRP-CRRPSLSSND-----DGYENIDSTTKRVRTYRDAPETEYALIKMTCVTR 120
ELW59994      45 EEMSSSPI-QDNADQTYTEDLFYTLISHKV-LKRPSGNSAE-----EYYENIPCKAERPRECSGGTETEYSLLRVSSMPK 117
XP_003752560  69 EGMTSAPI-QDNANETYTEELCYILVDHKALRGRPSGKPAE-----GLYENISNKVDRHRESSRGTETEYSVLRFSSTSQ 142
EGW03422     417 pflipvTChQDNASQIYTEELCYVLVDHKALGGRPSGNSVE-----EFYENIPSKAERHRASSRGAETEYSVLRFPSTPQ 491
NP_001231059 140 HPSS-SENEYELLMP 153
EHB03100     114 NSPC-PEDEYELLIP 127
XP_004002963 140 HPPS-PEDEYELLMP 153
XP_005639532 139 HSSS-PEDAYELIIP 152
ELK18162     381 HPPF-PEDEYEFLMP 394
XP_012033759 118 SSSCtAENDYEIVLP 132
XP_005623208 121 PSSCsLEHDYELVLP 135
ELW59994     118 LPPF-PGDEYELLMP 131
XP_003752560 143 PLPS-TEDEYELLVP 156
EGW03422     492 TPPS-AEDEYELLVP 505
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