1YRV


Conserved Protein Domain Family
UBCc_UBE2U
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cd23806: UBCc_UBE2U 
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 U and related proteins
The E2U subfamily includes mammalian ubiquitin-conjugating enzymes E2 U (UBE2U/, EC 2.3.2.23) and similar proteins. They are ubiquitin-conjugating enzymes that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins.
Links
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Statistics
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PSSM-Id: 467426
Aligned: 22 rows
Threshold Bit Score: 192.834
Created: 11-Aug-2017
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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active site
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1: active site cysteine [active site], 1 residue position
Conserved feature residue pattern:CClick to see conserved feature residue pattern help
Evidence:
  • Comment:forms a thioester with ubiquitin or ubiquitin-like proteins; some members of this subfamily lack this cysteine and may have a different function
  • Comment:serves as the point of attachment of ubiquitin prior to transfer to cellular target
  • Citation:PMID 9497353
  • Citation:PMID 9705497
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
1YRV_A        26 LLLHRDFCDLKENNy-kGITAKPVSe-DMMEWEVEIEGLQnsVWQGLVFQLTIHFTseYNYAPPVVKFIt--IPFHPNVD 101 human
KNC96524       7 LLLQREQYRLRKADkcwGIETSIVKn-DIFHWQATIEGLPntPWEGGLFKIEMFFDeeYNEKPPEIYFMt--VPFHPNVD 83  Spizellomyces p...
XP_030852652   7 LLLDREYYMLQRDPv-wGINAHPLSedNMMEWTATIRGLKgtIWEGGIFVLSLKFDenFNYRPPDVRFHt--IPFHPNID 83  purple sea urchin
XP_011402518   7 LLLKRDLLNFERLPi-eGLTASPVSedDLYNWNAVIKGLAgtPWEGGIFHLRLKFTnaYNTSPPFVQFMt--IPYHPNVH 83  Amphimedon quee...
XP_026694493   7 LLLQHELFELHENPl-wGISLQYYPs-SPLNLFVNLSGLQntSWGDGQFHLTLHFSehYNYEVPSITFNt--VPFHPNVD 82  vase tunicate
RDD37528       7 LLLDREYMLLQRRPi-wGISAAPLNtnDMFLWSAIVRGLNdtIWEGGIFRVLLYFSenYNVKPPRLLFHt--IPFHPNVD 83  Trichoplax sp. H2
PAA71701      13 LLIEQELLKFERNPv-kGIRVYPTRagNLFSLSAKIKGLPdtLWDGGVLKLRLRFSesYNYVPPEANFVt--VPFHPNVE 89  Macrostomum lig...
RNA12794       7 LLIEREINEIESEK---GLTIIRLDdnNIFELIALIEGIPktVWERGIFQIYLKFSenYNFVPPKVFFQt--VPYHPNID 81  Brachionus plic...
XP_035699831   7 LLLEREFYKLHDDPp-wGIDAGPVGdeNIFDWSATIMGLKdtIWEGGIFQVQLKFNefYNEEPPEVAFHt--IPFHPNVH 83  Branchiostoma f...
CAF1180227     7 LLIKRDLYLLENSPv-nGIEIERITndNCFDLTLFLRPARssIWYGCVFRIFCSFYdtYNVQPPILQFDqlnIPYHPNVD 85  Adineta ricciae

Feature 1              #                                                           
1YRV_A       102 PhTGQPCIDFLDnpeKWNTNYtLSSILLALQVMLSNPVLen--pVNLEAARILVkdESLYRTILRL 165 human
KNC96524      84 MnTGRPCVPFLEdsnEWDPETpILSILVYLQAILANPGLdr--pVNIAASEIYTssPRLYDQLVRD 147 Spizellomyces punctatus DAOM ...
XP_030852652  84 MqTGCPCVEFLDdvnYWKETYsLQSILLAIQSMLSNPVVeg--aVNEEAVTILQnsPGLYKQMVID 147 purple sea urchin
XP_011402518  84 PvSGVPALEILSk-eHWNETYtMSSILMKIQVLLSEPELdsgciYNQQAAYYYVhaNHTYKQLVFD 148 Amphimedon queenslandica
XP_026694493  83 PlSGRLSAGFLEr--EGKRVTsVRGILLGVQALLSEPDLdd--vVNKEAAEMLQdsPHGYEEMVMS 144 vase tunicate
RDD37528      84 MqTGRPCIDFLDdesLWSDKYdIKYILQTLQTMLSNPVLdn--aVNIEACRAIEssQDVYEAMVKD 147 Trichoplax sp. H2
PAA71701      90 PdTGRVACPYLDdpqKWNASVsLADLLSSIQQQLTEPNAql--iLNPEAAEMMStdYEQYKSVVAQ 153 Macrostomum lignano
RNA12794      82 ItTGKPSLDFLDdisKWRQDYsIKHILRSLQHLLAYPLLdr--sVNMDAVFMLKgnPKQYAEMARK 145 Brachionus plicatilis
XP_035699831  84 SiTGRPCIDYLDniqEWKESYsLVHVLLSIQTLLSNPVVed--aVNDDAARMLVtnPDRYLEMVRS 147 Branchiostoma floridae
CAF1180227    86 PiTGRITLTTSE---KWNPSLtLKMLFEELVNVFIEPNEkt--tINPDAMRMLKyrIHDYQNLIDE 146 Adineta ricciae

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