6M4N


Conserved Protein Domain Family
SPT_ssu-like

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pfam11779: SPT_ssu-like 
Small subunit of serine palmitoyltransferase-like
Serine palmitoyltransferase (SPT) catalyzes the first committed step in sphingolipid biosynthesis. In mammals, two small subunits of serine palmitoyltransferase, ssSPTa and ssSPTb, substantially enhance the activity of SPT, conferring full enzyme activity upon it. The 2 ssSPT isoforms share a conserved hydrophobic central domain, which is predicted to reside in the membrane.
Statistics
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PSSM-Id: 463347
Aligned: 62 rows
Threshold Bit Score: 44.8789
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6M4N_D        31 WKQMSWFYYQYLLVTALYMLEPWERTVF------------NSM----------LVSIVGMALYTGYVF----MPQHIMAI 84 
NP_973572      1 MNWVQRKIYLYNVTFGLYMLDWWERYLF------------NSL----------VLILMWFILYNGSRY----FSELCKRh 54 
Q0D6S2         4 MNWVSRKIHLYNVTMGLYMLDWWERCLF------------SILfhltpycllqIIIIAIFLLILSSGF----WLDSirfg 67  Japanese rice
EEC81956       4 MNWVSRKIHLYNVTMGLYMLDWWERCLF------------NMM----------VLILLWFVCFNGSRFasdvFDSHLKAR 61 
XP_007873056   7 iRFLKKKYIQYEVTFALNMLTTTEKIIV------------NFI----------FISITALVLMSVYVY----FPEHLRQL 60 
ELU43916     231 KRFLWRRQIWFESTFALSMLEPWEKILIsesscsaadaeeLAL----------IF-VWSLFITGAVRY----LPNHISTM 295
1_pfamImport   1 -NKIKRLKLALEATTAMNMLEPFEYYAM------------YTV----------ILLLFFLALYGCYWF----LPSHLRHL 53 
SAM75609      82 QRKLFRAYWNVEATFVLSMLEAWEVFLV------------IMV----------FLTLTLLLWYSAYHY----FPRHAREV 135
EST10136      80 ERNLFRTYWNIEGTFVLSMLEAWEVFLV------------ICV----------FITLTLLLCYTVVHY----LPRHASEV 133
KIS70990      79 ERTLFRAYWNIEGTFVLSMLEVWEVFLV------------IVV----------FCLLTLLLWYSLIHY----FPRHAQQV 132
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