Conserved Protein Domain Family
YIF1

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pfam03878: YIF1 
YIF1
YIF1 (Yip1 interacting factor) is an integral membrane protein that is required for membrane fusion of ER derived vesicles. It also plays a role in the biogenesis of ER derived COPII transport vesicles.
Statistics
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PSSM-Id: 461081
Aligned: 103 rows
Threshold Bit Score: 175.442
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EHY57539      73 ND----PAAQMGF----QVGQTAMKA--GQEYMEQ--NLNRYISVSALKHYFNVSNSYVVRKLLLVLFPWRH--KPWTRQ 138
XP_656389     29 NNiatnPLASAGL----SVAQNYLNQ--GDQLLKS--QLGGIFSFDAWRYYFNVNTSFVLKKILMIIMPYPFl-GTWERK 99 
XP_004349338  74 AN----PATNLAL----QHGFSVA-----ENYVGK--NLSRFVTINKLKYYFAVNTSYVARKLRLVLFPFLN--RDWSRK 136
2_pfamImport   1 SE----PMSNFAM----TYGSSLASQ--GKEIVGR--NIDRFIPVSKLKYYFAVDTLYVGKKLGLLIFPYLH--QNWEVK 66 
XP_001171153  56 GD----PMANVAM----AYGSSIASH--GKDMVHK--ELHRFVSVSKLKYFFAVDTAYVAKKLGLLVFPYTH--QNWEVQ 121
EFC49411      92 QN----PTADFMI----NMGVNQLYGsvGEKTNEVtsRYWQWFDg--LKCYFNVTNSYVSRKLLLVLFPFKKfdTSYEYN 161
Q54XV4       133 SQisdnPLTQAGLtyglNYGQTLFSG--GKQYVDS--NFGKYFSFSTLKSYFNVNNSYVFNKIKLLIFPYTQ--KTWKRR 206 Dictyostelium d...
EFA81589      87 SNfssnPLAQASLsygiNYGQTLFNG--GKQYVDS--NLGKYISFSSLKGYFNVNTSYVFNKIKLILFPFRQ--KLWKRR 160
XP_004361058  90 SSissnPLAQVGF----SYGQSLFND--GKQYVDS--NIGKYFSFSSLKSYFNVNTSYVFNKIKLIIFPFPQ--KTWKRR 159
XP_014345204  58 AD----PMANVAM----AYGSTIANQ--GKDIVNK--ELNRVVSVNKLKYFFEVDTKYVMKKLGLLVFPYTH--QNWEVR 123 coelacanth
EHY57539     139 QARMTTsSTaadgtmsqqtysfNYLPPRDDLNSPDMYIPIMALITYILLSTVLAGIRGSFH-PELLGSITSTAIAVVIFE 217
XP_656389    100 YVIGEDqSK-------------LYNVPQEDIYAPDLYIPLMGFISYVLAIGFYYGSKGTFT-PETLSMTTTLCLILISLE 165
XP_004349338 137 HGTDPStNSi------------SFLPPRDDVNAPDLYIPVMAFVTYVLLVGFWLGVQNKFT-IELLGMTASSALVWYIFE 203
2_pfamImport  67 YQQDTP------------------VAPRFDVNAPDLYIPVMAFITYILVAGLALGTQNRFSySECLFVQF---------- 118
XP_001171153 122 YSRDAP------------------LPPRQDLNAPDLYIPTMAFITYVLLAGMALGIQKRFS-PEVLGLCASTALVWVVME 182
EFC49411     162 NNNQNQtQE-------------------RHLSDPDLYIPLMGYITYVLLVCFIMGAHKEFK-PELLYSIGMKGFITSLLE 221
Q54XV4       207 IGRTSDvDS--------------YLPPRDDINAPDLYIPLMAFITYFLLYGFQMGMEKKFS-PDYLGACITKGIVFWAIE 271 Dictyostelium d...
