1DAW,1DS5,1JWH,3JUH,3H30,3NSZ


Conserved Protein Domain Family
STKc_CK2_alpha

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cd14132: STKc_CK2_alpha 
Click on image for an interactive view with Cn3D
Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CK2 is a tetrameric protein with two catalytic (alpha) and two regulatory (beta) subunits. It is constitutively active and ubiquitously expressed, and is found in the cytoplasm, nucleus, as well as in the plasma membrane. It phosphorylates a wide variety of substrates including gylcogen synthase, cell cycle proteins, nuclear proteins (e.g. DNA topoisomerase II), and ion channels (e.g. ENaC), among others. It may be considered a master kinase controlling the activity or lifespan of many other kinases and exerting its effect over cell fate, gene expression, protein synthesis and degradation, and viral infection. CK2 is implicated in every stage of the cell cycle and is required for cell cycle progression. It plays crucial roles in cell differentiation, proliferation, and survival, and is thus implicated in cancer. CK2 is not an oncogene by itself but elevated CK2 levels create an environment that enhances the survival of tumor cells. The CK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 271034
Aligned: 52 rows
Threshold Bit Score: 337.977
Created: 3-Jul-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:1DAW; Zea mays CK2 alpha subunit binds Mg-AMPPNP (ATP analog); contacts at 4A.
  • Structure:1JWH; Human CK2 alpha subunit binds ANP; contacts at 4A.
  • Structure:3NSZ; Human CK2 binds AMP-PNP; contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                             ## ## #                                    
1DAW_A        14 PKEYWDYE-----ALTVQWGEQ-----DDYEVVRKVGRGKYSEVFEGINVn----------------------------- 54  Zea mays
CAI39005      17 SRIYPDVNrnqvlPYNIQQGNM-----SDYVVKKYLGDGTFAFVQSAIRMs----------------------------- 62  Paramecium tetr...
XP_668610     50 VESHEDFS-----SLENILEMSrlsrkNFYIKGNTIGTGRYSNVFFAWKIdlspetknkigeetlvidpnflnltdhqis 124 Cryptosporidium...
XP_001311342   6 AQKYQESEg---dELNYPLGNI-----DDYSVNNRIGRGKYSNVFSGHIId----------------------------- 48  Trichomonas vag...
XP_001299783  31 GPAWYESE-----NWKLPTVPP-----DGYEIGEWIGTGKYSDVFLGYKG------------------------------ 70  Trichomonas vag...
EAY20947      24 GPSWYDHK-----NFEPTWNSP-----ENYALIKKVGRGKYSIVFKAIHNr----------------------------- 64  Trichomonas vag...
XP_001318782  58 GPDHWRFR-----SWNPNFGDI-----NRYTLEEWVGDGRYSDVFMGFQDg----------------------------- 98  Trichomonas vag...
XP_001315409  22 TPEEIQKEtd--eSSDFKFSTP-----DNYELIKPLGSGKYSVVFLGCMNg----------------------------- 65  Trichomonas vag...
EAY18760      23 IKDAHELE-----SIVVDFPIElt-diERFQVISPVGTGKYSTVFLGRMDg----------------------------- 67  Trichomonas vag...
XP_001328407  31 GPKWYDVD-----NYELPRESP-----EPYLLVDWIGTGKYSDVFTAKKG------------------------------ 70  Trichomonas vag...
Feature 1               # #                                                 #                    
1DAW_A        55 --nNEKCIIKILKPVkkKKIKREIKILQNLc-----------------------GGPNIVKLLDIVRDQhs--------- 100 Zea mays
CAI39005      63 --dGLPVVLKQIKKEytWWAKMEAQVLNTLne---------------------eSNPNIVRLVDAFFNDs---------- 109 Paramecium tetr...
XP_668610    125 slrGFPVALKELKNVqeWKIIREVSILKLLngysdhhvnqtlslensqlydqiqGKNSIVKLLDIVKYHnpiknlnqksi 204 Cryptosporidium...
XP_001311342  49 --sGKPIVVKVLKPVriMKINREIAILNVLr-----------------------NGPNISQLLDVVKDPds--------- 94  Trichomonas vag...
XP_001299783  71 ---DKKVALKVMKPVrpQKYNREAKIMLNLk-----------------------DGTSIVKLLDIVQTEds--------- 115 Trichomonas vag...
