6T36,1WCH,2G59,6J6U,2C7S,6UZT,6J6U,2QEP,4GFV,3BRH,1L8K,4GE2,1ZC0,2CJZ,6KRX


Conserved Protein Domain Family
Y_phosphatase

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pfam00102: Y_phosphatase 
Protein-tyrosine phosphatase
Statistics
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PSSM-Id: 459674
Aligned: 90 rows
Threshold Bit Score: 150.47
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6T36_A  670 NLDKNRYKDVLPYDTTRVLL--------------------------------QGNE---D--YINASYVnm--------- 703  human
Q18385  174 NTFKNQRKDVPCIDDTRVKL-----------------------------------AdpnIvyYIHANHIm---------- 208  Caenorhabditis elegans
Q9VUH6 1557 FPEKNRSLDCLPYDHARVKLdk------------------------------------qTddYINAAYM----------- 1589 fruit fly
Q18652  243 NMDKNRFVDVICMDHSRVKLt--------------------------------------DssYIHANWV----------- 273  Caenorhabditis elegans
Q20179  225 NMHKNRFADVICLDHSKVHLs--------------------------------------DssYIHASYL----------- 255  Caenorhabditis elegans
O45079  180 NLQMNQADNYPILDSTIVKNpa------------------------------------qPdsYVNMSSVi---------- 213  Caenorhabditis elegans
O45095  243 NKVRNREGCPKIYDENRVQL---------------------------------NRPgheDvnYINASVItltdvcrrmac 289  Caenorhabditis elegans
O01923  808 EQMKQRLPIPLVMD-TRVVL--------------------------------KDYGtlfNddYIHANRV----------- 843  Caenorhabditis elegans
Q20402  237 YLTKARSKMVPCAEFSRVKLndglgrlddrnelrngmfsdeheflqeegytaKSTYgttD--FIHANYV----------- 303  Caenorhabditis elegans
O61789  432 NQEKCRNPRVHCRDSTRIAL--------------------------------QFPRgqyLgdFIHANRI----------- 468  Caenorhabditis elegans
6T36_A  704 ------eiPAAN-L---VNKYIATQGP-------LP-HTCAQFWQVVWDQK-LSLIVMLTTLTER---------GR-TKC 754  human
Q18385  209 -------------FdhlKKTYITTQHP-------LP-GTLNDFWAMVADQK-VETIVSLTSSSSAsn---------pNVY 257  Caenorhabditis elegans
Q9VUH6 1590 -----------KnLsagCPNFIVAQTP-------QP-NTINDFWSMIWSEK-SRTVVCLHTPNE--------------LF 1635 fruit fly
Q18652  274 --------DLNS-----SKKAILTQLP-------LS-HTASDFWQMIIDQK-IKCVLLIMTDGEF---------NK-FGG 321  Caenorhabditis elegans
Q20179  256 --------ELDT-----QKRAILTQLP-------LP-HTSADFWQMIIEQR-VKCVLLLLTDSEY---------DS-LGG 303  Caenorhabditis elegans
O45079  214 -------------VphcRYPILMAQMP--------KrGFEEEFWRAAFNESvVIMYVLMGTEDEK--------------- 257  Caenorhabditis elegans
O45095  290 vpayvhlvVLYFvIfqfEHKLIVAQLPqm---enE--SFVEDFWYMIYQEQ-IHLVYLMVPDDKl---------KN-TTT 353  Caenorhabditis elegans
O01923  844 -------------TcshGLQLILSQAPqeangesCE-STIESYWWTAKQEK-STQLVMMCDFDEKc-------pGKtNSC 901  Caenorhabditis elegans
Q20402  304 --------KGGP-L---LNTFICAQAP-------LK-NTQEDFWRMVFQEK-CQFIVMLNSAVDSstlgpldsaNR-NHC 361  Caenorhabditis elegans
O61789  469 --------SGKPlF----NEFIMTQAP-------MK-NTVDDFWRMVWQEE-VPYIVMLTSRKEP------------ERC 515  Caenorhabditis elegans
6T36_A  755 HQYWPd-pPD--VMNHGGFHIQCQ----SED-CTiAYVSREMLVTNTQTG---EeHTV-THLQYVAWP-DHGVP--DD-- 817  human