EFA81589     161 ILKQGDnDH--------------YLPPRDDINAPDLYIPMMAFVTYFLLFGFQMGMKNSFS-PDKLGASISKGIIFWLLE 225
XP_004361058 160 IYRVGDvDS--------------YLPPRDDINAPDLYIPLMAFVTYYLLYGFQLGMGREFS-PDKLGTAISKGIVGWLIE 224
XP_014345204 124 YHRDLP------------------LTPRQDVNAPDLYIPTMAFITYVLLAGTALGIQKRFS-PEVLGICASTALVWMVIE 184 coelacanth
EHY57539     218 IIVLKLAMYML-SI----------Sn---D-SQLLDLVAYSGYKFVG-VIVTLFLSEVltggrGTNNwVGWTLFLYTWYA 281
XP_656389    166 VMILKFLEYMLfNY----------S----SdFRI--YLSYVSYVFVP-VLMCTFVGSL-----QIPY-LTYIALLFFGTS 222
XP_004349338 204 VAAMSLSMYIM-NI----------N----CpIQTMDLMAYCGYKYVG-MIVTIISMFV-----LNSL-GSSAVLLFCCLS 261
2_pfamImport 119 LLIIFFKLFFF-FIisescvalqcNedysS--SHTVVTNFSNVSDVGlMIVGVLSGLL-----FGKT-GYYLLLGWCCMA 189
XP_001171153 183 VLALLLGLYLA-TV----------R----SdLSTFHLLAYSGYKYVG-MILSVLTGLL-----FGSD-GYYVALAWTSSA 240
EFC49411     222 IAIVKFGFYAL-GV----------Q----SsLGVLDVAAFSGYKYIG-IIITLVLSLL-----FGNY-AYYPSLLILGIM 279
Q54XV4       272 LLIFKCGFFFS-NS----------Ns-----IPFYDMISYSGYKYVL-MVIFQIATIL-----LGSY-VSYIIKCVLSVS 328 Dictyostelium d...
EFA81589     226 IGFFKLGFFFT-NS----------Ys-----IPMYDMIAYSGYKYVL-LVLTMVATML-----AGGA-VSLFVRLYTIAC 282
XP_004361058 225 IGIFRLGSFFS-NS----------Ys-----IPIYDMIAYSGYKYVL-MVITIISSIL-----TGGY-ISFFVKIYLVAC 281
XP_014345204 185 VLALLLGLYLV-TI----------Q----SdLTTFDLVAYCGYKYVG-MILTVLSGLV-----FGND-GYHVTLAWMSCA 242 coelacanth
EHY57539     282 NAFFLLRSLKYVLLPDSSSDptamrggsSYTvaRAQKNRRTYFLALYAfLIQMLFMWILS 341
XP_656389    223 YAFFLYKTFFGSLASIQT------------------EENKKRIYSICVgVFQIILIFFMM 264
XP_004349338 262 LSFYLVKTLRLAMVDEGGAQ---------DH-----GYKRRTYFILSIvAAQVLLSFYLT 307
2_pfamImport 190 IVVFMIRTLRLKILSEAAAEg-------VLV--RGAKNQLRMYLTMAIaAVQPIVMYWLT 240
XP_001171153 241 LMYFIVRSLRTAALGPDSMGg-------PVP-----RQRLQLYLTLGAaAFQPLIIYWLT 288
EFC49411     280 MVTFMIKSLRRSSVHSSDNSmrl---rlDTN-----TAKRNYFIFIVA-ILQIPLFFFLT 330
Q54XV4       329 IAFFMLKTLRLVFSSVSGAHdhis-pdyHES-----GKIKNYFVFGFS-VAQALLCFLV- 380 Dictyostelium discoideum AX4
EFA81589     283 IGWFMICTLRVVLLNDNNMHsdm---hhFEG-----TTKRKYFVFAVA-ILQVVLILLYS 333
XP_004361058 282 LGVFILKTLRVVMVSDNSANshhdmhqqHEG-----SAMRNYFVFGVA-MLQCVILFFFN 335
XP_014345204 243 LMYFIVRSLRMKILSTLTADg-------VVG--HNTKNRMRMYITVAVaGFQPLIIYWLT 293 coelacanth
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