EAY20947      65 ---RTECAIKILVPLdpKRYNREIKILTNLk-----------------------GERNILQLYDLIKDPvt--------- 109 Trichomonas vag...
XP_001318782  99 ---QKKCAIKLLKPVntDRVRRELKILTIIq-----------------------GHPCILNLMDIVIDGke--------- 143 Trichomonas vag...
XP_001315409  66 ---KTKVAIKILKSIplYKVYREIAILKKVs-----------------------SVPNVVGFTDAIKDEqs--------- 110 Trichomonas vag...
EAY18760      68 ---KKKCAIKTLKNVphFKIQKEICLLTKIk-----------------------DIPNTVQLYGVVVDPlt--------- 112 Trichomonas vag...
XP_001328407  71 ---DTIVAIKVLKPVrlQKYNREAKILENLw-----------------------NGPNIVKLKSVVQNPqt--------- 115 Trichomonas vag...
Feature 1                 ## #                                                ## #          ##   
1DAW_A       101 ---kTPSLIFEYVN-NTDFKVLYp----tLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHelRKLRLIDWGL 172 Zea mays
CAI39005     110 ----SPVLVFQELQnCTTFDYRIynyyhdLTPEDIKNLYFKLFQALATSHAKGIMHLDIKPANIIVNN--DQIQLIDWGV 183 Paramecium tetr...
XP_668610    205 slkkHIGLVMEYIN-NEQFYSLLp----kLTYIDLQNYMRQLLQGLSYANSLGVFHRDIKPQNIVIDInkESLKIIDWGL 279 Cryptosporidium...
XP_001311342  95 ---kYISLILNYAE-NNDVKTLFg----kMTTRDIALYIYGVLRALAFAHKNGIMHRDVKPGNIMWNQttKEVSLIDWGL 166 Trichomonas vag...
XP_001299783 116 ---kRYIFVQEYVE-AVEFNLLYp----nFTDNEARIYLYQLLRALEYAHSRGIMHRDIKPQNVLYDPttKKLRLIDWGL 187 Trichomonas vag...
EAY20947     110 ---gVYSFVSEWVE-FYDWRSLYs----sFSIDDIRLYMYKLIDALDTSHSHGIMHRDIKPQNIAIDKehHRLRLLDWGL 181 Trichomonas vag...
XP_001318782 144 ---gIPSMITEYVP-NSTWRTLFs----tMDLEDIRFYTYRILQALSYTHSKGIMHRDVKPLNILCNSprNKVILADWGL 215 Trichomonas vag...
XP_001315409 111 ---rTISIVTEYFD-NVAFKSLGp----vISMNDIRNIMYSLLQSLDCCHSKGIMHRDIKPGNILVHQnkAQICIIDWGL 182 Trichomonas vag...
EAY18760     113 ---dTFSIITDYLK-SESPRTLFp----kLTLENIRILMWQLLTCLNESHKRGIMHRDVKPGNILFGQnrKSMKLIDWGL 184 Trichomonas vag...
XP_001328407 116 ---qQYSFVFEHVN-GIGFDRMIk----tTNDEDSRFYLFQLMRAIHYSHSQGVMHRDVKPLNVLYDRskKKLRLIDWGL 187 Trichomonas vag...
Feature 1                                                                                        
1DAW_A       173 AEFYHPG-KEYNVRVASRYFKGPELLVDLqDYDYSLDMWSLGCMFAGMIFRk---------------------------- 223 Zea mays
CAI39005     184 SDFYFPM-KEYRTRVGTRHYRAPEQLIHYkYYDYAVDVWALGSIFATAVFKk---------------------------- 234 Paramecium tetr...
XP_668610    280 AEYYSKDdPDFSPRVASKYYKAPELLLGIrNYDFSVDSWSVGCLFSQMLFRlgtlktnyftrvftkypktfvgiflknsl 359 Cryptosporidium...
XP_001311342 167 AEFYTPD-SEYQVRVATKYYKGPELLLSYlKYTPSLDIWCLGCTLAGLLFHk---------------------------- 217 Trichomonas vag...
XP_001299783 188 AEFYHPG-THYNIHVASKHFKPIELLVDYqCYDYSIDMWGFGVTMLGIIFGk---------------------------- 238 Trichomonas vag...
EAY20947     182 ADFYHPK-QAYNSHVATRVFKPPELLFAYpYYDYSMDIWSAGLTLSIMMFKr---------------------------- 232 Trichomonas vag...