Q18385  258 PMYYPnkpET--FNNFGQFFVYCKtvtqPKTkYGcKEYKFELVVQADNEEr-----RSvRLYHYPHWT-KNMVP--AS-- 325  Caenorhabditis elegans
Q9VUH6 1636 DPYWPqalDQ--PTHYDDYTVTCLk--vQQLsHCsEYQLK---LSMHGADa----VLDlSLLQLKQWT-KGA-------- 1695 fruit fly
Q18652  322 NSVFPq-nQD--FLKFEDRFIRVGe--fKQVeLGkGWNLKVLSVSNGTYKt-----FI-HVHHYKNWP-HGSIP--SD-- 385  Caenorhabditis elegans
Q20179  304 DFVFPr-nQD--FLNFEERSIRVGe--fKRVeIMdGWVLKVVSVSNGDYKs-----FL-HIHHYNAWP-HNNIP--GNgs 369  Caenorhabditis elegans
O45079  258 NDFFPttmGA--YVYYGAMFVNIRk---VEKmDEeRTRYTIEVLPNGFSNs-----VMmNVYVHTGWE-ASGVPvrYAn- 325  Caenorhabditis elegans
O45095  354 SLFNDe-nGG--YQYTGKMFINNRr--aDVSgDPkEYTIEVLPEGNSDS-------VIcQVHHHAPWK-HLQQP--PK-- 416  Caenorhabditis elegans
O01923  902 ARYYPesvGE--SMKFKNLTVECK-----SKiAEkDFETRELEVKFDGHEp-----HTvTHSRLVGWN-PLNVQ--PD-- 964  Caenorhabditis elegans
Q20402  362 PYYWPraeNE--SLRFGSFHITCMk--vDSKaDP-LFTITKLKVQKVGGNlldA--EFdEELFLEHWQwDWQ-------- 426  Caenorhabditis elegans
O61789  516 EYYWPkspSDpaVTVPGGLRIENF-----GVyQApDPLFRVTHLRLIGPDr--------EERHVEHWQgDVN-------- 574  Caenorhabditis elegans
6T36_A  818 ---SSDFL----EFVNYVRSLR-V-D--SEPVLVHCSAGIGRTGVLVTMETAMCLTERNLP---IYPLDIVRKMRDQRAM 883  human
Q18385  326 ---SKVVL----NLVKKIGKKKs-----QAPVVVQCETGVNQSAELVFVDAMCTLLTRqv---eVNFDVLFRQMRSQKAL 390  Caenorhabditis elegans
Q9VUH6 1696 ---PAQLLgvaeNALETHRQRCkAaNapQSPLIMNCLTGSERS-ELVAIGVCAIIATQNKQpilLNTIDVWSRICAQRQN 1771 fruit fly
Q18652  386 ---VKQIW----QVQSYLRKYTd-----GHPPVYMSMSGCGRAGTFALFETAHMSLHNEQPs--LNMVKCLENVRNGRLH 451  Caenorhabditis elegans
Q20179  370 pkfVKQIW----QLQSVLRKYSp-----STPTVYMSLSGCGRAGTFALFETAHLSLHSEQAt--LDLVKCLEMVRNGRIH 438  Caenorhabditis elegans
O45079  326 --tTRSVV----DVMNFVKTSSg-----TEKMLVVSKNGCGRAGFFLSLGAAFCCLNDns---ePRIGEIVKAIRSQRPN 391  Caenorhabditis elegans
O45095  417 ---TLPII----KMIHQFLSEK---QvqNAGVCVVSLFGCGRACSFIGALYAINQLNNGIE---PNICEIMKNIKQQRPG 483  Caenorhabditis elegans
O01923  965 ---TLLFT----SLIQKIKNST-------TPVMVHCIDGISRSAAFASMIIGYQLVIQ--SlgsVKLEAVVSYIRSQRAM 1028 Caenorhabditis elegans
Q20402  427 ---YLGDVhwpfRVLRKARQLS-------TPTIVQCIDGCSKSGTLVSIETALMHFIRGSPitkSLILQSCVFVRLQRRL 496  Caenorhabditis elegans
O61789  575 ---NSSNMysplNILRLLRNAS-------KPVVIHDHLGVSRAACLVAAEIAICSLLR-GPtykYPVQRAVQFLRQRRPF 643  Caenorhabditis elegans
6T36_A  884 MVQTSSQYKFVCEAILR 900  human
Q18385  391 AMTQLLHFLHSIATVMK 407  Caenorhabditis elegans
Q9VUH6 1772 SLRDSAILEQSMQIVLC 1788 fruit fly
Q18652  452 SVQNLSQFSVVYTLIAE 468  Caenorhabditis elegans
Q20179  439 ACQNLTQFSFVYTLLAE 455  Caenorhabditis elegans
O45079  392 AVDSIKQYASIYLCFVY 408  Caenorhabditis elegans
O45095  484 GVESFAQYASIYAIVFD 500  Caenorhabditis elegans
O01923 1029 AITSALELAFVDAGIVK 1045 Caenorhabditis elegans
Q20402  497 SVSSVLLYLFIYRVILR 513  Caenorhabditis elegans
O61789  644 SIETPMQYIFVHRLVAF 660  Caenorhabditis elegans
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