2WP8,2DOK


Conserved Protein Domain Family
PINc

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smart00670: PINc 
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Large family of predicted nucleotide-binding domains
From similarities to 5'-exonucleases, these domains are predicted to be RNases. PINc domains in nematode SMG-5 and yeast NMD4p are predicted to be involved in RNAi.
Statistics
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PSSM-Id: 214771
Aligned: 86 rows
Threshold Bit Score: 33.5513
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2WP8_J         62 HYVVLDTNVVLQAI-DLLENP--Nc-----fFDVIVPQIVLDEVRNK-----------S-------------YPVYTRLR 109  baker's yeast
Q12129          4 YNFIIDASAFEKGL-GNIKRWc-SdcteavtLNFYIPTFTLNELDFL-----------Qqrrk-----sfaaRESLKFID 65   Saccharomyces...
Q9RVB1        144 GGKILDSNVIIDGR-IVALAQt-Gfl----dGDLIVPAFILRELQTL-----------S---------------DNADAN 191  Deinococcus r...
XP_002800291 1375 lfLVPDTNGFIDHLasLARLLe-Sr-----kYILVVPLIVINELDGL-----------Akgq-------etdHRAGGYAR 1430 rhesus monkey
NP_497566    1065 EYLIPDTNVLIGDLq-LMKNLl-EtaqknkkFQILVPTTVLDELQYIakls---pldsK-------------SNSEAHDP 1126 nematode
EGA78387      943 lYFVIDATSWLRHFa-hIFKLakNn-----tLKFAICLTTFQELRYLrgskddtvveaA-------------TRSVITIR 1003 Saccharomyces...
NP_441523     160 PPKVVDTSCIIDGRiEPLLATg-Fi-----eGQVLVPQFVLAELQQL-----------Adasn-----dqkrVRGRRGLD 217  Synechocystis...
NP_387970     166 KLKILDTSVIIDGR-IADICQt-Gfl----eGVIVIPQFVLEELQHI-----------Adssd-----vlkrNRGRRGLD 223  Bacillus subt...
EDZ70807     1024 TYFVFDATSWLRHS-ARIFKLa-Qnr----lLRFAICLTTFQELRFL-----------Rkskden--vmeaaTRGIITIR 1084 Saccharomyces...
CAD89221      772 RYLLPDTNCFIDCL-EDFEKLs-Tef---krYTLIIPLTVVKELDGL-----------SkgvkldsyrsskqTQRIHHFD 835  fruit fly
2WP8_J        110 TLCRdsDDHKRFIVFHNE-F-----------SEHT----------FVERLPNETi-----ND------R-----NDRAIR 151  baker's yeast
Q12129         66 RLDD--SKFANLKVFIEF-Pevl-----diiLWSD----------VMEHNDSSGkiniakLP------K-----RLKNLL 116  Saccharomyces...
Q9RVB1        192 KRTR---GKRGLSVLEEL-Re----------LRPL----------RIEDWDDPH------LP------T-----TDDKLI 230  Deinococcus r...
XP_002800291 1431 VVQE--KARKSIEFLEQR-Fe----------SRDSclraltsrgnELESIAFRSe-----dI------TgqlgnNDDLIL 1486 rhesus monkey
NP_497566    1127 ERIS--KAKIAVAWLKEQ-AkqktghlytltTTGK----------RLPTLSIVSe-----dLeghemtT-----NDDMIL 1183 nematode
EGA78387     1004 QLYD--EKKIIPMRFTGNiAt----------HVEE----------NLEFEEQITw-----kT------H-----VDEFVI 1045 Saccharomyces...
NP_441523     218 ILGS---IQADFPES----------------IVIH----------SADYDDIAT--------------------VDAKLV 248  Synechocystis...
NP_387970     224 ILNR---IQKELDIE----------------VEIY----------EGDFEDIQE--------------------VDSKLV 254  Bacillus subt...
EDZ70807     1085 QLYY--ENKVLPLRFTGNva----------tHIEE----------NLEFEEQITw-----rT------H-----VDEFVI 1126 Saccharomyces...
CAD89221      836 EVSS--RAKKSLEFIKSA-Kgnvk----catTKGS----------FVNASVFALvee--eyL------S-----NDDKIL 885  fruit fly
2WP8_J        152 KTCQWYSehlk----------pydiN--------------------VVLVTNDRLNRE 179  baker's yeast
Q12129        117 KSCIYKCyleg----------neglH--------------------WFLISEDPQIRE 144  Saccharomyces cerevisiae S288c
Q9RVB1        231 RLARET-------------------G--------------------AKLLTNDTNLAK 249  Deinococcus radiodurans
XP_002800291 1487 SCCLHYC------------------KdkakdfmpaskeepirllreVVLLTDDRNLRV 1526 rhesus monkey
NP_497566    1184 NSALRWSeslpgsta--psateisqK--------------------CVLITGDRGLti 1219 nematode
EGA78387     1046 DAIAKLN------------------Qrfqaerltd--enknkgkefAVLVTDDDNMNQ 1083 Saccharomyces cerevisiae Vin13
NP_441523     249 HLAQEI-------------------N--------------------GILLTNDYNLSK 267  Synechocystis sp. PCC 6803
NP_387970     255 KLAKLT-------------------S--------------------GVVVTNDFNLNK 273  Bacillus subtilis subsp. subtilis s...
EDZ70807     1127 ESVMKAQeklesasep-rlsprrfnY--------------------VVLISDDDAMKK 1163 Saccharomyces cerevisiae AWRI1631
CAD89221      886 ATAMAVSktakteqctadgkcfiqtE--------------------LVLITTDRNLRV 923  fruit fly
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