Conserved Protein Domain Family
Hva1_TUDOR

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pfam11160: Hva1_TUDOR 
Hypervirulence associated proteins TUDOR domain
Family members include HVA1 (hypervirulence-associated protein 1) whose absence is associated with a hypervirulent phenotype in mice. Metabolomics analysis suggests that when HVA1 is absent there is a block in the citric acid cycle, while structural analysis of the Hva1 protein suggests a potential interaction with NADPH. The structural architecture of Hva1 bears similarity with Tudor domains.
Statistics
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PSSM-Id: 431691
Aligned: 177 rows
Threshold Bit Score: 38.6316
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EKM78071       7 GDRVKYHAVGGrssgtdtsTTTGEIVDVL---TEPQPAGEtgVTAKASEDEPRYLIRNDnTGKETAYKGTNI 75 
XP_003029106  17 GDTVASKARGG--------RQYGEVTDIV---TTKEEAEE-----AGAKNPPKVLYEDQ-HGHLVSHNPGTV 71 
EOA81181      40 GDHVYTRIRGG--------RHEGNVDKVV---TSEEEAASegV-----KNPPKVLFTDQ-KGKNVAHNPSTL 94 
KNB17811      16 GDHVWTRIRGG--------RHEGDVERIV---TTAKDAEKe--EVKNP---PKVLFEDQ-HGHRVAHNPGTL 70 
KZT06060      16 GDEVFTRIRGG--------THEGKVEAVLrteEDIKNAGDlgITVKHP---PKVIFTDQ-HGHRVSHNPETL 75 
KZT27257       7 GDRVKTRFRSG--------KREGVVQKIVt--SEPQDTSDlpVDVKHP---PKVLV--S-HGHMASHNPGTL 62 
XP_007867296  17 GDKVGTKFRGG--------RREGLVEKIVt--SDSQDTSDlpIDVQNA---PKVVFKDQ-HGHTVSHNPGTL 74 
XP_005649067  18 GDFVSTKYRGG--------TREGVVERIA---KTPEEH----------PHPPKVIFTNQ-RGKEVAHNPSTL 67 
XP_013269465  15 GDTVATPYRGG--------KHEGKVEQII---TDEEEARK--LDAKGASHAPAVVFTDQ-NDKKVVHKPETV 72 
XP_007757756  15 GDTVSTPYRGG--------KHEGEVEQII---TDEKQAKQleNAKGAG-HAPAVVFTDQ-NNKKVAHKPNTV 73 
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