XP_001318782 216 AEFYHPM-RKYSVHVATRYYKSPEILLDYeYYDYSLDIWSVGVILLELLTLk---------------------------- 266 Trichomonas vag...
XP_001315409 183 SDYYLAH-QQYSCRVSTLRYKAPELLLNYqYYDYGIDVWGAGCVFAELLFK----------------------------- 232 Trichomonas vag...
EAY18760     185 GDFYLAK-EAYSPRVSTLRYKAPELLLNYqYYDYGIDVWGAGCVLAEMLVR----------------------------- 234 Trichomonas vag...
XP_001328407 188 ADFYIPK-TRYSIHVASRNFKPIELLLDYqCYDYSVDIWSFGVTMASLIFKk---------------------------- 238 Trichomonas vag...
Feature 1                                                                                        
1DAW_A       224 --EPFFYGHDNHDQLVKIAKVLGTDGLNVYLNKYrieldpqlealvgrHSRKPWLKFMNADnq----------------h 285 Zea mays
CAI39005     235 --YPFFNGRNNDDQLLKVVKVLGSKDFFKFCDKYsisipddlhskligHEKIPLETFINDEnr----------------e 296 Paramecium tetr...
XP_668610    360 spDVLFPGWDNNDQIVKIASLLGGDNIISISNKYngtisd---ditfsYLKRTKKIFNSTSpiftdprtfdflitqenqd 436 Cryptosporidium...
XP_001311342 218 --LPFFKGRDSNEQIERMCVYLGGQAMLDYAEKYdlklssslkarlseLKGTMWAGLINESnr----------------d 279 Trichomonas vag...
XP_001299783 239 --TPYFRGSDDYDMVSKIVGLLGRNDFDAYVKKYgiqlpe---alirsLPKNPNRKDLHTIaska------------prg 301 Trichomonas vag...
EAY20947     233 --IPIECGEDDTEQLLKVAELVGGKGIIEYADSLgmkleestknallkKRGTGWQKHVAKAsp----------------d 294 Trichomonas vag...
XP_001318782 267 --LHVFDGGDNEHQIDSIVEVIGGAPILDWARKYrvkihreererfsqMKGQSFETLIPFSrr----------------k 328 Trichomonas vag...
XP_001315409 233 --YPFFEGKTVDEMIASVAGLCGMDSIINYVEKYglsvpegamalfpsNQKANWNWYFSMCrq----------------a 294 Trichomonas vag...
EAY18760     235 --FPFFEGRDIDEMVGDVSSVCGTNAITAYVNKYglql-------tpeMQKNLSNTQTPQFnkltqnp-------sfnqa 298 Trichomonas vag...
XP_001328407 239 --DPFFRGSDDLDMVKKISSELGGDKLKQYMDKYglplpdglpktifkKKPKPLNSHINLGnq----------------d 300 Trichomonas vag...
Feature 1                                          
1DAW_A       286 lVSPEAIDFLDKLLRYDHQERLTaLEAMTHPYFQ 319 Zea mays
CAI39005     297 lVTPQAIDLLNKIFVYDHAFRITaEDILQHEYFT 330 Paramecium tetraurelia
XP_668610    437 lVTVQALDLLSKLLTLDYKFRIHpKDALKHPFFT 470 Cryptosporidium hominis TU502
XP_001311342 280 iCTPQALDLLTKMLTIDHNLRPTaEQAMKHPFFD 313 Trichomonas vaginalis G3
XP_001299783 302 lINNESIDLIDRCLRYDHMERISaEEALKHPYFD 335 Trichomonas vaginalis G3
EAY20947     295 lCPPDAVDLLQRMTAIDHRQRVTaHDALKHPFFK 328 Trichomonas vaginalis G3
XP_001318782 329 fRDPEALDLVNKMLTIDHKERITaDEALQHPFFE 362 Trichomonas vaginalis G3
XP_001315409 295 kKDENAFDLIQKLLTVDHNERITaHEALEHPFFD 328 Trichomonas vaginalis G3
EAY18760     299 kNDHDALDLLQKLLTVDHEERITaAEALEHKFFD 332 Trichomonas vaginalis G3
XP_001328407 301 lVSPEALDLLEKCLRYDHQERITaFEALKHPYFD 334 Trichomonas vaginalis G3

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